02881nam a2200397 a 450000100080000000500110000800800410001910000230006024501420008326002050022550000540043052015880048465000180207265000190209065000100210965000130211965000170213265000230214965000210217265000120219365000200220565000160222565000250224165000100226665000110227665000200228765000210230765300280232865300190235665300160237565300130239165300200240470000200242470000220244470000170246620792642019-09-23       2017    bl uuuu     u00u1 u    #d1 aMESQUITA, R. J. M.  aChemical composition and anthelmintic activity in vitro of the essential oil of Mentha piperitabpreliminary data.h[electronic resource]  aIn: INTERNATIONAL CONFERENCE OF THE WORLD ASSOCIATION FOR THE ADVANCEMENT OF VETERINARY PARASITOLOGY, 26., 2017, Kuala Lumpur, Malaysia. Abstract book. Perth: WAAVP, 2017. p. 445. Abstract 4884.c4884  aIn conjunction with 53rd MSPTM Annual Conference.  aAbstract: Research towards plant compounds with activity against worm parasites has been carried out for a number of decades; however it is especially important now when drench resistance has compromised the effectiveness of present control methods. In this study we characterized the composition of Mentha piperita essential oil and evaluated its anthelmintic effect against developmental stages of trichostrongylids from naturally infected goats (95% Haemonchus contortus and 5% Trichostrogylus spp.) through the egg hatch and larval development assays. The major constituent of the tested substance quantified by gas chromatography was menthol (58.35%). The lowest concentration of essential oil with 100% efficacy in all in vitro tests against caprine trichostrongylids was 0.35%. However, the equivalent dose of menthol alone (0.4%) was not fully effective against nematode egg eclosion. The anthelmintic activity of the essential oil of M. piperita showed good effectiveness in previous studies but also showed the presence of toxic compounds such as pulegone which could be toxic to goats according to allometric extrapolation. Our results show that the major component in the essential oil is not the only one responsible for the antiparasitic effect of M. piperita. Also, our data support the idea there is a wide variation in the composition of essential oils obtained from different sources. Thus, it is important that in assessing anthelmintic activity of plant candidates, the chemical composition should be thoroughly investigated before proceeding to the in vivo step.  aAnthelmintics  aEssential oils  aGoats  aNematoda  aPhytotherapy  aTrichostrongylidae  aAnti-helmíntico  aCaprino  aExtrato vegetal  aFitoterapia  aHaemonchus Contortus  aMenta  aMentha  aÓleo essencial  aPlanta medicinal  aAção antiparasitária  aCulinary herbs  aDrug plants  aPulegone  aTrichostrogylus1 aMONTEIRO, J. P.1 aCATUNDA, F. E. A.1 aTEIXEIRA, M.