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Registros recuperados : 86 | |
61. | | CINTRA, L. C.; ZERLOTINI NETO, A.; LOBO, F. P.; GIACHETTO, P. F.; FALCAO, P. R. K.; SILVA, L. O. C. da; EGITO, A. A. do; SIQUEIRA, F.; SILVA, N. M. A. da; PAIVA, S. R.; YAMAGISHI, M. E. B.; CAETANO, A. R. Next generation sequencing and de novo assembly of a Nelore (Bos indicus) bull genome. In: ANNUAL MEETING OF THE EUROPEAN FEDERATION OF ANIMAL SCIENCE, 64., 2013, Nantes. Abstracts... Session 25, Poster 34 Biblioteca(s): Embrapa Gado de Corte. |
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62. | | CRUZ, I. R.; GERALDO, L. A.; OLIVEIRA, F. S. DE; LEITE, L. R.; ARAUJO, F.; ZERLOTINI NETO, A.; LOPES, B. C.; ARBEX, W. A.; MACHADO, M. A.; PEIXOTO, M. G. C. D.; VERNEQUE, R. da S.; MARTINS, M. F.; SILVA, M. V. G. B.; COIMBRA, R. S.; CARVALHO, M. R. S.; OLIVEIRA, G. New single nucleotide polymorphisms in guzerá breed revealed by whole-genome re-sequencing. In: INTERNATIONAL CONFERENCE OF THE AB3C; BRAZILIAN SYMPOSIUM ON BIOINFORMATICS, 2013, Recife. Abstract book... Recife: Brazilian Association for Bioinformatics and Computer Biology; Braziian Computer Society, 2013. Biblioteca(s): Embrapa Gado de Leite. |
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63. | | SOUZA, M. M.; ZERLOTINI NETO, A.; TIZIOTO, P. C.; OLIVEIRA, P. S. N.; SOMAVILLA, A. L.; MOKRY, F. B.; CESAR, A. S. M.; DINIZ, W. J. S.; MUDADU, M. de A.; NICIURA, S. C. M.; COUTINHO, L. L.; REGITANO, L. C. de A. Monoallelic expression of NNAT gene in Nelore steers skeletal muscle. In:WORLD CONGRESS OF GENETICS APPLIED TO LIVESTOK PRODUCTION, 10; . 2014, Vancouver. Proceedings... Vancouver: American Society of animal Science, 2014 Biblioteca(s): Embrapa Pecuária Sudeste. |
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64. | | CARDOSO, T. F.; BRUSCADIN, J. J.; AFONSO, J.; PETRINI, J.; ANDRADE, B. G. N.; OLIVEIRA, P. S. N. de; MALHEIROS, J. M.; ROCHA, M. I. P.; ZERLOTINI NETO, A.; FERRAZ, J. B. S.; MOURÃO, G. B.; COUTINHO, L. L.; REGITANO, L. C. de A. EEF1A1 transcription cofactor gene polymorphism is associated with muscle gene expression and residual feed intake in Nelore cattle. Mammalian Genome, v. 33, n. 4, p. 619-628, Dec. 2022. Biblioteca(s): Embrapa Agricultura Digital; Embrapa Pecuária Sudeste. |
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65. | | CESAR, A. S. M.; REGITANO, L. C. de A.; POLETI, M. D.; ANDRADE, S. C. da S.; TIZIOTO, P. C.; OLIVEIRA, P. S. N. de; FELICIO, A. M.; NASCIMENTO, M. L. do; CHAVES, A. S.; LANNA, D. P. D.; TULLIO, R. R.; NASSU, R. T.; KOLTES, J. E.; FRITZ-WATERS, E.; MOURÃO, G. B.; ZERLOTINI NETO, A.; REECY, J. M.; COUTINHO, L. L. Differences in the skeletal muscle transcriptome profile associated with extreme values of fatty acids content. BMC Genomics, London, v. 17, p. 1-16, 2016. Biblioteca(s): Embrapa Agricultura Digital. |
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66. | | CESAR, A. S. M.; REGITANO, L. C. de A.; POLETI, M. D.; ANDRADE, S. C. da S.; TIZIOTO, P. C.; OLIVEIRA, P. S. N. de; FELICIO, A. M.; NASCIMENTO, M. L. do; CHAVES, A. S.; LANNA, D. P. D.; TULLIO, R. R.; NASSU, R. T.; KOLTES, J. E.; WATERS, E. F.; MOURAO, G. B.; ZERLOTINI NETO, A.; REECY, J. M.; COUTINHO, L. L. Differences in the skeletal muscle transcriptome profile associated with extreme values of fatty acids content. BMC Genomics, v. 17, n. 961, p. 1-16, 2016. Biblioteca(s): Embrapa Pecuária Sudeste. |
