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| Registros recuperados : 32 | |
| 1. |  | MALHEIROS, J. M.; CORREIA, B. S. B.; CERIBELI, C.; CARDOSO, D. R.; COLNAGO, L. A.; BOGUSZ JUNIOR, S.; REECY, J. M.; MOURÃO, G. B.; COUTINHO, L. L.; PALHARES, J. C. P.; BERNDT, A.; REGITANO, L. C. de A. Comparative untargeted metabolome analysis of ruminal fluid and feces of Nelore steers (Bos indicus). Scientific Reports, v.11, n.1, e12752, 2021. 13 p.| Biblioteca(s): Embrapa Pecuária Sudeste. |
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| 2. | | MALHEIROS, J. M.; CORREIA, B. S. B.; CERIBELI, C.; CARDOSO, D. R.; COLNAGO, L. A.; BOGUSZ JUNIOR, S.; REECY, J. M.; MOURÃO, G. B.; COUTINHO, L. L.; PALHARES, J. C. P.; BERNDT, A.; REGITANO, L. C. de A. Comparative untargeted metabolome analysis of ruminal fuid and feces of Nelore steers (Bos indicus). Scientific Reports, v. 11, n. 1, e12752, 2021.| Biblioteca(s): Embrapa Instrumentação; Embrapa Pecuária Sudeste. |
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| 3. | | MOREIRA, G. C. M.; SALVIAN, M.; BOSCHIERO, C.; CESAR, A. S. M.; REECY, J. M.; GODOY, T. F.; LEDUR, M. C.; GARRICK, D.; MOURÃO, G. B.; COUTINHO, L. L. Genome-wide association scan for QTL and their positional candidate genes associated with internal organ traits in chickens. BMC Genomics, v. 20, n. 669, 2019.| Biblioteca(s): Embrapa Suínos e Aves. |
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| 4. | | MOREIRA, G. C. M.; BOSCHIERO, C.; CESAR, A. S. M.; REECY, J. M.; GODOY, T. F.; TREVISOLI, P. A.; CANTAO, M. E.; LEDUR, M. C.; IBELLI, A. M. G.; MOURA, A. S. M. T.; GARRICK, D.; COUTINHO, L. L. A genome-wide association study reveals novel genomic regions and positional candidate genes for fat deposition in broiler chickens. BMC Genomics, v. 19, n. 374, 2018.| Biblioteca(s): Embrapa Suínos e Aves. |
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| 5. | | GONÇALVES, T. M.; REGITANO, L. C. de A.; KOLTES, J. E.; CESAR, A. S. M.; ANDRADE, S. C. da S.; MOURAO, G. B.; GASPARIN, G.; MOREIRA, G. C. M.; FRITZ-WATERS, E.; REECY, J. M.; COUTINHO, L. L. Gene co-expression analysis indicates potential pathways and regulators of beef tenderness in Nellore cattle. Frontiers in Genetics, v.9, n. 441, p. 1-18, 2018.| Biblioteca(s): Embrapa Pecuária Sudeste. |
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| 6. | | OLIVEIRA, P. S. N. de; TIZIOTO, P. C.; OLIVEIRA, G. B.; CESAR, A. S. M.; DINIZ, W. J. da S.; LIMA, A. O. de; REECY, J. M.; COUTINHO, L. L.; REGITANO, L. C. de A. Differentially expressed miRNAs in skeletal muscle related to feed efficiency in Nellore cattle. Journal of Animal Science, v. 94, e-suppl. 5; Journal of Dairy Science, v. 99, e-suppl. 1, p. 159, jul. 2016.| Biblioteca(s): Embrapa Pecuária Sudeste. |
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| 7. | | OLIVEIRA, P. S. N. DE; ANDRADE, B. G.; CARDOSO, T. F.; PASCHOAL, J. J.; JOSAHKIAN, L. A.; ALMEIDA, L. F.; MARCONDES, C. R.; MOURÃO, G. B.; COUTINHO, L. L.; REECY, J. M.; REGITANO, L. C. de A. Differentially expressed miRNAs in the stool of Bos indicus divergent for feed efficiency. Italian Journal of Animal Science, v. 22, supplement 1, 2023. p. 193-194. Congress of the Animal Science and Production Association, 25., Monopoli (BARI – ITALY), June 13–16, 2023.| Biblioteca(s): Embrapa Pecuária Sudeste. |
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| 8. | | MOREIRA, G. C. M.; BOSCHIERO, C.; CESAR, A. S. M.; REECY, J. M.; GODOY, T. F.; PÉRTILLE, F.; LEDUR, M. C.; MOURA, A. S. A. M. T. M.; GARRICK, D. J.; COUTINHO, L. L. Integration of genome wide association studies and whole genome sequencing provides novel insights into fat deposition in chicken. Scientific Reports, v. 8, n. 16222, 2018.| Biblioteca(s): Embrapa Suínos e Aves. |
