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Registros recuperados : 209 | |
161. | | MARCIANO, C. M. M.; IBELLI, A. M. G.; MARCHESI, J. A. P.; PEIXOTO, J. de O.; FERNANDES, L. T.; SAVOLDI, I. R.; CARMO, K. B. do; LEDUR, M. C. Differential expression of myogenic and calcium signaling-related genes in broilers affected with white striping. Frontiers in Physiology, v. 12, n. 712464, 2021. Biblioteca(s): Embrapa Suínos e Aves. |
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162. | | IBELLI, A. M. G.; PEIXOTO, J. de O.; ZANELLA, R.; GOUVEIA, J. J. de S.; CANTAO, M. E.; COUTINHO, L. L.; MARCHESI, J. A. P.; DAL PIZZOL, M. S.; MARCELINO, D. E. P.; LEDUR, M. C. Downregulation of growth plate genes involved with the onset of femoral head separation in young broilers. Frontiers in Physiology, v. 3, n. 941134, 2022. doi: 10.3389/fphys.2022.941134 Biblioteca(s): Embrapa Suínos e Aves. |
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163. | | SALMÓRIA, L. A.; IBELLI, A. M. G.; TAVERNARI, F. de C.; PEIXOTO, J. de O.; MARCELINO, D. E. P.; DAL PIZZOL, M. S.; CANTAO, M. E.; LEDUR, M. C. Expressão diferencial de genes relacionados ao metabolismo de cálcio e fósforo em poedeiras com diferentes níveis de desempenho. In: SIMPÓSIO BRASILEIRO DE MELHORAMENTO ANIMAL ON-LINE, 14., 2021. Anais.... Chapecó: UDESC: Concórdia: Embrapa Suínos e Aves, 2022. Biblioteca(s): Embrapa Suínos e Aves. |
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164. | | SALMÓRIA, L. A.; IBELLI, A. M. G.; TAVERNARI, F. de C.; PEIXOTO, J. de O.; MARCELINO, D. E. P.; DAL PIZZOL, M. S.; PINTO, K. D. S.; LEDUR, M. C. Expressão de genes candidatos no rim de poedeiras submetidas a dietas com diferentes níveis de cálcio e fósforo. In: SIMPÓSIO BRASILEIRO DE MELHORAMENTO ANIMAL ON-LINE, 14., 2021. Anais.... Chapecó: UDESC: Concórdia: Embrapa Suínos e Aves, 2022. Biblioteca(s): Embrapa Suínos e Aves. |
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165. | | PEIXOTO, J. de O.; IBELLI, A. M. G.; CANTAO, M. E.; ZANELLA, R.; JAENISCH, F. R. F.; GIACHETTO, P. F.; SETTLES, M. L.; PANDOLFI, J. R. C.; COUTINHO, L. L.; LEDUR, M. C. Expressão gênica diferencial envolvida com condronecrose bacteriana com osteomielite em frangos de corte com 35 dias de idade. In: REUNIÃO ANUAL DA SOCIEDADE BRASILEIRA DE ZOOTECNIA, 52., 2015, Belo Horizonte. Zootecnia: otimizando recursos e potencialidades: anais. Brasília, DF: Sociedade Brasileira de Zootecnia, 2015. Biblioteca(s): Embrapa Agricultura Digital; Embrapa Suínos e Aves. |
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166. | | NASCIMENTO, C. S.; MACHADO, M. A.; GUIMARÃES, S. E. F.; MARTINS, M. F.; PEIXOTO, J. de O.; FURLONG, J.; PRATA, M. C. de A.; VERNEQUE, R. da S.; TEODORO, R. L.; LOPES, P. S. Expressed sequenced tags profiling of resistant and susceptible Gyr x Holstein cattle infested with the tick Rhipicephalus (Boophilus) microplus. Genetics and Molecular Research, v. 10, n. 4, 2011. 14 p. Biblioteca(s): Embrapa Gado de Leite; Embrapa Suínos e Aves. |
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167. | | ONO, R. K.; PALUDO, E.; IBELLI, A. M. G.; PEIXOTO, J. de O.; PETRY, B.; PANDOLFI, J. R. C.; LOPES, L. dos S.; JAENISCH, F. R. F.; LEDUR, M. C. Fatores relacionados à variação na expressão gênica no fêmur de frangos de corte. In: SIMPÓSIO BRASILEIRO DE MELHORAMENTO ANIMAL, 12., 2017, Ribeirão Preto. Anais... Ribeirão Preto: SBMA, 2017. 1 CD-ROM. Biblioteca(s): Embrapa Suínos e Aves. |
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168. | | MARCHESI, J. A. P.; ONO, R. K.; CANTAO, M. E.; IBELLI, A. M. G.; PEIXOTO, J. de O.; MOREIRA, G. C. M.; GODOY, T. F.; COUTINHO, L. L.; MUNARI, D. P.; LEDUR, M. C. Exploring the genetic architecture of feed efficiency traits in chickens. Scientific Reports, v. 11, n. 4622, 2021. Biblioteca(s): Embrapa Suínos e Aves. |