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67. | | SOUZA, M. M. de; NICIURA, S. C. M.; ROCHA, M. I. P.; PAN, Z.; ZHOU, H.; BRUSCADIN, J. J.; DINIZ, W. J. da S.; AFONSO, J.; OLIVEIRA, P. S. N. de; MOURÃO, G. B.; ZERLOTINI NETO, A.; COUTINHO, L. L.; KOLTES, J. E.; REGITANO, L. C. de A. DNA methylation may affect beef tenderness through signal transduction in Bos indicus. Epigenetics & Chromatin, v. 15, n. 1, p. 1-16, 2022. Article number: 15. Biblioteca(s): Embrapa Agricultura Digital; Embrapa Pecuária Sudeste. |
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68. | | BRUSCADIN, J. J.; CARDOSO, T. F.; DINIZ, W. J. da S.; SOUZA, M. M. de; AFONSO, J.; VIEIRA, D.; MALHEIROS, J. M.; ANDRADE, B. G. N.; PETRINI, J.; FERRAZ, J. B. S.; ZERLOTINI NETO, A.; MOURÃO, G. B.; COUTINHO, L. L.; REGITANO, L. C. de A. Differential allele-specific expression revealed functional variants and candidate genes related to meat quality traits in B. indicus muscle. Genes, v. 13, n. 12, 2336, 2022. Biblioteca(s): Embrapa Agricultura Digital; Embrapa Pecuária Sudeste. |
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69. | | BRUSCADIN, J. J.; CARDOSO, T. F.; DINIZ, W. J. da S.; SOUZA, M. M. de; AFONSO, J.; VIEIRA, D. da S.; MALHEIROS, J.; ANDRADE, B. G.; PETRINI, J.; FERRAZ, J. B. S.; ZERLOTINI NETO, A.; MOURÃO, G.; COUTINHO, L. L. L; REGITANO, L. C. de A. Differential allelic expression and co-expression revealed oxidative stress-dependent proteolysis as a key regulator of nelore beef tenderness. In: BRAZILIAN CONGRESS OF GENETICS, 67., 2022, Natal. [Abstracts]. Ribeirão Preto: Sociedade Brasileira de Genética, 2022. p. 207. e-book. Na publicação: Adhemar Zerlotini. Biblioteca(s): Embrapa Agricultura Digital; Embrapa Pecuária Sudeste. |
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70. | | LIMA, A. O. de; KOLTES, J. E.; DINIZ, W. J. S.; OLIVEIRA, P. S. N. de; CESAR, A. S. M.; TIZIOTO, P. L.; AFONSO, J.; SOUZA, M. de S.; PETRINI, J.; ROCHA, M. I. P.; CARDOSO, T. F.; ZERLOTINI NETO, A.; COUTINHO, L. L.; MOURÃO, G. B.; REGITANO, L. C. de A. Potential biomarkers for feed efficiency-related traits in nelore cattle identified by co-expression network and integrative genomics analyses. Frontiers in Genetics, v. 11, p. 1-14, Mar. 2020. Article 189. Na publicação: Luciana C. A. Regitano. Biblioteca(s): Embrapa Agricultura Digital; Embrapa Pecuária Sudeste. |
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71. | | LIMA, A. O.; MALHEIROS, J. M.; AFONSO, J.; PETRINI, J.; COUTINHO, L. L.; DINIZ, W. J. da S.; DONATONI, F. A. B.; TIZIOTO, P. C.; OLIVEIRA, P. S. N. de; RIBEIRO, J. A. S.; OLIVEIRA, K. S. de; ROCHA, M. I. P.; ANDRADE, B. G. N.; FUKUMASU, H.; BEIKI, H.; REECY, J. M.; ZERLOTINI NETO, A.; MOURAO, G. B.; REGITANO, L. C. de A. Prune homolog 2 with BCH domain (PRUNE2) gene expression is associated with feed efficiency related traits in Nelore steers. Mammalian Genome, 2022. Biblioteca(s): Embrapa Agricultura Digital; Embrapa Pecuária Sudeste. |
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72. | | TIZIOTO, P.; COUTINHO, L. L.; DECKER, J. E.; SCHNABEL, R. D.; ROSA, C. O.; OLIVEIRA, P. S. N.; SOUZA, M. M.; MOURÃO, G. B.; TULLIO, R. R.; CHAVES, A. S.; LANNA, D. P. D.; ZERLOTINI NETO, A.; MUDADU, M. A.; TAYLOR, J. F.; REGITANO, L. C. A. Global liver gene expression differences in Nelore steers with divergent residual feed intake phenotypes. BMC Genomics, London, v. 16, p. 1-14, 2015. Biblioteca(s): Embrapa Agricultura Digital. |
