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| Registros recuperados : 82 | |
| 8. |  | MELO, A. L. de; SOUZA, M. M. de; REGITANO, L. C. de A. Identificação de possíveis causas de expressão alelo-específica em músculo de novilhos da raça Nelore. In: JORNADA CIENTÍFICA DA EMBRAPA SÃO CARLOS, 10., 2018, São Carlos, SP. Anais... São Carlos, SP: Embrapa Instrumentação; Embrapa Pecuária Sudeste, 2018. p. 43. (Embrapa Instrumentação. Documentos, 68). Editores técnicos: Daniel Souza Corrêa, Elaine Cristina Paris, Maria Alice Martins, Paulino Ribeiro Villas Boas, Wilson Tadeu Lopes da Silva.| Biblioteca(s): Embrapa Pecuária Sudeste. |
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| 15. | | SOUZA, G. F. J. P. de; OLIVEIRA, A. L. P. C. de; SOUZA, M. M. de. Contribuição ao conhecimento do lenho de Laguncularia racemosa (L.). Silvicultura em São Paulo, São Paulo, v. 16-A, pt. 1, p. 280-292, 1982. Edição dos Anais do Congresso Nacional sobre Essências Nativas, 1982, Campos do Jordão.| Biblioteca(s): Embrapa Florestas. |
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| 18. | | DANTAS, A. P.; FERRAZ, L.; SILVA, A. Q. da; SOUZA, M. M. de; REIS, O. V. dos. Estudo de adubacao fosfatada em bananeira Cv. Prata (Musa sp.) Salvador: SBF, 1977 p.59-64 In: CONGRESSO BRASILEIRO DE FRUTICULTURA, 4., 1997, Salvador. Anais...Cruz das Almas: SBF, 1978.| Biblioteca(s): Embrapa Mandioca e Fruticultura. |
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| Registros recuperados : 82 | |
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Registro Completo
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Biblioteca(s): |
Embrapa Agricultura Digital; Embrapa Pecuária Sudeste. |
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Data corrente: |
09/10/2020 |
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Data da última atualização: |
09/10/2020 |
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Tipo da produção científica: |
Artigo em Periódico Indexado |
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Circulação/Nível: |
A - 1 |
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Autoria: |
SOUZA, M. M. de; ZERLOTINI NETO, A.; ROCHA, M. I. P.; BRUSCADIN, J. J.; DINIZ, W. J. da S.; CARDOSO, T. F.; CESAR, A. S. M.; AFONSO, J.; ANDRADE, B. G. N.; MUDADU, M. de A.; MOKRY, F. B.; TIZIOTO, P. C.; OLIVEIRA, P. S. N. de; NICIURA, S. C. M.; COUTINHO, L. L.; REGITANO, L. C. de A. |
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Afiliação: |
MARCELA MARIA DE SOUZA, UFSCar; ADHEMAR ZERLOTINI NETO, CNPTIA; MARINA IBELLI PEREIRA ROCHA, UFSCar; JENNIFER JESSICA BRUSCADIN, UFSCar; WELLISON JARLES DA SILVA DINIZ, UFSCar; TAINÃ FIGUEIREDO CARDOSO; ALINE SILVA MELLO CESAR, ESALQ/USP; JULIANA AFONSO, UFSCar; BRUNO GABRIEL NASCIMENTO ANDRADE, UFSCar; MAURICIO DE ALVARENGA MUDADU, CNPTIA; FABIANA BARICHELLO MOKRY, UFSCar; POLYANA CRISTINE TIZIOTO, NGS Soluções Genômicas, Piracicaba; PRISCILA SILVA NEUBERN DE OLIVEIRA; SIMONE CRISTINA MEO NICIURA, CPPSE; LUIZ LEHMANN COUTINHO, ESALQ/USP; LUCIANA CORREIA DE ALMEIDA REGITANO, CPPSE. |
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Título: |
Allele-specific expression is widespread in Bos indicus muscle and affects meat quality candidate genes. |
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Ano de publicação: |
2020 |
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Fonte/Imprenta: |
Scientific Reports, v. 10, n. 1, p. 1-11, 2020. |
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DOI: |
https://doi.org/10.1038/S41598-020-67089-0 |
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Idioma: |
Inglês |
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Notas: |
Na publicação: Adhemar Zerlotini. Article number: 10204. |
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Conteúdo: |
