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 | Acesso ao texto completo restrito à biblioteca da Embrapa Mandioca e Fruticultura. Para informações adicionais entre em contato com cnpmf.biblioteca@embrapa.br. |
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Registro Completo |
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Biblioteca(s): |
Embrapa Mandioca e Fruticultura. |
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Data corrente: |
28/03/2009 |
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Data da última atualização: |
10/07/2023 |
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Tipo da produção científica: |
Resumo em Anais de Congresso |
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Autoria: |
BERGER, I. J.; FREITAS-ÁSTUA, J.; SILVA-PINHATI, A. C. O.; BASILIO-PALMIERI, A. C.; LUCHETA, A. R.; NOVELLI, V. M.; MACHADO, M. A. |
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Afiliação: |
Irving J. Berger, APTA; Juliana Freitas-Ástua, CNPMF; Ana Carla O. Silva-Pinhati, APTA; Ana Carolina Basílio-Palmieri, APTA; Adriano R. Lucheta, APTA; Valdenice M. Novelli, APTA; Marcos A. Machado, APTA. |
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Título: |
Chalcone isomerase is likely encoded by a multigene family in citrus sinensis. |
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Ano de publicação: |
2008 |
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Fonte/Imprenta: |
In: THE INTERNATIONAL CONFERENCE ON THE STATUS OF PLANT & ANIMAL GENOME RESEARCH, 16., 2008, San Diego. Final abstracts guide. San Diego: Illumina, 2008. |
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Idioma: |
Inglês |
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Notas: |
P21 |
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Conteúdo: |
Flavanones are the predominant group of flavonoids in the juice of sweet orange. In addition to their flavor-related role, flavanoves have been considered important dietary components with a role in maintaining healthy blood vessels and bones, as cancer and mutagenesis-suppressing agents and as anti-allergic, anti-inflamatory and anti-microbial compounds. Chalcone isomerase (CHI) catalyses the committed cyclization of bicyclic chalcones into tricyclic (S)-flavanones and is the key enzyme on directing the flavonoid pathway to the synthesis of flavanones, flavones, flavonols, isoflavones, tannins and anthocyanins. While it is suggested in the literature that a single-copy gene codes for CHI in sweet orange (Citrus sinensis L. Osb.), analysis of Citrus ESTs (CitEST) database indicates the presence of at least three putative chi transcripts, which supports the hypothesis of a multigene family coding for chalcone isomerase isoforms in fruits of sweet orange with the expression of the enzyme in both early and late fruit developmental stages. |
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Thesagro: |
Flavonóide; Fruta Cítrica. |
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Categoria do assunto: |
F Plantas e Produtos de Origem Vegetal |
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Marc: |
LEADER 01794nam a2200217 a 4500
001 1655628
005 2023-07-10
008 2008 bl uuuu u00u1 u #d
100 1 $aBERGER, I. J.
245 $aChalcone isomerase is likely encoded by a multigene family in citrus sinensis.$h[electronic resource]
260 $aIn: THE INTERNATIONAL CONFERENCE ON THE STATUS OF PLANT & ANIMAL GENOME RESEARCH, 16., 2008, San Diego. Final abstracts guide. San Diego: Illumina$c2008
500 $aP21
520 $aFlavanones are the predominant group of flavonoids in the juice of sweet orange. In addition to their flavor-related role, flavanoves have been considered important dietary components with a role in maintaining healthy blood vessels and bones, as cancer and mutagenesis-suppressing agents and as anti-allergic, anti-inflamatory and anti-microbial compounds. Chalcone isomerase (CHI) catalyses the committed cyclization of bicyclic chalcones into tricyclic (S)-flavanones and is the key enzyme on directing the flavonoid pathway to the synthesis of flavanones, flavones, flavonols, isoflavones, tannins and anthocyanins. While it is suggested in the literature that a single-copy gene codes for CHI in sweet orange (Citrus sinensis L. Osb.), analysis of Citrus ESTs (CitEST) database indicates the presence of at least three putative chi transcripts, which supports the hypothesis of a multigene family coding for chalcone isomerase isoforms in fruits of sweet orange with the expression of the enzyme in both early and late fruit developmental stages.