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73. | | TIZIOTO, P.; COUTINHO, L. L.; DECKER, J. E.; SCHNABEL, R. D.; ROSA, K. O.; OLIVEIRA, P. S. N.; SOUZA, M. M.; MOURÃO, G. B.; TULLIO, R. R.; CHAVES, A. S.; LANNA, D. P. D.; ZERLOTINI NETO, A.; MUDADU, M. de A.; TAYLOR, J. F.; REGITANO, L. C. de A. Global liver gene expression differences in Nelore steers with divergent residual feed intake phenotypes. BMC Genomics, v. 16, n. 242, 2015. Biblioteca(s): Embrapa Pecuária Sudeste. |
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74. | | TIZIOTO, P. L.; COUTINHO, L. L.; OLIVEIRA, P. S. N.; CESAR, A. S. M.; DINIZ, W. J. S.; LIMA, A. O.; ROCHA, M. I.; DECKER, J. E.; SCHNABEL, R. D.; MOURÃO, G. B.; TULLIO, R. R.; ZERLOTINI NETO, A.; TAYLOR, J. F.; REGITANO, L. C. de A. Gene expression differences in Longissimus muscle of Nelore steers genetically divergent for residual feed intake. Scientific Reports, v. 6, p. 1-12, 2016. Biblioteca(s): Embrapa Agricultura Digital; Embrapa Pecuária Sudeste. |
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75. | | AFONSO, J.; FORTES, M. R. S.; REVERTER, A.; DINIZ, W. J. da S.; CESAR, A. S. M.; LIMA, A. O. de; PETRINI, J.; SOUZA, M. de S.; COUTINHO, L. L.; MOURÃO, G. B.; ZERLOTINI NETO, A.; GROMBONI, C. F.; NOGUEIRA, A. R. A.; REGITANO, L. C. de A. Genetic regulators of mineral amount in Nelore cattle muscle predicted by a new co-expression and regulatory impact factor approach. Scientific Reports, v. 10, n. 1, p. 1-16, 2020 Article: 8436. Biblioteca(s): Embrapa Agricultura Digital; Embrapa Pecuária Sudeste. |
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76. | | STAFUZZA, N. B.; ZERLOTINI NETO, A.; LOBO, F. P.; YAMAGISHI, M. E. B.; BUZANSKAS, M. E.; CHUD, T. C. S.; CAETANO, A. R.; MUNARI, D. P.; GARRICK, D. J.; MACHADO, M. A.; MARTINS, M. F.; CARVALHO, M. R.; COLE, J. B.; SILVA, M. V. G. B. Genetic variants with potential loss of function in Gyr, Girolando, and Guzerat cattle breeds by resequencing. Journal of Animal Science, v. 95, p. 81, 2017. Suplemento 4, Resumo 165. Edição de Abstracts do ASAS-CSAS Annual Meeting and Trade Show, Baltimore, 2017. Na publicação: A. Zerlotini, M. V. G. B. da Silva. Biblioteca(s): Embrapa Agricultura Digital. |
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77. | | STAFUZZA, N. B.; ZERLOTINI NETO, A.; LOBO, F. P.; YAMAGISHI, M. E. B.; BUZANSKAS, M. E.; CHUD, T. C.; CAETANO, A. R.; MUNARI, D. P.; GARRICK, D. J.; MACHADO, M. A.; MARTINS, M. F.; CARVALHO, M. R. S.; COLE, J. B.; SILVA, M. V. G. B. Genetiv variants with potencial loss of function in Gyr, Girolando, and Guzerat cattle breeds by resequencing. Journal of Animal Science, v. 95, n. suppl. 4, p. 81, 2017. Abstract of Breeding and Genetics Symposium, Baltimore, 2017. Biblioteca(s): Embrapa Recursos Genéticos e Biotecnologia. |
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78. | | CESAR, A. S. M.; REGITANO, L. C. de A.; REECY, J. M.; POLETI, M. D.; OLIVEIRA, P. S. N. de; OLIVEIRA, G. B. de; MOREIRA, G. C. M.; MUDADU, M. de A.; TIZIOTO, P. L.; KOLTES, J. E.; Fritz-Waters, E.; KRAMER, L.; GARRICK, D.; BEIKI, H.; GEISTLINGER, L.; MOURÃO, G. B.; ZERLOTINI NETO, A.; COUTINHO, L. L. Identification of putative regulatory regions and transcription factors associated with intramuscular fat content traits. BMC Genomics, v. 19, p. 1-20, 2018. Article number: 499. Na publicação: Luciana C. A. Regitano, Maurício A. Mudadu, Adhemar Zerlotini. Biblioteca(s): Embrapa Agricultura Digital; Embrapa Pecuária Sudeste. |
