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Registro Completo |
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Biblioteca(s): |
Embrapa Instrumentação. |
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Data corrente: |
06/05/2016 |
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Data da última atualização: |
06/05/2016 |
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Tipo da produção científica: |
Artigo em Anais de Congresso |
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Autoria: |
PILON, L.; SPRICIGO, P. C.; MOURA, M. R. de; MIRANDA, M.; OHASHI, T. L.; MATTOSO, L. H. C.; FERREIRA, M. D. |
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Afiliação: |
LUIZ HENRIQUE CAPPARELLI MATTOSO, CNPDIA; MARCOS DAVID FERREIRA, CNPDIA. |
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Título: |
Microbiological quality of fresh-cut apple treated with chitosan nanoparticles-based edible coatings. |
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Ano de publicação: |
2012 |
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Fonte/Imprenta: |
In: WORLD CONGRESS OF FOOD SCIENCE AND TECHNOLOGY, 16.; LATIN AMERICAN SEMINAR OF FOOD SCIENCE AND TECHNOLOGY, 17., 2012, Foz do Iguaçu. Addressing global food security and wellness through food science and technology: abstracts. Foz do Iguaçu: [s.n.], 2012. 1 CD-ROM. IUFoST 2012. |
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Idioma: |
Inglês |
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Palavras-Chave: |
EVENTOS. |
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Categoria do assunto: |
-- |
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Marc: |
LEADER 00799naa a2200193 a 4500
001 2044639
005 2016-05-06
008 2012 bl --- 0-- u #d
100 1 $aPILON, L.
245 $aMicrobiological quality of fresh-cut apple treated with chitosan nanoparticles-based edible coatings.
260 $c2012
653 $aEVENTOS
700 1 $aSPRICIGO, P. C.
700 1 $aMOURA, M. R. de
700 1 $aMIRANDA, M.
700 1 $aOHASHI, T. L.
700 1 $aMATTOSO, L. H. C.
700 1 $aFERREIRA, M. D.
773 $tIn: WORLD CONGRESS OF FOOD SCIENCE AND TECHNOLOGY, 16.; LATIN AMERICAN SEMINAR OF FOOD SCIENCE AND TECHNOLOGY, 17., 2012, Foz do Iguaçu. Addressing global food security and wellness through food science and technology: abstracts. Foz do Iguaçu: [s.n.], 2012. 1 CD-ROM. IUFoST 2012.
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Registro original: |
Embrapa Instrumentação (CNPDIA) |
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Registro Completo
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Biblioteca(s): |
Embrapa Gado de Corte. |
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Data corrente: |
30/12/2019 |
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Data da última atualização: |
30/12/2019 |
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Tipo da produção científica: |
Artigo em Periódico Indexado |
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Circulação/Nível: |
A - 2 |
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Autoria: |
BIGI, M.; VAZQUEZ, C. L.; CASTELÃO, A. B. C.; GARCÍA, E. A.; CATALDI, A. A.; JACKSON, M.; MAcNEIL, M.; SORIA, M.; ZUMÁRRAGA, M. J.; MATIAS, C.; GAGO, G.; BLANCO, F. C.; NISHIBEF, C.; ALMEIDA, N. F.; ARAUJO, F. R.; BIGI, F. |
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Afiliação: |
Mercedes Bigi, Universidad de Buenos Aires, Facultad de Agronomía, Cátedra de Microbiología Agrícola, INBA-CONICET; Cristina Lourdes Vazquez, Universidad de Buenos Aires, Facultad de Agronomía, Cátedra de Microbiología Agrícola, INBA-CONICET; Ana Beatriz C Castelão, Universidad de Buenos Aires, Facultad de Agronomía, Cátedra de Microbiología Agrícola, INBA-CONICET; Elizabeth Andrea García, Instituto de Biotecnología, IABIMO, CICVyA/INTA; Angel A Cataldi, Instituto de Biotecnología, IABIMO, CICVyA/INTA; Mary Jackson, Colorado State University, Dept. of Microbiology, Immunology and Pathology; Michael McNeil, Colorado State University, Dept. of Microbiology, Immunology and Pathology; Marcelo Soria, Universidad de Buenos Aires, Facultad de Agronomía, Cátedra de Microbiología Agrícola, INBA-CONICET; Martín J Zumárraga, Instituto de Biotecnología, IABIMO, CICVyA/INTA; Matias Cabruja, Laboratory of Physiology and Genetics of Actinomycetes, Instituto de Biología Molecular y Celular de Rosario (IBR-CONICET), Facultad de Ciencias Bioquímicas y Farmacéuticas, Universidad Nacional de Rosario; Gabriela Gago, Laboratory of Physiology and Genetics of Actinomycetes, Instituto de Biología Molecular y Celular de Rosario (IBR-CONICET), Facultad de Ciencias Bioquímicas y Farmacéuticas, Universidad Nacional de Rosario; Federico C Blanco, Instituto de Biotecnología, IABIMO, CICVyA/INTA; Christiane Nishibef, Universidade Federal de Mato Grosso do Sul - UFMS/Faculdade de Computação; Nalvo F Almeida, Universidade Federal de Mato Grosso do Sul - UFMS/Faculdade de Computação; FLABIO RIBEIRO DE ARAUJO, CNPGC; Fabiana Bigi, Instituto de Biotecnología, IABIMO, CICVyA/INTA. |
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Título: |
Analysing nonsynonymous mutations between two Mycobacterium bovis strains with contrasting pathogenic profiles. |
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Ano de publicação: |
2019 |
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Fonte/Imprenta: |
Veterinary Microbiology, v. 239, 2019. |
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Idioma: |
Inglês |
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Conteúdo: |
