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Registro Completo |
Biblioteca(s): |
Embrapa Amazônia Oriental. |
Data corrente: |
06/10/2017 |
Data da última atualização: |
22/12/2021 |
Tipo da produção científica: |
Artigo em Periódico Indexado |
Autoria: |
GHIZONI, C. V. C.; AMES, A. P. A.; LAMEIRA, O. A.; AMADO, C. A. B.; NAKANISHI, A. B. S.; BRACHT, L.; NATALI, M. R. M.; PERALTA, R. M.; BRACHT, A.; COMAR, J. F. |
Afiliação: |
Cristiane V. Castro Ghizoni, UEM; Ana P. Arssufi Ames, UEM; OSMAR ALVES LAMEIRA, CPATU; Ciomar A. Bersani Amado, UEM; Anacharis B. Sá Nakanishi, UEM; Lívia Bracht, UEM; Maria R. Marçal Natali, UEM; Rosane M. Peralta, UEM; Adelar Bracht, UEM; Jurandir F. Comar, UEM. |
Título: |
Anti-inflammatory and antioxidant actions of Copaiba oil are related to liver cell modifications in arthritic rats. |
Ano de publicação: |
2017 |
Fonte/Imprenta: |
Journal of Cellular Biochemistry, v. 118, n. 10, p. 3409-3423, 2017. |
DOI: |
10.1002/jcb.25998 |
Idioma: |
Inglês |
Conteúdo: |
The present study investigated the action of copaiba oil (Copaifera reticulata) on the systemic inflammation, oxidative status, and liver cell metabolism of rats with adjuvant-induced arthritis. The later is an experimental autoimmune pathology that shares many features with the human rheumatoid arthritis. Holtzman rats were distributed into the following groups: control (healthy) rats; control rats treated with copaiba oil at the doses of 0.58 and 1.15, arthritic rats, and arthritic rats treated with copaiba oil . The oil was administrated orally once a day during 18 days after arthritis induction. Both doses of copaiba oil improved the paw edema and the dose of improved the swollen adrenals and lymph nodes besides decreasing the plasmatic myeloperoxidase activity (30%) of arthritic rats. Copaiba oil abolished the increases of protein carbonyl groups and reactive oxygen species in the liver and both doses increased the liver GSH content and the catalase activity in arthritic rats. Copaiba oil decreased glycolysis (65%), glycogenolysis (58%), and gluconeogenesis (30%) in the liver of arthritic animals. However, gluconeogenesis was also diminished by the treatment of control rats, which presented lower body weight gain (45%) and diminished number of hepatocytes per liver area (20%) associated to higher liver weight (+29%) and increased hepatocyte area (+13%). The results reveal that copaiba oil presented systemic anti-inflammatory and antioxidant actions in arthritic rats. These beneficial effects, however, were counterbalanced by harmful modifications in the liver cell metabolism and morphology of healthy control rats. J. MenosThe present study investigated the action of copaiba oil (Copaifera reticulata) on the systemic inflammation, oxidative status, and liver cell metabolism of rats with adjuvant-induced arthritis. The later is an experimental autoimmune pathology that shares many features with the human rheumatoid arthritis. Holtzman rats were distributed into the following groups: control (healthy) rats; control rats treated with copaiba oil at the doses of 0.58 and 1.15, arthritic rats, and arthritic rats treated with copaiba oil . The oil was administrated orally once a day during 18 days after arthritis induction. Both doses of copaiba oil improved the paw edema and the dose of improved the swollen adrenals and lymph nodes besides decreasing the plasmatic myeloperoxidase activity (30%) of arthritic rats. Copaiba oil abolished the increases of protein carbonyl groups and reactive oxygen species in the liver and both doses increased the liver GSH content and the catalase activity in arthritic rats. Copaiba oil decreased glycolysis (65%), glycogenolysis (58%), and gluconeogenesis (30%) in the liver of arthritic animals. However, gluconeogenesis was also diminished by the treatment of control rats, which presented lower body weight gain (45%) and diminished number of hepatocytes per liver area (20%) associated to higher liver weight (+29%) and increased hepatocyte area (+13%). The results reveal that copaiba oil presented systemic anti-inflammatory and antioxidant actions in arthritic rats. Th... Mostrar Tudo |
