02703naa a2200313 a 450000100080000000500110000800800410001902400300006010000190009024501230010926000090023252018390024165000140208065000150209465000190210965000170212865000140214565000140215965000100217365000160218365300190219965300110221865300230222965300220225270000150227470000150228970000180230477300670232220713522017-06-22       1989    bl uuuu     u00u1 u    #d7 a0.1677/joe.0.12206332DOI1 aBASSETT, J. M.  aEffects of altered photoperiod or maternal melatonin administration on plasma prolactin concentrations in fetal lambs.  c1989  aAbstract: During winter (December to March), when late-pregnant ewes were maintained under an artificial long-day photoperiod (16 h light) for 3 weeks or more before insertion of fetal vascular cannulae between 118 and 120 days of gestation (full term, 147 days), plasma prolactin concentrations in their fetal lambs were significantly increased throughout the last 3 weeks of gestation in comparison with values in similar aged fetuses from ewes experiencing only the natural short-day (less than 9 h light) winter photoperiod. When additional lighting was given only after vascular cannulation, fetal plasma prolactin increased steadily from low values, characteristic of winter pregnancies, to high values, characteristic of long-day (16 h light:8 h darkness) pregnancies. Maternal plasma prolactin concentrations changed in a similar way. During summer pregnancies (greater than 16 h light), plasma prolactin in fetal lambs was significantly reduced within 48 h when ewes were given melatonin by i.v. infusion for 14 h each night to simulate the winter duration of the nocturnal increase in plasma melatonin. Maternal plasma prolactin concentrations also decreased significantly when melatonin was given for 3 weeks, but not in a shorter experiment. Increases in fetal plasma prolactin were proportional to the basal prolactin concentration in fetuses injected i.v. with TRH or a dopaminergic antagonist, metoclopramide, to assess how photoperiod influenced the responsiveness of prolactin secretion to acute stimulation. The results confirm that photoperiod, rather than developmental maturity, is the principal determinant of plasma prolactin in the fetal lamb during the last third of gestation, and provide evidence that photoperiodic information is transmitted to the fetus through the diurnal rhythm of melatonin in the ewe.  aMelatonin  aMetabolism  ametoclopramide  aPharmacology  aPregnancy  aProlactin  aSheep  aThyrotropin  aFetal Exchange  aFoetus  aMaternal behaviour  aReleasing Hormone1 aCURTIS, N.1 aHANSON, C.1 aWEEDING C. M.  tJournal of Endocrinologygv. 122, n. 3, p. 633-644, Jul. 1989.