| |
|
|
|
Registro Completo |
|
Biblioteca(s): |
Embrapa Agroindústria de Alimentos. |
|
Data corrente: |
21/05/2021 |
|
Data da última atualização: |
15/06/2021 |
|
Tipo da produção científica: |
Artigo em Periódico Indexado |
|
Autoria: |
NIGRA, A. D.; GUIMAREAES, D. de A. B.; PRUCCA, C. G.; FREITAS-SILVA, O.; TEODORO, A. J.; GIL, G. A. |
|
Afiliação: |
AYELÉN D. NIGRA, Universidad Nacional de Córdoba; DEBORAH DE ALMEIDA BAUER GUIMARÃES, Universidade Federal do Estado do Rio de Janeiro -UNIRIO; CÉSAR G. PRUCCA, Universidad Nacional de Córdoba; OTNIEL FREITAS SILVA, CTAA; ANDERSON J. TEODORO, Universidade Federal do Estado do Rio de Janeiro - UNIRIO; GERMÁN A. GIL, Universidad Nacional de Córdoba. |
|
Título: |
Antitumor Effects of Freeze-Dried Robusta Coffee (Coffea canephora) Extracts on Breast Cancer Cell Lines. |
|
Ano de publicação: |
2021 |
|
Fonte/Imprenta: |
Oxidative Medicine and Cellular Longevity, 2021, ID 5572630, p. 1-16. |
|
DOI: |
https://doi.org/10.1155/2021/5572630 |
|
Idioma: |
Inglês |
|
Notas: |
Research Article. |
|
Conteúdo: |
Coffee consumption is believed to have chemopreventive and chemotherapeutic effects and to contribute to preventing thedevelopment and progression of cancer. However, there is still controversy around these claims. As indicated in our previousworks, diet can influence the risk of breast cancer. Intake of coffee is hypothesized to reduce this risk, but current scientificevidence is not conclusive. This work is aimed at studying the effects of Robusta coffee bean extract on cell viability,proliferation, and apoptosis of different human cancers, especially breast cancer cell lines. To this end, cell viability wasevaluated by Alamar Blue in 2D and 3D models, the cell cycle by PI, apoptosis by annexin V, mitochondrial morphology, andfunctionality by mitoTracker, and colony formation capacity by the clonogenic assay. Green and dark coffee extract significantlyreduced viability in human breast, colorectal, brain, and bone cancer cells. Coffee anticancer activity was clearly evidenced inMDA-MB-231 (ER-) and MCF-7 (ER+) breast cancer cells but not in the normal breast cell line. In addition, coffee extractinduces an increase S phase and a decrease G2/M population in breast cancer cells, affected the mitochondrial morphology, andtriggered apoptosis. MDA-MB-231 breast cancer cells lost their clonogenic capacity after treatment. The antitumor activity wasdemonstrated in both 2D and 3D culture cell models |
|
Thesagro: |
Café Robusta; Câncer; Extrato Vegetal; Grão; Produto de Origem Vegetal. |
|
Thesaurus Nal: |
Food technology. |
|
Categoria do assunto: |
-- |
|
URL: |
https://ainfo.cnptia.embrapa.br/digital/bitstream/item/223364/1/Antitumor-Effects-of-Freeze-Dried-Robusta-Coffee-Coffea-canephora-Extracts-on-Breast-Cancer-Cell-Lines.pdf
|
|
Marc: |
LEADER 02271naa a2200277 a 4500
001 2131938
005 2021-06-15
008 2021 bl uuuu u00u1 u #d
024 7 $ahttps://doi.org/10.1155/2021/5572630$2DOI
100 1 $aNIGRA, A. D.
245 $aAntitumor Effects of Freeze-Dried Robusta Coffee (Coffea canephora) Extracts on Breast Cancer Cell Lines.$h[electronic resource]
260 $c2021
500 $aResearch Article.