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79. | | ROSSE, I. C.; OLIVEIRA, F. S.; LEITE, L. R.; ARAUJO, F.; ZERLOTINI NETO, A.; LOPES, B. C.; ARBEX, W. A.; MACHADO, M. A.; PEIXOTO, M. G. C. D.; VERNEQUE, R. da S.; GUIMARAES, M. F. M.; SILVA, M. V. G. B.; COIMBRA, R. S.; OLIVEIRA, G.; CARVALHO, M. R. S. Novel polymorphisms in genes associated with milk and meat production and disease resistance in the guzera breed identified by whole-genome sequencing. In: ENCONTRO DE GENÉTICA DE MINAS GERAIS: PESQUISA E PÓS GRADUAÇÃO, 5., 2014, Belo Horizonte. Anais... Belo Horizonte: Sociedade Brasileira de Genética, 2014. Biblioteca(s): Embrapa Gado de Leite. |
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80. | | STAFUZZA, N. B.; ZERLOTINI NETO, A.; LOBO, F. P.; YAMAGISHI, M. E. B.; CHUD, T. C. S.; CAETANO, A. R.; MUNARI, D. P.; GARRICK, D. J.; MACHADO, M. A.; MARTINS, M. F.; CARVALHO, M. R.; COLE, J. B.; SILVA, M. V. G. B. Single nucleotide variants and InDels identified from whole-genome re-sequencing of Guzerat, Gyr, Girolando and Holstein cattle breeds. Plos One, v. 12, n. 3, p. 1-15, 2017. Artigo e0173954. Na publicação: Adhemar Zerlotini, Marcos Vinicius Gualberto Barbosa da Silva. Biblioteca(s): Embrapa Agricultura Digital; Embrapa Gado de Leite; Embrapa Recursos Genéticos e Biotecnologia. |
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Registros recuperados : 86 | |
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Registro Completo
Biblioteca(s): |
Embrapa Agricultura Digital; Embrapa Pecuária Sudeste. |
Data corrente: |
20/12/2018 |
Data da última atualização: |
19/02/2019 |
Tipo da produção científica: |
Artigo em Periódico Indexado |
Circulação/Nível: |
A - 1 |
Autoria: |
CESAR, A. S. M.; REGITANO, L. C. de A.; REECY, J. M.; POLETI, M. D.; OLIVEIRA, P. S. N. de; OLIVEIRA, G. B. de; MOREIRA, G. C. M.; MUDADU, M. de A.; TIZIOTO, P. L.; KOLTES, J. E.; Fritz-Waters, E.; KRAMER, L.; GARRICK, D.; BEIKI, H.; GEISTLINGER, L.; MOURÃO, G. B.; ZERLOTINI NETO, A.; COUTINHO, L. L. |
Afiliação: |
ALINE S. M. CESAR, USP, Iowa State University; LUCIANA CORREIA DE ALMEIDA REGITANO, CPPSE; JAMES M. REECY, Iowa State University; MIRELE D. POLETI, USP; Priscila Silva Neubern de Oliveira, Bolsista/Embrapa Pecuária Sudeste; GABRIELLA B. DE OLIVEIRA, USP; GABRIEL C. M. MOREIRA, USP; MAURICIO DE ALVARENGA MUDADU, CNPTIA; POLYANA C. TIZIOTO, USP; JAMES EUGENE KOLTES, Iowa State University; Elyn Fritz-Waters, Iowa State University; LUKE KRAMER, Iowa State University; DORIAN GARRICK, Massey University; HAMID BEIKI, Iowa State University; LUDWIG GEISTLINGER, Bolsista/Embrapa Pecuária Sudeste; GERSON B. MOURÃO, USP; ADHEMAR ZERLOTINI NETO, CNPTIA; Luiz Lehmann Coutinho, USP. |
Título: |
Identification of putative regulatory regions and transcription factors associated with intramuscular fat content traits. |
Ano de publicação: |
2018 |
Fonte/Imprenta: |
BMC Genomics, v. 19, p. 1-20, 2018. |
DOI: |
https://doi.org/10.1186/s12864-018-4871-y |
Idioma: |
Inglês |
Notas: |
Article number: 499. Na publicação: Luciana C. A. Regitano, Maurício A. Mudadu, Adhemar Zerlotini. |
Conteúdo: |
