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Registro Completo |
Biblioteca(s): |
Embrapa Amapá; Embrapa Caprinos e Ovinos; Embrapa Meio-Norte; Embrapa Semiárido; Embrapa Unidades Centrais. |
Data corrente: |
05/06/1998 |
Data da última atualização: |
25/07/2017 |
Tipo da produção científica: |
Comunicado Técnico/Recomendações Técnicas |
Autoria: |
BARROS, N. N.; ARAUJO, A. M. de; SILVA, F. L. R. da. |
Afiliação: |
Nelson Nogueira Barros, CNPC; Adriana Mello de Araújo, CNPC; Francisco Luiz Ribeiro da Silva, CNPC. |
Título: |
Teste de desempenho de ovinos Santa Inês e Somalis Brasileira da EMBRAPA-CNPC. |
Ano de publicação: |
1998 |
Fonte/Imprenta: |
Sobral: EMBRAPA-CNPC, 1998. |
Páginas: |
2 p. |
Série: |
(EMBRAPA-CNPC. Comunicado Tecnico, 36). |
Idioma: |
Português |
Palavras-Chave: |
Brasil; Ceará; Desempenho; Hair sheep; Melhoramento genético; Ovino deslanado; Performance test; Performance testing; Raca Santa Ines; Raca Somalis; Santa Ines; Test; Teste; Teste de desempenho. |
Thesagro: |
Genética animal; Melhoramento; Melhoramento genético animal; Ovino; Performance; Produção. |
Thesaurus Nal: |
Brazil; genetic improvement; sheep. |
Categoria do assunto: |
-- L Ciência Animal e Produtos de Origem Animal |
URL: |
https://ainfo.cnptia.embrapa.br/digital/bitstream/item/26702/1/COT-36.pdf
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Marc: |
LEADER 01109nam a2200421 a 4500 001 1514956 005 2017-07-25 008 1998 bl uuuu u0uu1 u #d 100 1 $aBARROS, N. N. 245 $aTeste de desempenho de ovinos Santa Inês e Somalis Brasileira da EMBRAPA-CNPC. 260 $aSobral: EMBRAPA-CNPC$c1998 300 $a2 p. 490 $a(EMBRAPA-CNPC. Comunicado Tecnico, 36). 650 $aBrazil 650 $agenetic improvement 650 $asheep 650 $aGenética animal 650 $aMelhoramento 650 $aMelhoramento genético animal 650 $aOvino 650 $aPerformance 650 $aProdução 653 $aBrasil 653 $aCeará 653 $aDesempenho 653 $aHair sheep 653 $aMelhoramento genético 653 $aOvino deslanado 653 $aPerformance test 653 $aPerformance testing 653 $aRaca Santa Ines 653 $aRaca Somalis 653 $aSanta Ines 653 $aTest 653 $aTeste 653 $aTeste de desempenho 700 1 $aARAUJO, A. M. de 700 1 $aSILVA, F. L. R. da
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Embrapa Caprinos e Ovinos (CNPC) |
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Registro Completo
Biblioteca(s): |
Embrapa Caprinos e Ovinos. |
Data corrente: |
13/12/2017 |
Data da última atualização: |
10/01/2019 |
Tipo da produção científica: |
Artigo em Periódico Indexado |
Circulação/Nível: |
A - 2 |
Autoria: |
SANTOS, J. M. L. dos; VASCONCELOS, J. F.; FROTA, G. A.; RIBEIRO, W. L. C.; ANDDRÉ, W. P. P.; VIEIRA, L. da S.; TEIXEIRA, M.; BEVILAQUA, C. M. L.; MONTEIRO, J. P. |
Afiliação: |
Jessica Maria Leite dos Santos, Pós-graduação - Universidade Estadual do Ceará (UECe) - Fortaleza, CE, Brazil; Janaelia Ferreira Vasconcelos, Universidade Estadual Vale do Acaraú (UVA) - Sobral, CE, Brazil; Gracielle Araújo Frota, UVA - Sobral, CE, Brazil; Wesley Lyeverton Correia Ribeiro, UECe - Fortaleza, CE, Brazil; Weibson Paz Pinheiro André, UECe - Fortaleza, CE, Brazil; LUIZ DA SILVA VIEIRA, CNPC; MARCEL TEIXEIRA, CNPC; Claudia Maria Leal Bevilaqua, UECe - Fortaleza, CE, Brazil; JOMAR PATRICIO MONTEIRO, CNPC. |
Título: |
Haemonchus contortus Beta-tubulin isotype 1 gene F200Y and F167Y SNPs are both selected by ivermectin and oxfendazole treatments with differing impacts on anthelmintic resistance. |
