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| 1. |  | LAU, H. D.; FAN, L. C. R.; FIALHO, S. A. G.; PIPPI, N. L.; RAISER, A. G. Efeitos adversos da levomepromazina em ovinos. Pesquisa Agropecuária Brasileira, Brasília, DF, v. 18, n. 2, p. 181-185, fev. 1983.| Biblioteca(s): Embrapa Amazônia Oriental; Embrapa Unidades Centrais. |
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| 2. | | SPRADA, A. G.; ROSA, M. P. da; MACHADO, A. K.; PIPPI, N. L.; BAYARD, P.; CRUZ, I. B. M. da. Toxicity and oxidative stress of canine mesanchymal stromal cells from adipose tissue in different culture passages. Pesquisa Veterinária Brasileira, Brasília, DF, v. 35, supl. 1, p. 15-20, dez. 2015.| Biblioteca(s): Embrapa Unidades Centrais. |
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| Registros recuperados : 2 | |
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Registro Completo
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Biblioteca(s): |
Embrapa Unidades Centrais. |
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Data corrente: |
29/04/2016 |
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Data da última atualização: |
29/04/2016 |
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Autoria: |
SPRADA, A. G.; ROSA, M. P. da; MACHADO, A. K.; PIPPI, N. L.; BAYARD, P.; CRUZ, I. B. M. da. |
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Afiliação: |
ARÍCIA GOMES SPRADA, CCR/UFSM; MATHEUS PIPPI DA ROSA, CCR/UFSM; ALENCAR KOLINSKI MACHADO, CCS/UFSM; NEY LUIS PIPPI, CCR/UFSM; PAULO BAYARD, CCR/UFSM; IVANA BEATRICE MÂNICA DA CRUZ, CCS/UFSM. |
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Título: |
Toxicity and oxidative stress of canine mesanchymal stromal cells from adipose tissue in different culture passages. |
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Ano de publicação: |
2015 |
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Fonte/Imprenta: |
Pesquisa Veterinária Brasileira, Brasília, DF, v. 35, supl. 1, p. 15-20, dez. 2015. |
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Idioma: |
Inglês |
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Conteúdo: |
Stem cells in regenerative therapy have received attention from researchers in recent decades. The culture of these cells allows studies about their behavior and metabolism. Thus, cell culture is the basis for cell therapy and tissue engineering researches. A major concern regarding the use of cultivated stem cell in human or veterinary clinical routine is the risk of carcinogenesis. Cellular activities require a balanced redox state. However, when there is an imbalance in this state, oxidative stress occurs. Oxidative stress contributes to cytotoxicity, which may result in cell death or genomic alterations, favoring the development of cancer cells. The aim of this study was to determine whether there are differences in the behavior of cultured mesenchymal stem cells from canine adipose tissue according to its site of collection (omentum and subcutaneous) evaluating the rate of proliferation, viability, level of oxidative stress and cytotoxicity over six passages. For this experiment, two samples of adipose tissue from subcutaneous and omentum where taken from a female dog corpse, 13 years old, Pitbull. The results showed greater levels of oxidative stress in the first and last passages of both groups, favoring cytotoxicity and cell death. |
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Palavras-Chave: |
Células-tronco; Culture; Passage; Passagem; Radicais livres; Stem cell; Viabilidade celular. |
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Thesagro: |
Produção vegetal. |
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Thesaurus NAL: |
Cell viability; Free radicals. |
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Categoria do assunto: |
-- |
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URL: |
https://ainfo.cnptia.embrapa.br/digital/bitstream/item/142669/1/Toxicity-and-oxidative-stress.pdf
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Marc: |
LEADER 02131naa a2200301 a 4500
001 2044244
005 2016-04-29
008 2015 bl uuuu u00u1 u #d
100 1 $aSPRADA, A. G.
245 $aToxicity and oxidative stress of canine mesanchymal stromal cells from adipose tissue in different culture passages.
260 $c2015
520 $aStem cells in regenerative therapy have received attention from researchers in recent decades. The culture of these cells allows studies about their behavior and metabolism. Thus, cell culture is the basis for cell therapy and tissue engineering researches. A major concern regarding the use of cultivated stem cell in human or veterinary clinical routine is the risk of carcinogenesis. Cellular activities require a balanced redox state. However, when there is an imbalance in this state, oxidative stress occurs. Oxidative stress contributes to cytotoxicity, which may result in cell death or genomic alterations, favoring the development of cancer cells. The aim of this study was to determine whether there are differences in the behavior of cultured mesenchymal stem cells from canine adipose tissue according to its site of collection (omentum and subcutaneous) evaluating the rate of proliferation, viability, level of oxidative stress and cytotoxicity over six passages. For this experiment, two samples of adipose tissue from subcutaneous and omentum where taken from a female dog corpse, 13 years old, Pitbull. The results showed greater levels of oxidative stress in the first and last passages of both groups, favoring cytotoxicity and cell death.
650 $aCell viability
650 $aFree radicals
650 $aProdução vegetal
653 $aCélulas-tronco
653 $aCulture
653 $aPassage
653 $aPassagem
653 $aRadicais livres
653 $aStem cell
653 $aViabilidade celular
700 1 $aROSA, M. P. da
700 1 $aMACHADO, A. K.
700 1 $aPIPPI, N. L.
700 1 $aBAYARD, P.
700 1 $aCRUZ, I. B. M. da
773 $tPesquisa Veterinária Brasileira, Brasília, DF$gv. 35, supl. 1, p. 15-20, dez. 2015.
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Embrapa Unidades Centrais (AI-SEDE) |
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