Background: Integration of high throughput DNA genotyping and RNA-sequencing data allows for the identification of genomic regions that control gene expression, known as expression quantitative trait loci (eQTL), on a whole genome scale. Intramuscular fat (IMF) content and carcass composition play important roles in metabolic and physiological processes in mammals because they influence insulin sensitivity and consequently prevalence of metabolic diseases such as obesity and type 2 diabetes. However, limited information is available on the genetic variants and mechanisms associated with IMF deposition in mammals. Thus, our hypothesis was that eQTL analyses could identify putative regulatory regions and transcription factors (TFs) associated with intramuscular fat (IMF) content traits. Results: We performed an integrative eQTL study in skeletal muscle to identify putative regulatory regions and factors associated with intramuscular fat content traits. Data obtained from skeletal muscle samples of 192 animals was used for association analysis between 461,466 SNPs and the transcription level of 11,808 genes. This yielded 1268 cis- and 10,334 trans-eQTLs, among which we identified nine hotspot regions that each affected the expression of > 119 genes. These putative regulatory regions overlapped with previously identified QTLs for IMF content. Three of the hotspots respectively harbored the transcription factors USF1, EGR4 and RUNX1T1, which are known to play important roles in lipid metabolism. From co-expression network analysis, we further identified modules significantly correlated with IMF content and associated with relevant processes such as fatty acid metabolism, carbohydrate metabolism and lipid metabolism. Conclusion: This study provides novel insights into the link between genotype and IMF content as evident from the expression level. It thereby identifies genomic regions of particular importance and associated regulatory factors. These new findings provide new knowledge about the biological processes associated with genetic variants and mechanisms associated with IMF deposition in mammals. MenosBackground: Integration of high throughput DNA genotyping and RNA-sequencing data allows for the identification of genomic regions that control gene expression, known as expression quantitative trait loci (eQTL), on a whole genome scale. Intramuscular fat (IMF) content and carcass composition play important roles in metabolic and physiological processes in mammals because they influence insulin sensitivity and consequently prevalence of metabolic diseases such as obesity and type 2 diabetes. However, limited information is available on the genetic variants and mechanisms associated with IMF deposition in mammals. Thus, our hypothesis was that eQTL analyses could identify putative regulatory regions and transcription factors (TFs) associated with intramuscular fat (IMF) content traits. Results: We performed an integrative eQTL study in skeletal muscle to identify putative regulatory regions and factors associated with intramuscular fat content traits. Data obtained from skeletal muscle samples of 192 animals was used for association analysis between 461,466 SNPs and the transcription level of 11,808 genes. This yielded 1268 cis- and 10,334 trans-eQTLs, among which we identified nine hotspot regions that each affected the expression of > 119 genes. These putative regulatory regions overlapped with previously identified QTLs for IMF content. Three of the hotspots respectively harbored the transcription factors USF1, EGR4 and RUNX1T1, which are known to play important roles in l... Mostrar Tudo |
Palavras-Chave: |
Ácidos graxos; Doenças metabólicas; EQTL; Expressão gênica; Expression quantitative trait loci. |
Thesaurus NAL: |
Fatty acids; Gene expression; Mammals; Metabolic diseases. |
Categoria do assunto: |