Palavras-Chave: |
Toxicidade. |
Thesagro: |
Copaíba; Fígado; Metabolismo; Óleo. |
Categoria do assunto: |
F Plantas e Produtos de Origem Vegetal |
Marc: |
LEADER 02525naa a2200301 a 4500 001 2076843 005 2021-12-22 008 2017 bl uuuu u00u1 u #d 024 7 $a10.1002/jcb.25998$2DOI 100 1 $aGHIZONI, C. V. C. 245 $aAnti-inflammatory and antioxidant actions of Copaiba oil are related to liver cell modifications in arthritic rats.$h[electronic resource] 260 $c2017 520 $aThe present study investigated the action of copaiba oil (Copaifera reticulata) on the systemic inflammation, oxidative status, and liver cell metabolism of rats with adjuvant-induced arthritis. The later is an experimental autoimmune pathology that shares many features with the human rheumatoid arthritis. Holtzman rats were distributed into the following groups: control (healthy) rats; control rats treated with copaiba oil at the doses of 0.58 and 1.15, arthritic rats, and arthritic rats treated with copaiba oil . The oil was administrated orally once a day during 18 days after arthritis induction. Both doses of copaiba oil improved the paw edema and the dose of improved the swollen adrenals and lymph nodes besides decreasing the plasmatic myeloperoxidase activity (30%) of arthritic rats. Copaiba oil abolished the increases of protein carbonyl groups and reactive oxygen species in the liver and both doses increased the liver GSH content and the catalase activity in arthritic rats. Copaiba oil decreased glycolysis (65%), glycogenolysis (58%), and gluconeogenesis (30%) in the liver of arthritic animals. However, gluconeogenesis was also diminished by the treatment of control rats, which presented lower body weight gain (45%) and diminished number of hepatocytes per liver area (20%) associated to higher liver weight (+29%) and increased hepatocyte area (+13%). The results reveal that copaiba oil presented systemic anti-inflammatory and antioxidant actions in arthritic rats. These beneficial effects, however, were counterbalanced by harmful modifications in the liver cell metabolism and morphology of healthy control rats. J. 650 $aCopaíba 650 $aFígado 650 $aMetabolismo 650 $aÓleo 653 $aToxicidade 700 1 $aAMES, A. P. A. 700 1 $aLAMEIRA, O. A. 700 1 $aAMADO, C. A. B. 700 1 $aNAKANISHI, A. B. S. 700 1 $aBRACHT, L. 700 1 $aNATALI, M. R. M. 700 1 $aPERALTA, R. M. 700 1 $aBRACHT, A. 700 1 $aCOMAR, J. F. 773 $tJournal of Cellular Biochemistry$gv. 118, n. 10, p. 3409-3423, 2017.
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Registro original: |
Embrapa Amazônia Oriental (CPATU) |
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Biblioteca(s): |
Embrapa Gado de Leite. |
Data corrente: |
20/12/2018 |
Data da última atualização: |
22/08/2022 |
Tipo da produção científica: |
Artigo em Periódico Indexado |
Circulação/Nível: |
A - 2 |
Autoria: |
MOREIRA, E. de A.; SOUZA, S. M. de; FERREIRA, A. L.; TOMICH, T. R.; AZEVÊDO, J. A. G.; SOUZA SOBRINHO, F. de; BENITES, F. R. G.; MACHADO, F. S.; CAMPOS, M. M.; PEREIRA, L. G. R. |
Afiliação: |
ELLEN DE ALMEIDA MOREIRA, UESC, Ilhéus, BA; SHIRLEY MOTTA DE SOUZA; ALEXANDRE LIMA FERREIRA, UFSJ; THIERRY RIBEIRO TOMICH, CNPGL; JOSÉ AUGUSTO GOMES AZEVÊDO, UESC, Ilhéus, BA; FAUSTO DE SOUZA SOBRINHO, CNPGL; FLAVIO RODRIGO GANDOLFI BENITES, CNPGL; FERNANDA SAMARINI MACHADO, CNPGL; MARIANA MAGALHAES CAMPOS, CNPGL; LUIZ GUSTAVO RIBEIRO PEREIRA, CNPGL. |
Título: |
Nutritional diversity of Brachiaria ruziziensis clones. |
Ano de publicação: |
2018 |
Fonte/Imprenta: |
Ciência Rural, v. 48, n. 2, e20160855, 2018. |
DOI: |
http://dx.doi.org/10.1590/0103-8478cr20160855 |
Idioma: |
Inglês |
Conteúdo: |
