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| 81. |  | CHICRALA, P. C. M. S.; SANTOS, V. R. V. dos. Despesca e abate de peixes. In: RODRIGUES, A. P. O.; LIMA, A. F.; ALVES, A. L.; ROSA, D. K.; TORATI, L. S.; SANTOS, V. R. V. dos (Ed.). Piscicultura de água doce: multiplicando conhecimentos. Brasília, DF: Embrapa, 2013. p. 379-399. il.| Biblioteca(s): Embrapa Pesca e Aquicultura. |
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| 85. | | MELO, S.; SANTOS, V.; AZEVEDO, V.; WADT, L.; MESQUITA, G. Extração de DNA da espécie arbórea Hymenaea courbaril L. utilizando os maceradores automáticos Tissue Lyser e Bead Beater para otimização de protocolo. In: SEMINÁRIO ANUAL DE COOPERAÇÃO UFAC/UF, 7., 2009, Rio Branco. Parcerias em pesquisa e ação para conservação e desenvolvimento sustentável: anais. Rio Branco, AC: Ufac, 2009. p. 316. 1 CD-ROM.| Biblioteca(s): Embrapa Acre. |
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| Registros recuperados : 1.179 | |
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Registro Completo
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Biblioteca(s): |
Embrapa Pecuária Sudeste. |
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Data corrente: |
08/03/2021 |
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Data da última atualização: |
26/04/2021 |
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Tipo da produção científica: |
Artigo em Periódico Indexado |
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Circulação/Nível: |
A - 1 |
|
Autoria: |
LIMA, C. S.; PEREIRA, M. H.; ALEMÁN GAINZA, Y.; HOSTE, H.; REGASINI, L. O.; CHAGAS, A. C. de S. |
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Afiliação: |
CAROLINE SPRENGEL LIMA, UNESP; MATHEUS HENRIQUE PEREIRA, UNESP; YOUSMEL ALEMÁN GAINZA, CNPq; HERVÉ HOSTE, INRA; LUÍS OCTAVIO REGASINI, UNESP; ANA CAROLINA DE SOUZA CHAGAS, CPPSE. |
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Título: |
Anthelmintic effect of Pterogyne nitens (Fabaceae) on eggs and larvae of Haemonchus contortus: analyses of structure-activity relationships based on phenolic compounds. |
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Ano de publicação: |
2021 |
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Fonte/Imprenta: |
Industrial Crops and Products, v.164, june 2021, 113348. |
|
Páginas: |
8 p. |
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Idioma: |
Inglês |
|
Conteúdo: |
Due to high prevalence and large pathogenicity, Haemonchus contortus is the main gastrointestinal nematode in tropical and subtropical regions. This species is responsible for severe economic losses to sheep and goat breeders in Brazil. The control of this parasite is currently compromised, mainly, due to anthelmintic resistance. In the search for natural anthelmintic alternatives, Pterogyne nitens, a native Brazilian tree with potential ethnopharmacological activity, has been identified. The aim of this study was to evaluate the anthelmintic activity of ethanolic extracts and phenolic compounds from P. nitens, as well as two commercial flavonoids (chrysin and morin), to derive the chemical structure and anthelmintic activity. The ovicidal and larvicidal activity of ethanolic extracts from leaves (EEL) and fruits (EEFR), as well as natural compounds from P. nitens on H. contortus were evaluated through egg hatch assay (EHA) and larval development assay (LDA). The results showed that all extracts, especially the phenolic compounds were active in the EHA and LDA. The egg hatch inhibitory effects of EEL (EC50 = 316 μg/mL) were more potent than EEFR (EC50 = 512 μg/mL). However, larval development inhibitory effects of EEL (EC50 = 47 μg/mL) and EEFR (EC50 = 35 μg/mL) were similar. Among the compounds, the flavones (sorbifolin, pedalitin, and chrysin) did not have inhibitory effects on egg hatching but presented some activity against larval development of H. contortus. In contrast, the flavonols (quercetin, rutin, and morin) showed high activity in the EHA but were inactive in the LDA. The addition of at hydroxyl group and rutinose group to the flavonoid structure increased the ovicidal and larvicidal activity, respectively. The phenolic acids showed potent anthelmintic activity: caffeic acid, ferulic acid, and gallic acid had the highest anthelmintic effects, presenting EC50 values of 1.48, 0.56, and 4.93 μg/mL in the EHA; and 31, 22, and 33 μg/mL in the LDA, respectively. These results suggest that P. nitens might be a source of effective alternative compounds to control H. contortus. MenosDue to high prevalence and large pathogenicity, Haemonchus contortus is the main gastrointestinal nematode in tropical and subtropical regions. This species is responsible for severe economic losses