Ano de publicação: |
2017 |
Fonte/Imprenta: |
Veterinary Parasitology, v. 248, p. 90-95, Dec. 2017. |
DOI: |
10.1016/j.vetpar.2017.11.003 |
Idioma: |
Inglês |
Conteúdo: |
Abstract: Parasitism by Haemonchus contortus is one of the main limiting factors in small ruminant production in tropical areas. Benzimidazoles (BZ) and macrocyclic lactones (ML) are the most used anthelmintic classes in gastrointestinal nematodes control. There is considerable scientific evidence of a possible relation between the anthelmintic resistance to BZ and ML. This study aimed to characterize the dynamics of anthelmintic resistance in an H. contortus susceptible isolate under selection pressure for BZ and ML alone or in combination and the role of isotype 1 Beta-tubulin gene SNPs in these situations. A total of 12 Somali sheep were infected with 5000 third stage larvae of H. contortus Inbred-Susceptible Edinburgh (ISE) isolate. Once infection was established, animals were distributed in three groups (n=4), each treated with crescent doses of oxfendazole (OXF), ivermectin (IVM) and oxfendazole plus ivermectin (IVMOXF). An additional control group with untreated animals was maintained during the entire experiment. After each treatment, eggs were collected and real-time PCR was performed to identify single nucleotide polymorphisms (SNPs) F167Y, F200Y and E198A, in addition to egg hatch test (EHT) for BZ and larval development test (LDT) for ivermectin resistance. All treatments led to increased resistance allelic frequencies at SNPs F200Y and F167Y (p <0.05). In vitro results showed increased phenotypic resistance against both anthelmintic classes in groups IVM and IVMOXF while group OXF only developed resistance against BZ. Finally, we provide evidence that while isotype 1 ?-tubulin gene SNPs may have some involvement with ML resistance, the presence of these ?-tubulin SNPs alone are not sufficient to develop ML resistance. MenosAbstract: Parasitism by Haemonchus contortus is one of the main limiting factors in small ruminant production in tropical areas. Benzimidazoles (BZ) and macrocyclic lactones (ML) are the most used anthelmintic classes in gastrointestinal nematodes control. There is considerable scientific evidence of a possible relation between the anthelmintic resistance to BZ and ML. This study aimed to characterize the dynamics of anthelmintic resistance in an H. contortus susceptible isolate under selection pressure for BZ and ML alone or in combination and the role of isotype 1 Beta-tubulin gene SNPs in these situations. A total of 12 Somali sheep were infected with 5000 third stage larvae of H. contortus Inbred-Susceptible Edinburgh (ISE) isolate. Once infection was established, animals were distributed in three groups (n=4), each treated with crescent doses of oxfendazole (OXF), ivermectin (IVM) and oxfendazole plus ivermectin (IVMOXF). An additional control group with untreated animals was maintained during the entire experiment. After each treatment, eggs were collected and real-time PCR was performed to identify single nucleotide polymorphisms (SNPs) F167Y, F200Y and E198A, in addition to egg hatch test (EHT) for BZ and larval development test (LDT) for ivermectin resistance. All treatments led to increased resistance allelic frequencies at SNPs F200Y and F167Y (p <0.05). In vitro results showed increased phenotypic resistance against both anthelmintic classes in groups IVM and IVM... Mostrar Tudo |