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169. | | FERNANDES, L. T.; PEIXOTO, J. de O.; DAL PIZZOL, M. S.; IBELLI, A. M. G.; MORES, M. A. Z.; TAVERNARI, F. de C.; COLDEBELLA, A.; CANTAO, M. E.; LEDUR, M. C. Effects of age, line and diet on the occurrence of white striping lesions in broiler breast muscle. In: WORLD CONGRESS ON GENETICS APPLIED TO LIVESTOCK PRODUCTION, 12., 2022, Rotterdam. Proceedings: technical and species orientated innovations in animal breeding, and contribution of genetics to solving societal challenges. Wageningen: Wageningen Academic Publishers, 2022. Edited by R. F. Veerkamp and Y. de Haas. Biblioteca(s): Embrapa Suínos e Aves. |
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170. | | KOWACIC, R. da C.; IBELLI, A. M. G.; PEIXOTO, J. de O.; MORES, N.; MORES, M. A. Z.; CANTAO, M. E.; SAVOLDI, I. R.; CARMO, K. B. do; COUTINHO, L. L.; LEDUR, M. C. Genes Col16A1 e ANGPT4 são menos expressos em suínos afetados com osteocondrose latens. In: JORNADA DE INICIAÇÃO CIENTÍFICA, 10., 2016, Concórdia. Anais... Concórdia: Embrapa Suínos e Aves: UNC, 2017. p. 15-16. JINC. Biblioteca(s): Embrapa Suínos e Aves. |
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171. | | ROMANO, G. de S.; IBELLI, A. M. G.; PEIXOTO, J. de O.; CANTAO, M. E.; WEBER, T.; MORES, M. A. Z.; MORES, N.; PEDROSA, V. B.; PINTO, L. F. B.; COUTINHO, L. L.; LEDUR, M. C. Genes diferencialmente expressos no transcriptoma de suínos normais e afetados com hérnia escrotal. In: SIMPÓSIO BRASILEIRO DE MELHORAMENTO ANIMAL, 12., 2017, Ribeirão Preto. Anais... Ribeirão Preto: SBMA, 2017. 1 CD-ROM. Biblioteca(s): Embrapa Suínos e Aves. |
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172. | | PINTO, K. D. S.; SALMÓRIA, L. A.; TAVERNARI, F. de C.; PEIXOTO, J. de O.; IBELLI, A. M. G.; DAL PIZZOL, M. S.; GAYA, L. de G.; LEDUR, M. C. Genes de referência para estudos de expressão gênica no rim e no duodeno de galinhas poedeiras submetidas a diferentes níveis de cálcio e fósforo na dieta. In: SIMPÓSIO BRASILEIRO DE MELHORAMENTO ANIMAL ON-LINE, 14., 2021. Anais.... Chapecó: UDESC: Concórdia: Embrapa Suínos e Aves, 2022. Biblioteca(s): Embrapa Suínos e Aves. |
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173. | | RODRIGUES, A. F. G.; IBELLI, A. M. G.; PEIXOTO, J. de O.; CANTAO, M. E.; OLIVEIRA, H. C. de; SAVOLDI, I. R.; SOUZA, M. R.; MORES, M. A. Z.; CARREÑO, L. O. D.; LEDUR, M. C. Genes and SNPs Involved with Scrotal and Umbilical Hernia in Pigs. Genes, v. 12, n. 166, 2021. Biblioteca(s): Embrapa Suínos e Aves. |
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174. | | SAVOLDI, I. R.; IBELLI, A. M. G.; CANTAO, M. E.; PEIXOTO, J. de O.; MORES, M. A. Z.; LAGOS, E. B.; LOPES, J. S.; ZANELLA, R.; LEDUR, M. C. A joint analysis using exome and transcriptome data identifiescandidate polymorphisms and genes involved with umbilical hernia in pigs. BMC Genomics, v. 22, n. 818, 2021. Biblioteca(s): Embrapa Suínos e Aves. |
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175. | | ROMANO, G. de S.; IBELLI, A. M. G.; LORENZETTI, W. R.; WEBER, T.; PEIXOTO, J. de O.; CANTAO, M. E.; MORES, M. A. Z.; MORÉS, N.; PEDROSA, V. B.; COUTINHO. L. L.; LEDUR, M. C. Inguinal ring RNA sequencing reveals downregulation of muscular genes related to scrotal hernia in pigs. Genes, v. 11, n. 117, 2020. Biblioteca(s): Embrapa Suínos e Aves. |
