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| Registros recuperados : 81 | |
| 41. |  | SUPERTI, B. F. V.; SOUZA, A. P. de; MÜLLER, B. C.; SILVA, Z. da; ZANELLA, R.; ZANELLA, E. L.; MARQUES, M. G. Comparison of different surgical procedures to prepare teaser boars. In: ANNUAL MEETING OF THE BRAZILIAN EMBRYO TECHNOLOGY SOCIETY, 31., 2017, Cabo de Santo Agostinho, PE. Proceedings... Belo Horizonte: Colégio Brasileiro de Reprodução Animal, 2017. p. 809.| Biblioteca(s): Embrapa Suínos e Aves. |
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| 42. | | CAMARGO, J. de; MARQUES, M. G.; FACCIN, J. C. V.; JORGE NETO, P. N.; KICH, J. D.; SCARIOT, C. A.; ZANELLA, R. The feasibility of a swine semen storage system produced with bacteriostatic molecules to control bacterial proliferation. In: INTERNATIONAL SYMPOSIUM ON ANIMAL BIOLOGY OF REPRODUCTION, 9., 2022, Bento Gonçalves. Abstracts...Belo Horizonte: CBRA, 2022. Animal Reproduction, v. 19, n. 4, 2022.| Biblioteca(s): Embrapa Suínos e Aves. |
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| 43. | | SILVA, A. N. da; LAGO, L. V.; ZANELLA, E. L.; MARQUES, M. G.; PEIXOTO, J. de O.; SILVA, M. V. G. B.; LEDUR, M. C.; ZANELLA, R. Genome wide association test with scrotal hérnias in pigs. In: ANNUAL MEETING OF THE BRAZILIAN EMBRYO TECHNOLOGY SOCIETY, 31., 2017, Cabo de Santo Agostinho, PE. Proceedings... Belo Horizonte: Colégio Brasileiro de Reprodução Animal, 2017. p. 845.| Biblioteca(s): Embrapa Suínos e Aves. |
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| 44. | | ZANELLA, R.; PEIXOTO, J. de O.; CARDOSO, F. F.; CARDOSO, L. L.; BIEGELMEYER, P.; CANTAO, M. E.; OTAVIANO, A.; FREITAS, M. S.; CAETANO, A. R.; LEDUR, M. C. Genetic diversity analysis of two commercial breeds of pigs using genomic and pedigree data. Genetics Selection Evolution, v. 48, n. 24, 30 Mar. 2016.| Biblioteca(s): Embrapa Pecuária Sul; Embrapa Recursos Genéticos e Biotecnologia; Embrapa Suínos e Aves. |
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| 45. | | PEIXOTO, J. de O.; KAWSKI, V. L.; IBELLI, A. M. G.; ZANELLA, R.; MAZZUCO, H.; SOUZA, C. G.; MUNARI, D. P.; JAENISCH, F. R. F.; LEDUR, M. C. Genetic evaluation of body weight and tibia resistance in broilers. In: WORLD CONGRESS OF GENETICS APPLIED TO LIVESTOCK PRODUCTION, 10., 2014, Vancouver. Proceedings... Vancouver: WCGALP: American Society of Animal Science, 2014.| Biblioteca(s): Embrapa Suínos e Aves. |
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| 46. | | WOYANN, L. G.; ZDZIARSKI, A. D.; ZANELLA, R.; ROSA, A. C.; CASTRO, R. L. de; CAIERÃO, E.; TOIGO, M. D.; STORCK, L.; WU, J.; BENIN, G. Genetic gain over 30 years of spring wheat breeding in Brazil. Crop Science, v. 59, Sep./Oct. 2019.| Biblioteca(s): Embrapa Trigo. |
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| 47. | | ZANELLA, R.; GAVA, D.; PEIXOTO, J. de O.; SCHAEFER, R.; ZANELLA, J. R. C.; BIONDO, N.; SILVA, M. V. G. B.; CANTAO, M. E.; LEDUR, M. C. Genetic markers associated with influenza vaccination efficacy in swine. In: INTERNATIONAL SYMPOSIUM ON EMERGING AND RE-EMERGING PIG DISEASES, 7., 2015, Kyoto. Proceedings... Kyoto: Science Council of Japan; JSVS; JPVS; JASV, 2015.| Biblioteca(s): Embrapa Suínos e Aves. |
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| 48. | | ZANELLA, R.; IBELLI, A. M. G.; PEIXOTO, J. de O.; CANTAO, M. E.; SILVA, M. V. G. B.; GIACHETTO, P. F.; FREITAS, M.; LOPES, J.; LEDUR, M. C. Genetic associations of farrowing length in two maternal lines of pigs. In: WORLD CONGRESS OF GENETICS APPLIED TO LIVESTOCK PRODUCTION, 10., 2014, Vancouver. Proceedings... Vancouver: WCGALP: American Society of Animal Science, 2014.| Biblioteca(s): Embrapa Gado de Leite; Embrapa Suínos e Aves. |