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| 9. | | MOREIRA, G. C. M.; GODOY, T. F.; BOSCHIERO, C.; CESAR, A. S. M.; REECY, J. M.; LEDUR, M. C.; GARRICK, D.; SILVA, V. H. da; CROOIJAMANS, R. P.; GROENEN, M. A. M.; COUTINHO, L. L. Integration of GWAS, CNV and sele ction signature reveals candidate genes for abdominal fat regulation in chickens. In: WORLD CONGRESS ON GENETICS APPLIED TO LIVESTOCK PRODUCTION, 11., 2018, Auckland, New Zealand. Proceedings... Massey University, 2018. Digital Archive.| Biblioteca(s): Embrapa Suínos e Aves. |
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| 10. | | OLIVEIRA, G. B.; REGITANO, L. C. de A.; CESAR, A. S. M.; REECY, J. M.; DEGAKI, K. Y.; POLETI, M. D.; FELICIO, A. M.; KOLTES, J. E.; COUTINHO, L. L. Integrative analysis of microRNAs and mRNAs revealed regulation of composition and metabolism in Nelore cattle. BMC Genomics, v. 19, n. 126, p. 2-16, 2018.| Biblioteca(s): Embrapa Pecuária Sudeste. |
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| 11. | | CESAR, A. S. M.; REGITANO, L. C. de A.; LANNA, D. P. D.; POLETI, M. D.; KOLTES, J. E.; REECY, J. M.; FRITZ-WATERS, E.; KRAMER, L.; GARRICK, D.; MUDADU, M. de A.; TULLIO, R. R.; COUTINHO, L. L. Expression quantitative trait loci (eQTL) hotspot regions from whole genome analysis of Nellore steers. In: PLANT AND ANIMAL GENOME CONFERENCE, 24., 2016, San Diego. Anais... San Diego: PAG, 2016.| Biblioteca(s): Embrapa Pecuária Sudeste. |
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| 12. | | OLIVEIRA, P. S. N. DE; ANDRADE, B. G.; CONTEVILLE, L. C.; CARDOSO, T. F.; PASCHOAL, J. J.; JOSAHKIAN, L. A.; ALMEIDA, L. F.; MARCONDES, C. R.; MOURÃO, G. B.; COUTINHO, L. L.; REECY, J. M.; REGITANO, L. C. de A. Microbial diversity in the stool of Bos indicus divergent for feed efficiency. Italian Journal of Animal Science, v. 22, supplement 1, 2023. p. 194. Congress of the Animal Science and Production Association, 25., Monopoli (BARI – ITALY), June 13–16, 2023.| Biblioteca(s): Embrapa Pecuária Sudeste. |
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| 13. | | OLIVEIRA, P. S. N. de; CESAR, A. S. M.; OLIVEIRA, G. B. de; TIZIOTO, P. C.; POLETI, M. D.; DINIZ, W. J. da S.; LIMA, A. O. de; REECY, J. M.; COUTINHO, L. L.; REGITANO, L. C. de A. miRNAs related to fatty acids composition in Nellore cattle. Journal of Animal Science, v. 94, e-suppl. 5; Journal of Dairy Science, v. 99, e-suppl. 1, p. 159, jul. 2016. p. 160.| Biblioteca(s): Embrapa Pecuária Sudeste. |
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| 14. | | CESAR, A. S. M.; REGITANO, L. C. de A.; KOLTES, J.; FRITZ-WATERS, E. R.; TULLIO, R. R.; LANNA, D. P. D.; REECY, J. M.; MOURÃO, G. B.; GASPARIN, G.; COUTINHO, L. L. Transcriptome profile in Longissimus dorsi muscle from Nellore steers with extreme GEBV for intramuscular fat percentage. In: INTERNATIONAL SYMPOSIUM ON ANIMAL FUNCTIONAL GENOMICS, 5., 2013, Guarujá. Abstract... Guarujá:[ s.n.], 2013. AB.07.| Biblioteca(s): Embrapa Pecuária Sudeste. |
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| 15. | | MOREIRA, G. C. M.; POLETI, M. D.; PÉRTILLE, F.; BOSCHIERO, C.; CESAR, A. S. M.; GODOY, T. F.; LEDUR, M. C.; REECY, J. M.; GARRICK, D. J.; COUTINHO, L. L. Unraveling genomic associations with feed efficiency and body weight traits in chickens through an integrative approach. BMC Genetics, v. 20, n. 83, 2019.| Biblioteca(s): Embrapa Suínos e Aves. |
