| |
|
|
| Registros recuperados : 10 | |
| 7. |  | ZUCCHI, T. D.; ZUCCHI, F. D.; POLI, P.; MELO, I. S. de; ZUCCHI, T. M. A. D. A short-term test adapted to detect the genotoxic effects of environmental volatile pollutants (benzene fumes) using the filamentous fungus Aspergillus nidulans. Journal of Environmental Monitoring, Washington, DC, v. 7, n. 6, p. 598-602, 2005.| Biblioteca(s): Embrapa Meio Ambiente. |
|    |
| 9. | | POLI, P.; MELLO, M. A. de; BUSCHINI, A.; CASTRO, V. L. S. S. de; RESTIVO, F. M.; ROSSI, C.; ZUCCHI, T. M. A. D. Evaluation of the genotoxicity induced by the fungicide fenarimol in mammalian and plant cells by use of the single-cell gel electrophoresis assay. Mutation Research, Amsterdam, v. 540, p. 57-66, 2003.| Biblioteca(s): Embrapa Meio Ambiente. |
|  |
| 10. | | CASTRO, V. L. S. S. de; MELLO, M. A. de; DINIZ, C. A. R.; MORITA, L. H. M.; ZUCCHI, T.; POLI, P. Neurodevelopmental effects of perinatal fenarimol exposure on rats. Reproductive Toxicology, Elmsford, v. 23, n. 1, p. 98-105, 2007.| Biblioteca(s): Embrapa Meio Ambiente. |
| |
| Registros recuperados : 10 | |
|
|
|
 | Acesso ao texto completo restrito à biblioteca da Embrapa Meio Ambiente. Para informações adicionais entre em contato com cnpma.biblioteca@embrapa.br. |
Registro Completo
|
Biblioteca(s): |
Embrapa Meio Ambiente. |
|
Data corrente: |
23/05/2007 |
|
Data da última atualização: |
08/06/2015 |
|
Tipo da produção científica: |
Artigo em Periódico Indexado |
|
Circulação/Nível: |
Internacional - A |
|
Autoria: |
CASTRO, V. L. S. S. de; MELLO, M. A. de; POLI, P.; ZUCCHI, T. M. A. D. |
|
Afiliação: |
VERA LUCIA SCHERHOLZ S DE CASTRO, CNPMA; Michel e A. de Mello, Departamento de Parasitologia, Instituto de Ciências Biomédicas, USP.; Paola Poli, Departamento de Parasitologia, Instituto de Ciências Biomédicas, USP; Tânia M.A.D. Zucchi, Dipartimento di Genetica Antropologia Evoluzione, Uniiversità degli Studi di Parma. |
|
Título: |
Prenatal and perinatal fenarimol-induced genotoxicity in leukocytes of in vivo treated rats. |
|
Ano de publicação: |
2005 |
|
Fonte/Imprenta: |
Mutation Research, Amsterdam, v. 583, v.1, p. 95-104, 2005. |
|
Idioma: |
Inglês |
|
Conteúdo: |
The identification of environmental compounds that have adverse effects on reproductive health and animal development is particularly challenging. Fenarimol, a systemic fungicide, is considered non or weakly genotoxic. However, its available toxicological data are controversial and incomplete. This study was conducted in rat in vivo to determine whether this compound (150 and 300 mg/kg) had adverse effects on DNA integrity in dams and pups after maternal subcutaneous exposure. The animals were exposed during early gestation (1-6 days), late gestation (last 6 days), or first 6 days of lactation. Findings on fenarimol genotoxicity showed an adverse effect when detected by the Comet assay, both in dams and pup, and state that animal sensitivity to fenarimol is higher during postnatal period. Since the DNA damage increases during the time of exposure (2 h to 6 days after the birth), our data on pups suggest that fenarimol can mainly act on cell DNA through direct exposure of litter via milk. |
|
Palavras-Chave: |
Efeito; Genotoxicidade; Gestação; Prenez. |
|
Thesagro: |
Fungicida sistêmico; Lactação; Rato. |
|
Thesaurus NAL: |
testes. |
|
Categoria do assunto: |
P Recursos Naturais, Ciências Ambientais e da Terra |
|
Marc: |
LEADER 01714naa a2200253 a 4500
001 1015468
005 2015-06-08
008 2005 bl uuuu u00u1 u #d
100 1 $aCASTRO, V. L. S. S. de
245 $aPrenatal and perinatal fenarimol-induced genotoxicity in leukocytes of in vivo treated rats.$h[electronic resource]
260 $c2005
520 $aThe identification of environmental compounds that have adverse effects on reproductive health and animal development is particularly challenging. Fenarimol, a systemic fungicide, is considered non or weakly genotoxic. However, its available toxicological data are controversial and incomplete. This study was conducted in rat in vivo to determine whether this compound (150 and 300 mg/kg) had adverse effects on DNA integrity in dams and pups after maternal subcutaneous exposure. The animals were exposed during early gestation (1-6 days), late gestation (last 6 days), or first 6 days of lactation. Findings on fenarimol genotoxicity showed an adverse effect when detected by the Comet assay, both in dams and pup, and state that animal sensitivity to fenarimol is higher during postnatal period. Since the DNA damage increases during the time of exposure (2 h to 6 days after the birth), our data on pups suggest that fenarimol can mainly act on cell DNA through direct exposure of litter via milk.
650 $atestes
650 $aFungicida sistêmico
650 $aLactação
650 $aRato
653 $aEfeito
653 $aGenotoxicidade
653 $aGestação
653 $aPrenez
700 1 $aMELLO, M. A. de
700 1 $aPOLI, P.
700 1 $aZUCCHI, T. M. A. D.
773 $tMutation Research, Amsterdam$gv. 583, v.1, p. 95-104, 2005.
Download
Esconder MarcMostrar Marc Completo |
|
Registro original: |
Embrapa Meio Ambiente (CNPMA) |
|
|
Biblioteca |
ID |
Origem |
Tipo/Formato |
Classificação |
Cutter |
Registro |
Volume |
Status |
Fechar
|
| Nenhum registro encontrado para a expressão de busca informada. |
|
|