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| 49. | | ZANELLA, R.; PEIXOTO, J. de O.; IBELLI, A. M. G.; CANTAO, M. E.; SETTLES, M.; COUTINHO, L. L.; LEDUR, M. C. RNA-Seq to identify genes involved with femoral head necrosis in broilers. In: INTERNATIONAL PLANT & ANIMAL GENOME, 23., 2015, San Diego, CA. Abstracts? San Diego, 2015.| Biblioteca(s): Embrapa Suínos e Aves. |
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| 50. | | FACIOLI, F. L.; BEZUTTI, G. da F.; BENDER, R. S.; MARQUES, M. G.; BONDAN, C.; ZANELLA, E. L; BERTOLINI, M.; ZANELLA, R. A rare case of heteropaternal twin calves after natural mating in Brazil. Animal Reproduction, v. 17, n. 4, e20200217, 2020.| Biblioteca(s): Embrapa Suínos e Aves. |
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| 51. | | KICH, J. D.; UTHE, J. J.; BENAVIDES, M. V.; CANTAO, M. E.; ZANELLA, R.; TUGGLE, C. K.; BEARSON, S. M. D. TLR4 Single Nucleotide Polymorphisms (SNPs) Associated with Salmonella Shedding in Pigs. In: SAFEPORK, 2013, Portland. Proceeding... Portland, 2013. 1 Pen drive.| Biblioteca(s): Embrapa Suínos e Aves. |
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| 52. | | KICH, J. D.; UTHE, J. J.; BENAVIDES, M. V.; CANTAO, M. E.; ZANELLA, R.; TUGGLE, C. K.; BEARSON, S. M. D. TLR4 single nucleotide polymorphisms (SNPs) associated with Salmonella shedding in pigs. Journal of Applied Genetics, v. 55, n. 2, p. 267-71, 2014.| Biblioteca(s): Embrapa Pecuária Sul; Embrapa Suínos e Aves. |
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| 53. | | FORNARI, M. B.; ZANELLA, R.; IBELLI, A. M. G.; FERNANDES, L. T.; CANTAO, M. E.; SOCCOL, V. T.; LEDUR, M. C.; PEIXOTO, J. de O. Unraveling the associations of osteoprotegerin gene with production traits in a paternal broiler line. SpringerPlus, v. 3, n. 682, 2014.| Biblioteca(s): Embrapa Suínos e Aves. |
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| 54. | | PETRY, B.; ZANELLA, R.; IBELLI, A. M. G.; FORNARI, M. B.; PANDOLFI, J. R. C.; CANTAO, M. E.; COUTINHO, L. L.; PEIXOTO, J. de O.; LEDUR, M. C. Unraveling the associations of SOST gene with production traits in an F2 Chicken Resource Population. In: CONGRESSO BRASILEIRO DE GENÉTICA, 59., 2013, Águas de Lindóia. Resumos... Ribeirão Preto: SBG, 2013. p. 152.| Biblioteca(s): Embrapa Suínos e Aves. |
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| 55. | | ZANELLA, R.; GAVA, D.; PEIXOTO, J. de O.; SCHAEFER, R.; CIACCI-ZANELLA, J. R.; BIONDO, N.; SILVA, M. V. G. B.; CANTÃO, M. E.; LEDUR, M. C. Unravelling the genetic components involved in the immune response of pigs vaccinated against influenza virus. Virus Research, v. 210, p. 327-336, 2015.| Biblioteca(s): Embrapa Gado de Leite. |
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| 56. | | ZANELLA, R.; GAVA, D.; PEIXOTO, J. de O.; SCHAEFER, R.; ZANELLA, J. R. C.; BIONDO, N.; SILVA, M. V. G. B.; CANTAO, M. E.; LEDUR, M. C. Unravelling the genetic components involved in the immune response of pigs vaccinated against influenza virus. Virus Research, v. 210, p. 327-336, 2015.| Biblioteca(s): Embrapa Suínos e Aves. |
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| 57. | | ZANELLA, R.; IBELLI, A. M. G.; CANTAO, M. E.; PEIXOTO, J. de O.; PANDOLFI, J. R. C.; COUTINHO, L. L.; LEDUR, M. C. Unrevealing the genetic pathways involved with bone integrity traits in poultry. In: INTERNATIONAL SYMPOSIUM ON ANIMAL FUNCTIONAL GENOMICS, 5., 2013, Guarujá. Programme and abstract book... [S.l.: s.n.], 2013. p. 31. ISAFG 2013. AB. 25.| Biblioteca(s): Embrapa Suínos e Aves. |
