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Registro Completo |
Biblioteca(s): |
Embrapa Pecuária Sudeste. |
Data corrente: |
09/11/1995 |
Data da última atualização: |
18/08/2021 |
Tipo da produção científica: |
Resumo em Anais de Congresso |
Autoria: |
OLIVEIRA, J. A. L.; ALENCAR, M. M. de; LIMA, R. |
Afiliação: |
UNOESTE; MAURICIO MELLO DE ALENCAR, EMBRAPA-CPPSE, São Carlos, SP.; UFSCAR. |
Título: |
Causas de variação não genética sobre características de peso de animais de um rebanho Nelore. |
Ano de publicação: |
1994 |
Fonte/Imprenta: |
In: REUNIÃO ANUAL DA SOCIEDADE BRASILEIRA DE ZOOTECNIA, 31., 1994, Maringá, PR. Anais... Maringá : SBZ, 1994. p.157. |
Idioma: |
Português |
Notas: |
Resumo. |
Conteúdo: |
Estudaram-se os efeitos dos fatores não genético sobre 6581, 5418 e 1800 observações de pesos ao nascimento, a desmama e sobreano respectivamente, de animais de um rebanho Nelore comercial, criado em regime de pastagens na região Oeste do Estado de São Paulo. |
Palavras-Chave: |
Animal genético. |
Thesagro: |
Gado de Corte; Gado Nelore; Genética Animal; Peso. |
Thesaurus Nal: |
beef cattle; Nellore; weight. |
Categoria do assunto: |
L Ciência Animal e Produtos de Origem Animal |
URL: |
https://ainfo.cnptia.embrapa.br/digital/bitstream/item/119940/1/digitalizar0005.pdf
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Marc: |
LEADER 01023nam a2200241 a 4500 001 1042641 005 2021-08-18 008 1994 bl uuuu u00u1 u #d 100 1 $aOLIVEIRA, J. A. L. 245 $aCausas de variação não genética sobre características de peso de animais de um rebanho Nelore.$h[electronic resource] 260 $aIn: REUNIÃO ANUAL DA SOCIEDADE BRASILEIRA DE ZOOTECNIA, 31., 1994, Maringá, PR. Anais... Maringá : SBZ, 1994. p.157.$c1994 500 $aResumo. 520 $aEstudaram-se os efeitos dos fatores não genético sobre 6581, 5418 e 1800 observações de pesos ao nascimento, a desmama e sobreano respectivamente, de animais de um rebanho Nelore comercial, criado em regime de pastagens na região Oeste do Estado de São Paulo. 650 $abeef cattle 650 $aNellore 650 $aweight 650 $aGado de Corte 650 $aGado Nelore 650 $aGenética Animal 650 $aPeso 653 $aAnimal genético 700 1 $aALENCAR, M. M. de 700 1 $aLIMA, R.
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Embrapa Pecuária Sudeste (CPPSE) |
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| Acesso ao texto completo restrito à biblioteca da Embrapa Instrumentação. Para informações adicionais entre em contato com cnpdia.biblioteca@embrapa.br. |
Registro Completo
Biblioteca(s): |
Embrapa Instrumentação. |
Data corrente: |
26/04/2021 |
Data da última atualização: |
10/06/2022 |
Tipo da produção científica: |
Artigo em Periódico Indexado |
Circulação/Nível: |
A - 1 |
Autoria: |
CARVALHO JUNIOR, P. S.; DINIZ, L. F.; SILVA, G. T. S. T. da; COUTINHO, N. D.; SANTOS, P. G. dos; CARVALHO-SILVA, V. H.; RIBEIRO, C.; ELLENA, J. |
Afiliação: |
CAUE RIBEIRO DE OLIVEIRA, CNPDIA. |
Título: |
Amino - imino tautomerism in the salt formation of Albendazole: Hydrobromide and nitrate salts. |
Ano de publicação: |
2021 |
Fonte/Imprenta: |
Crystal Growth & Design, v. 21, 2021. |
Páginas: |
1122?1135 |
ISSN: |
1528-7843 |
DOI: |
https://dx.doi.org/10.1021/acs.cgd.0c01444 |
Idioma: |
Inglês |
Conteúdo: |
Albendazole (ABZ) is a poorly soluble anthelmintic drug that can exist in amine and imine desmotropic forms. These facts can affect the solubility and bioavailability of the drug product. Here, we investigate the salt formation of ABZ with the acids HCl, HBr, and HNO3 associated with the tautomerism of the ABZ molecule. The reaction of ABZ with an excess of the acids HCl, HBr, and HNO3 results in the protonation of the imidazole ring, hiding the occurrence of tautomeric states. Thus, the ABZ HCl, ABZ HBr, and ABZ HNO3 salts were obtained and characterized by single-crystal X-ray diffraction, powder X-ray diffraction, FT-infrared spectroscopy (FTIR), differential scanning calorimetry (DSC), thermal gravimetric analysis (TGA), and aqueous solubility measurements. Furthermore, static and dynamic DFT calculations were carried out to understand how the albendazolium cation (ABZ-H+ ) is obtained from ABZ in amine and imine forms. An analysis of crystal structures reveals that cations and anions aggregate in 1D chains stabilized by NH···X (X = Cl−, Br−, O−) interactions, generating layered structures. In solution, the intramolecular amine ↔ imine conversion (ΔG⧧ ≈ 50 kcal mol−1 ) and the solvent-mediated deprotonation of the ABZ-H+ cation (ΔG⧧ ≈ 20 kcal mol−1 ) requires