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176. | | ONO, R. K.; IBELLI, A. M. G.; CANTAO, M. E.; PEIXOTO, J. de O.; SOLLERO, B. P.; SUREK, D.; MOREIRA, G. C. M.; GODOY, T. F.; COUTINHO, L. L.; LEDUR, M. C. Genome-wide association study for femur-related traits in broilers. In: WORLD CONGRESS ON GENETICS APPLIED TO LIVESTOCK PRODUCTION, 11., 2018, Auckland, New Zealand. Proceedings... Massey University, 2018. Digital Archive. Biblioteca(s): Embrapa Suínos e Aves. |
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177. | | ZANELLA, R.; MORES, N.; MORES, M. A. Z.; PEIXOTO, J. de O.; ZANELLA, E. L.; ZANELLA, J. R. C.; IBELLI, A. M. G.; GAVA, D.; CANTAO, M. E.; LEDUR, M. C. Genome-wide association study of periweaning failure-to-thrive syndrome (PFTS) in pigs. Veterinary Record, v. 178, n. 26, p. 1-7, 2016. Biblioteca(s): Embrapa Suínos e Aves. |
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178. | | ZANELLA, R.; MORES, N.; MORES, M. A. Z.; PEIXOTO, J. de O.; ZANELLA, E. L.; ZANELLA, J. R. C.; IBELLI, A. M. G.; GAVA, D.; CANTAO, M. E.; LEDUR, M. C. Genome-wide association study of periweaning failure-to-thrive syndrome (PFTS) in swine suggests genes involved with depression. In: INTERNATIONAL PIG VETERINARY SOCIETY CONGRESS, 24., Dublin. Abstracts Book... Dublin, Ireland: IPVS, 2016. p. 352. Biblioteca(s): Embrapa Suínos e Aves. |
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179. | | FERNANDES, A. C.; SILVA, V. H. da; GOES, C. P.; MOREIRA, G. C. M.; GODOY, T. F.; IBELLI, A. M. G.; PEIXOTO, J. de O.; CANTAO, M. E.; LEDUR, M. C.; REZENDE, F. M. de; COUTINHO, L. L. Genome-wide detection of CNVs and their association with performance traits in broilers. BMC Genomics, v. 22, n. 354, 2021. Biblioteca(s): Embrapa Suínos e Aves. |
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180. | | PANDOLFI, J. R. C.; IBELLI, A. M. G.; CANTAO, M. E.; PEIXOTO, J. de O.; KRABBE, E. L.; AVILA, V. S. de; KRAMER, B.; ZANELLA, R.; JAENISCH, F. R. F.; MORES, M. A. Z.; COUTINHO, L. L.; LEDUR, M. C. Genetic characterization of poultry gut microbiota by 16S-rRNA gene sequencing. In: CONGRESSO BRASILEIRO DE MICROBIOLOGIA, 28., 2015, Florianópolis. Resumos. Florianópolis: Sociedade Brasileira de Microbiologia, 2015. Biblioteca(s): Embrapa Suínos e Aves. |
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Registro Completo
Biblioteca(s): |
Embrapa Suínos e Aves. |
Data corrente: |
16/11/2021 |
Data da última atualização: |
16/11/2021 |
Tipo da produção científica: |
Artigo em Periódico Indexado |
Circulação/Nível: |
A - 1 |
Autoria: |
SAVOLDI, I. R.; IBELLI, A. M. G.; CANTAO, M. E.; PEIXOTO, J. de O.; MORES, M. A. Z.; LAGOS, E. B.; LOPES, J. S.; ZANELLA, R.; LEDUR, M. C. |
Afiliação: |
IGOR RICARDO SAVOLDI, UDESC/Chapecó; ADRIANA MERCIA GUARATINI IBELLI, CNPSA; MAURICIO EGIDIO CANTAO, CNPSA; JANE DE OLIVEIRA PEIXOTO, CNPSA; MARCOS ANTONIO ZANELLA MORES, CNPSA; ESSAMAI BRIZOLA LAGOS, UEPG; JADER SILVA LOPES, BRF/Curitiba; RICARDO ZANELLA, UPF; MONICA CORREA LEDUR, CNPSA. |
Título: |
A joint analysis using exome and transcriptome data identifiescandidate polymorphisms and genes involved with umbilical hernia in pigs. |
Ano de publicação: |
2021 |
Fonte/Imprenta: |
BMC Genomics, v. 22, n. 818, 2021. |
DOI: |
https://doi.org/10.1186/s12864-021-08138-4 |
Idioma: |
Inglês |
Conteúdo: |
