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Registro Completo |
Biblioteca(s): |
Embrapa Pecuária Sudeste. |
Data corrente: |
09/11/2017 |
Data da última atualização: |
21/11/2017 |
Tipo da produção científica: |
Artigo em Periódico Indexado |
Autoria: |
SILVA, I. C. da; MAGALHAES, P. M. de; SOUSA, I. M. de O.; FOGLIO, M. A.; LEONARDECZ, E.; ESTEVES, S. N.; CHAGAS, A. C. de S. |
Afiliação: |
Ives Charlie da Silva, UNESP; Pedro Melillo de Magalhães, UNICAMP; Ilza Maria de Oliveira Sousa, UNICAMP; Mary Ann Foglio, UNICAMP; Eduardo Leonardecz, UFSCar; SERGIO NOVITA ESTEVES, CPPSE; ANA CAROLINA DE SOUZA CHAGAS, CPPSE. |
Título: |
Anthelmintic activity of Artemisia annua in sheepmodel. |
Ano de publicação: |
2017 |
Fonte/Imprenta: |
Journal of Medicinal Plants Research, v. 11, n. 7, p. 137-143, 2017. |
DOI: |
10.5897/JMPR2016.6318 |
Idioma: |
Inglês |
Conteúdo: |
Artemisia annua L. is a well-known source of artemisinin, an antimalarial drug. This compound has been used in traditional medicine to treat malaria for many years. The anthelmintic property of A. annua has also been attributed to artemisinin, hence the belief that artemisinin could be useful as an alternative anthelmintic to control Haemonchus contortus in livestock. The present study focused on evaluating the anthelmintic activity of A. annua against H. contortus by oral administration on infected sheep in a controlled clinical trial. The trial was conducted using 24 male sheep of the Santa Inês breed, with average weight of 20 kg, artificially infected with H. contortus (Embrapa 2010 isolate). The animals were kept in metabolic cages and randomly divided into four homogeneous groups with six animals each, being: (T1) negative control (untreated), (T2) positive control: 10 mg/kg BW of levamisole phosphate, (T3) fed 10% A. annua (0.2% BW), (T4) fed 20% A. annua (0.4% BW). EPG counts were conducted on days -3, -2, -1, 0 (treatment day), 3, 7, 10, 14, 17, 21, 24 and 28 post-treatment. After extraction of the artemisinin in plant material, it was quantified in triplicate and analyzed by high-performance liquid chromatography with infrared detection. The average efficacy in the positive control treated with levamisole was 89%. Moderate anthelmintic efficacy against H. contortus was observed in the groups fed 0.2 and 0.4% BW A. annua for 30 days (32.9 and 14.8%, respectively), mainly from day 21 post treatment (47.1 and 25.2%, respectively). At the highest dose, the animals avoided eating due to the compound?s bitter taste. It is concluded that A. annua presents moderate anthelmintic activity in sheep in both doses. The lowest dose was accepted by animals and seems to have practical use. Oral administration was safe and after further in vivo trials could be introduced in organic farms in tropical countries. MenosArtemisia annua L. is a well-known source of artemisinin, an antimalarial drug. This compound has been used in traditional medicine to treat malaria for many years. The anthelmintic property of A. annua has also been attributed to artemisinin, hence the belief that artemisinin could be useful as an alternative anthelmintic to control Haemonchus contortus in livestock. The present study focused on evaluating the anthelmintic activity of A. annua against H. contortus by oral administration on infected sheep in a controlled clinical trial. The trial was conducted using 24 male sheep of the Santa Inês breed, with average weight of 20 kg, artificially infected with H. contortus (Embrapa 2010 isolate). The animals were kept in metabolic cages and randomly divided into four homogeneous groups with six animals each, being: (T1) negative control (untreated), (T2) positive control: 10 mg/kg BW of levamisole phosphate, (T3) fed 10% A. annua (0.2% BW), (T4) fed 20% A. annua (0.4% BW). EPG counts were conducted on days -3, -2, -1, 0 (treatment day), 3, 7, 10, 14, 17, 21, 24 and 28 post-treatment. After extraction of the artemisinin in plant material, it was quantified in triplicate and analyzed by high-performance liquid chromatography with infrared detection. The average efficacy in the positive control treated with levamisole was 89%. Moderate anthelmintic efficacy against H. contortus was observed in the groups fed 0.2 and 0.4% BW A. annua for 30 days (32.9 and 14.8%, respectively), m... Mostrar Tudo |
Thesaurus Nal: |
artemisinin; gastrointestinal nematodes; sesquiterpenoids. |
Categoria do assunto: |
L Ciência Animal e Produtos de Origem Animal |
Marc: |
