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Registro Completo |
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Biblioteca(s): |
Embrapa Gado de Leite. |
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Data corrente: |
21/11/2023 |
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Data da última atualização: |
21/11/2023 |
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Tipo da produção científica: |
Artigo em Periódico Indexado |
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Autoria: |
GOUVEIA, G. C.; RIBEIRO, V. M. P.; FORTES, M. R. S.; RAIDAN, F. S. S.; REVERTER, A.; PORTO-NETO, L. R.; MORAES, M. M. de; GONÇALVES, D. R.; SILVA, M. V. G. B.; TORAL, F. L. B. |
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Afiliação: |
GABRIELA CANABRAVA GOUVEIA, UNIVERSIDADE FEDERAL DE MINAS GERAIS; VIRGÍNIA MARA PEREIRA RIBEIRO, UNIVERSIDADE FEDERAL DE MINAS GERAIS; MARINA RUFINO SALINAS FORTES, UNIVERSITY OF QUEENSLAND; FERNANDA SANTOS SILVA RAIDAN, CSIRO; ANTONIO REVERTER, CSIRO; LAERCIO RIBEIRO PORTO‑NETO, CSIRO; MARIANA MAMEDES DE MORAES, UNIVERSIDADE FEDERAL DE MINAS GERAIS; DANIEL RESENDE GONÇALVES, MUNDO NOVO FARM; MARCOS VINICIUS GUALBERTO B SILVA, CNPGL; FABIO LUIZ BURANELO TORAL, UNIVERSIDADE FEDERAL DE MINAS GERAIS. |
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Título: |
Unravelling the genetic variability of host resilience to endo and ectoparasites in Nellore commercial herds. |
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Ano de publicação: |
2023 |
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Fonte/Imprenta: |
Genetics Selection Evolution, v. 55, article 81, 2023. |
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Idioma: |
Inglês |
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Conteúdo: |
BACKGROUND- Host resilience (HR) to parasites can afect the performance of animals. Therefore, the aim of this study was to present a detailed investigation of the genetic mechanisms of HR to ticks (TICK), gastrointestinal nematodes (GIN), and Eimeria spp. (EIM) in Nellore cattle that were raised under natural infestation and a prophylactic parasite control strategy. In our study, HR was defned as the slope coefcient of body weight (BW) when TICK, GIN, and EIM burdens were used as environmental gradients in random regression models. In total, 1712 animals were evaluated at fve measurement events (ME) at an average age of 331, 385, 443, 498, and 555 days, which generated 7307 body weight (BW) records. Of the 1712 animals, 1075 genotyped animals were used in genome-wide association studies to identify genomic regions associated with HR. RESULTS- Posterior means of the heritability estimates for BW ranged from 0.09 to 0.54 across parasites and ME. The single nucleotide polymorphism (SNP)-derived heritability for BW at each ME ranged from a low (0.09 at ME.331) to a moderate value (0.23 at ME.555). Those estimates show that genetic progress can be achieved for BW through selection. Both genetic and genomic associations between BW and HR to TICK, GIN, and EIM confrmed that parasite infestation impacted the performance of animals. Selection for BW under an environment with a controlled parasite burden is an alternative to improve both, BW and HR. There was no impact of age of measurement on the estimates of genetic variance for HR. Five quantitative trait loci (QTL) were associated with HR to EIM but none with HR to TICK and to GIN. These QTL contain genes that were previously shown to be associated with the production of antibody modulators and chemokines that are released in the intestinal epithelium. CONCLUSIONS- Selection for BW under natural infestation and controlled parasite burden, via prophylactic parasite control, contributes to the identifcation of animals that are resilient to nematodes and Eimeria ssp. Although we verifIed that sufcient genetic variation existed for HR, we did not fnd any genes associated with mechanisms that could justify the expression of HR to TICK and GIN. MenosBACKGROUND- Host resilience (HR) to parasites can afect the performance of animals. Therefore, the aim of this study was to present a detailed investigation of the genetic mechanisms of HR to ticks (TICK), gastrointestinal nematodes (GIN), and Eimeria spp. (EIM) in Nellore cattle that were raised under natural infestation and a prophylactic parasite control strategy. In our study, HR was defned as the slope coefcient of body weight (BW) when TICK, GIN, and EIM burdens were used as environmental gradients in random regression models. In total, 1712 animals were evaluated at fve measurement events (ME) at an average age of 331, 385, 443, 498, and 555 days, which generated 7307 body weight (BW) records. Of the 1712 animals, 1075 genotyped animals were used in genome-wide association studies to identify genomic regions associated with HR. RESULTS- Posterior means of the heritability estimates for BW ranged from 0.09 to 0.54 across parasites and ME. The single nucleotide polymorphism (SNP)-derived heritability for BW at each ME ranged from a low (0.09 at ME.331) to a moderate value (0.23 at ME.555). Those estimates show that genetic progress can be achieved for BW through selection. Both genetic and genomic associations between BW and HR to TICK, GIN, and EIM confrmed that parasite infestation impacted the performance of animals. Selection for BW under an environment with a controlled parasite burden is an alternative to improve both, BW and HR. There was no impact of age of meas... Mostrar Tudo |
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Palavras-Chave: |
Variabilidade genética. |
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Thesagro: |
Bovino; Gado Nelore; Hospedeiro Animal; Parasito de Animal. |
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Categoria do assunto: |
L Ciência Animal e Produtos de Origem Animal |
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URL: |
https://ainfo.cnptia.embrapa.br/digital/bitstream/doc/1158625/1/Unravelling-the-genetic-variability-of-host-resilience-to-endo-and-ectoparasites-in-Nellore.pdf
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Marc: |
LEADER 03090naa a2200289 a 4500
001 2158625
005 2023-11-21
008 2023 bl uuuu u00u1 u #d
100 1 $aGOUVEIA, G. C.