520 $aCoffee consumption is believed to have chemopreventive and chemotherapeutic effects and to contribute to preventing thedevelopment and progression of cancer. However, there is still controversy around these claims. As indicated in our previousworks, diet can influence the risk of breast cancer. Intake of coffee is hypothesized to reduce this risk, but current scientificevidence is not conclusive. This work is aimed at studying the effects of Robusta coffee bean extract on cell viability,proliferation, and apoptosis of different human cancers, especially breast cancer cell lines. To this end, cell viability wasevaluated by Alamar Blue in 2D and 3D models, the cell cycle by PI, apoptosis by annexin V, mitochondrial morphology, andfunctionality by mitoTracker, and colony formation capacity by the clonogenic assay. Green and dark coffee extract significantlyreduced viability in human breast, colorectal, brain, and bone cancer cells. Coffee anticancer activity was clearly evidenced inMDA-MB-231 (ER-) and MCF-7 (ER+) breast cancer cells but not in the normal breast cell line. In addition, coffee extractinduces an increase S phase and a decrease G2/M population in breast cancer cells, affected the mitochondrial morphology, andtriggered apoptosis. MDA-MB-231 breast cancer cells lost their clonogenic capacity after treatment. The antitumor activity wasdemonstrated in both 2D and 3D culture cell models
650 $aFood technology
650 $aCafé Robusta
650 $aCâncer
650 $aExtrato Vegetal
650 $aGrão
650 $aProduto de Origem Vegetal
700 1 $aGUIMAREAES, D. de A. B.
700 1 $aPRUCCA, C. G.
700 1 $aFREITAS-SILVA, O.
700 1 $aTEODORO, A. J.
700 1 $aGIL, G. A.
773 $tOxidative Medicine and Cellular Longevity, 2021, ID 5572630, p. 1-16.
Download
Esconder MarcMostrar Marc Completo |
|
Registro original: |
Embrapa Agroindústria de Alimentos (CTAA) |
|
|
Biblioteca |
ID |
Origem |
Tipo/Formato |
Classificação |
Cutter |
Registro |
Volume |
Status |
URL |
Voltar
|
|
|
 | Acesso ao texto completo restrito à biblioteca da Embrapa Tabuleiros Costeiros. Para informações adicionais entre em contato com cpatc.biblioteca@embrapa.br. |
Registro Completo
|
Biblioteca(s): |
Embrapa Tabuleiros Costeiros. |
|
Data corrente: |
07/08/2014 |
|
Data da última atualização: |
07/08/2014 |
|
Tipo da produção científica: |
Artigo em Anais de Congresso |
|
Autoria: |
NASCIMENTO, I. R. do; SANTOS, A. M. B. dos; SANTOS, D. G.; SA, C. O. de; SILVA, H. O. |
|
Afiliação: |
IRENIA ROSA DO NASCIMENTO; AGDA MARIA BEZERRA DOS SANTOS; DANIELLE GOMES SANTOS; CRISTIANE OTTO DE SA, CPATC; HUNALDO OLIVEIRA SILVA. |
|
Título: |
Relação entre a CCS e a concentração dos componemtes orgânicos e inorgânicos de amostras de leite obtidas em Nossa Senhora da Glória-SE. |
|
Ano de publicação: |
2013 |
|
Fonte/Imprenta: |
In: Congresso Brasileiro de Qualidade do Leite do Conselho Brasileiro de Qualidade do Leite, 5., 2013, Botucatu. Anais... p. 322-323 Veterinária e Zootecnia, v. 20, n. 2, p. 230-231, 2013. Supl. 1 |
|
Idioma: |
Português |
|
Palavras-Chave: |
Mastite. |
|
Thesagro: |
Doença Animal; Leite. |
|
Categoria do assunto: |
-- |
|
Marc: |
LEADER 00764nam a2200181 a 4500
001 1992020
005 2014-08-07
008 2013 bl uuuu u00u1 u #d
100 1 $aNASCIMENTO, I. R. do
245 $aRelação entre a CCS e a concentração dos componemtes orgânicos e inorgânicos de amostras de leite obtidas em Nossa Senhora da Glória-SE.$h[electronic resource]
260 $aIn: Congresso Brasileiro de Qualidade do Leite do Conselho Brasileiro de Qualidade do Leite, 5., 2013, Botucatu. Anais... p. 322-323 Veterinária e Zootecnia, v. 20, n. 2, p. 230-231, 2013. Supl. 1$c2013
650 $aDoença Animal
650 $aLeite
653 $aMastite
700 1 $aSANTOS, A. M. B. dos
700 1 $aSANTOS, D. G.
700 1 $aSA, C. O. de
700 1 $aSILVA, H. O.
Download
Esconder MarcMostrar Marc Completo |
|
Registro original: |
Embrapa Tabuleiros Costeiros (CPATC) |
|
|
Biblioteca |
ID |
Origem |
Tipo/Formato |
Classificação |
Cutter |
Registro |
Volume |
Status |
Fechar
|
| Nenhum registro encontrado para a expressão de busca informada. |
|
|