Mycobacterium bovis (M. bovis) is the causative agent of bovine tuberculosis, a chronic infectious disease that can affect cattle, other domesticated species, wild animals and humans. This disease produces important economic losses worldwide. Two M. bovis strains (04-303 and 534) have been isolated in Argentina. Whereas the 04-303 strain was isolated from a wild boar, the 534 strain was obtained from cattle. In a previous study, six weeks after infection, the 04-303 strain induced 100% mortality in mice. By contrast, mice infected with the 534 strain survived, with limited tissue damage, after four months. In this study we compared all predictive proteins encoded in both M. bovis genomes. The comparative analysis revealed 141 polymorphic proteins between both strains. From these proteins, nine virulence proteins showed polymorphisms in 04-303, whereas five did it in the 534 strain. Remarkably, both strains contained a high level of polymorphism in proteins related to phthiocerol dimycocerosate (PDIM) synthesis or transport. Further experimental evidence indicated that only mutations in the 534 strain have an impact on PDIM synthesis. The observed reduction in PDIM content in the 534 strain, together with its low capacity to induce phagosome arrest, may be associated with the reported deficiency of this strain to replicate and survive inside bovine macrophages. The findings of this study could contribute to a better understanding of pathogenicity and virulence aspects of M. bovis, which is essential for further studies aiming at developing new vaccines and diagnostic techniques for bovines. MenosMycobacterium bovis (M. bovis) is the causative agent of bovine tuberculosis, a chronic infectious disease that can affect cattle, other domesticated species, wild animals and humans. This disease produces important economic losses worldwide. Two M. bovis strains (04-303 and 534) have been isolated in Argentina. Whereas the 04-303 strain was isolated from a wild boar, the 534 strain was obtained from cattle. In a previous study, six weeks after infection, the 04-303 strain induced 100% mortality in mice. By contrast, mice infected with the 534 strain survived, with limited tissue damage, after four months. In this study we compared all predictive proteins encoded in both M. bovis genomes. The comparative analysis revealed 141 polymorphic proteins between both strains. From these proteins, nine virulence proteins showed polymorphisms in 04-303, whereas five did it in the 534 strain. Remarkably, both strains contained a high level of polymorphism in proteins related to phthiocerol dimycocerosate (PDIM) synthesis or transport. Further experimental evidence indicated that only mutations in the 534 strain have an impact on PDIM synthesis. The observed reduction in PDIM content in the 534 strain, together with its low capacity to induce phagosome arrest, may be associated with the reported deficiency of this strain to replicate and survive inside bovine macrophages. The findings of this study could contribute to a better understanding of pathogenicity and virulence aspects of M. b... Mostrar Tudo |
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Palavras-Chave: |
Mutations. |
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Thesagro: |
Gene. |
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Thesaurus NAL: |
Genome; Mycobacterium bovis BCG; Virulence. |
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Categoria do assunto: |
-- |
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URL: |
https://ainfo.cnptia.embrapa.br/digital/bitstream/item/207981/1/Analysing-nonsynonymous-mutations.pdf
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Marc: |
LEADER 02585naa a2200361 a 4500
001 2117921
005 2019-12-30
008 2019 bl uuuu u00u1 u #d
100 1 $aBIGI, M.
245 $aAnalysing nonsynonymous mutations between two Mycobacterium bovis strains with contrasting pathogenic profiles.$h[electronic resource]
260 $c2019
520 $aMycobacterium bovis (M. bovis) is the causative agent of bovine tuberculosis, a chronic infectious disease that can affect cattle, other domesticated species, wild animals and humans. This disease produces important economic losses worldwide. Two M. bovis strains (04-303 and 534) have been isolated in Argentina. Whereas the 04-303 strain was isolated from a wild boar, the 534 strain was obtained from cattle. In a previous study, six weeks after infection, the 04-303 strain induced 100% mortality in mice. By contrast, mice infected with the 534 strain survived, with limited tissue damage, after four months. In this study we compared all predictive proteins encoded in both M. bovis genomes. The comparative analysis revealed 141 polymorphic proteins between both strains. From these proteins, nine virulence proteins showed polymorphisms in 04-303, whereas five did it in the 534 strain. Remarkably, both strains contained a high level of polymorphism in proteins related to phthiocerol dimycocerosate (PDIM) synthesis or transport. Further experimental evidence indicated that only mutations in the 534 strain have an impact on PDIM synthesis. The observed reduction in PDIM content in the 534 strain, together with its low capacity to induce phagosome arrest, may be associated with the reported deficiency of this strain to replicate and survive inside bovine macrophages. The findings of this study could contribute to a better understanding of pathogenicity and virulence aspects of M. bovis, which is essential for further studies aiming at developing new vaccines and diagnostic techniques for bovines.
650 $aGenome
650 $aMycobacterium bovis BCG
650 $aVirulence
650 $aGene
653 $aMutations
700 1 $aVAZQUEZ, C. L.
700 1 $aCASTELÃO, A. B. C.
700 1 $aGARCÍA, E. A.
700 1 $aCATALDI, A. A.
700 1 $aJACKSON, M.
700 1 $aMAcNEIL, M.
700 1 $aSORIA, M.
700 1 $aZUMÁRRAGA, M. J.
700 1 $aMATIAS, C.
700 1 $aGAGO, G.
700 1 $aBLANCO, F. C.
700 1 $aNISHIBEF, C.
700 1 $aALMEIDA, N. F.
700 1 $aARAUJO, F. R.
700 1 $aBIGI, F.
773 $tVeterinary Microbiology$gv. 239, 2019.
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