02484naa a2200337 a 450000100080000000500110000800800410001910000210006024501090008126000090019050001110019952013420031065000310165265000130168365000320169665000370172865000200176565000130178565300390179865300220183765300130185965300330187270000190190570000190192470000190194370000300196270000220199270000200201470000210203477300910205520737282017-12-29       2017    bl uuuu     u00u1 u    #d1 aDANIEL, A. G. S.  aMinimum inhibitory concentration of Brazilian Brachyspira hyodysenteriae strains.h[electronic resource]  c2017  aTítulo em português: Concentração inibitória mínima de cepas Brachyspira hyodysenteriae brasileiras.  aThe objectives of this study were to characterize Brachyspira hyodysenteriae isolates and to evaluate the antimicrobial susceptibility patterns of strains obtained from pigs in Brazil based on the minimal inhibitory concentration test (MIC). The MIC was performed for 22 B. hyodysenteriae isolates obtained from 2011 to 2013 using the following antimicrobial drugs: tylosin, tiamulin, valnemulin, doxycycline, lincomycin and tylvalosin. Outbreaks of swine dysentery were diagnosed based on clinical presentation, bacterial isolation, gross and microscopic lesions, duplex PCR for B. hyodysenteriae and B. pilosicoli and nox gene sequencing. All obtained MIC values were consistently higher or equal to the microbiological cut-off described in the literature. The MIC 90 values for the tested drugs were 8?g/ml for doxycycline, &gt4?g/ml for valnemulin, 8?g/ml for tiamulin, 32?g/ml for tylvalosin, &gt64?g/ ml for lincomycin and &gt128?g/ml for tylosin. These results largely corroborate those reported in the literature. Tiamulin, doxycycline and tylvalosin showed the lowest MIC results. All of the samples subjected to phylogenetic analysis based on the nox gene sequence exhibited similar results, showing 100% identity to B. hyodysenteriae. This is the first study describing the MIC pattern of B. hyodysenteriae isolated in Brazil.  aBrachyspira hyodysenteriae  aDiarrhea  aInhibitory concentration 50  aMinimum inhibitory concentration  aSwine dysentery  aDiarreia  aConcentração inibitória mínima  aDisenteria suína  aNox gene  aSensibilidade antimicrobiana1 aSATO, J. P. H.1 aGABARDO, M. P.1 aRESENDE, T. P.1 aBARCELLOS, D. E. S. N. de1 aPEREIRA, C. E. R.1 aVANNUCCI, F. A.1 aGUEDES, R. M. C.  tPesquisa Veterinária Brasileira, Rio de Janeirogv. 37, n. 4, p. 331-338, abril 2017.