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| Registros recuperados : 13 | |
| 2. |  | DOKKEDAL, A. L.; VILEGAS, W.; NEHME, C. J.; RASTRELLI, S. P. L.; PIZZA, C. Fitoquimica das folhas de Paepalanthus vellozioides Ruhland e Paepalanthus latipes Silveira. In: CONGRESSO NACIONAL DE BOTANICA, 49., 1998, Salvador, BA. Resumos. Salvador: UFBA/SBB, 1998. p.226-227.| Biblioteca(s): Embrapa Cerrados. |
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| 4. | | MENDES, L.; QUINTINO, C.; RODRIGUES, C. M.; OLIVEIRA, V.; VILEGAS, W. Phytochemical analysis from Rhizophora mangle barks: FIA-ESI-IT-MS/MS and MALDI-TOF approach. In: ITALO LATIN AMERICAN CONGRESS OF ETNOMEDICINA, 26.; COLOMBIAN CONGRESS OF CHROMATOGRAPHY, 9., 2017, Cartagena das Indias. [Anais ...]. [S.l.]: SILAE, 2017. Não paginado.| Biblioteca(s): Embrapa Agroenergia. |
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| 5. | | HIRUMA-LIMA, C. A.; RODRIGUES, C. M.; SANTOS, L. C. DOS; SILVA, V. C. DA; VILEGAS, W. Flavonoides. In: FURTADO, N. A. J. C.; VENEZIANI, R. C. S.; AMBRÓSIO, S. R. (Ed.). Farmacognosia. Rio de Janeiro : Atheneu, 2017. p. 387-406. (Coleção Farmácia, 7).| Biblioteca(s): Embrapa Agroenergia. |
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| 6. | | DOKKEDAL, A. L.; SANTOS, L. C.; ANDRADE, F. D.; NEHME, C. J.; COELHO, R. G.; OLIVEIRA, R. A.; VILEGAS, W. Estudos fitoquimicos de capitulos e escapos de especies de Paepalanthus Kunth. In: CONGRESSO NACIONAL DE BOTANICA, 49., 1998, Salvador, BA. Resumos. Salvador: UFBA/SBB, 1998. p.226.| Biblioteca(s): Embrapa Cerrados. |
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| 8. | | SANNOMIYA, M.; RODRIGUES, C. M.; OLIVEIRA, G. C. A.; CARVALHO, J. C. S.; COSTA, L. S. DA; SPADARI, C. DE C.; FERREIRA, M. J. P.; VILEGAS, W.; ISHIDA, K. Galloylquinic acid derivatives from Byrsonima fagifolia leaf extract and potential antifungal activity. Journal of Ethnopharmacology, n. 297, e115534, 2022. 5 p.| Biblioteca(s): Embrapa Agroenergia. |
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| 9. | | NISHIJIMA, C. M.; DELELLA, F. K.; RODRIGUES, C. M.; RINALDO, D.; LOPES-FERREIRA, M. V. dos Anjos; ROCHA, L. R. M. da; VILEGAS, W.; FELISBINO, S. L.; HIRUMA-LIMA, C. A. The anti-inflammatory effects of the methanolic extract and fractions from Davilla elliptica St Hil (Dilleniaceae) on Bothrops jararaca envenomation. International Journal of Molecular Sciences, v. 16, n. 6, 2015| Biblioteca(s): Embrapa Agroenergia. |
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| 10. | | FANTATTO, R. R.; CHAGAS, A. C. de S.; ALEMAN GAINZA, Y.; POLITI, F. A. S.; MESQUITA, L. M. DE S.; VILEGAS, W.; BIZZO, H. R.; MONTANARI JUNIOR, I.; PIETRO, R. C. L. R. Acaricidal and anthelmintic action of ethanolic extract and essential oil of Achyrocline satureioides. Experimental Parasitology, v236?237, may-june 2022, 108252. 8 p.| Biblioteca(s): Embrapa Agroindústria de Alimentos; Embrapa Pecuária Sudeste. |
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| 11. | | MESQUITA, L. M. de S.; RODRIGUES, C. F. B.; ROCHA, C. Q. da; BIANCHIM, M. S.; RODRIGUES, C. M.; OLIVEIRA, V. de; GAETA, H. H.; BELCHOR, M. N.; TOYAMA. M. H.; VILEGAS, W. LC-ESI-IT-MS/MS and MALDI-TOF approach: identification of natural polymers from rhizophora mangle barks and determination of their analgesic and anti-inflammatory properties. Natural Products and Bioprospecting, v. 9, p. 23-34, 2019.| Biblioteca(s): Embrapa Agroenergia. |
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| 12. | | SANTOS, R. de C. dos; BONAMINA, F.; PÉRICO, L. L.; RODRIGUES, V. P.; ZANATTA, A. C.; RODRIGUES, C. M.; SANNOMIYA, M.; RAMOS. M. A. dos S.; BONIFÁCIO, B. V.; BAUAB, T. M.; TAMASHIRO, J.; ROCHA, L. R. M. da; VILEGAS, W.; HIRUMA-LIMA, C. A. Byrsonima intermedia A. Juss partitions promote gastroprotection against peptic ulcers and improve healing through antioxidant and antiinflammatory activities. Biomedicine & Pharmacotherapy, v. 111, p. 1112-1123, 2019.| Biblioteca(s): Embrapa Agroenergia. |
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| 13. | | RODRIGUES, C. M.; BENTO, C. C.; MORAES, C. B.; GOMES, C.; IOSHINO, R. S.; FREITAS-JUNIOR, L. H.; SPADARI, C. de C.; ISHIDA, K.; VILEGAS, W.; CARVALHO, J. C. S.; FERREIRA, M. J. P.; CARBONE, V.; PIACENTE, S.; ANGELO, R. M. de; HONORIO, K. M.; SANNOMIYA, M. A potential antiviral against COVID-19 obtained from Byrsonima coccolobifolia leaves extract. Fitoterapia, v. 173, Mar. 2024.| Biblioteca(s): Embrapa Agroenergia. |
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| Registros recuperados : 13 | |
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Registro Completo
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Biblioteca(s): |
Embrapa Agroenergia. |
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Data corrente: |
