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| Registros recuperados : 82 | |
| 7. |  | SOUZA, G. F. J. P. de; OLIVEIRA, A. L. P. C. de; SOUZA, M. M. de. Contribuição ao conhecimento do lenho de Laguncularia racemosa (L.). Silvicultura em São Paulo, São Paulo, v. 16-A, pt. 1, p. 280-292, 1982. Edição dos Anais do Congresso Nacional sobre Essências Nativas, 1982, Campos do Jordão.| Biblioteca(s): Embrapa Florestas. |
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| 16. | | MELO, A. L. de; SOUZA, M. M. de; REGITANO, L. C. de A. Identificação de possíveis causas de expressão alelo-específica em músculo de novilhos da raça Nelore. In: JORNADA CIENTÍFICA DA EMBRAPA SÃO CARLOS, 10., 2018, São Carlos, SP. Anais... São Carlos, SP: Embrapa Instrumentação; Embrapa Pecuária Sudeste, 2018. p. 43. (Embrapa Instrumentação. Documentos, 68). Editores técnicos: Daniel Souza Corrêa, Elaine Cristina Paris, Maria Alice Martins, Paulino Ribeiro Villas Boas, Wilson Tadeu Lopes da Silva.| Biblioteca(s): Embrapa Pecuária Sudeste. |
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| 20. | | SOUZA, M. M. de; PEREIRA, T. N. S.; AMARAL JUNIOR, A. T.; RODRIGUES, R.; DUTRA, G. A.; SUDRE, C. P. Polimorfismo polinico em acessos de pimenta com base em microscopia eletronica de varredura e analise multivariada. Horticultura Brasileira, Brasilia, v.18, p.749-750, jul. 2000.| Biblioteca(s): Embrapa Hortaliças. |
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| Registros recuperados : 82 | |
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Registro Completo
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Biblioteca(s): |
Embrapa Agricultura Digital; Embrapa Pecuária Sudeste. |
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Data corrente: |
01/09/2016 |
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Data da última atualização: |
19/03/2019 |
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Tipo da produção científica: |
Artigo em Periódico Indexado |
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Circulação/Nível: |
A - 1 |
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Autoria: |
SOUZA, M. M. de; NICIURA, S. C. M.; TIZIOTO, P. C.; IBELLI, A. M. G.; GASPARIN, G.; ROCHA, M. I. P.; DONATONI, F. A. B.; MALAGO JUNIOR, W.; DINIZ, W. J. S.; OLIVEIRA, P. S. N. de; LIMA, A. O.; MUDADU, M. de A.; BARIONI JUNIOR, W.; COUTINHO, L. L.; REGITANO, L. C. de A. |
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Afiliação: |
M.M. de Souza, UFSCAR; SIMONE CRISTINA MEO NICIURA, CPPSE; P.C. Tizioto, FAPESP; ADRIANA MERCIA GUARATINI IBELLI, CNPSA; G. Gasparin, USP-ESALQ; M. I. P. Rocha, UFSCAR; FLAVIA ALINE BRESSANI DONATONI, CPPSE; WILSON MALAGO JUNIOR, CPPSE; W. J. S. Diniz, UFSCAR; Priscila Silva Neubern de Oliveira, FAPESP; A. O. Lima, UFSCAR; MAURICIO DE ALVARENGA MUDADU, CNPTIA; WALDOMIRO BARIONI JUNIOR, CPPSE; L. L. Coutinho, USP-ESALQ; LUCIANA CORREIA DE ALMEIDA REGITANO, CPPSE. |
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Título: |
Allele- and parent-of-origin-specific effects on expression of the KCNJ11 gene: a candidate for meat tenderness in cattle. |
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Ano de publicação: |
2016 |
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Fonte/Imprenta: |
Genetics and Molecular Research, v.15, n.3, aug. 2016. |
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Volume: |
15 |
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DOI: |
http://dx.doi.org/10.4238/gmr.15038549 |
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Idioma: |
Inglês
Português |
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Conteúdo: |