Differences between the expression of the two alleles of a gene are known as allele-specific expression (ASE), a common event in the transcriptome of mammals. Despite ASE being a source of phenotypic variation, its occurrence and effects on genetic prediction of economically relevant traits are still unexplored in bovines. Furthermore, as ASE events are likely driven by cis-regulatory mutations, scanning them throughout the bovine genome represents a significant step to elucidate the mechanisms underlying gene expression regulation. To address this question in a Bos indicus population, we built the ASE profile of the skeletal muscle tissue of 190 Nelore steers, using RNA sequencing data and SNPs genotypes from the Illumina BovineHD BeadChip (770 K bp). After quality control, 820 SNPs showed at least one sample with ASE. These SNPs were widespread among all autosomal chromosomes, being 32.01% found in 3'UTR and 31.41% in coding regions. We observed a considerable variation of ASE profile among individuals, which highlighted the need for biological replicates in ASE studies. Functional analysis revealed that ASE genes play critical biological functions in the development and maintenance of muscle tissue. Additionally, some of these genes were previously reported as associated with beef production and quality traits in livestock, thus indicating a possible source of bias on genomic predictions for these traits. |
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Palavras-Chave: |
Allele-specific expression; Allelic expression; Expressão gênica; Regulação da expressão gênica. |
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Thesagro: |
Bos Indicus. |
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Thesaurus NAL: |
Gene expression regulation. |
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Categoria do assunto: |
--
G Melhoramento Genético |
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URL: |
https://ainfo.cnptia.embrapa.br/digital/bitstream/item/216548/1/AP-Allele-specific-2020.pdf
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|
Marc: |
LEADER 02698naa a2200397 a 4500
001 2125395
005 2020-10-09
008 2020 bl uuuu u00u1 u #d
024 7 $ahttps://doi.org/10.1038/S41598-020-67089-0$2DOI
100 1 $aSOUZA, M. M. de
245 $aAllele-specific expression is widespread in Bos indicus muscle and affects meat quality candidate genes.$h[electronic resource]
260 $c2020
500 $aNa publicação: Adhemar Zerlotini. Article number: 10204.
520 $aDifferences between the expression of the two alleles of a gene are known as allele-specific expression (ASE), a common event in the transcriptome of mammals. Despite ASE being a source of phenotypic variation, its occurrence and effects on genetic prediction of economically relevant traits are still unexplored in bovines. Furthermore, as ASE events are likely driven by cis-regulatory mutations, scanning them throughout the bovine genome represents a significant step to elucidate the mechanisms underlying gene expression regulation. To address this question in a Bos indicus population, we built the ASE profile of the skeletal muscle tissue of 190 Nelore steers, using RNA sequencing data and SNPs genotypes from the Illumina BovineHD BeadChip (770 K bp). After quality control, 820 SNPs showed at least one sample with ASE. These SNPs were widespread among all autosomal chromosomes, being 32.01% found in 3'UTR and 31.41% in coding regions. We observed a considerable variation of ASE profile among individuals, which highlighted the need for biological replicates in ASE studies. Functional analysis revealed that ASE genes play critical biological functions in the development and maintenance of muscle tissue. Additionally, some of these genes were previously reported as associated with beef production and quality traits in livestock, thus indicating a possible source of bias on genomic predictions for these traits.
650 $aGene expression regulation
650 $aBos Indicus
653 $aAllele-specific expression
653 $aAllelic expression
653 $aExpressão gênica
653 $aRegulação da expressão gênica
700 1 $aZERLOTINI NETO, A.
700 1 $aROCHA, M. I. P.
700 1 $aBRUSCADIN, J. J.
700 1 $aDINIZ, W. J. da S.
700 1 $aCARDOSO, T. F.
700 1 $aCESAR, A. S. M.
700 1 $aAFONSO, J.
700 1 $aANDRADE, B. G. N.
700 1 $aMUDADU, M. de A.
700 1 $aMOKRY, F. B.
700 1 $aTIZIOTO, P. C.
700 1 $aOLIVEIRA, P. S. N. de
700 1 $aNICIURA, S. C. M.
700 1 $aCOUTINHO, L. L.
700 1 $aREGITANO, L. C. de A.
773 $tScientific Reports$gv. 10, n. 1, p. 1-11, 2020.
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Embrapa Agricultura Digital (CNPTIA) |
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