650 $aFlavonóide
650 $aFruta Cítrica
700 1 $aFREITAS-ÁSTUA, J.
700 1 $aSILVA-PINHATI, A. C. O.
700 1 $aBASILIO-PALMIERI, A. C.
700 1 $aLUCHETA, A. R.
700 1 $aNOVELLI, V. M.
700 1 $aMACHADO, M. A.
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Registro original: |
Embrapa Mandioca e Fruticultura (CNPMF) |
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Registro Completo
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Biblioteca(s): |
Embrapa Gado de Leite. |
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Data corrente: |
14/03/2013 |
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Data da última atualização: |
09/02/2024 |
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Tipo da produção científica: |
Artigo em Periódico Indexado |
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Circulação/Nível: |
A - 2 |
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Autoria: |
MAZZOCCOLI, L.; CARDOSO, SILVIA H.; AMARANTE, G. W.; SOUZA, M. V. N. DE; DOMINGUES, R.; MACHADO, M. A.; ALMEIDA, M. V. DE; TEIXEIRA, H. C. |
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Afiliação: |
LUCIANO MAZZOCCOLI, UFJF; SILVIA H. CARDOSO, UFJF; GIOVANNI W. AMARANTE, UFJF; MARCUS V. N. DE SOUZA, UFJF; ROBERT DOMINGUES, CPPSUL; MARCO ANTONIO MACHADO, CNPGL; MAURO V. DE ALMEIDA, UFJF; HENRIQUE C. TEIXEIRA, UFJF. |
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Título: |
Novel thalidomide analogues from diamines inhibit pro-inflammatory cytokine production and CD80 expression while enhancing IL-10. |
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Ano de publicação: |
2012 |
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Fonte/Imprenta: |
Biomedicine & Pharmacotherapy, v. 66, p. 323-329, 2012. |
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DOI: |
https://doi.org/10.1016/j.biopha.2012.05.001 |
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Idioma: |
Inglês |
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Notas: |
Não consta da meta de 2012. |
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Conteúdo: |
Thalidomide is used to treat a variety of diseases including erythema nodosum leprosum, an inflammatory complication of leprosy. However, this drug has severe teratogenic activity and novel thalidomide analogues might be used to treat diseases without this severe side effect. A series of diamine compounds containing two hydrolyzed phthalimide units were chosen as analogues of thalidomide and evaluated regarding their capacity to regulate the production of molecules involved in inflammatory responses. TNF-α, IL-12 and IL-10 production, and the expression of CD80 and CD86 were investigated in LPS plus IFN-γ-stimulated J774A.1 cells by ELISA and flow cytometry, respectively. The expression of TNF-α and IL-10 mRNA was analyzed by real time RT-PCR. TNF-α, IL-6, IFN-γ, CXCL9 and CXCL10 production by human peripheral blood mononuclear cells (PBMC) were evaluated by flow cytometry. Compounds 3, 6 and 9 greatly inhibited TNF-α and IL-12 production while enhancing IL-10. In addition, CD80 expression was inhibited, but not CD86. The compounds inhibited TNF-α production by PBMC more than thalidomide and also had an inhibitory effect on the production of IL-6, IFN-γ, CXCL9 and CXCL10. Levels of mRNA for TNF-α were reduced after treatment with the compounds, suggesting post- transcriptional effects. The compounds had no effect on cell viability. Our results indicate that the novel diamine compounds 3, 6 and 9 inhibit critical pro-inflammatory cytokines and stimulate IL-10, which make them attractive candidate drugs for the treatment of certain inflammatory conditions and cancer. MenosThalidomide is used to treat a variety of diseases including erythema nodosum leprosum, an inflammatory complication of leprosy. However, this drug has severe teratogenic activity and novel thalidomide analogues might be used to