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| 58. | | SUPERTI, B. F. V.; SOUZA, A. P. de; MÜLLER, B. C.; SILVA, Z. da; ZANELLA, R.; ZANELLA, E. L.; MARQUES, M. G. Técnicas cirúrgicas para preparo de rufiões suínos. Suinocultura Industrial, Itu, ed. 281, ano 40, n. 02, p. 14-17, 2018.| Biblioteca(s): Embrapa Suínos e Aves. |
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| 59. | | MARCHESI, J. A. P.; IBELLI, A. M. G.; CANTAO, M. E.; ZANELLA, R.; SETTLES, M. L.; PEIXOTO, J. de O.; COUTINHO, L. L.; LEDUR, M. C. Whole transcriptome analysis of pectoralis major muscle reveals differences in calcium signaling pathway between white striping affected and unaffected broilers. In: CONGRESSO BRASILEIRO DE GENÉTICA, 61., 2015, Águas de Lindóia. Resumos... Ribeirão Preto: Sociedade Brasileira de Genética, 2015.| Biblioteca(s): Embrapa Suínos e Aves. |
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| 60. | | TONATTO, M.; ZDZIARSKI, A. D.; MEIRA, D.; PANHO, M. C.; ZANELLA, R.; MENEGAZZI, C. P.; COLONELLI, L. L.; FERNANDES, R. A. T.; CAMPAGNOLLI, O. R.; BENIN, G. Yield potential of modern soybean cultivars under high and low input levels. Pesquisa Agropecuária Brasileira, v. 57, e02852, 2022. Título em português: Potencial de rendimento de cultivares de soja modernas sob níveis alto e baixo de insumos.| Biblioteca(s): Embrapa Unidades Centrais. |
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| Registros recuperados : 81 | |
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 | Acesso ao texto completo restrito à biblioteca da Embrapa Suínos e Aves. Para informações adicionais entre em contato com cnpsa.biblioteca@embrapa.br. |
Registro Completo
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Biblioteca(s): |
Embrapa Gado de Leite; Embrapa Suínos e Aves. |
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Data corrente: |
09/03/2023 |
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Data da última atualização: |
09/03/2023 |
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Tipo da produção científica: |
Artigo em Periódico Indexado |
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Circulação/Nível: |
A - 3 |
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Autoria: |
SILVA, A. N. da; IBELLI, A. M. G.; SAVOLDI, I. R.; CANTAO, M. E.; ZANELLA, E. L.; MARQUES, M. G.; SILVA, M. V. G. B.; PEIXOTO, J. de O.; LEDUR, M. C.; LOPES, J. S.; VARGAS, J. E.; ZANELLA, R. |
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Afiliação: |
ARTHUR NERY DA SILVA, Universidade de Passo Fundo; ADRIANA MERCIA GUARATINI IBELLI, CNPSA; IGOR RICARDO SAVOLDI, Universidade do Contestado/Concórdia; MAURICIO EGIDIO CANTAO, CNPSA; ERALDO LOURENSO ZANELLA, UNIVERSIDADE; MARIANA GROKE MARQUES, CNPSA; MARCOS VINICIUS GUALBERTO B SILVA, CNPGL; JANE DE OLIVEIRA PEIXOTO, CNPSA; MONICA CORREA LEDUR, CNPSA; JADER SILVA LOPES, BRF/Curitiba; JOSÉ EDUARDO VARGAS, Universidade Federal do Paraná; RICARDO ZANELLA, Universidade de Passo Fundo. |
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Título: |
Whole-exome sequencing indicated new candidate genes associated with unilateral cryptorchidism in pigs. |
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Ano de publicação: |
2023 |
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Fonte/Imprenta: |
Sexual Development, 9 Feb 2023. |
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DOI: |
10.1159/000528360 |
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Idioma: |
Inglês |
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Conteúdo: |
Abstract:
Introduction: Cryptorchidism is a hereditary anomaly characterized by the incomplete descent of one or both testicles to the scrotum. One of the challenges of this anomaly is that the retained testicle maintains its endocrine function. As a consequence, cryptorchid animals produce hormone-tainted meat in comparison to castrated animals and are likely to be more aggressive. Cryptorchidism can lead to reduced animal welfare outcomes and cause economic losses. Identifying genetic markers for cryptorchidism is an essential step toward mitigating these negative outcomes and may facilitate genome manipulation to reduce the occurrence of cryptorchidism. Attempts to identify such markers have used genome-wide association studies. Using whole-exome sequencing, we aimed to identify single nucleotide polymorphisms (SNPs) in the coding regions of cryptorchid pigs and to characterize functional pathways concerning these SNPs.
Methods: DNA was extracted and sequenced from 5 healthy and 5 cryptorchid animals from the Landrace breed, using the Illumina HiSeq 2500 platform. Data were pre-processed using the SeqyClean tool and further mapped against the swine reference genome (Sus scrofa 11.1) using BWA software. GATK was used to identify polymorphisms (SNPs and InDels), which were annotated using the VEP tool. Network prediction and gene ontology enrichment analysis were conducted using the Cytoscape platform, and STRING software was used for visualization.
Results: A total of 63 SNPs were identified across the genes PIGB, CCPG1, COMMD9, LDLRAD3, TRIM44, MYLPF, SEPTIN, ZNF48, TIA1, FAIM2, KRT18, FBP1, FBP2, CTSL, DAPK1, DHX8, GPR179, DEPDC1B, ENSSSCG00000049573, ENSSSCG00000016384, ENSSSCG00000022657, ENSSSCG00000038825, and ENSSSCG00000001229. Using pathway enrichment analyses and network prospection, we have identified the following significant adjusted p value threshold of 0.001 involved with the biological function pathways of estrogen signaling, cytoskeleton organization, and the pentose phosphate pathway.
Conclusion: Our data suggest the involvement of new SNPs and genes in developing cryptorchidism in pigs. However, further studies are needed to validate our results in a larger cohort population. Variations in the GPR179 gene, with implications at the protein level, may be associated with the appearance of this anomaly in the swine. Finally, we are showing that the estrogen signaling pathway may be involved in the pathophysiological mechanisms of this congenital anomaly as previously reported in GWAS. MenosAbstract:
Introduction: Cryptorchidism is a hereditary anomaly characterized by the incomplete descent of one or both testicles to the scrotum. One of the challenges of this anomaly is that the retained testicle maintains its endocrine function. As a consequence, cryptorchid animals produce hormone-tainted meat in comparison to castrated animals and are likely to be more aggressive. Cryptorchidism can lead to reduced animal welfare outcomes and cause economic losses. Identifying genetic markers for cryptorchidism is an essential step toward mitigating these negative outcomes and may facilitate genome manipulation to reduce the occurrence of cryptorchidism. Attempts to identify such markers have used genome-wide association studies. Using whole-exome sequencing, we aimed to identify single nucleotide polymorphisms (SNPs) in the coding regions of cryptorchid pigs and to characterize functional pathways concerning these SNPs.
Methods: DNA was extracted and sequenced from 5 healthy and 5 cryptorchid animals from the Landrace breed, using the Illumina HiSeq 2500 platform. Data were pre-processed using the SeqyClean tool and further mapped against the swine reference genome (Sus scrofa 11.1) using BWA software. GATK was used to identify polymorphisms (SNPs and InDels), which were annotated using the VEP tool. Network prediction and gene ontology enrichment analysis were conducted using the Cytoscape platform, and STRING software was used for visualization.
