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Registro Completo |
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Biblioteca(s): |
Embrapa Gado de Leite. |
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Data corrente: |
18/02/2016 |
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Data da última atualização: |
03/02/2024 |
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Tipo da produção científica: |
Artigo em Periódico Indexado |
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Autoria: |
SILVA, A. P. C.; MACÊDO, A. A.; COSTA, L. F.; ROCHA, C. E.; GARCIA, L. N. N.; FARIAS, J. R. D.; GOMES, P. P. R.; TEIXEIRA, G. C.; FONSECA, K. W. J.; MAIA, A. R. F.; NEVES, G. G.; ROMÃO, E. L.; SILVA, T. M. A.; MOL, J. P. S.; OLIVEIRA, R. M.; ARAÚJO, M. S. S.; NASCIMENTO, E. F.; MARTINS-FILHO, O. A.; BRANDAO, H. de M.; PAIXÃO, T. A.; SANTOS, R. L. |
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Afiliação: |
Ana P. C. SILVA, UFMG; Auricélio A. Macêdo, UFMG; Luciana F. Costa, UFMG; Cláudia E. Rocha, UFMG; Luize N. N. Garcia, UFMG; Jade R. D. Farias, UFMG; Priscilla P. R. Gomes, UFMG; Gustavo C. Teixeira, UFMG; Kessler W. J. Fonseca, UFMG; Andréa R. F. Maia, UFMG; Gabriela G. Neves, UFMG; Everton L. Romão, UFMG; Teane M. A. Silva, UFMG; Juliana P. S. Mol, UFMG; Renata M. Oliveira, Universidade Estadual do Maranhão; Márcio S. S. Araújo, Fundação Oswaldo Cruz, MG; Ernane F. Nascimento, UFMG; Olindo A. Martins-Filho, Fundação Oswaldo Cruz, MG; HUMBERTO DE MELLO BRANDAO, CNPGL; Tatiane A. Paixão, UFMG; Renato L. Santos, UFMG. |
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Título: |
Encapsulated Brucella ovis Lacking a Putative ATP-Binding Cassette Transporter (delta-abcBA) Protects against Wild Type Brucella ovis in Rams. |
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Ano de publicação: |
2015 |
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Fonte/Imprenta: |
Plos One, v. 10, n. 8, e013865, 2015. |
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Idioma: |
Inglês |
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Conteúdo: |
This study aimed to evaluate protection induced by the vaccine candidate B. ovis ΔabcBA against experimental challenge with wild type B. ovis in rams. Rams were subcutaneously immunized with B. ovis ΔabcBA encapsulated with sterile alginate or with the non encapsulated vaccine strain. Serum, urine, and semen samples were collected during two months after immunization. The rams were then challenged with wild type B. ovis (ATCC25840), and the results were compared to non immunized and experimentally challenged rams. Immunization, particularly with encapsulated B. ovis ΔabcBA, prevented infection, secretion of wild type B. ovis in the semen and urine, shedding of neutrophils in the semen, and the development of clinical changes, gross and microscopic lesions induced by the wild type B. ovis reference strain. Collectively, our data indicates that the B. ovis ΔabcBA strain is an exceptionally good vaccine strain for preventing brucellosis caused by B. ovis infection in rams. |
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Thesaurus Nal: |
animal health. |
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Categoria do assunto: |
L Ciência Animal e Produtos de Origem Animal |
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URL: |
https://ainfo.cnptia.embrapa.br/digital/bitstream/item/139391/1/Cnpgl-2015-PlosOne-Encapsulated.pdf
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Marc: |
LEADER 02099naa a2200373 a 4500
001 2037631
005 2024-02-03
008 2015 bl uuuu u00u1 u #d
100 1 $aSILVA, A. P. C.
245 $aEncapsulated Brucella ovis Lacking a Putative ATP-Binding Cassette Transporter (delta-abcBA) Protects against Wild Type Brucella ovis in Rams.$h[electronic resource]
260 $c2015
520 $aThis study aimed to evaluate protection induced by the vaccine candidate B. ovis ΔabcBA against experimental challenge with wild type B. ovis in rams. Rams were subcutaneously immunized with B. ovis ΔabcBA encapsulated with sterile alginate or with the non encapsulated vaccine strain. Serum, urine, and semen samples were collected during two months after immunization. The rams were then challenged with wild type B. ovis (ATCC25840), and the results were compared to non immunized and experimentally challenged rams. Immunization, particularly with encapsulated B. ovis ΔabcBA, prevented infection, secretion of wild type B. ovis in the semen and urine, shedding of neutrophils in the semen, and the development of clinical changes, gross and microscopic lesions induced by the wild type B. ovis reference strain. Collectively, our data indicates that the B. ovis ΔabcBA strain is an exceptionally good vaccine strain for preventing brucellosis caused by B. ovis infection in rams.
650 $aanimal health
700 1 $aMACÊDO, A. A.
700 1 $aCOSTA, L. F.
700 1 $aROCHA, C. E.
700 1 $aGARCIA, L. N. N.
700 1 $aFARIAS, J. R. D.
700 1 $aGOMES, P. P. R.
700 1 $aTEIXEIRA, G. C.
700 1 $aFONSECA, K. W. J.
700 1 $aMAIA, A. R. F.
700 1 $aNEVES, G. G.
700 1 $aROMÃO, E. L.
700 1 $aSILVA, T. M. A.
700 1 $aMOL, J. P. S.
700 1 $aOLIVEIRA, R. M.
700 1 $aARAÚJO, M. S. S.
700 1 $aNASCIMENTO, E. F.
700 1 $aMARTINS-FILHO, O. A.
700 1 $aBRANDAO, H. de M.
700 1 $aPAIXÃO, T. A.
700 1 $aSANTOS, R. L.
773 $tPlos One$gv. 10, n. 8, e013865, 2015.
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Embrapa Gado de Leite (CNPGL) |
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