15/03/2019 |
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Data da última atualização: |
18/11/2019 |
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Tipo da produção científica: |
Artigo em Periódico Indexado |
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Circulação/Nível: |
A - 2 |
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Autoria: |
SANTOS, R. de C. dos; BONAMINA, F.; PÉRICO, L. L.; RODRIGUES, V. P.; ZANATTA, A. C.; RODRIGUES, C. M.; SANNOMIYA, M.; RAMOS. M. A. dos S.; BONIFÁCIO, B. V.; BAUAB, T. M.; TAMASHIRO, J.; ROCHA, L. R. M. da; VILEGAS, W.; HIRUMA-LIMA, C. A. |
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Afiliação: |
Raquel de Cássia dos Santos; Flavia Bonamina; Larissa Lucena Périco; Vinícius Peixoto Rodrigues; Ana Caroline Zanatta; CLENILSON MARTINS RODRIGUES, CNPAE; Miriam Sannomiya; Matheus Aparecido dos Santos Ramos; Bruna Vidal Bonifácio; Taís Maria Bauab; Jorge Tamashiro; Lúcia Regina Machado da Rocha; Wagner Vilegas; Clelia Akiko Hiruma-Lima. |
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Título: |
Byrsonima intermedia A. Juss partitions promote gastroprotection against peptic ulcers and improve healing through antioxidant and antiinflammatory activities. |
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Ano de publicação: |
2019 |
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Fonte/Imprenta: |
Biomedicine & Pharmacotherapy, v. 111, p. 1112-1123, 2019. |
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Idioma: |
Inglês |
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Conteúdo: |
Byrsonima intermedia is a species of bush popularly used to treat gastrointestinal disorders, such as gastric ulcers, gastritis, and diarrhea. Previous studies have revealed that the methanolic crude extract of B. intermedia leaves has gastroprotective and healing properties. In this new study, we specifically investigated two purified partitions, ethyl acetate (EtOAc) and water (AcoAq), obtained from the crude extract to characterize the antiulcer effects of these two partitions and the mechanisms of action of this medicinal plant. The healing effects of these partitions on the gastric and duodenal mucosa were assessed after ischemia-reperfusion (I/R) or acetic acidinduced injury. The involvement of tumor necrosis factor-alpha (TNF-alpha), interleukin 1β (IL-1β), interleukin 10 (IL-10), and myeloperoxidase (MPO) activity and glutathione (GSH) levels were determined. The antibacterial activity against Helicobacter pylori was evaluated using microdilution methods. The phytochemical analysis of AcoAq revealed a predominance of oligomeric proanthocyanidins and galloyl quinic esters, whereas EtOAc was found to contain concentrated flavonoids. Both partitions led to a significant reduction in gastric lesions, but AcoAq was more effective than EtOAc with regard to anti-Helicobacter pylori activity in addition to protecting the gastric mucosa against ethanol, non-steroidal anti-inflammatory drugs (NSAIDs) and duodenal mucosal damage induced by cysteamine. Additionally, both partitions were associated with a significant increase in gastric and duodenal healing and increased gastric mucosal GSH content after damage induced by acetic acid. On the other hand, after 6 days of treatment, EtOAc was more effective than AcoAq in ameliorating gastric damage upon initiation of the gastric I/R, which was accompanied by a significant reduction in the activity of gastric mucosal MPO, IL 1-β and TNFalpha, as well as an elevation in IL-10 and GSH content. These results demonstrate that the oligomeric proanthocyanidins and galloyl quinic esters present in AcoAq were more effective in the prevention of gastric and duodenal ulcers due to the antioxidant effects of these compounds, whereas the flavonoids present in EtOAc were more effective due to their anti-inflammatory activity on the gastric and duodenal tissue. All these results confirm that the rich phytochemical diversity of B. intermedia contributes to the pharmacological actions of this medicinal plant on the gastrointestinal tract in addition to its activity against H. pylori. MenosByrsonima intermedia is a species of bush popularly used to treat gastrointestinal disorders, such as gastric ulcers, gastritis, and diarrhea. Previous studies have revealed that the methanolic crude extract of B. intermedia leaves has gastroprotective and healing properties. In this new study, we specifically investigated two purified partitions, ethyl acetate (EtOAc) and water (AcoAq), obtained from the crude extract to characterize the antiulcer effects of these two partitions and the mechanisms of action of this medicinal plant. The healing effects of these partitions on the gastric and duodenal mucosa were assessed after ischemia-reperfusion (I/R) or acetic acidinduced injury. The involvement of tumor necrosis factor-alpha (TNF-alpha), interleukin 1β (IL-1β), interleukin 10 (IL-10), and myeloperoxidase (MPO) activity and glutathione (GSH) levels were determined. The antibacterial activity against Helicobacter pylori was evaluated using microdilution methods. The phytochemical analysis of AcoAq revealed a predominance of oligomeric proanthocyanidins and galloyl quinic esters, whereas EtOAc was found to contain concentrated flavonoids. Both partitions led to a significant reduction in gastric lesions, but AcoAq was more effective than EtOAc with regard to anti-Helicobacter pylori activity in addition to protecting the gastric mucosa against ethanol, non-steroidal anti-inflammatory drugs (NSAIDs) and duodenal mucosal damage induced by cysteamine. Additionally, bo... Mostrar Tudo |
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Palavras-Chave: |
Healing effect; Peptic ulcer. |
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Thesaurus NAL: |
Anti-inflammatory activity. |
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Categoria do assunto: |
-- |
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URL: |
https://ainfo.cnptia.embrapa.br/digital/bitstream/item/194314/1/CLENILSON-039-Biomedicine-and-Pharmacotherapy-V.111-Issue.3-2019-1112-1123.pdf
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Marc: |
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001 2107125
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100 1 $aSANTOS, R. de C. dos
245 $aByrsonima intermedia A. Juss partitions promote gastroprotection against peptic ulcers and improve healing through antioxidant and antiinflammatory activities.$h[electronic resource]
260 $c2019
520 $aByrsonima intermedia is a species of bush popularly used to treat gastrointestinal disorders, such as gastric ulcers, gastritis, and diarrhea. Previous studies have revealed that the methanolic crude extract of B. intermedia leaves has gastroprotective and healing properties. In this new study, we specifically investigated two purified partitions, ethyl acetate (EtOAc) and water (AcoAq), obtained from the crude extract to characterize the antiulcer effects of these two partitions and the mechanisms of action of this medicinal plant. The healing effects of these partitions on the gastric and duodenal mucosa were assessed after ischemia-reperfusion (I/R) or acetic acidinduced injury. The involvement of tumor necrosis factor-alpha (TNF-alpha), interleukin 1β (IL-1β), interleukin 10 (IL-10), and myeloperoxidase (MPO) activity and glutathione (GSH) levels were determined. The antibacterial activity against Helicobacter pylori was evaluated using microdilution methods. The phytochemical analysis of AcoAq revealed a predominance of oligomeric proanthocyanidins and galloyl quinic esters, whereas EtOAc was found to contain concentrated flavonoids. Both partitions led to a significant reduction in gastric lesions, but AcoAq was more effective than EtOAc with regard to anti-Helicobacter pylori activity in addition to protecting the gastric mucosa against ethanol, non-steroidal anti-inflammatory drugs (NSAIDs) and duodenal mucosal damage induced by cysteamine. Additionally, both partitions were associated with a significant increase in gastric and duodenal healing and increased gastric mucosal GSH content after damage induced by acetic acid. On the other hand, after 6 days of treatment, EtOAc was more effective than AcoAq in ameliorating gastric damage upon initiation of the gastric I/R, which was accompanied by a significant reduction in the activity of gastric mucosal MPO, IL 1-β and TNFalpha, as well as an elevation in IL-10 and GSH content. These results demonstrate that the oligomeric proanthocyanidins and galloyl quinic esters present in AcoAq were more effective in the prevention of gastric and duodenal ulcers due to the antioxidant effects of these compounds, whereas the flavonoids present in EtOAc were more effective due to their anti-inflammatory activity on the gastric and duodenal tissue. All these results confirm that the rich phytochemical diversity of B. intermedia contributes to the pharmacological actions of this medicinal plant on the gastrointestinal tract in addition to its activity against H. pylori.
650 $aAnti-inflammatory activity
653 $aHealing effect
653 $aPeptic ulcer
700 1 $aBONAMINA, F.
700 1 $aPÉRICO, L. L.
700 1 $aRODRIGUES, V. P.
700 1 $aZANATTA, A. C.
700 1 $aRODRIGUES, C. M.
700 1 $aSANNOMIYA, M.
700 1 $aRAMOS. M. A. dos S.
700 1 $aBONIFÁCIO, B. V.
700 1 $aBAUAB, T. M.
700 1 $aTAMASHIRO, J.
700 1 $aROCHA, L. R. M. da
700 1 $aVILEGAS, W.
700 1 $aHIRUMA-LIMA, C. A.
773 $tBiomedicine & Pharmacotherapy$gv. 111, p. 1112-1123, 2019.
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