ABSTRACT - The aim of this study was to evaluate the nutritional diversity of Brachiaria ruziziensis clones through chemical composition and in vitro kinetics of ruminal fermentation. Twenty three clones of Brachiaria ruziziensis were used (15, 16, 46, 174, 411, 590, 651, 670, 768, 776, 844, 859, 950, 965, 970, 975, 1067, 1093, 1296, 1765, 1806, 1894 and 1972) and Brachiaria ruziziensis cv. '?Kennedy', Brachiaria brizantha cv. 'Marandu' and Brachiaria decumbens cv. 'Basilisk' as controls within 27 days of harvesting. The experimental design used randomized blocks with 26 treatments (genotypes) and three replications. Evaluation of the nutritional divergence was performed using principal components analysis, based on the following discriminatory variables: in vitro dry matter digestibility (IVDMD), neutral detergent fiber (NDF), lignin, crude protein (CP), degradation rate of non-fibrous carbohydrates (KdNFC) and degradation rate of fibrous carbohydrates (KdFC). The evaluation of the nutritional diversity of Brachiaria genotypes was based on the two main components (IVDMD and NDF), which explains 96.2% of the total variance Variables of lower contribution to the discrimination of the clones were as degradation rates of the fibrous and non-fibrous carbohydrates. In the agglomerative hierarchical grouping analysis, five distinct groups were identified, where V group, formed by clones 46, 768 and 1067 have higher values of IVDMD compared to the other clones. RESUMO - O objetivo deste estudo foi avaliar a divergência nutricional de clones de Brachiaria ruziziensis através da composição química e cinética de fermentação ruminal in vitro. Os tratamentos consistiram de 23 clones de Brachiaria ruziziensis (15, 16, 46, 174, 411, 590, 651, 670, 768, 776, 844, 859, 950, 965, 970, 975, 1067, 1093, 1296, 1765, 1806, 1894 e 1972), e as testemunhas Brachiaria ruziziensis cv ?Kennedy?, Brachiaria brizantha cv ?Marandu? e a Brachiaria decumbens cv ?Basilisk?, colhidas com 27 dias de rebrota. O delineamento experimental utilizado foi o de blocos casualizados, com 26 tratamentos (genótipos) e três repetições. A avaliação da divergência nutricional foi realizada utilizando-se a análise de componentes principais e agrupamento aglomerativo hierárquico. Com base nas seguintes variáveis discriminatórias: digestibilidade in vitro da matéria seca; fibra em detergente neutro; lignina; proteína bruta; taxa de degradação de carboidratos não fibrosos e; taxa de degradação de carboidratos fibrosos. A avaliação da divergência nutricional dos clones de B. ruziziensis baseou-se nos dois primeiros componentes principais (DIVMS e FDN), explicando 96.2% da variância total. As variáveis de menor contribuição para a discriminação dos clones foram as taxas de degradação dos carboidratos fibrosos e não fibrosos. Na análise de agrupamento aglomerativo hierárquico foram identificados cinco grupos distintos, em que o grupo V, formado pelos clones 46, 768 e 1067 destacou-se em relação aos demais por apresentar valores superiores de digestibilidade in vitro da matéria seca. MenosABSTRACT - The aim of this study was to evaluate the nutritional diversity of Brachiaria ruziziensis clones through chemical composition and in vitro kinetics of ruminal fermentation. Twenty three clones of Brachiaria ruziziensis were used (15, 16, 46, 174, 411, 590, 651, 670, 768, 776, 844, 859, 950, 965, 970, 975, 1067, 1093, 1296, 1765, 1806, 1894 and 1972) and Brachiaria ruziziensis cv. '?Kennedy', Brachiaria brizantha cv. 'Marandu' and Brachiaria decumbens cv. 'Basilisk' as controls within 27 days of harvesting. The experimental design used randomized blocks with 26 treatments (genotypes) and three replications. Evaluation of the nutritional divergence was performed using principal components analysis, based on the following discriminatory variables: in vitro dry matter digestibility (IVDMD), neutral detergent fiber (NDF), lignin, crude protein (CP), degradation rate of non-fibrous carbohydrates (KdNFC) and degradation rate of fibrous carbohydrates (KdFC). The evaluation of the nutritional diversity of Brachiaria genotypes was based on the two main components (IVDMD and NDF), which explains 96.2% of the total variance Variables of lower contribution to the discrimination of the clones were as degradation rates of the fibrous and non-fibrous carbohydrates. In the agglomerative hierarchical grouping analysis, five distinct groups were identified, where V group, formed by clones 46, 768 and 1067 have higher values of IVDMD compared to the other clones. RESUMO - O objetivo ... Mostrar Tudo |
