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Registro Completo |
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Biblioteca(s): |
Embrapa Semiárido. |
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Data corrente: |
24/01/2020 |
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Data da última atualização: |
12/01/2023 |
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Tipo da produção científica: |
Artigo em Periódico Indexado |
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Autoria: |
CASTRO, C. B. DE; LUZ, L. DOS R.; GUEDES, J. A. C.; PORTO, D. D.; SILVA, M. F. S.; SILVA, G. S. DA; RIBEIRO, P. R. V.; CANUTO, K. M.; BRITO, E. S. de; ZAMPIERI, D. DE S.; PESSOA, C. do Ó.; ZOCOLO, G. J. |
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Afiliação: |
CAIO BEZERRA DE CASTRO, Universidade Federal de São Carlos. Departamento de Química; LICIA DOS REIS LUZ, Universidade Federal do Ceará. Departamento de Química Analítica e Físico-Química.; JHONYSON ARRUDA CARVALHO GUEDES, CNPAT; DIOGO DENARDI PORTO, CPATSA; MARIA FRANCILENE SOUZA SILVA, Universidade Federal do Ceará. Núcleo de Pesquisa e Desenvolvimento de Medicamentos (NPDM); GISELE SILVESTRE DA SILVA, CNPAT; PAULO RICELI VASCONCELOS RIBEIRO, CNPAT; KIRLEY MARQUES CANUTO, CNPAT; EDY SOUSA DE BRITO, CNPAT; DÁVILA DE SOUZA ZAMPIERI, Universidade Federal do Ceará. Departamento de Química Orgânica e Inorgânica.; ClLAUDIA DO Ó PESSOA, Universidade Federal do Ceará. Núcleo de Pesquisa e Desenvolvimento de Medicamentos (NPDM).; GUILHERME JULIAO ZOCOLO, CNPAT. |
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Título: |
Metabolomics-based discovery of biomarkers with cytotoxic potential in extracts of Myracrodruon urundeuva. |
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Ano de publicação: |
2020 |
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Fonte/Imprenta: |
Journal of the Brazilian Chemical Society, v. 31, n. p. 775-787, 2020. |
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DOI: |
http://dx.doi.org/10.21577/0103-5053.20190242 |
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Idioma: |
Inglês |
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Conteúdo: |
Myracrodruon urundeuva (aroeira-do-sertão) is a species threatened with extinction due to anthropogenic exploitation. Phytochemical analysis of bark, branch and leaf extracts revealed the presence of several compounds such as flavonoids, phenols, tannins, quercetin derivatives and anacardic acids. Dereplication methodology was performed to tentatively identify 50 compounds analyzed by ultra-performance liquid chromatography coupled with an electrospray ionization quadrupole time-of-flight mass spectrometry operating in MSE mode (UPLC-QTOF-MSE). The extracts exhibited anti-tumor effect in cancer cells HCT-116 (colorectal), SF-295 (glioblastoma), HL-60 (leukemia), and RAJI (leukemia). Also, these results correlate with the principal component analysis (PCA) data that identified three distinct groups indicating, efficiently, metabolic differences between organs of M. urundeuva. Through discriminatory analysis of the orthogonal partial least squares (OPLS-DA), the variable of importance in the projection (VIP) and S-Plot, we were able to determine 30 potential biomarkers. The fingerprint of hydroethanolic extracts was correlated with the cytotoxicity assay and demonstrated a significant difference in the composition of plant extract. |
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Palavras-Chave: |
Aroeira do sertão; Atividade citotóxica; Bioma Caatinga; Quimiometria; UPLC-MS/MS. |
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Thesagro: |
Aroeira; Caatinga; Espécie Nativa; Myracrodruon Urundeuva; Vegetação Nativa. |
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Thesaurus Nal: |
Chemometrics; Cytotoxicity. |
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Categoria do assunto: |
X Pesquisa, Tecnologia e Engenharia |
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URL: |
https://ainfo.cnptia.embrapa.br/digital/bitstream/doc/1119316/1/Metabolomics-based-discovery-of-biomarkers-with-cytotoxic-potential-in-extracts-of-Myracrodruon-urundeuva-2020.pdf
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Marc: |
LEADER 02468naa a2200409 a 4500
001 2119316
005 2023-01-12
008 2020 bl uuuu u00u1 u #d
024 7 $ahttp://dx.doi.org/10.21577/0103-5053.20190242$2DOI
100 1 $aCASTRO, C. B. DE
245 $aMetabolomics-based discovery of biomarkers with cytotoxic potential in extracts of Myracrodruon urundeuva.$h[electronic resource]
260 $c2020
520 $aMyracrodruon urundeuva (aroeira-do-sertão) is a species threatened with extinction due to anthropogenic exploitation. Phytochemical analysis of bark, branch and leaf extracts revealed the presence of several compounds such as flavonoids, phenols, tannins, quercetin derivatives and anacardic acids. Dereplication methodology was performed to tentatively identify 50 compounds analyzed by ultra-performance liquid chromatography coupled with an electrospray ionization quadrupole time-of-flight mass spectrometry operating in MSE mode (UPLC-QTOF-MSE). The extracts exhibited anti-tumor effect in cancer cells HCT-116 (colorectal), SF-295 (glioblastoma), HL-60 (leukemia), and RAJI (leukemia). Also, these results correlate with the principal component analysis (PCA) data that identified three distinct groups indicating, efficiently, metabolic differences between organs of M. urundeuva. Through discriminatory analysis of the orthogonal partial least squares (OPLS-DA), the variable of importance in the projection (VIP) and S-Plot, we were able to determine 30 potential biomarkers. The fingerprint of hydroethanolic extracts was correlated with the cytotoxicity assay and demonstrated a significant difference in the composition of plant extract.
