Data/hora: 08/06/2024 21:09:51

Biblioteca(s): 	Embrapa Meio Ambiente.	
Tipo da produção científica: 	Artigo em Periódico Indexado	
Circulação/Nível: 	A - 1	
Data corrente: 	01/11/2018	
Data da última atualização: 	01/11/2018	
Autoria: 	BARRETO, F. M.; SILVA, M. R. da; BRAGA, P. A. C.; BRAGOTTO, A. P. A.; HISANO, H.; REYES, F. G. R.	
Afiliação: 	FABIOLA MALAGA BARRETO, FEA-UNICAMP; MARIANA R DA SILVA, FEA-UNICAMP; PATRICIA APARECIDA DE CAMPOS BRAGA, FEA-UNICAMP; ADRIANA PAVESI ARISSETO BRAGOTTO, FEA-UNICAMP; HAMILTON HISANO, CNPMA; FELIX GUILLERMO REYES REYES, FEA-UNICAMP.	
Título: 	Evaluation of the leaching of florfenicol from coated medicated fish feed into water.	
Ano de publicação: 	2018	
Fonte/Imprenta: 	Environmental Pollution, v. 242, Part B, p. 1245-1252, 2018.	
ISSN: 	0269-7491	
DOI: 	https://doi.org/10.1016/j.envpol.2018.08.017	
Idioma: 	Inglês	
Conteúdo: 	Florfenicol is one of the most-used antimicrobial agents in global fish farming. Nevertheless, in most countries, its use is not conducted in accordance with good practices. The aim of this work was to evaluate the leaching of florfenicol from coated fish feed into the water. Analytical methods were developed and validated for the quantitation of florfenicol in medicated feed and water by UHPLC-MS/MS. Florfenicol residues in the water were quantified after 5- and 15-min exposures of the medicated feed in the water at 22 and 28°C and at pH 4.5 and 8.0. The influence of pellet size and three coating agents (vegetable oil, carboxymethylcellulose, and low-methoxylated pectin) on the leaching of the drug was also assessed. Pellet size, coating agent, water temperature, and time of exposure significantly (p <0.05) affected florfenicol leaching, while water pH did not interfere with the leaching. Coating with vegetable oil was the most efficient method to reduce florfenicol leaching, while coating with carboxymethylcellulose presented the highest leaching (approximately 60% after 15 min at 28°C). Thus, the coating agent has a significant effect on the florfenicol leaching rate and, consequently, on the necessary dose of the drug to be administered. Moreover, it is worth mentioning that higher florfenicol leaching will pose a greater risk to environmental health, specifically in terms of the development of bacteria resistant to florfenicol. Additional studies are needed with other polymers and veterinary drugs used in medicated feed for fish farming.	
Thesagro: 	Antibiótico; Florfenicol; Lixiviação; Piscicultura.	
Thesaurus Nal: 	Antibiotics; Carboxymethylcellulose; Fish feeds; Leaching; Pectins.	
Categoria do assunto: 	P Recursos Naturais, Ciências Ambientais e da Terra	
Registro original: 	Embrapa Meio Ambiente (CNPMA)	
Exemplares: 	CNPMA - (16189-1) - UPC - AP - DD -  -  -  - DIS