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| 16. | | OLIVEIRA, P. S. N. de; COUTINHO, L. L.; CESAR, A. S. M.; DINIZ, W. J. da S.; SOUZA, M. de S.; ANDRADE, B. G.; KOLTES, J. E.; MOURÃO, G. B.; ZERLOTINI NETO, A.; REECY, J. M.; REGITANO, L. C. de A. Co-expression networks reveal potential regulatory roles of miRNAs in fatty acid composition of nelore cattle. Frontiers in Genetics, v. 10, p. 1-14, July 2019. Article 651. Na publicação: Adhemar Zerlotini, Luciana C.A. Regitano.| Biblioteca(s): Embrapa Agricultura Digital; Embrapa Pecuária Sudeste. |
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| 17. | | ANDRADE, B. G. N.; DONATONI, F. A. B.; CUADRAT, R. R. C.; TIZIOTO, P. C.; OLIVEIRA, P. S. N. de; MOURÃO, G. B.; COUTINHO, L. L.; REECY, J. M.; KOLTES, J. E.; WALSH, P.; BERNDT, A.; PALHARES, J. C. P.; REGITANO, L. C. de A. The structure of microbial populations in Nelore GIT reveals inter-dependency of methanogens in feces and rumen. Journal of Animal Science and Biotechnology, v.11, n. 6, 2020. 10 p.| Biblioteca(s): Embrapa Pecuária Sudeste. |
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| 18. | | ANDRADE, B. G. N.; DONATONI, F. A. B.; CUADRAT, R. R.; CARDOSO, T. F.; MALHEIROS, J. M.; OLIVEIRA, P. S. N. DE; PETRINI, J.; MOURÃO, G. B.; COUTINHO, L. L.; REECY, J. M.; KOLTES, J. E.; ZERLOTINI NETO, A.; MEDEIROS, S. R. de; BERNDT, A.; PALHARES, J. C. P.; AFLI, H.; REGITANO, L. C. de A. Stool and ruminal microbiome components associated with methane emission and feed efficiency in Nelore beef cattle. Frontiers in Genetics, v. 13, 812828, may, 2022. 12 p.| Biblioteca(s): Embrapa Agricultura Digital; Embrapa Pecuária Sudeste. |
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| 19. | | CESAR, A. S. M.; REGITANO, L. C. de A.; MOURÃO, G. B.; TULLIO, R. R.; LANNA, D. P. D.; NASSU, R. T.; MUDADU, M. de A.; OLIVEIRA, P. S. N.; NASCIMENTO, M. L. do; CHAVES, A. S.; ALENCAR, M. M. de; SONSTEGRAD, T. S.; GARRICK, D. J.; REECY, J. M.; COUTINHO, L. L. Genome-wide association study for intramuscular fat deposition and composition in Nellore cattle. BMC Genetics, v. 15, p. 39, 2014| Biblioteca(s): Embrapa Pecuária Sudeste. |
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| 20. | | OLIVEIRA, P. S. N.; CESAR, A. S. M.; NASCIMENTO, M. L. do; CHAVES, A. S.; TIZIOTO, P. C.; TULLIO, R. R.; LANNA, D. P. D.; ROSA, A. do N.; SONSTEGARD, T. S.; MOURÃO, G. B.; REECY, J. M.; GARRICK, D. J.; MUDADU, M. de A.; COUTINHO, L. L.; REGITANO, L. C. de A. Identification of genomic regions associated with feed efficiency in Nelore cattle. BMC Genetics, v. 15, n. 1, 2014 10 p.| Biblioteca(s): Embrapa Pecuária Sudeste. |
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| Registros recuperados : 32 | |
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Registro Completo
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Biblioteca(s): |
Embrapa Agricultura Digital; Embrapa Pecuária Sudeste. |
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Data corrente: |
24/07/2019 |
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Data da última atualização: |
09/01/2020 |
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Tipo da produção científica: |
Artigo em Periódico Indexado |
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Circulação/Nível: |
A - 1 |
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Autoria: |
OLIVEIRA, P. S. N. de; COUTINHO, L. L.; CESAR, A. S. M.; DINIZ, W. J. da S.; SOUZA, M. de S.; ANDRADE, B. G.; KOLTES, J. E.; MOURÃO, G. B.; ZERLOTINI NETO, A.; REECY, J. M.; REGITANO, L. C. de A. |
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Afiliação: |
PRISCILA S. N. DE OLIVEIRA, CPPSE; LUIZ L. COUTINHO, Esalq/USP; ALINE S. M. CESAR, Esalq/USP; WELLISON J. DA SILVA DINIZ, UFSCar; MARCELA M. DE SOUZA, Iowa State University; BRUNO G. ANDRADE, CPPSE; JAMES E. KOLTES, Iowa State University; GERSON B. MOURÃO, Esalq/USP; ADHEMAR ZERLOTINI NETO, CNPTIA; JAMES M. REECY, Iowa State University; LUCIANA CORREIA DE ALMEIDA REGITANO, CPPSE. |