Results: A total of 63 ... Mostrar Tudo |
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Palavras-Chave: |
Criptorquidismo; Sequenciamento completo do exoma; Whole-Exome Sequencing. |
|
Thesagro: |
Gene Marcador; Genética Animal; Marcador Genético; Porco; Suíno. |
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Thesaurus NAL: |
Cryptorchidism. |
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Categoria do assunto: |
-- |
|
Marc: |
LEADER 03604naa a2200373 a 4500
001 2152220
005 2023-03-09
008 2023 bl uuuu u00u1 u #d
024 7 $a10.1159/000528360$2DOI
100 1 $aSILVA, A. N. da
245 $aWhole-exome sequencing indicated new candidate genes associated with unilateral cryptorchidism in pigs.$h[electronic resource]
260 $c2023
520 $aAbstract: Introduction: Cryptorchidism is a hereditary anomaly characterized by the incomplete descent of one or both testicles to the scrotum. One of the challenges of this anomaly is that the retained testicle maintains its endocrine function. As a consequence, cryptorchid animals produce hormone-tainted meat in comparison to castrated animals and are likely to be more aggressive. Cryptorchidism can lead to reduced animal welfare outcomes and cause economic losses. Identifying genetic markers for cryptorchidism is an essential step toward mitigating these negative outcomes and may facilitate genome manipulation to reduce the occurrence of cryptorchidism. Attempts to identify such markers have used genome-wide association studies. Using whole-exome sequencing, we aimed to identify single nucleotide polymorphisms (SNPs) in the coding regions of cryptorchid pigs and to characterize functional pathways concerning these SNPs. Methods: DNA was extracted and sequenced from 5 healthy and 5 cryptorchid animals from the Landrace breed, using the Illumina HiSeq 2500 platform. Data were pre-processed using the SeqyClean tool and further mapped against the swine reference genome (Sus scrofa 11.1) using BWA software. GATK was used to identify polymorphisms (SNPs and InDels), which were annotated using the VEP tool. Network prediction and gene ontology enrichment analysis were conducted using the Cytoscape platform, and STRING software was used for visualization. Results: A total of 63 SNPs were identified across the genes PIGB, CCPG1, COMMD9, LDLRAD3, TRIM44, MYLPF, SEPTIN, ZNF48, TIA1, FAIM2, KRT18, FBP1, FBP2, CTSL, DAPK1, DHX8, GPR179, DEPDC1B, ENSSSCG00000049573, ENSSSCG00000016384, ENSSSCG00000022657, ENSSSCG00000038825, and ENSSSCG00000001229. Using pathway enrichment analyses and network prospection, we have identified the following significant adjusted p value threshold of 0.001 involved with the biological function pathways of estrogen signaling, cytoskeleton organization, and the pentose phosphate pathway. Conclusion: Our data suggest the involvement of new SNPs and genes in developing cryptorchidism in pigs. However, further studies are needed to validate our results in a larger cohort population. Variations in the GPR179 gene, with implications at the protein level, may be associated with the appearance of this anomaly in the swine. Finally, we are showing that the estrogen signaling pathway may be involved in the pathophysiological mechanisms of this congenital anomaly as previously reported in GWAS.
650 $aCryptorchidism
650 $aGene Marcador
650 $aGenética Animal
650 $aMarcador Genético
650 $aPorco
650 $aSuíno
653 $aCriptorquidismo
653 $aSequenciamento completo do exoma
653 $aWhole-Exome Sequencing
700 1 $aIBELLI, A. M. G.
700 1 $aSAVOLDI, I. R.
700 1 $aCANTAO, M. E.
700 1 $aZANELLA, E. L.
700 1 $aMARQUES, M. G.
700 1 $aSILVA, M. V. G. B.
700 1 $aPEIXOTO, J. de O.
700 1 $aLEDUR, M. C.
700 1 $aLOPES, J. S.
700 1 $aVARGAS, J. E.
700 1 $aZANELLA, R.
773 $tSexual Development, 9 Feb 2023.
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