02378naa a2200289 a 450000100080000000500110000800800410001910000230006024501490008326000090023250001690024152013530041065000090176365000200177265000250179265000160181765000090183365000170184265300260185965300150188565300150190070000180191570000220193370000200195570000220197577300910199720784362017-12-29       2017    bl uuuu     u00u1 u    #d1 aCARAGELASCO, D. S.  aUrine protein electrophoresis study in dogs with pituitary dependent hyperadrenocorticism during therapy with trilostane.h[electronic resource]  c2017  aTítulo em português: Avaliação da proteína urinária por eletroforese em cães com hiperadrenocorticismo hipófise dependente durante a terapia com trilostano.  aHyperadrenocorticism is one of the most common endocrine disorders in dogs. Regarding to the kidneys, chronic hypercortisolemia can cause damage to the glomerulus, and evolve into chronic kidney disease. This study evaluated nine normotensive dogs with pituitary dependent hyperadrenocorticism, before and after therapy with trilostane, during the follow-up period of six months, in order to investigate the development of pathological proteinuria by quantitative (urinary protein-to-creatinine ratio) and qualitative (urinary protein electrophoresis) methods, and also to monitor its intensity over the course of the disease and therapy. The main renal lesion detected in dogs with hyperadrenocorticism was in the tubular segment, evidenced by the prevalence of urinary protein bands of lower molecular weight, indicating the lack absorption of these proteins in the proximal segment of the nephron. Low molecular weight proteins persisted throughout the follow-up. Regarding the future of routine veterinary medical clinic in the care of patients with hyperadrenocorticism, the assessments of proteinuria determinations by the urinary protein-to-creatinin ratio and urinary protein electrophoresis, according to the results obtained in this study, can add more information about the renal damage in these animals, and contribute to the prognosis.  aDogs  aElectrophoresis  aHyperadrenocorticism  aproteinuria  aCão  aEletroforese  aHiperadrenocorticismo  aTrilostane  aTrilostano1 aKOGIKA, M. M.1 aMARTORELLI, C. R.1 aKANAYAMA, K. K.1 aSIMÕES, D. M. N.  tPesquisa Veterinária Brasileira, Rio de Janeirogv. 37, n. 7, p. 734-740, julho 2017.