01323nam a2200253 a 450000100080000000500110000800800410001910000170006024501120007726002740018930000120046350000110047552003720048665000190085865000230087765300200090065300120092065300320093265300420096470000190100670000140102570000140103970000160105320322732020-01-21       2015    bl uuuu     u00u1 u    #d1 aFULAZ, S. F.  aComputational Biology tools in design of an agrochemical against Xylella fastidiosa.h[electronic resource]  aIn: CONGRESS OF THE INTERNATIONAL UNION FOR BIOCHEMISTRY AND MOLECULAR BIOLOGY, 23.; ANNUAL MEETING OF THE BRAZILIAN SOCIETY FOR BIOCHEMISTRY AND MOLECULAR BIOLOGY, 44., 2015, Foz do Iguaçu. Biochemistry for a better world: abstracts book. [Foz do Iguaçu]: SBBqc2015  ap. 143.  aC.016.  aSince its pathogenicity is related to bacterial motility, the protein PilT from the twitching motility system has been chosen as the host target. Using rational drug design, based on a detailed comprehension of the protein host structure, small molecules were designed in order to block the activity of the protein and provoke the loss of the bacterium pathogenicity.  aBioinformatics  aXylella Fastidiosa  aBioinformática  aBiology  aComputational biology tools  aFerramentas de biologia computacional1 aCABRINI, F. M.1 aBORRO, L.1 aTASIC, L.1 aNESHICH, G.