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| Registros recuperados : 306 | |
| 3. |  | FRANCO, A. A.; BALIEIRO, F. de C. Fixacao biologica de nitrogenio: alternativa aos fertilizantes nitrogenados. In: SIQUEIRA, J.O.; MOREIRA, F.M.S.; LOPES, A.S.; GUILHERME, L.R.G.; FAQUIN, V.; FURTINI NETO, A.E.; CARVALHO, J.G., eds. Inter-relacao fertilidade, biologia do solo e nutricao de plantas. Vicosa: SBCS; Lavras: UFLA/DCS, 1999. p.577-595.| Biblioteca(s): Embrapa Agrobiologia. |
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| 9. | | CHAER, G. M.; SANTOS, F. M.; BALIEIRO, F. de C. Atividade microbiana do solo em plantios puros e mistos de Eucalyptus urograndis com Acacia mangium. In: REUNIÃO BRASILEIRA DE FERTILIDADE DO SOLO E NUTRIÇÃO DE PLANTAS, 32.; REUNIÃO BRASILEIRA SOBRE MICORRIZAS, 16.; SIMPÓSIO BRASILEIRO DE MICROBIOLOGIA DO SOLO, 14.; REUNIÃO BRASILEIRA DE BIOLOGIA DO SOLO, 11., 2016, Goiânia. Rumo aos novos desafios: anais. Goiânia: SBCS, Núcleo Regional Centro-Oeste, 2016. FertBio 2016.| Biblioteca(s): Embrapa Agrobiologia; Embrapa Solos. |
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| 13. | | BALIEIRO, F. de C.; ALVES, B. J. R. Nitrogênio total: Kjeldahl. In: TEIXEIRA, P. C.; DONAGEMMA, G. K.; FONTANA, A.; TEIXEIRA, W. G. (Ed.). Manual de métodos de análise de solo. 3. ed. rev. e ampl. Brasília, DF: Embrapa, 2017. pt. 3, cap. 2, p. 368-376.| Biblioteca(s): Embrapa Solos. |
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| 14. | | BALIEIRO, F. de C.; CESÁRIO, F. V.; SANTOS, F. M. Litter decomposition and soil carbon stocks in mixed plantations of Eucalyptus spp. and nitrogen-fixing trees. In: CARDOSO, E. J. B. N.; GONÇALVES, J. L. de M.; BALIEIRO, F. de C.; FRANCO, A. A. (ed.). Mixed plantations of Eucalyptus and leguminous trees: soil, microbiology and ecosystem services. Cham: Springer, 2020. cap. 4, p. 57-90.| Biblioteca(s): Embrapa Solos. |
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| 15. | | TURETTA, A. P. D.; BALIEIRO, F. de C. A proposal to mapping ecosystem service in rural landscape at atlantic forest in Brazil. In: ESP CONFERENCE, 6., 2013, Bali, Indonésia. Resumo... Indonésia: World Agroflorestry Centre, Kibon Nanas, Jakarta Timur: Ministry of Environment Republic of Indonesia, Wageningen, The Netherlands: Foundation for Sustainable Development, Wageningen: Wageningen University, 2013. 1 p.| Biblioteca(s): Embrapa Solos. |
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| 18. | | BALIEIRO, F. C.; FRANCO, A. A.; CAMPELLO, E. F. C.; FARIA, S. M. Biomassa acumulada da parte aérea de Acacia mangium Willd e Albizia guachapele (Kunth) Dugand cinco anos após o plantio no sudeste brasileiro. In: INTERNATIONAL CONGRESS AND EXHIBITION ON FOREST, 5., 1999, Curitiba. Forest 99: [resumos]. Rio de Janeiro: BIOSFERA, 1999. 1 CD-ROM. Autoria bilíngue: CONGRESSO E EXPOSICAO INTERNACIONAL SOBRE FLORESTAS, 5., 1999, Curitiba.| Biblioteca(s): Embrapa Florestas. |
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| Registros recuperados : 306 | |
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Registro Completo
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Biblioteca(s): |
Embrapa Suínos e Aves; Embrapa Unidades Centrais. |
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Data corrente: |
11/09/2023 |
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Data da última atualização: |
11/09/2023 |
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Tipo da produção científica: |
Artigo em Periódico Indexado |
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Circulação/Nível: |
A - 3 |
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Autoria: |
HAACH, V.; BASTOS, A. P. A.; GAVA, D.; FONSECA, F. M. da; MORES, M. A. Z.; COLDEBELLA, A.; FRANCO, A. C.; SCHAEFER, R. |
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Afiliação: |
VANESSA HAACH, Universidade Federal do Rio Grande do Sul; ANA PAULA ALMEIDA BASTOS, CNPSA; DANIELLE GAVA, CNPSA; FRANCISCO NOE DA FONSECA, GEM; MARCOS ANTONIO ZANELLA MORES, CNPSA; ARLEI COLDEBELLA, CNPSA; ANA CLÁUDIA FRANCO, Universidade Federal do Rio Grande do Sul; REJANE SCHAEFER, CNPSA. |
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Título: |
A polyvalent virosomal infuenza vaccine induces broad cellular and humoral immunity in pigs. |
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Ano de publicação: |
2023 |
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Fonte/Imprenta: |
Virology Journal, v. 20, article number 181, 2023. |