Palavras-Chave: |
Discriminating variables; Main components; Nutritional value. |
Thesaurus NAL: |
Digestibility. |
Categoria do assunto: |
F Plantas e Produtos de Origem Vegetal |
URL: |
https://ainfo.cnptia.embrapa.br/digital/bitstream/item/189074/1/Artigo-Ci-Rural-Thierry-Nutritional.pdf
|
Marc: |
LEADER 03977naa a2200289 a 4500 001 2102212 005 2022-08-22 008 2018 bl uuuu u00u1 u #d 024 7 $ahttp://dx.doi.org/10.1590/0103-8478cr20160855$2DOI 100 1 $aMOREIRA, E. de A. 245 $aNutritional diversity of Brachiaria ruziziensis clones.$h[electronic resource] 260 $c2018 520 $aABSTRACT - The aim of this study was to evaluate the nutritional diversity of Brachiaria ruziziensis clones through chemical composition and in vitro kinetics of ruminal fermentation. Twenty three clones of Brachiaria ruziziensis were used (15, 16, 46, 174, 411, 590, 651, 670, 768, 776, 844, 859, 950, 965, 970, 975, 1067, 1093, 1296, 1765, 1806, 1894 and 1972) and Brachiaria ruziziensis cv. '?Kennedy', Brachiaria brizantha cv. 'Marandu' and Brachiaria decumbens cv. 'Basilisk' as controls within 27 days of harvesting. The experimental design used randomized blocks with 26 treatments (genotypes) and three replications. Evaluation of the nutritional divergence was performed using principal components analysis, based on the following discriminatory variables: in vitro dry matter digestibility (IVDMD), neutral detergent fiber (NDF), lignin, crude protein (CP), degradation rate of non-fibrous carbohydrates (KdNFC) and degradation rate of fibrous carbohydrates (KdFC). The evaluation of the nutritional diversity of Brachiaria genotypes was based on the two main components (IVDMD and NDF), which explains 96.2% of the total variance Variables of lower contribution to the discrimination of the clones were as degradation rates of the fibrous and non-fibrous carbohydrates. In the agglomerative hierarchical grouping analysis, five distinct groups were identified, where V group, formed by clones 46, 768 and 1067 have higher values of IVDMD compared to the other clones. RESUMO - O objetivo deste estudo foi avaliar a divergência nutricional de clones de Brachiaria ruziziensis através da composição química e cinética de fermentação ruminal in vitro. Os tratamentos consistiram de 23 clones de Brachiaria ruziziensis (15, 16, 46, 174, 411, 590, 651, 670, 768, 776, 844, 859, 950, 965, 970, 975, 1067, 1093, 1296, 1765, 1806, 1894 e 1972), e as testemunhas Brachiaria ruziziensis cv ?Kennedy?, Brachiaria brizantha cv ?Marandu? e a Brachiaria decumbens cv ?Basilisk?, colhidas com 27 dias de rebrota. O delineamento experimental utilizado foi o de blocos casualizados, com 26 tratamentos (genótipos) e três repetições. A avaliação da divergência nutricional foi realizada utilizando-se a análise de componentes principais e agrupamento aglomerativo hierárquico. Com base nas seguintes variáveis discriminatórias: digestibilidade in vitro da matéria seca; fibra em detergente neutro; lignina; proteína bruta; taxa de degradação de carboidratos não fibrosos e; taxa de degradação de carboidratos fibrosos. A avaliação da divergência nutricional dos clones de B. ruziziensis baseou-se nos dois primeiros componentes principais (DIVMS e FDN), explicando 96.2% da variância total. As variáveis de menor contribuição para a discriminação dos clones foram as taxas de degradação dos carboidratos fibrosos e não fibrosos. Na análise de agrupamento aglomerativo hierárquico foram identificados cinco grupos distintos, em que o grupo V, formado pelos clones 46, 768 e 1067 destacou-se em relação aos demais por apresentar valores superiores de digestibilidade in vitro da matéria seca. 650 $aDigestibility 653 $aDiscriminating variables 653 $aMain components 653 $aNutritional value 700 1 $aSOUZA, S. M. de 700 1 $aFERREIRA, A. L. 700 1 $aTOMICH, T. R. 700 1 $aAZEVÊDO, J. A. G. 700 1 $aSOUZA SOBRINHO, F. de 700 1 $aBENITES, F. R. G. 700 1 $aMACHADO, F. S. 700 1 $aCAMPOS, M. M. 700 1 $aPEREIRA, L. G. R. 773 $tCiência Rural$gv. 48, n. 2, e20160855, 2018.
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