treat diseases without this severe side effect. A series of diamine compounds containing two hydrolyzed phthalimide units were chosen as analogues of thalidomide and evaluated regarding their capacity to regulate the production of molecules involved in inflammatory responses. TNF-α, IL-12 and IL-10 production, and the expression of CD80 and CD86 were investigated in LPS plus IFN-γ-stimulated J774A.1 cells by ELISA and flow cytometry, respectively. The expression of TNF-α and IL-10 mRNA was analyzed by real time RT-PCR. TNF-α, IL-6, IFN-γ, CXCL9 and CXCL10 production by human peripheral blood mononuclear cells (PBMC) were evaluated by flow cytometry. Compounds 3, 6 and 9 greatly inhibited TNF-α and IL-12 production while enhancing IL-10. In addition, CD80 expression was inhibited, but not CD86. The compounds inhibited TNF-α production by PBMC more than thalidomide and also had an inhibitory effect on the production of IL-6, IFN-γ, CXCL9 and CXCL10. Levels of mRNA for TNF-α were reduced after treatment with the compounds, suggesting post- transcriptional effects. The compounds had no effect on cell viability. Our results indicate that the novel diamine compounds 3, 6 and 9 inhibit critical pro-inflammatory cytokines and stimulate IL-10, which make them... Mostrar Tudo |
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Palavras-Chave: |
IL-10; Resposta inflamatória; Talidomida analógico; TNF-a. |
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Categoria do assunto: |
H Saúde e Patologia |
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Marc: |
LEADER 02493naa a2200277 a 4500
001 1953088
005 2024-02-09
008 2012 bl uuuu u00u1 u #d
024 7 $ahttps://doi.org/10.1016/j.biopha.2012.05.001$2DOI
100 1 $aMAZZOCCOLI, L.
245 $aNovel thalidomide analogues from diamines inhibit pro-inflammatory cytokine production and CD80 expression while enhancing IL-10.$h[electronic resource]
260 $c2012
500 $aNão consta da meta de 2012.
520 $aThalidomide is used to treat a variety of diseases including erythema nodosum leprosum, an inflammatory complication of leprosy. However, this drug has severe teratogenic activity and novel thalidomide analogues might be used to treat diseases without this severe side effect. A series of diamine compounds containing two hydrolyzed phthalimide units were chosen as analogues of thalidomide and evaluated regarding their capacity to regulate the production of molecules involved in inflammatory responses. TNF-α, IL-12 and IL-10 production, and the expression of CD80 and CD86 were investigated in LPS plus IFN-γ-stimulated J774A.1 cells by ELISA and flow cytometry, respectively. The expression of TNF-α and IL-10 mRNA was analyzed by real time RT-PCR. TNF-α, IL-6, IFN-γ, CXCL9 and CXCL10 production by human peripheral blood mononuclear cells (PBMC) were evaluated by flow cytometry. Compounds 3, 6 and 9 greatly inhibited TNF-α and IL-12 production while enhancing IL-10. In addition, CD80 expression was inhibited, but not CD86. The compounds inhibited TNF-α production by PBMC more than thalidomide and also had an inhibitory effect on the production of IL-6, IFN-γ, CXCL9 and CXCL10. Levels of mRNA for TNF-α were reduced after treatment with the compounds, suggesting post- transcriptional effects. The compounds had no effect on cell viability. Our results indicate that the novel diamine compounds 3, 6 and 9 inhibit critical pro-inflammatory cytokines and stimulate IL-10, which make them attractive candidate drugs for the treatment of certain inflammatory conditions and cancer.
653 $aIL-10
653 $aResposta inflamatória
653 $aTalidomida analógico
653 $aTNF-a
700 1 $aCARDOSO, SILVIA H.
700 1 $aAMARANTE, G. W.
700 1 $aSOUZA, M. V. N. DE
700 1 $aDOMINGUES, R.
700 1 $aMACHADO, M. A.
700 1 $aALMEIDA, M. V. DE
700 1 $aTEIXEIRA, H. C.
773 $tBiomedicine & Pharmacotherapy$gv. 66, p. 323-329, 2012.
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