Palavras-Chave: |
Nematode; Nematódeo gastrintestinal; Pequeno ruminante; Resistance to anthelmintics. |
Thesagro: |
Anti-helmíntico; Caprino; Haemonchus Contortus; Helminto gastrintestinal; Nematóide; Ovino; Resistência química; Verminose. |
Thesaurus NAL: |
Anthelmintics; Benzimidazoles; Drug resistance; Goats; Ivermectin; Nematode control; Oxfendazole; Parasitism; Polymorphism; Sheep; Small ruminants. |
Categoria do assunto: |
H Saúde e Patologia |
Marc: |
LEADER 03267naa a2200505 a 4500 001 2082384 005 2019-01-10 008 2017 bl uuuu u00u1 u #d 024 7 $a10.1016/j.vetpar.2017.11.003$2DOI 100 1 $aSANTOS, J. M. L. dos 245 $aHaemonchus contortus Beta-tubulin isotype 1 gene F200Y and F167Y SNPs are both selected by ivermectin and oxfendazole treatments with differing impacts on anthelmintic resistance.$h[electronic resource] 260 $c2017 520 $aAbstract: Parasitism by Haemonchus contortus is one of the main limiting factors in small ruminant production in tropical areas. Benzimidazoles (BZ) and macrocyclic lactones (ML) are the most used anthelmintic classes in gastrointestinal nematodes control. There is considerable scientific evidence of a possible relation between the anthelmintic resistance to BZ and ML. This study aimed to characterize the dynamics of anthelmintic resistance in an H. contortus susceptible isolate under selection pressure for BZ and ML alone or in combination and the role of isotype 1 Beta-tubulin gene SNPs in these situations. A total of 12 Somali sheep were infected with 5000 third stage larvae of H. contortus Inbred-Susceptible Edinburgh (ISE) isolate. Once infection was established, animals were distributed in three groups (n=4), each treated with crescent doses of oxfendazole (OXF), ivermectin (IVM) and oxfendazole plus ivermectin (IVMOXF). An additional control group with untreated animals was maintained during the entire experiment. After each treatment, eggs were collected and real-time PCR was performed to identify single nucleotide polymorphisms (SNPs) F167Y, F200Y and E198A, in addition to egg hatch test (EHT) for BZ and larval development test (LDT) for ivermectin resistance. All treatments led to increased resistance allelic frequencies at SNPs F200Y and F167Y (p <0.05). In vitro results showed increased phenotypic resistance against both anthelmintic classes in groups IVM and IVMOXF while group OXF only developed resistance against BZ. Finally, we provide evidence that while isotype 1 ?-tubulin gene SNPs may have some involvement with ML resistance, the presence of these ?-tubulin SNPs alone are not sufficient to develop ML resistance. 650 $aAnthelmintics 650 $aBenzimidazoles 650 $aDrug resistance 650 $aGoats 650 $aIvermectin 650 $aNematode control 650 $aOxfendazole 650 $aParasitism 650 $aPolymorphism 650 $aSheep 650 $aSmall ruminants 650 $aAnti-helmíntico 650 $aCaprino 650 $aHaemonchus Contortus 650 $aHelminto gastrintestinal 650 $aNematóide 650 $aOvino 650 $aResistência química 650 $aVerminose 653 $aNematode 653 $aNematódeo gastrintestinal 653 $aPequeno ruminante 653 $aResistance to anthelmintics 700 1 $aVASCONCELOS, J. F. 700 1 $aFROTA, G. A. 700 1 $aRIBEIRO, W. L. C. 700 1 $aANDDRÉ, W. P. P. 700 1 $aVIEIRA, L. da S. 700 1 $aTEIXEIRA, M. 700 1 $aBEVILAQUA, C. M. L. 700 1 $aMONTEIRO, J. P. 773 $tVeterinary Parasitology$gv. 248, p. 90-95, Dec. 2017.
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