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Registro Completo |
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Biblioteca(s): |
Embrapa Pecuária Sudeste. |
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Data corrente: |
20/02/2019 |
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Data da última atualização: |
08/03/2019 |
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Tipo da produção científica: |
Artigo em Periódico Indexado |
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Autoria: |
BEHURA, S. K.; TIZIOTO, P. C.; KIM, J.; GRUPIONI, N. V.; SEABURY, C. M.; SCHNABEL, R. D.; GERSHWIN, L. J.; VAN EEnenNAAM, A. L.; TOAF-FROSENSTEIN, R.; NEIBERGS, H. L.; REGITANO, L. C. de A.; TAYLOR, J. F. |
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Afiliação: |
Susanta K. Behura, University of Missouri; Polyana C. Tizioto, University of Missouri; JaeWoo Kim, University of Missouri; Natalia V. Grupioni, UNESP; Christopher M. Seabury, Texas A&M University; Robert D. Schnabel, University of Missouri; Laurel J. Gershwin, University of California; Alison L. Van Eenennaam, University of California; Rachel Toaff-Rosenstein, University of California; Holly L. Neibergs, Washington State University; LUCIANA CORREIA DE ALMEIDA REGITANO, CPPSE; Jeremy F. Taylor, University of Missouri. |
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Título: |
Tissue tropism in host transcriptional response to members of the bovine respiratory disease complex. |
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Ano de publicação: |
2017 |
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Fonte/Imprenta: |
Scientific Reports, v.7, n. 17938, p. 1-15, 2017. |
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DOI: |
10.1038/s41598-017-18205-0 |
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Idioma: |
Inglês |
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Conteúdo: |
Bovine respiratory disease (BRD) is the most common infectious disease of beef and dairy cattle and is characterized by a complex infectious etiology that includes a variety of viral and bacterial pathogens. We examined the global changes in mRNA abundance in healthy lung and lung lesions and in the lymphoid tissues bronchial lymph node, retropharyngeal lymph node, nasopharyngeal lymph node and pharyngeal tonsil collected at the peak of clinical disease from beef cattle experimentally challenged with either bovine respiratory syncytial virus, infectious bovine rhinotracheitis, bovine viral diarrhea virus, Mannheimia haemolytica or Mycoplasma bovis. We identified signatures of tissue-specific transcriptional responses indicative of tropism in the coordination of host?s immune tissue responses to infection by viral or bacterial infections. Furthermore, our study shows that this tissue tropism in host transcriptional response to BRD pathogens results in the activation of different networks of response genes. The differential crosstalk among genes expressed in lymphoid tissues was predicted to be orchestrated by specific immune genes that act as ?key players? within expression networks. The results of this study serve as a basis for the development of innovative therapeutic strategies and for the selection of cattle with enhanced resistance to BRD. |
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Palavras-Chave: |
Bovinos de corte; BRD; MRNA. |
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Thesagro: |
Doença Respiratória; Gado de Corte. |
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Thesaurus Nal: |
Beef cattle; Bovine respiratory disease. |
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Categoria do assunto: |
L Ciência Animal e Produtos de Origem Animal |
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URL: |
https://ainfo.cnptia.embrapa.br/digital/bitstream/item/193126/1/11-Tissue-Tropism-in-Host-Transcriptional-Response-to-Members-of-the-Bovine-Respiratory-Disease-Complex.pdf
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Marc: |
LEADER 02380naa a2200349 a 4500
001 2106292
005 2019-03-08
008 2017 bl uuuu u00u1 u #d
024 7 $a10.1038/s41598-017-18205-0$2DOI
100 1 $aBEHURA, S. K.
245 $aTissue tropism in host transcriptional response to members of the bovine respiratory disease complex.$h[electronic resource]
260 $c2017
520 $aBovine respiratory disease (BRD) is the most common infectious disease of beef and dairy cattle and is characterized by a complex infectious etiology that includes a variety of viral and bacterial pathogens. We examined the global changes in mRNA abundance in healthy lung and lung lesions and in the lymphoid tissues bronchial lymph node, retropharyngeal lymph node, nasopharyngeal lymph node and pharyngeal tonsil collected at the peak of clinical disease from beef cattle experimentally challenged with either bovine respiratory syncytial virus, infectious bovine rhinotracheitis, bovine viral diarrhea virus, Mannheimia haemolytica or Mycoplasma bovis. We identified signatures of tissue-specific transcriptional responses indicative of tropism in the coordination of host?s immune tissue responses to infection by viral or bacterial infections. Furthermore, our study shows that this tissue tropism in host transcriptional response to BRD pathogens results in the activation of different networks of response genes. The differential crosstalk among genes expressed in lymphoid tissues was predicted to be orchestrated by specific immune genes that act as ?key players? within expression networks. The results of this study serve as a basis for the development of innovative therapeutic strategies and for the selection of cattle with enhanced resistance to BRD.