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DOI: |
https://doi.org/10.1186/s12985-023-02153-5 |
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Idioma: |
Inglês |
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Conteúdo: |
Abstract: Background: Influenza A virus (IAV) is endemic in pigs globally and co-circulation of genetically and antigenically diverse virus lineages of subtypes H1N1, H1N2 and H3N2 is a challenge for the development of effective vaccines. Virosomes are virus-like particles that mimic virus infection and have proven to be a successful vaccine platform against several animal and human viruses. Methods: This study evaluated the immunogenicity of a virosome-based influenza vaccine containing the surface glycoproteins of H1N1 pandemic, H1N2 and H3N2 in pigs. Results: A robust humoral and cellular immune response was induced against the three IAV subtypes in pigs after two vaccine doses. The influenza virosome vaccine elicited hemagglutinin-specific antibodies and virus-neutralizing activity. Furthermore, it induced a significant maturation of macrophages, and proliferation of B lymphocytes, effector and central memory CD4+ and CD8+ T cells, and CD8+ T lymphocytes producing interferon-γ. Also, the vaccine demonstrated potential to confer long-lasting immunity until the market age of pigs and proved to be safe and non-cytotoxic to pigs. Conclusions: This virosome platform allows flexibility to adjust the vaccine content to reflect the diversity of circulating IAVs in swine in Brazil. The vaccination of pigs may reduce the impact of the disease on swine production and the risk of swine-to-human transmission. |
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Palavras-Chave: |
Cellular immunity; Virosomal vaccine. |
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Thesagro: |
Imunidade; Suíno; Vacina. |
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Thesaurus NAL: |
Humoral immunity; Influenza A virus; Swine. |
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Categoria do assunto: |
--
L Ciência Animal e Produtos de Origem Animal |
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URL: |
https://ainfo.cnptia.embrapa.br/digital/bitstream/doc/1156557/1/final10093.pdf
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|
Marc: |
LEADER 02316naa a2200313 a 4500
001 2156557
005 2023-09-11
008 2023 bl uuuu u00u1 u #d
024 7 $ahttps://doi.org/10.1186/s12985-023-02153-5$2DOI
100 1 $aHAACH, V.
245 $aA polyvalent virosomal infuenza vaccine induces broad cellular and humoral immunity in pigs.$h[electronic resource]
260 $c2023
520 $aAbstract: Background: Influenza A virus (IAV) is endemic in pigs globally and co-circulation of genetically and antigenically diverse virus lineages of subtypes H1N1, H1N2 and H3N2 is a challenge for the development of effective vaccines. Virosomes are virus-like particles that mimic virus infection and have proven to be a successful vaccine platform against several animal and human viruses. Methods: This study evaluated the immunogenicity of a virosome-based influenza vaccine containing the surface glycoproteins of H1N1 pandemic, H1N2 and H3N2 in pigs. Results: A robust humoral and cellular immune response was induced against the three IAV subtypes in pigs after two vaccine doses. The influenza virosome vaccine elicited hemagglutinin-specific antibodies and virus-neutralizing activity. Furthermore, it induced a significant maturation of macrophages, and proliferation of B lymphocytes, effector and central memory CD4+ and CD8+ T cells, and CD8+ T lymphocytes producing interferon-γ. Also, the vaccine demonstrated potential to confer long-lasting immunity until the market age of pigs and proved to be safe and non-cytotoxic to pigs. Conclusions: This virosome platform allows flexibility to adjust the vaccine content to reflect the diversity of circulating IAVs in swine in Brazil. The vaccination of pigs may reduce the impact of the disease on swine production and the risk of swine-to-human transmission.
650 $aHumoral immunity
650 $aInfluenza A virus
650 $aSwine
650 $aImunidade
650 $aSuíno
650 $aVacina
653 $aCellular immunity
653 $aVirosomal vaccine
700 1 $aBASTOS, A. P. A.
700 1 $aGAVA, D.
700 1 $aFONSECA, F. M. da
700 1 $aMORES, M. A. Z.
700 1 $aCOLDEBELLA, A.
700 1 $aFRANCO, A. C.
700 1 $aSCHAEFER, R.
773 $tVirology Journal$gv. 20, article number 181, 2023.
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Embrapa Suínos e Aves (CNPSA) |
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