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 | Acesso ao texto completo restrito à biblioteca da Embrapa Gado de Leite. Para informações adicionais entre em contato com cnpgl.biblioteca@embrapa.br. |
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Registro Completo |
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Biblioteca(s): |
Embrapa Gado de Leite; Embrapa Pecuária Sudeste; Embrapa Pecuária Sul. |
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Data corrente: |
25/03/2024 |
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Data da última atualização: |
25/03/2024 |
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Tipo da produção científica: |
Artigo em Periódico Indexado |
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Autoria: |
CARVALHO, W. A.; GASPAR, E. B.; DOMINGUES, R.; REGITANO, L. C. de A.; CARDOSO, F. F. |
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Afiliação: |
WANESSA ARAUJO CARVALHO, CNPGL; EMANUELLE BALDO GASPAR, CNPGL; ROBERT DOMINGUES, CNPGL; LUCIANA CORREIA DE ALMEIDA REGITANO, CPPSE; FERNANDO FLORES CARDOSO, CPPSUL. |
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Título: |
Genetic factors underlying host resistance to Rhipicephalus microplus tick infestation in Braford cattle: a systems biology perspective. |
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Ano de publicação: |
2024 |
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Fonte/Imprenta: |
Mammalian Genome, 2024. |
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DOI: |
https://doi.org/10.1007/s00335-024-10030-x |
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Idioma: |
Inglês |
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Notas: |
First online. |
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Conteúdo: |
Approximately 80% of the world's cattle are raised in regions with a high risk of tick-borne diseases, resulting in significant economic losses due to parasitism by Rhipicephalus(Boophilus)microplus. However, the lack of a systemic biology approach hampers a comprehensive understanding of tick-host interactions that mediate tick resistance phenotypes. Here, we conducted a genome-wide association study (GWAS) of 2933 Braford cattle and found 340 single-nucleotide polymorphisms (SNPs) associated with tick counts. Gene expression analyses were performed on skin samples obtained from previously tick-exposed heifers with extremely high or low estimated breeding values for R.microplus counts. Evaluations were performed both before and after artificial infestation with ticks. Differentially expressed genes were found within 1-Mb windows centered at significant SNPs from GWAS. A total of 330 genes were related to the breakdown of homeostasis that was induced by larval attachment to bovine skin. Enrichment analysis pointed to a key role of proteolysis and signal transduction via JAK/STAT, NFKB and WNT/beta catenin signaling pathways. Integrative analysis on matrixEQTL revealed two cis-eQTLs and four significant SNPs in the genes peptidylargininedeiminasetypeIV (PADI4) and LOC11449251. The integration of genomic data from QTL maps and transcriptome analyses has identified a set of twelve key genes that show significant associations with tick loads. These genes could be key candidates to improve the accuracy of genomic predictions for tick resistance in Braford cattle. MenosApproximately 80% of the world's cattle are raised in regions with a high risk of tick-borne diseases, resulting in significant economic losses due to parasitism by Rhipicephalus(Boophilus)microplus. However, the lack of a systemic biology approach hampers a comprehensive understanding of tick-host interactions that mediate tick resistance phenotypes. Here, we conducted a genome-wide association study (GWAS) of 2933 Braford cattle and found 340 single-nucleotide polymorphisms (SNPs) associated with tick counts. Gene expression analyses were performed on skin samples obtained from previously tick-exposed heifers with extremely high or low estimated breeding values for R.microplus counts. Evaluations were performed both before and after artificial infestation with ticks. Differentially expressed genes were found within 1-Mb windows centered at significant SNPs from GWAS. A total of 330 genes were related to the breakdown of homeostasis that was induced by larval attachment to bovine skin. Enrichment analysis pointed to a key role of proteolysis and signal transduction via JAK/STAT, NFKB and WNT/beta catenin signaling pathways. Integrative analysis on matrixEQTL revealed two cis-eQTLs and four significant SNPs in the genes peptidylargininedeiminasetypeIV (PADI4) and LOC11449251. The integration of genomic data from QTL maps and transcriptome analyses has identified a set of twelve key genes that show significant associations with tick loads. These genes could be key candidates ... Mostrar Tudo |
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Thesagro: |
Bovino; Carrapato; Doença Animal; Parasitismo; Resistência. |
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Thesaurus Nal: |
Amber disease; Parasitism; Ticks. |
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Categoria do assunto: |
L Ciência Animal e Produtos de Origem Animal |
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Marc: |
LEADER 02431naa a2200289 a 4500
001 2163111
005 2024-03-25
008 2024 bl uuuu u00u1 u #d
024 7 $ahttps://doi.org/10.1007/s00335-024-10030-x$2DOI
100 1 $aCARVALHO, W. A.
245 $aGenetic factors underlying host resistance to Rhipicephalus microplus tick infestation in Braford cattle$ba systems biology perspective.$h[electronic resource]
260 $c2024
500 $aFirst online.