to sheep and goat breeders in Brazil. The control of this parasite is currently compromised, mainly, due to anthelmintic resistance. In the search for natural anthelmintic alternatives, Pterogyne nitens, a native Brazilian tree with potential ethnopharmacological activity, has been identified. The aim of this study was to evaluate the anthelmintic activity of ethanolic extracts and phenolic compounds from P. nitens, as well as two commercial flavonoids (chrysin and morin), to derive the chemical structure and anthelmintic activity. The ovicidal and larvicidal activity of ethanolic extracts from leaves (EEL) and fruits (EEFR), as well as natural compounds from P. nitens on H. contortus were evaluated through egg hatch assay (EHA) and larval development assay (LDA). The results showed that all extracts, especially the phenolic compounds were active in the EHA and LDA. The egg hatch inhibitory effects of EEL (EC50 = 316 μg/mL) were more potent than EEFR (EC50 = 512 μg/mL). However, larval development inhibitory effects of EEL (EC50 = 47 μg/mL) and EEFR (EC50 = 35 μg/mL) were similar. Among the compounds, the flavones (sorbifolin, pedalitin, and chrysin) did not have inhibitory effects on egg hatching but presented some activity against larval development of H. co... Mostrar Tudo |
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Palavras-Chave: |
Egg hatch assay (EHA); Ethanolic extracts; In vitro; Larval development assay (LDA). |
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Thesaurus NAL: |
Anthelmintics; Phenolic compounds. |
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Categoria do assunto: |
H Saúde e Patologia |
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URL: |
https://ainfo.cnptia.embrapa.br/digital/bitstream/item/221715/1/AnthelminticEffectPterogyne.pdf
|
|
Marc: |
LEADER 03007naa a2200265 a 4500
001 2130547
005 2021-04-26
008 2021 bl uuuu u00u1 u #d
100 1 $aLIMA, C. S.
245 $aAnthelmintic effect of Pterogyne nitens (Fabaceae) on eggs and larvae of Haemonchus contortus$banalyses of structure-activity relationships based on phenolic compounds.$h[electronic resource]
260 $c2021
300 $a8 p.
520 $aDue to high prevalence and large pathogenicity, Haemonchus contortus is the main gastrointestinal nematode in tropical and subtropical regions. This species is responsible for severe economic losses to sheep and goat breeders in Brazil. The control of this parasite is currently compromised, mainly, due to anthelmintic resistance. In the search for natural anthelmintic alternatives, Pterogyne nitens, a native Brazilian tree with potential ethnopharmacological activity, has been identified. The aim of this study was to evaluate the anthelmintic activity of ethanolic extracts and phenolic compounds from P. nitens, as well as two commercial flavonoids (chrysin and morin), to derive the chemical structure and anthelmintic activity. The ovicidal and larvicidal activity of ethanolic extracts from leaves (EEL) and fruits (EEFR), as well as natural compounds from P. nitens on H. contortus were evaluated through egg hatch assay (EHA) and larval development assay (LDA). The results showed that all extracts, especially the phenolic compounds were active in the EHA and LDA. The egg hatch inhibitory effects of EEL (EC50 = 316 μg/mL) were more potent than EEFR (EC50 = 512 μg/mL). However, larval development inhibitory effects of EEL (EC50 = 47 μg/mL) and EEFR (EC50 = 35 μg/mL) were similar. Among the compounds, the flavones (sorbifolin, pedalitin, and chrysin) did not have inhibitory effects on egg hatching but presented some activity against larval development of H. contortus. In contrast, the flavonols (quercetin, rutin, and morin) showed high activity in the EHA but were inactive in the LDA. The addition of at hydroxyl group and rutinose group to the flavonoid structure increased the ovicidal and larvicidal activity, respectively. The phenolic acids showed potent anthelmintic activity: caffeic acid, ferulic acid, and gallic acid had the highest anthelmintic effects, presenting EC50 values of 1.48, 0.56, and 4.93 μg/mL in the EHA; and 31, 22, and 33 μg/mL in the LDA, respectively. These results suggest that P. nitens might be a source of effective alternative compounds to control H. contortus.
650 $aAnthelmintics
650 $aPhenolic compounds
653 $aEgg hatch assay (EHA)
653 $aEthanolic extracts
653 $aIn vitro
653 $aLarval development assay (LDA)
700 1 $aPEREIRA, M. H.
700 1 $aALEMÁN GAINZA, Y.
700 1 $aHOSTE, H.
700 1 $aREGASINI, L. O.
700 1 $aCHAGAS, A. C. de S.
773 $tIndustrial Crops and Products$gv.164, june 2021, 113348.
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Embrapa Pecuária Sudeste (CPPSE) |
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