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| 1. |  | BRUNES, L. C.; BALDI, F.; LOPES, F. B.; LOBO, R. B.; ESPIGOLAN, R.; COSTA, M. F. O. e; STAFUZZA, N. B.; MAGNABOSCO, C. de U. Weighted single-step genome-wide association study and pathway analyses for feed efficiency traits in Nellore cattle. Journal of Animal Breeding and Genetics, v. 138, n. 1, p. 23-44, Jan. 2021.| Biblioteca(s): Embrapa Arroz e Feijão; Embrapa Cerrados. |
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| Registros recuperados : 1 | |
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Registro Completo
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Biblioteca(s): |
Embrapa Arroz e Feijão; Embrapa Cerrados. |
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Data corrente: |
25/11/2021 |
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Data da última atualização: |
29/11/2021 |
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Tipo da produção científica: |
Artigo em Periódico Indexado |
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Circulação/Nível: |
A - 1 |
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Autoria: |
BRUNES, L. C.; BALDI, F.; LOPES, F. B.; LOBO, R. B.; ESPIGOLAN, R.; COSTA, M. F. O. e; STAFUZZA, N. B.; MAGNABOSCO, C. de U. |
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Afiliação: |
LUDMILLA C. BRUNES; FERNANDO BALDI; FERNANDO B. LOPES; RAYSILDO B. LÔBO; RAFAEL ESPIGOLAN; MARCOS FERNANDO OLIVEIRA E COSTA, CNPAF; NEDENIA B. STAFUZZA; CLAUDIO DE ULHOA MAGNABOSCO, CPAC. |
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Título: |
Weighted single-step genome-wide association study and pathway analyses for feed efficiency traits in Nellore cattle. |
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Ano de publicação: |
2021 |
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Fonte/Imprenta: |
Journal of Animal Breeding and Genetics, v. 138, n. 1, p. 23-44, Jan. 2021. |
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ISSN: |
1439-0388 |
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DOI: |
https://doi.org/10.1111/jbg.12496 |
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Idioma: |
Inglês |
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Conteúdo: |
Abstract The aim was to conduct a weighted single-step genome-wide association study to detect genomic regions and putative candidate genes related to residual feed intake, dry matter intake, feed efficiency (FE), feed conversion ratio, residual body weight gain, residual intake and weight gain in Nellore cattle. Several protein-coding genes were identified within the genomic regions that explain more than 0.5% of the ad- ditive genetic variance for these traits. These genes were associated with insulin, leptin, glucose, protein and lipid metabolisms; energy balance; heat and oxidative stress; bile secretion; satiety; feed behaviour; salivation; digestion; and nutrient ab- sorption. Enrichment analysis revealed functional pathways (p-value<.05) such as neuropeptide signalling (GO:0007218), negative regulation of canonical Wingless/ Int-1 (Wnt) signalling (GO:0090090), bitter taste receptor activity (GO:0033038), neuropeptide hormone activity (GO:0005184), bile secretion (bta04976), taste trans- duction (bta0742) and glucagon signalling pathway (bta04922). The identification of these genes, pathways and their respective functions should contribute to a better understanding of the genetic and physiological mechanisms regulating Nellore FE- related traits. |
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Palavras-Chave: |
Etapa única ponderada; Ração residual. |
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Thesagro: |
Gado; Gado Nelore; Ganho de Peso. |
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Thesaurus NAL: |
Body weight; Cattle; Feed intake; Nellore. |
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Categoria do assunto: |
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L Ciência Animal e Produtos de Origem Animal |
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URL: |
https://ainfo.cnptia.embrapa.br/digital/bitstream/item/228117/1/Marcos-Fernando-Weighted-single-step-genome-wiede-association.pdf
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Marc: |
LEADER 02281naa a2200337 a 4500
001 2136743
005 2021-11-29
008 2021 bl uuuu u00u1 u #d
022 $a1439-0388
024 7 $ahttps://doi.org/10.1111/jbg.12496$2DOI
100 1 $aBRUNES, L. C.
245 $aWeighted single-step genome-wide association study and pathway analyses for feed efficiency traits in Nellore cattle.$h[electronic resource]
260 $c2021
520 $aAbstract The aim was to conduct a weighted single-step genome-wide association study to detect genomic regions and putative candidate genes related to residual feed intake, dry matter intake, feed efficiency (FE), feed conversion ratio, residual body weight gain, residual intake and weight gain in Nellore cattle. Several protein-coding genes were identified within the genomic regions that explain more than 0.5% of the ad- ditive genetic variance for these traits. These genes were associated with insulin, leptin, glucose, protein and lipid metabolisms; energy balance; heat and oxidative stress; bile secretion; satiety; feed behaviour; salivation; digestion; and nutrient ab- sorption. Enrichment analysis revealed functional pathways (p-value<.05) such as neuropeptide signalling (GO:0007218), negative regulation of canonical Wingless/ Int-1 (Wnt) signalling (GO:0090090), bitter taste receptor activity (GO:0033038), neuropeptide hormone activity (GO:0005184), bile secretion (bta04976), taste trans- duction (bta0742) and glucagon signalling pathway (bta04922). The identification of these genes, pathways and their respective functions should contribute to a better understanding of the genetic and physiological mechanisms regulating Nellore FE- related traits.
650 $aBody weight
650 $aCattle
650 $aFeed intake
650 $aNellore
650 $aGado
650 $aGado Nelore
650 $aGanho de Peso
653 $aEtapa única ponderada
653 $aRação residual
700 1 $aBALDI, F.
700 1 $aLOPES, F. B.
700 1 $aLOBO, R. B.
700 1 $aESPIGOLAN, R.
700 1 $aCOSTA, M. F. O. e
700 1 $aSTAFUZZA, N. B.
700 1 $aMAGNABOSCO, C. de U.
773 $tJournal of Animal Breeding and Genetics$gv. 138, n. 1, p. 23-44, Jan. 2021.
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Registro original: |
Embrapa Arroz e Feijão (CNPAF) |
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