a higher energy barrier to occur, allowing the independence between tautomers to propitiate the crystallization process. Consequently, the process is dependent on the tautomer population in the starting material. All salts were demonstrated to be more soluble than pure ABZ. Given the good physical−chemical profile of these salts, our results show a notable effect on the multicomponent crystal design, manufacturability, and processing of the drug ABZ. MenosAlbendazole (ABZ) is a poorly soluble anthelmintic drug that can exist in amine and imine desmotropic forms. These facts can affect the solubility and bioavailability of the drug product. Here, we investigate the salt formation of ABZ with the acids HCl, HBr, and HNO3 associated with the tautomerism of the ABZ molecule. The reaction of ABZ with an excess of the acids HCl, HBr, and HNO3 results in the protonation of the imidazole ring, hiding the occurrence of tautomeric states. Thus, the ABZ HCl, ABZ HBr, and ABZ HNO3 salts were obtained and characterized by single-crystal X-ray diffraction, powder X-ray diffraction, FT-infrared spectroscopy (FTIR), differential scanning calorimetry (DSC), thermal gravimetric analysis (TGA), and aqueous solubility measurements. Furthermore, static and dynamic DFT calculations were carried out to understand how the albendazolium cation (ABZ-H+ ) is obtained from ABZ in amine and imine forms. An analysis of crystal structures reveals that cations and anions aggregate in 1D chains stabilized by NH···X (X = Cl−, Br−, O−) interactions, generating layered structures. In solution, the intramolecular amine ↔ imine conversion (ΔG⧧ ≈ 50 kcal mol−1 ) and the solvent-mediated deprotonation of the ABZ-H+ cation (ΔG⧧ ≈ 20 kcal mol−1 ) requires a higher energy barrier to occur, allowing the independence between tautomers to propitiate the crystallization process. Consequently, the process is dependent on the tautomer population in the starting material. Al... Mostrar Tudo |
Palavras-Chave: |
Anthelmintic; Crystal structures; Crystallization process. |
Categoria do assunto: |
-- |
Marc: |
LEADER 02599naa a2200277 a 4500 001 2131514 005 2022-06-10 008 2021 bl uuuu u00u1 u #d 022 $a1528-7843 024 7 $ahttps://dx.doi.org/10.1021/acs.cgd.0c01444$2DOI 100 1 $aCARVALHO JUNIOR, P. S. 245 $aAmino - imino tautomerism in the salt formation of Albendazole$bHydrobromide and nitrate salts.$h[electronic resource] 260 $c2021 300 $a1122?1135 520 $aAlbendazole (ABZ) is a poorly soluble anthelmintic drug that can exist in amine and imine desmotropic forms. These facts can affect the solubility and bioavailability of the drug product. Here, we investigate the salt formation of ABZ with the acids HCl, HBr, and HNO3 associated with the tautomerism of the ABZ molecule. The reaction of ABZ with an excess of the acids HCl, HBr, and HNO3 results in the protonation of the imidazole ring, hiding the occurrence of tautomeric states. Thus, the ABZ HCl, ABZ HBr, and ABZ HNO3 salts were obtained and characterized by single-crystal X-ray diffraction, powder X-ray diffraction, FT-infrared spectroscopy (FTIR), differential scanning calorimetry (DSC), thermal gravimetric analysis (TGA), and aqueous solubility measurements. Furthermore, static and dynamic DFT calculations were carried out to understand how the albendazolium cation (ABZ-H+ ) is obtained from ABZ in amine and imine forms. An analysis of crystal structures reveals that cations and anions aggregate in 1D chains stabilized by NH···X (X = Cl−, Br−, O−) interactions, generating layered structures. In solution, the intramolecular amine ↔ imine conversion (ΔG⧧ ≈ 50 kcal mol−1 ) and the solvent-mediated deprotonation of the ABZ-H+ cation (ΔG⧧ ≈ 20 kcal mol−1 ) requires a higher energy barrier to occur, allowing the independence between tautomers to propitiate the crystallization process. Consequently, the process is dependent on the tautomer population in the starting material. All salts were demonstrated to be more soluble than pure ABZ. Given the good physical−chemical profile of these salts, our results show a notable effect on the multicomponent crystal design, manufacturability, and processing of the drug ABZ. 653 $aAnthelmintic 653 $aCrystal structures 653 $aCrystallization process 700 1 $aDINIZ, L. F. 700 1 $aSILVA, G. T. S. T. da 700 1 $aCOUTINHO, N. D. 700 1 $aSANTOS, P. G. dos 700 1 $aCARVALHO-SILVA, V. H. 700 1 $aRIBEIRO, C. 700 1 $aELLENA, J. 773 $tCrystal Growth & Design$gv. 21, 2021.
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