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Título: |
Co-expression networks reveal potential regulatory roles of miRNAs in fatty acid composition of nelore cattle. |
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Ano de publicação: |
2019 |
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Fonte/Imprenta: |
Frontiers in Genetics, v. 10, p. 1-14, July 2019. |
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DOI: |
10.3389/fgene.2019.00651 |
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Idioma: |
Inglês |
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Notas: |
Article 651. Na publicação: Adhemar Zerlotini, Luciana C.A. Regitano. |
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Conteúdo: |
Fatty acid (FA) content affects the sensorial and nutritional value of meat and plays a significant role in biological processes such as adipogenesis and immune response. It is well known that, in beef, the main FAs associated with these biological processes are oleic acid (C18:1 cis9, OA) and conjugated linoleic acid (CLA-c9t11), which may have beneficial effects on metabolic diseases such as type 2 diabetes and obesity. Here, we performed differential expression and co-expression analyses, weighted gene co-expression network analysis (WGCNA) and partial correlation with information theory (PCIT), to uncover the complex interactions between miRNAs and mRNAs expressed in skeletal muscle associated with FA content. miRNA and mRNA expression data were obtained from skeletal muscle of Nelore cattle that had extreme genomic breeding values for OA and CLA. Insulin and MAPK signaling pathways were identified by WGCNA as central pathways associated with both of these fatty acids. Co-expression network analysis identified bta-miR-33a/b, bta-miR-100, bta-miR-204, bta-miR-365-5p, btamiR-660, bta-miR-411a, bta-miR-136, bta-miR-30-5p, bta-miR-146b, bta-let-7a-5p, bta-let-7f, bta-let-7, bta-miR 339, bta-miR-10b, bta-miR 486, and the genes ACTA1 and ALDOA as potential regulators of fatty acid synthesis. This study provides evidence and insights into the molecular mechanisms and potential target genes involved in fatty acid content differences in Nelore beef cattle, revealing new candidate pathways of phenotype modulation that could positively benefit beef production and human consumption. MenosFatty acid (FA) content affects the sensorial and nutritional value of meat and plays a significant role in biological processes such as adipogenesis and immune response. It is well known that, in beef, the main FAs associated with these biological processes are oleic acid (C18:1 cis9, OA) and conjugated linoleic acid (CLA-c9t11), which may have beneficial effects on metabolic diseases such as type 2 diabetes and obesity. Here, we performed differential expression and co-expression analyses, weighted gene co-expression network analysis (WGCNA) and partial correlation with information theory (PCIT), to uncover the complex interactions between miRNAs and mRNAs expressed in skeletal muscle associated with FA content. miRNA and mRNA expression data were obtained from skeletal muscle of Nelore cattle that had extreme genomic breeding values for OA and CLA. Insulin and MAPK signaling pathways were identified by WGCNA as central pathways associated with both of these fatty acids. Co-expression network analysis identified bta-miR-33a/b, bta-miR-100, bta-miR-204, bta-miR-365-5p, btamiR-660, bta-miR-411a, bta-miR-136, bta-miR-30-5p, bta-miR-146b, bta-let-7a-5p, bta-let-7f, bta-let-7, bta-miR 339, bta-miR-10b, bta-miR 486, and the genes ACTA1 and ALDOA as potential regulators of fatty acid synthesis. This study provides evidence and insights into the molecular mechanisms and potential target genes involved in fatty acid content differences in Nelore beef cattle, revealing new candidate... Mostrar Tudo |