In contrast to the Mendelian inheritance model, parental alleles can contribute unequally to gene expression, which may result in phenotypic variance among individuals and bias in the predicted additive effect of molecular markers associated with production traits. Given the need to understand the effects of allelic variation and parent-of-origin effects on the expression of genes with a commercial interest in cattle, we analyzed the expression of KCNJ11 (potassium inwardly rectifying channel, subfamily J, member 11), which was previously described as a functional candidate gene for meat tenderness. Allele-specific and parent-of-origin-dependent expression of this gene were assessed in bovine muscle using the rs379610823 single nucleotide polymorphism as a reference. Biallelic expression was observed; however, the T allele was expressed at significantly higher levels than the C allele. Furthermore, increased expression of KCNJ11 was found in animals harboring the maternal T allele. This study is the first to describe the differential allelic expression of bovine KCNJ11. Our findings are important for understanding the mechanisms that underlie the pattern of KCNJ11 expression and its potential impact on the phenotypic variation of meat tenderness in Nelore beef cattle. This reinforces the need for further investigation of allelic- and parent-of-origin expression deviation in genetic markers eligible for the selection of target traits. |
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Palavras-Chave: |
Differential allelic expression; Expressão alélica diferencial; Maciez da carne; Nelore; Potassium inwardly rectifying channel. |
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Thesagro: |
Gado de corte; Gado Nelore; Gado Zebu. |
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Thesaurus NAL: |
Alleles; Beef cattle; Meat tenderness; Nellore; Zebu. |
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Categoria do assunto: |
G Melhoramento Genético
X Pesquisa, Tecnologia e Engenharia |
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URL: |
https://ainfo.cnptia.embrapa.br/digital/bitstream/item/147026/1/Souza-et-al-2016.pdf
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|
Marc: |
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024 7 $ahttp://dx.doi.org/10.4238/gmr.15038549$2DOI
100 1 $aSOUZA, M. M. de
245 $aAllele- and parent-of-origin-specific effects on expression of the KCNJ11 gene$ba candidate for meat tenderness in cattle.$h[electronic resource]
260 $c2016
300 $a15
490 $v15
520 $aIn contrast to the Mendelian inheritance model, parental alleles can contribute unequally to gene expression, which may result in phenotypic variance among individuals and bias in the predicted additive effect of molecular markers associated with production traits. Given the need to understand the effects of allelic variation and parent-of-origin effects on the expression of genes with a commercial interest in cattle, we analyzed the expression of KCNJ11 (potassium inwardly rectifying channel, subfamily J, member 11), which was previously described as a functional candidate gene for meat tenderness. Allele-specific and parent-of-origin-dependent expression of this gene were assessed in bovine muscle using the rs379610823 single nucleotide polymorphism as a reference. Biallelic expression was observed; however, the T allele was expressed at significantly higher levels than the C allele. Furthermore, increased expression of KCNJ11 was found in animals harboring the maternal T allele. This study is the first to describe the differential allelic expression of bovine KCNJ11. Our findings are important for understanding the mechanisms that underlie the pattern of KCNJ11 expression and its potential impact on the phenotypic variation of meat tenderness in Nelore beef cattle. This reinforces the need for further investigation of allelic- and parent-of-origin expression deviation in genetic markers eligible for the selection of target traits.
650 $aAlleles
650 $aBeef cattle
650 $aMeat tenderness
650 $aNellore
650 $aZebu
650 $aGado de corte
650 $aGado Nelore
650 $aGado Zebu
653 $aDifferential allelic expression
653 $aExpressão alélica diferencial
653 $aMaciez da carne
653 $aNelore
653 $aPotassium inwardly rectifying channel
700 1 $aNICIURA, S. C. M.
700 1 $aTIZIOTO, P. C.
700 1 $aIBELLI, A. M. G.
700 1 $aGASPARIN, G.
700 1 $aROCHA, M. I. P.
700 1 $aDONATONI, F. A. B.
700 1 $aMALAGO JUNIOR, W.
700 1 $aDINIZ, W. J. S.
700 1 $aOLIVEIRA, P. S. N. de
700 1 $aLIMA, A. O.
700 1 $aMUDADU, M. de A.
700 1 $aBARIONI JUNIOR, W.
700 1 $aCOUTINHO, L. L.
700 1 $aREGITANO, L. C. de A.
773 $tGenetics and Molecular Research$gv.15, n.3, aug. 2016.
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Embrapa Pecuária Sudeste (CPPSE) |
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