Data/hora: 05/06/2024 13:22:08

Biblioteca(s): 	Embrapa Gado de Leite; Embrapa Recursos Genéticos e Biotecnologia.	
Data corrente: 	14/01/2020	
Data da última atualização: 	09/08/2021	
Autoria: 	SIQUEIRA, L. G.; SILVA, M. V. G.; PANETTO, J. C.; VIANA, J. H.	
Afiliação: 	LUIZ GUSTAVO BRUNO SIQUEIRA, CNPGL; MARCOS VINICIUS GUALBERTO B SILVA, CNPGL; JOAO CLAUDIO DO CARMO PANETTO, CNPGL; JOAO HENRIQUE MOREIRA VIANA, Cenargen.	
Título: 	Consequences of assisted reproductive technologies for offspring function in cattle.	
Ano de publicação: 	2020	
Fonte/Imprenta: 	Reproduction, Fertility and Development, v. 32, p. 82-97, 2020.	
DOI: 	htttps://doi.org./10.1071/RD19278	
Idioma: 	Inglês	
Conteúdo: 	Abnormal fetuses, neonates and adult offspring derived by assisted reproductive technologies (ART) have been reported in humans, rodents and domestic animals. The use of ART has also been associated with an increased likelihood of certain adult diseases. These abnormalities may arise as a result of an excess of or missing maternally derived molecules during in vitro culture, because the in vitro environment is artificial and suboptimal for embryo development. Nonetheless, the success of ART in overcoming infertility or improving livestock genetics is undeniable. Limitations of in vitro embryo production (IVEP) in cattle include lower rates of the establishment and maintenance of pregnancy and an increased incidence of neonatal morbidity and mortality. Moreover, recent studies demonstrated long-term effects of IVEP in cattle, including increased postnatal mortality, altered growth and a slight reduction in the performance of adult dairy cows. This review addresses the effects of an altered preimplantation environment on embryo and fetal programming and offspring development. We discuss cellular and molecular responses of the embryo to the maternal environment, how ART may disturb programming, the possible role of epigenetic effects as a mechanism for altered phenotypes and long-term effects of ART that manifest in postnatal life.	
Palavras-Chave: 	Embrião in vitro; Epigenética; In vitro embryo; Pós-natal; Postnatal; Programming; Reprodução assistida.	
Thesagro: 	Bovino; Reprodução Animal.	
Thesaurus Nal: 	Epigenetics; Pregnancy.	
Categoria do assunto: 	--
L Ciência Animal e Produtos de Origem Animal	
Registro original: 	Embrapa Gado de Leite (CNPGL)	
Exemplares: 	CENARGEN - (38088-1) - UPC - AP - DD -  -  -  - DIS
CNPGL - (25143-1) - UPC - AP - DD -  -  -  - DIS