650 $aChemometrics
650 $aCytotoxicity
650 $aAroeira
650 $aCaatinga
650 $aEspécie Nativa
650 $aMyracrodruon Urundeuva
650 $aVegetação Nativa
653 $aAroeira do sertão
653 $aAtividade citotóxica
653 $aBioma Caatinga
653 $aQuimiometria
653 $aUPLC-MS/MS
700 1 $aLUZ, L. DOS R.
700 1 $aGUEDES, J. A. C.
700 1 $aPORTO, D. D.
700 1 $aSILVA, M. F. S.
700 1 $aSILVA, G. S. DA
700 1 $aRIBEIRO, P. R. V.
700 1 $aCANUTO, K. M.
700 1 $aBRITO, E. S. de
700 1 $aZAMPIERI, D. DE S.
700 1 $aPESSOA, C. do Ó.
700 1 $aZOCOLO, G. J.
773 $tJournal of the Brazilian Chemical Society$gv. 31, n. p. 775-787, 2020.
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Registro original: |
Embrapa Semiárido (CPATSA) |
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 | Acesso ao texto completo restrito à biblioteca da Embrapa Meio Ambiente. Para informações adicionais entre em contato com cnpma.biblioteca@embrapa.br. |
Registro Completo
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Biblioteca(s): |
Embrapa Meio Ambiente. |
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Data corrente: |
28/02/2018 |
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Data da última atualização: |
01/08/2023 |
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Tipo da produção científica: |
Capítulo em Livro Técnico-Científico |
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Autoria: |
CAPALBO, D. M. F.; SUZUKI, M. T. |
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Afiliação: |
DEISE MARIA FONTANA CAPALBO, CNPMA; MARISE TANAKA SUZUKI, CENTRO UNIVERSITÁRIO UNIRG, GURUPI/TO. |
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Título: |
The Importance of Bacillus thuringiensis in the context of genetically modified plants in Brazil. |
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Ano de publicação: |
2017 |
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Fonte/Imprenta: |
In: FIUZA, L. M.; POLANCZYK, R. A.; CRICKMORE, N. (Ed.). Bacillus thuringiensis and Lysinibacillus sphaericus: characterization and use in the field of biocontrol. Cham: Springer, 2017. cap. 16, p. 259-271. |
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DOI: |
10.1007/978-3-319-56678-8_16 |
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Idioma: |
Inglês |
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Conteúdo: |
Sustainable agriculture requires alternative interventions for pest control and management. In this context the use of microorganisms pathogenic to pests has become even more studied and widespread, especially in the successful case of bioinsecticides based on Bacillus thuringiensis. With advances in recombinant DNA biotechnology, B. thuringiensis has continued to show its potential with the insertion of its insecticide-encoding genes into plants, which thus become resistant to a varied range of pest insects. These Bt plants, often containing multiple Bt genes, are commercially available. And today, after assessing biosafety in several countries around the world, they are adequate to control pests without significant harm to humans or to the environment. If the required safety conditions are maintained, a greater use of these plants is anticipated, guaranteeing an effective tool for an environmentally friendly agriculture. |
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Palavras-Chave: |
Bt plants. |
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Thesagro: |
Biossegurança; Planta transgênica. |
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Thesaurus NAL: |
Agriculture; Biosafety; Genetically modified plants. |
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Categoria do assunto: |
--
S Ciências Biológicas |
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Marc: |
LEADER 01761naa a2200217 a 4500
001 2155533
005 2023-08-01
008 2017 bl uuuu u00u1 u #d
024 7 $a10.1007/978-3-319-56678-8_16$2DOI
100 1 $aCAPALBO, D. M. F.
245 $aThe Importance of Bacillus thuringiensis in the context of genetically modified plants in Brazil.$h[electronic resource]
260 $c2017
520 $aSustainable agriculture requires alternative interventions for pest control and management. In this context the use of microorganisms pathogenic to pests has become even more studied and widespread, especially in the successful case of bioinsecticides based on Bacillus thuringiensis. With advances in recombinant DNA biotechnology, B. thuringiensis has continued to show its potential with the insertion of its insecticide-encoding genes into plants, which thus become resistant to a varied range of pest insects. These Bt plants, often containing multiple Bt genes, are commercially available. And today, after assessing biosafety in several countries around the world, they are adequate to control pests without significant harm to humans or to the environment. If the required safety conditions are maintained, a greater use of these plants is anticipated, guaranteeing an effective tool for an environmentally friendly agriculture.
650 $aAgriculture
650 $aBiosafety
650 $aGenetically modified plants
650 $aBiossegurança
650 $aPlanta transgênica
653 $aBt plants
700 1 $aSUZUKI, M. T.
773 $tIn: FIUZA, L. M.; POLANCZYK, R. A.; CRICKMORE, N. (Ed.). Bacillus thuringiensis and Lysinibacillus sphaericus: characterization and use in the field of biocontrol. Cham: Springer, 2017. cap. 16, p. 259-271.
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Embrapa Meio Ambiente (CNPMA) |
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