-- L Ciência Animal e Produtos de Origem Animal |
URL: |
https://ainfo.cnptia.embrapa.br/digital/bitstream/item/189052/1/AP-Identification-Cesar-etal.pdf
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Marc: |
LEADER 03558naa a2200457 a 4500 001 2106227 005 2019-02-19 008 2018 bl uuuu u00u1 u #d 024 7 $ahttps://doi.org/10.1186/s12864-018-4871-y$2DOI 100 1 $aCESAR, A. S. M. 245 $aIdentification of putative regulatory regions and transcription factors associated with intramuscular fat content traits.$h[electronic resource] 260 $c2018 500 $aArticle number: 499. Na publicação: Luciana C. A. Regitano, Maurício A. Mudadu, Adhemar Zerlotini. 520 $aBackground: Integration of high throughput DNA genotyping and RNA-sequencing data allows for the identification of genomic regions that control gene expression, known as expression quantitative trait loci (eQTL), on a whole genome scale. Intramuscular fat (IMF) content and carcass composition play important roles in metabolic and physiological processes in mammals because they influence insulin sensitivity and consequently prevalence of metabolic diseases such as obesity and type 2 diabetes. However, limited information is available on the genetic variants and mechanisms associated with IMF deposition in mammals. Thus, our hypothesis was that eQTL analyses could identify putative regulatory regions and transcription factors (TFs) associated with intramuscular fat (IMF) content traits. Results: We performed an integrative eQTL study in skeletal muscle to identify putative regulatory regions and factors associated with intramuscular fat content traits. Data obtained from skeletal muscle samples of 192 animals was used for association analysis between 461,466 SNPs and the transcription level of 11,808 genes. This yielded 1268 cis- and 10,334 trans-eQTLs, among which we identified nine hotspot regions that each affected the expression of > 119 genes. These putative regulatory regions overlapped with previously identified QTLs for IMF content. Three of the hotspots respectively harbored the transcription factors USF1, EGR4 and RUNX1T1, which are known to play important roles in lipid metabolism. From co-expression network analysis, we further identified modules significantly correlated with IMF content and associated with relevant processes such as fatty acid metabolism, carbohydrate metabolism and lipid metabolism. Conclusion: This study provides novel insights into the link between genotype and IMF content as evident from the expression level. It thereby identifies genomic regions of particular importance and associated regulatory factors. These new findings provide new knowledge about the biological processes associated with genetic variants and mechanisms associated with IMF deposition in mammals. 650 $aFatty acids 650 $aGene expression 650 $aMammals 650 $aMetabolic diseases 653 $aÁcidos graxos 653 $aDoenças metabólicas 653 $aEQTL 653 $aExpressão gênica 653 $aExpression quantitative trait loci 700 1 $aREGITANO, L. C. de A. 700 1 $aREECY, J. M. 700 1 $aPOLETI, M. D. 700 1 $aOLIVEIRA, P. S. N. de 700 1 $aOLIVEIRA, G. B. de 700 1 $aMOREIRA, G. C. M. 700 1 $aMUDADU, M. de A. 700 1 $aTIZIOTO, P. L. 700 1 $aKOLTES, J. E. 700 1 $aFritz-Waters, E. 700 1 $aKRAMER, L. 700 1 $aGARRICK, D. 700 1 $aBEIKI, H. 700 1 $aGEISTLINGER, L. 700 1 $aMOURÃO, G. B. 700 1 $aZERLOTINI NETO, A. 700 1 $aCOUTINHO, L. L. 773 $tBMC Genomics$gv. 19, p. 1-20, 2018.
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