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Palavras-Chave: |
Ácido linoleico conjugado; Ácido oleico; Ácidos graxos; Genômica; Integrative genomics; MiRNA; MRNA; Redes de co-expressão. |
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Thesagro: |
Bos Indicus; Gado de Corte. |
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Thesaurus NAL: |
Beef cattle; Conjugated linoleic acid; Oleic acid. |
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Categoria do assunto: |
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L Ciência Animal e Produtos de Origem Animal |
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URL: |
https://ainfo.cnptia.embrapa.br/digital/bitstream/item/199817/1/AP-Coexpression-networks.pdf
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Marc: |
LEADER 02877naa a2200421 a 4500
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024 7 $a10.3389/fgene.2019.00651$2DOI
100 1 $aOLIVEIRA, P. S. N. de
245 $aCo-expression networks reveal potential regulatory roles of miRNAs in fatty acid composition of nelore cattle.$h[electronic resource]
260 $c2019
500 $aArticle 651. Na publicação: Adhemar Zerlotini, Luciana C.A. Regitano.
520 $aFatty acid (FA) content affects the sensorial and nutritional value of meat and plays a significant role in biological processes such as adipogenesis and immune response. It is well known that, in beef, the main FAs associated with these biological processes are oleic acid (C18:1 cis9, OA) and conjugated linoleic acid (CLA-c9t11), which may have beneficial effects on metabolic diseases such as type 2 diabetes and obesity. Here, we performed differential expression and co-expression analyses, weighted gene co-expression network analysis (WGCNA) and partial correlation with information theory (PCIT), to uncover the complex interactions between miRNAs and mRNAs expressed in skeletal muscle associated with FA content. miRNA and mRNA expression data were obtained from skeletal muscle of Nelore cattle that had extreme genomic breeding values for OA and CLA. Insulin and MAPK signaling pathways were identified by WGCNA as central pathways associated with both of these fatty acids. Co-expression network analysis identified bta-miR-33a/b, bta-miR-100, bta-miR-204, bta-miR-365-5p, btamiR-660, bta-miR-411a, bta-miR-136, bta-miR-30-5p, bta-miR-146b, bta-let-7a-5p, bta-let-7f, bta-let-7, bta-miR 339, bta-miR-10b, bta-miR 486, and the genes ACTA1 and ALDOA as potential regulators of fatty acid synthesis. This study provides evidence and insights into the molecular mechanisms and potential target genes involved in fatty acid content differences in Nelore beef cattle, revealing new candidate pathways of phenotype modulation that could positively benefit beef production and human consumption.
650 $aBeef cattle
650 $aConjugated linoleic acid
650 $aOleic acid
650 $aBos Indicus
650 $aGado de Corte
653 $aÁcido linoleico conjugado
653 $aÁcido oleico
653 $aÁcidos graxos
653 $aGenômica
653 $aIntegrative genomics
653 $aMiRNA
653 $aMRNA
653 $aRedes de co-expressão
700 1 $aCOUTINHO, L. L.
700 1 $aCESAR, A. S. M.
700 1 $aDINIZ, W. J. da S.
700 1 $aSOUZA, M. de S.
700 1 $aANDRADE, B. G.
700 1 $aKOLTES, J. E.
700 1 $aMOURÃO, G. B.
700 1 $aZERLOTINI NETO, A.
700 1 $aREECY, J. M.
700 1 $aREGITANO, L. C. de A.
773 $tFrontiers in Genetics$gv. 10, p. 1-14, July 2019.
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Embrapa Pecuária Sudeste (CPPSE) |
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