650 $aBeef cattle
650 $aBovine respiratory disease
650 $aDoença Respiratória
650 $aGado de Corte
653 $aBovinos de corte
653 $aBRD
653 $aMRNA
700 1 $aTIZIOTO, P. C.
700 1 $aKIM, J.
700 1 $aGRUPIONI, N. V.
700 1 $aSEABURY, C. M.
700 1 $aSCHNABEL, R. D.
700 1 $aGERSHWIN, L. J.
700 1 $aVAN EEnenNAAM, A. L.
700 1 $aTOAF-FROSENSTEIN, R.
700 1 $aNEIBERGS, H. L.
700 1 $aREGITANO, L. C. de A.
700 1 $aTAYLOR, J. F.
773 $tScientific Reports$gv.7, n. 17938, p. 1-15, 2017.
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Registro original: |
Embrapa Pecuária Sudeste (CPPSE) |
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Registro Completo
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Biblioteca(s): |
Embrapa Solos. |
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Data corrente: |
01/12/2008 |
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Data da última atualização: |
28/03/2022 |
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Tipo da produção científica: |
Artigo em Periódico Indexado |
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Circulação/Nível: |
Nacional - C |
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Autoria: |
NUNES FILHO, J.; SÁ, V. A. de L. e; SOUSA, A. R. de; FERRAZ, L. G. B.; TABOSA, J. N.; SANTOS, V. F. dos; SILVA, A. B. da. |
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Afiliação: |
JOÃO NUNES FILHO, IPA; VITAL ARTUR DE LIMA E SÁ, IPA; ANTÔNIO RAIMUNDO DE SOUSA, IPA; LUIZ GONZAGA BIONE FERRAZ, IPA; JOSÉ NILDO TABOSA, IPA; VENÉZIO FELIPE DOS SANTOS, IPA; ADEMAR BARROS DA SILVA, CNPS. |
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Título: |
Gramíneas forrageiras tropicais em solo salino-sódico, sob irrigação, no Vale do Rio Moxotó - Pernambuco. |
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Ano de publicação: |
2008 |
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Fonte/Imprenta: |
Pesquisa Agropecuária Pernambucana, v. 14, p. 19-24, jan./dez. 2003-2007. Número especial. |
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Idioma: |
Português |
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Thesagro: |
Forragem; Irrigação; Salinidade; Solo Salino. |
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Thesaurus NAL: |
forage crops; irrigation; salinity. |
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Categoria do assunto: |
P Recursos Naturais, Ciências Ambientais e da Terra |
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URL: |
https://ainfo.cnptia.embrapa.br/digital/bitstream/item/233041/1/Gramineas-forrageiras-tropicais-em-solo-salino-sodico-2008.pdf
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Marc: |
LEADER 00819naa a2200265 a 4500
001 1331619
005 2022-03-28
008 2008 bl uuuu u00u1 u #d
100 1 $aNUNES FILHO, J.
245 $aGramíneas forrageiras tropicais em solo salino-sódico, sob irrigação, no Vale do Rio Moxotó - Pernambuco.$h[electronic resource]
260 $c2008
650 $aforage crops
650 $airrigation
650 $asalinity
650 $aForragem
650 $aIrrigação
650 $aSalinidade
650 $aSolo Salino
700 1 $aSÁ, V. A. de L. e
700 1 $aSOUSA, A. R. de
700 1 $aFERRAZ, L. G. B.
700 1 $aTABOSA, J. N.
700 1 $aSANTOS, V. F. dos
700 1 $aSILVA, A. B. da
773 $tPesquisa Agropecuária Pernambucana$gv. 14, p. 19-24, jan./dez. 2003-2007. Número especial.
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Registro original: |
Embrapa Solos (CNPS) |
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