LEADER 02655naa a2200241 a 4500 001 2079284 005 2017-11-21 008 2017 bl uuuu u00u1 u #d 024 7 $a10.5897/JMPR2016.6318$2DOI 100 1 $aSILVA, I. C. da 245 $aAnthelmintic activity of Artemisia annua in sheepmodel.$h[electronic resource] 260 $c2017 520 $aArtemisia annua L. is a well-known source of artemisinin, an antimalarial drug. This compound has been used in traditional medicine to treat malaria for many years. The anthelmintic property of A. annua has also been attributed to artemisinin, hence the belief that artemisinin could be useful as an alternative anthelmintic to control Haemonchus contortus in livestock. The present study focused on evaluating the anthelmintic activity of A. annua against H. contortus by oral administration on infected sheep in a controlled clinical trial. The trial was conducted using 24 male sheep of the Santa Inês breed, with average weight of 20 kg, artificially infected with H. contortus (Embrapa 2010 isolate). The animals were kept in metabolic cages and randomly divided into four homogeneous groups with six animals each, being: (T1) negative control (untreated), (T2) positive control: 10 mg/kg BW of levamisole phosphate, (T3) fed 10% A. annua (0.2% BW), (T4) fed 20% A. annua (0.4% BW). EPG counts were conducted on days -3, -2, -1, 0 (treatment day), 3, 7, 10, 14, 17, 21, 24 and 28 post-treatment. After extraction of the artemisinin in plant material, it was quantified in triplicate and analyzed by high-performance liquid chromatography with infrared detection. The average efficacy in the positive control treated with levamisole was 89%. Moderate anthelmintic efficacy against H. contortus was observed in the groups fed 0.2 and 0.4% BW A. annua for 30 days (32.9 and 14.8%, respectively), mainly from day 21 post treatment (47.1 and 25.2%, respectively). At the highest dose, the animals avoided eating due to the compound?s bitter taste. It is concluded that A. annua presents moderate anthelmintic activity in sheep in both doses. The lowest dose was accepted by animals and seems to have practical use. Oral administration was safe and after further in vivo trials could be introduced in organic farms in tropical countries. 650 $aartemisinin 650 $agastrointestinal nematodes 650 $asesquiterpenoids 700 1 $aMAGALHAES, P. M. de 700 1 $aSOUSA, I. M. de O. 700 1 $aFOGLIO, M. A. 700 1 $aLEONARDECZ, E. 700 1 $aESTEVES, S. N. 700 1 $aCHAGAS, A. C. de S. 773 $tJournal of Medicinal Plants Research$gv. 11, n. 7, p. 137-143, 2017.
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Embrapa Pecuária Sudeste (CPPSE) |
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Biblioteca(s): |
Embrapa Hortaliças. |
Data corrente: |
22/07/1999 |
Data da última atualização: |
29/09/2014 |
Autoria: |
TEIXEIRA, D. M. C.; NASCIMENTO, A. S. |
Afiliação: |
EMBRAPA-CNPH, Brasilia, DF. |
Título: |
Reducao do crescimento in vitro de batata-doce pela adicao de acido abscisico. |
Ano de publicação: |
1999 |
Fonte/Imprenta: |
Brasilia: EMBRAPA-CNPH, 1999. |
Páginas: |
4p. |
Série: |
(EMBRAPA-CNPH. Pesquisa em Andamento da Embrapa Hortalicas, 22). |
Idioma: |
Português |
Conteúdo: |
O objetivo deste trabalho preliminar foi avaliar o efeito do ácido abscísico no crescimento e desenvolvimento in vitro de quatro genótipos de batata-doce. |
Palavras-Chave: |
Acido abcisico; Batata-doce; Brasil; Brasilia; Distrito Federal; In vitro; Reducao de crescimento; Slow growth; Sweetpotatoes. |
Thesagro: |
Cerrado; Germoplasma; Ipomoea Batatas; Sacarose. |
Thesaurus NAL: |
abscisic acid; Brazil; germplasm; sucrose. |
Categoria do assunto: |
-- |
URL: |
https://ainfo.cnptia.embrapa.br/digital/bitstream/item/109248/1/Reducao-do-crescimento-in-vitro-de-batata-doce-pela-adicao-de-acido-abscisico.pdf
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Marc: |
LEADER 01080nam a2200349 a 4500 001 1766625 005 2014-09-29 008 1999 bl uuuu u0uu1 u #d 100 1 $aTEIXEIRA, D. M. C. 245 $aReducao do crescimento in vitro de batata-doce pela adicao de acido abscisico. 260 $aBrasilia: EMBRAPA-CNPH$c1999 300 $a4p. 490 $a(EMBRAPA-CNPH. Pesquisa em Andamento da Embrapa Hortalicas, 22). 520 $aO objetivo deste trabalho preliminar foi avaliar o efeito do ácido abscísico no crescimento e desenvolvimento in vitro de quatro genótipos de batata-doce. 650 $aabscisic acid 650 $aBrazil 650 $agermplasm 650 $asucrose 650 $aCerrado 650 $aGermoplasma 650 $aIpomoea Batatas 650 $aSacarose 653 $aAcido abcisico 653 $aBatata-doce 653 $aBrasil 653 $aBrasilia 653 $aDistrito Federal 653 $aIn vitro 653 $aReducao de crescimento 653 $aSlow growth 653 $aSweetpotatoes 700 1 $aNASCIMENTO, A. S.
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