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| Registros recuperados : 3 | |
| 1. |  | JORGE, B. C.; REIS, A. C. C.; STERDE, E. T.; BALIN, P. da S.; SCARANO, W. R.; HISANO, H.; ARENA, A. C. Exposure to benzo(a)pyrene from juvenile period to peripubertal impairs male reproductive parameters in adult rats. Chemosphere, v. 263, article 128016, 2021.| Biblioteca(s): Embrapa Meio Ambiente. |
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| 2. | | MOREIRA, S. da S.; INOCÊNCIO, L. C. de L.; JORGE, B. C.; REIS, A. C. C.; HISANO, H.; ARENA, A. C. Effects of benzo(a)pyrene at environmentally relevant doses on embryo-fetal development in rats. Environmental Toxicology, v. 36, n. 5, p. 831-839, 2021.| Biblioteca(s): Embrapa Meio Ambiente. |
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| 3. | | REIS, A. C. C.; JORGE, B. C.; PASCHALINI, B. R.; BUENO, J. N.; STEIN, J.; MOREIRA, S. da S.; MANOEL, B. de M.; FERNANDES, G. S. A.; HISANO, H.; ARENA, A. C. Long-term reproductive effects of benzo(a)pyrene at environmentally relevant dose on juvenile female rats. Drug and Chemical Toxicology, 2022. On-line first.| Biblioteca(s): Embrapa Meio Ambiente. |
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| Registros recuperados : 3 | |
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 | Acesso ao texto completo restrito à biblioteca da Embrapa Meio Ambiente. Para informações adicionais entre em contato com cnpma.biblioteca@embrapa.br. |
Registro Completo
|
Biblioteca(s): |
Embrapa Meio Ambiente. |
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Data corrente: |
06/07/2021 |
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Data da última atualização: |
15/03/2022 |
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Tipo da produção científica: |
Artigo em Periódico Indexado |
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Circulação/Nível: |
A - 1 |
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Autoria: |
JORGE, B. C.; REIS, A. C. C.; STERDE, E. T.; BALIN, P. da S.; SCARANO, W. R.; HISANO, H.; ARENA, A. C. |
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Afiliação: |
BÁRBARA CAMPOS JORGE, IBB-UNESP; ANA CAROLINA CASALI REIS, IBB-UNESP; ÉRIKA TISSIANA STERDE, IBB-UNESP; PAOLA DA SILVA BALIN, IBB-UNESP; WELLERSON RODRIGO SCARANO, IBB-UNESP; HAMILTON HISANO, CNPMA; ARIELLE CRISTINA ARENA, IBB-UNESP. |
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Título: |
Exposure to benzo(a)pyrene from juvenile period to peripubertal impairs male reproductive parameters in adult rats. |
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Ano de publicação: |
2021 |
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Fonte/Imprenta: |
Chemosphere, v. 263, article 128016, 2021. |
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ISSN: |
0045-6535 |
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DOI: |
https://doi.org/10.1016/j.chemosphere.2020.128016 |
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Idioma: |
Inglês |
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Conteúdo: |
Abstract: Benzo(a)pyrene (BaP) is a persistent organic pollutant and endocrine disruptor that can compromise the steroidogenesis process by interacting with the StAR protein, causing adverse effects on male reproduction. However, consequences of prepubertal BaP exposure and its impacts on adult life are yet unknown. This study investigated the effects of BaP exposure from the juvenile period to peripubertal on reproductive parameters in adult male rats. Males were exposed to 0; 0.1; 1 or 10 microgram/kg/day of BaP from post-natal (PND) 23 to PND 53 (by gavage). The lowest dose of BaP was able to compromise the male copulatory behavior, as evidenced by the delay in the first mount, intromission and ejaculation. Furthermore, BaP-treated groups showed lower sperm quality (disrupted motility and morphology) and quantity, reduced relative weights of the thyroid and seminal gland. Serum testosterone levels and the Leydig cells nuclei volume were decreased by BaP exposure whereas the StAR expression was increased. Histopathological changes in the testis also were detected in the males exposed to BaP. These results showed that prepubertal BaP-exposure adversely influenced the male reproductive system in the adult life, indicating that a comprehensive risk assessment of BaP-exposure on prepubertal period is necessary. |
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Palavras-Chave: |
Hidrocarboneto policíclico aromático. |
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Thesagro: |
Fisiologia Reprodutiva; Hidrocarboneto; Impacto Ambiental; Rato. |
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Thesaurus NAL: |
Abnormal development; Benzo(a)pyrene; Ecotoxicology; Health effects assessments; Rats; Reproductive disorders. |
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Categoria do assunto: |
H Saúde e Patologia |
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Marc: |
LEADER 02391naa a2200349 a 4500
001 2132813
005 2022-03-15
008 2021 bl uuuu u00u1 u #d
022 $a0045-6535
024 7 $ahttps://doi.org/10.1016/j.chemosphere.2020.128016$2DOI
100 1 $aJORGE, B. C.
245 $aExposure to benzo(a)pyrene from juvenile period to peripubertal impairs male reproductive parameters in adult rats.$h[electronic resource]
260 $c2021
520 $aAbstract: Benzo(a)pyrene (BaP) is a persistent organic pollutant and endocrine disruptor that can compromise the steroidogenesis process by interacting with the StAR protein, causing adverse effects on male reproduction. However, consequences of prepubertal BaP exposure and its impacts on adult life are yet unknown. This study investigated the effects of BaP exposure from the juvenile period to peripubertal on reproductive parameters in adult male rats. Males were exposed to 0; 0.1; 1 or 10 microgram/kg/day of BaP from post-natal (PND) 23 to PND 53 (by gavage). The lowest dose of BaP was able to compromise the male copulatory behavior, as evidenced by the delay in the first mount, intromission and ejaculation. Furthermore, BaP-treated groups showed lower sperm quality (disrupted motility and morphology) and quantity, reduced relative weights of the thyroid and seminal gland. Serum testosterone levels and the Leydig cells nuclei volume were decreased by BaP exposure whereas the StAR expression was increased. Histopathological changes in the testis also were detected in the males exposed to BaP. These results showed that prepubertal BaP-exposure adversely influenced the male reproductive system in the adult life, indicating that a comprehensive risk assessment of BaP-exposure on prepubertal period is necessary.
650 $aAbnormal development
650 $aBenzo(a)pyrene
650 $aEcotoxicology
650 $aHealth effects assessments
650 $aRats
650 $aReproductive disorders
650 $aFisiologia Reprodutiva
650 $aHidrocarboneto
650 $aImpacto Ambiental
650 $aRato
653 $aHidrocarboneto policíclico aromático
700 1 $aREIS, A. C. C.
700 1 $aSTERDE, E. T.
700 1 $aBALIN, P. da S.
700 1 $aSCARANO, W. R.
700 1 $aHISANO, H.
700 1 $aARENA, A. C.
773 $tChemosphere$gv. 263, article 128016, 2021.
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Embrapa Meio Ambiente (CNPMA) |
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