245 $aUnravelling the genetic variability of host resilience to endo and ectoparasites in Nellore commercial herds.$h[electronic resource]
260 $c2023
520 $aBACKGROUND- Host resilience (HR) to parasites can afect the performance of animals. Therefore, the aim of this study was to present a detailed investigation of the genetic mechanisms of HR to ticks (TICK), gastrointestinal nematodes (GIN), and Eimeria spp. (EIM) in Nellore cattle that were raised under natural infestation and a prophylactic parasite control strategy. In our study, HR was defned as the slope coefcient of body weight (BW) when TICK, GIN, and EIM burdens were used as environmental gradients in random regression models. In total, 1712 animals were evaluated at fve measurement events (ME) at an average age of 331, 385, 443, 498, and 555 days, which generated 7307 body weight (BW) records. Of the 1712 animals, 1075 genotyped animals were used in genome-wide association studies to identify genomic regions associated with HR. RESULTS- Posterior means of the heritability estimates for BW ranged from 0.09 to 0.54 across parasites and ME. The single nucleotide polymorphism (SNP)-derived heritability for BW at each ME ranged from a low (0.09 at ME.331) to a moderate value (0.23 at ME.555). Those estimates show that genetic progress can be achieved for BW through selection. Both genetic and genomic associations between BW and HR to TICK, GIN, and EIM confrmed that parasite infestation impacted the performance of animals. Selection for BW under an environment with a controlled parasite burden is an alternative to improve both, BW and HR. There was no impact of age of measurement on the estimates of genetic variance for HR. Five quantitative trait loci (QTL) were associated with HR to EIM but none with HR to TICK and to GIN. These QTL contain genes that were previously shown to be associated with the production of antibody modulators and chemokines that are released in the intestinal epithelium. CONCLUSIONS- Selection for BW under natural infestation and controlled parasite burden, via prophylactic parasite control, contributes to the identifcation of animals that are resilient to nematodes and Eimeria ssp. Although we verifIed that sufcient genetic variation existed for HR, we did not fnd any genes associated with mechanisms that could justify the expression of HR to TICK and GIN.
650 $aBovino
650 $aGado Nelore
650 $aHospedeiro Animal
650 $aParasito de Animal
653 $aVariabilidade genética
700 1 $aRIBEIRO, V. M. P.
700 1 $aFORTES, M. R. S.
700 1 $aRAIDAN, F. S. S.
700 1 $aREVERTER, A.
700 1 $aPORTO-NETO, L. R.
700 1 $aMORAES, M. M. de
700 1 $aGONÇALVES, D. R.
700 1 $aSILVA, M. V. G. B.
700 1 $aTORAL, F. L. B.
773 $tGenetics Selection Evolution$gv. 55, article 81, 2023.
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Embrapa Gado de Leite (CNPGL) |
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 | Acesso ao texto completo restrito à biblioteca da Embrapa Agrobiologia. Para informações adicionais entre em contato com cnpab.biblioteca@embrapa.br. |
Registro Completo
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Biblioteca(s): |
Embrapa Agrobiologia. |
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Data corrente: |
10/12/2014 |
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Data da última atualização: |
10/12/2014 |
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Tipo da produção científica: |
Resumo em Anais de Congresso |
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Autoria: |
SANTOS, N. C. S. dos; AMANCIO, C. O. da G.; SILVA, L. L. da. |
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Afiliação: |
CRISTHIANE OLIVEIRA DA G AMANCIO, CNPAB. |
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Título: |
Vivência agroecológica da turma em educação do campo no assentamento prefeito Celso Daniel, Macaé, RJ. |
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Ano de publicação: |
2014 |
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Fonte/Imprenta: |
In: CONGRESSO DA SOCIEDADE BRASILEIRA DE SISTEMA DE PRODUÇÃO, 10., 2014. Enfoque sistêmico e agricultura familiar na construção do desenvolvimento rural sustentável: anais... Foz do Iguaçu: SBSP, 2014 |
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Idioma: |
Português |
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Palavras-Chave: |
Conhecimento agroecológico. |
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Thesagro: |
Educação Ambiental. |
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Categoria do assunto: |
-- |
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Marc: |
LEADER 00678naa a2200157 a 4500
001 2002230
005 2014-12-10
008 2014 bl --- 0-- u #d
100 1 $aSANTOS, N. C. S. dos
245 $aVivência agroecológica da turma em educação do campo no assentamento prefeito Celso Daniel, Macaé, RJ.
260 $c2014
650 $aEducação Ambiental
653 $aConhecimento agroecológico
700 1 $aAMANCIO, C. O. da G.
700 1 $aSILVA, L. L. da
773 $tIn: CONGRESSO DA SOCIEDADE BRASILEIRA DE SISTEMA DE PRODUÇÃO, 10., 2014. Enfoque sistêmico e agricultura familiar na construção do desenvolvimento rural sustentável: anais... Foz do Iguaçu: SBSP, 2014
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