520 $aApproximately 80% of the world's cattle are raised in regions with a high risk of tick-borne diseases, resulting in significant economic losses due to parasitism by Rhipicephalus(Boophilus)microplus. However, the lack of a systemic biology approach hampers a comprehensive understanding of tick-host interactions that mediate tick resistance phenotypes. Here, we conducted a genome-wide association study (GWAS) of 2933 Braford cattle and found 340 single-nucleotide polymorphisms (SNPs) associated with tick counts. Gene expression analyses were performed on skin samples obtained from previously tick-exposed heifers with extremely high or low estimated breeding values for R.microplus counts. Evaluations were performed both before and after artificial infestation with ticks. Differentially expressed genes were found within 1-Mb windows centered at significant SNPs from GWAS. A total of 330 genes were related to the breakdown of homeostasis that was induced by larval attachment to bovine skin. Enrichment analysis pointed to a key role of proteolysis and signal transduction via JAK/STAT, NFKB and WNT/beta catenin signaling pathways. Integrative analysis on matrixEQTL revealed two cis-eQTLs and four significant SNPs in the genes peptidylargininedeiminasetypeIV (PADI4) and LOC11449251. The integration of genomic data from QTL maps and transcriptome analyses has identified a set of twelve key genes that show significant associations with tick loads. These genes could be key candidates to improve the accuracy of genomic predictions for tick resistance in Braford cattle.
650 $aAmber disease
650 $aParasitism
650 $aTicks
650 $aBovino
650 $aCarrapato
650 $aDoença Animal
650 $aParasitismo
650 $aResistência
700 1 $aGASPAR, E. B.
700 1 $aDOMINGUES, R.
700 1 $aREGITANO, L. C. de A.
700 1 $aCARDOSO, F. F.
773 $tMammalian Genome, 2024.
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Registro original: |
Embrapa Gado de Leite (CNPGL) |
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Registro Completo
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Biblioteca(s): |
Embrapa Milho e Sorgo. |
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Data corrente: |
17/04/2024 |
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Data da última atualização: |
17/04/2024 |
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Tipo da produção científica: |
Artigo em Anais de Congresso |
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Autoria: |
PEREIRA, M. A. V.; ANDRADE, C. de L. T. de; SARAIVA JÚNIOR, L. A.; SILVA, A. P. F. da; SILVA, W. A. S. da; OLIVEIRA, A. C. de; GUIMARAES, P. E. de O.; TRINDADE, R. dos S. |
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Afiliação: |
MARIANA A. VIRIATO PEREIRA, UNIVERSIDADE FEDERAL DE SÃO JOÃO DEL-REI; CAMILO DE LELIS TEIXEIRA DE ANDRADE, CNPMS; LUIZ ANTÔNIO SARAIVA JÚNIOR, UNIVERSIDADE FEDERAL DE SÃO JOÃO DEL-REI; ANA PAULA FERNANDES DA SILVA, UNIVERSIDADE FEDERAL DE SÃO JOÃO DEL-REI; WENDEL ADELSON SOARES DA SILVA, UNIVERSIDADE FEDERAL DE SÃO JOÃO DEL-REI; ANTONIO CARLOS DE OLIVEIRA, CNPMS; PAULO EVARISTO DE O GUIMARAES, CNPMS; ROBERTO DOS SANTOS TRINDADE, CNPMS. |
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Título: |
Produtividade de grãos de milho para diferentes níveis de estresse hídrico. |
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Ano de publicação: |
2023 |
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Fonte/Imprenta: |
In: SEMINÁRIO NACIONAL DE MILHO SAFRINHA, 17., 2023, Campo Grande, MS. Preservar e produzir: anais. Maracaju: Fundação MS, 2023. |
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Páginas: |
p. 125-126. |
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Idioma: |
Português |
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Palavras-Chave: |
Line source. |
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Thesagro: |
Água; Irrigação; Produtividade; Safrinha; Zea Mays. |
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Categoria do assunto: |
F Plantas e Produtos de Origem Vegetal |
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URL: |
https://ainfo.cnptia.embrapa.br/digital/bitstream/doc/1163712/1/Produtividade-de-graos-de-milho-.pdf
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Marc: |
LEADER 00866nam a2200265 a 4500
001 2163712
005 2024-04-17
008 2023 bl uuuu u00u1 u #d
100 1 $aPEREIRA, M. A. V.
245 $aProdutividade de grãos de milho para diferentes níveis de estresse hídrico.$h[electronic resource]
260 $aIn: SEMINÁRIO NACIONAL DE MILHO SAFRINHA, 17., 2023, Campo Grande, MS. Preservar e produzir: anais. Maracaju: Fundação MS$c2023
300 $ap. 125-126.
650 $aÁgua
650 $aIrrigação
650 $aProdutividade
650 $aSafrinha
650 $aZea Mays
653 $aLine source
700 1 $aANDRADE, C. de L. T. de
700 1 $aSARAIVA JÚNIOR, L. A.
700 1 $aSILVA, A. P. F. da
700 1 $aSILVA, W. A. S. da
700 1 $aOLIVEIRA, A. C. de
700 1 $aGUIMARAES, P. E. de O.
700 1 $aTRINDADE, R. dos S.
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Embrapa Milho e Sorgo (CNPMS) |
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