Abstract: Background: Umbilical Hernia (UH) is characterized by the passage of part of the intestine through the umbilical canal forming the herniary sac. There are several potential causes that can lead to the umbilical hernia such as bacterial infections, management conditions and genetic factors. Since the genetic components involved with UH are poorly understood, this study aimed to identify polymorphisms and genes associated with the manifestation of umbilical hernia in pigs using exome and transcriptome sequencing in a case and control design. Results: In the exome sequencing, 119 variants located in 58 genes were identified differing between normal and UH-affected pigs, and in the umbilical ring transcriptome, 46 variants were identified, located in 27 genes. Comparing the two methodologies, we obtained 34 concordant variants between the exome and transcriptome analyses, which were located in 17 genes, distributed in 64 biological processes (BP). Among the BP involved with UH it is possible to highlight cell adhesion, cell junction regulation, embryonic morphogenesis, ion transport, muscle contraction, within others. Conclusions: We have generated the first exome sequencing related to normal and umbilical hernia-affected pigs, which allowed us to identify several variants possibly involved with this disorder. Many of those variants present in the DNA were confirmed with the RNA-Seq results. The combination of both exome and transcriptome sequencing approaches allowed us to better understand the complex molecular mechanisms underlying UH in pigs and possibly in other mammals, including humans. Some variants found in genes and other regulatory regions are highlighted as strong candidates to the development of UH in pigs and should be further investigated. MenosAbstract: Background: Umbilical Hernia (UH) is characterized by the passage of part of the intestine through the umbilical canal forming the herniary sac. There are several potential causes that can lead to the umbilical hernia such as bacterial infections, management conditions and genetic factors. Since the genetic components involved with UH are poorly understood, this study aimed to identify polymorphisms and genes associated with the manifestation of umbilical hernia in pigs using exome and transcriptome sequencing in a case and control design. Results: In the exome sequencing, 119 variants located in 58 genes were identified differing between normal and UH-affected pigs, and in the umbilical ring transcriptome, 46 variants were identified, located in 27 genes. Comparing the two methodologies, we obtained 34 concordant variants between the exome and transcriptome analyses, which were located in 17 genes, distributed in 64 biological processes (BP). Among the BP involved with UH it is possible to highlight cell adhesion, cell junction regulation, embryonic morphogenesis, ion transport, muscle contraction, within others. Conclusions: We have generated the first exome sequencing related to normal and umbilical hernia-affected pigs, which allowed us to identify several variants possibly involved with this disorder. Many of those variants present in the DNA were confirmed with the RNA-Seq results. The combination of both exome and transcriptome sequencing approaches allowed ... Mostrar Tudo |
Palavras-Chave: |
Defeitos congênitos; Hérnia umbilical; RNA sequencing; RNA-Seq; Sequenciamento de exoma; SNP. |
Thesagro: |
Abacate; Genética Animal; Suíno. |
Thesaurus NAL: |
Animal genetics; Sequence analysis; Single nucleotide polymorphism; Swine. |
Categoria do assunto: |
-- |
Marc: |
LEADER 02916naa a2200385 a 4500 001 2136149 005 2021-11-16 008 2021 bl uuuu u00u1 u #d 024 7 $ahttps://doi.org/10.1186/s12864-021-08138-4$2DOI 100 1 $aSAVOLDI, I. R. 245 $aA joint analysis using exome and transcriptome data identifiescandidate polymorphisms and genes involved with umbilical hernia in pigs.$h[electronic resource] 260 $c2021 520 $aAbstract: Background: Umbilical Hernia (UH) is characterized by the passage of part of the intestine through the umbilical canal forming the herniary sac. There are several potential causes that can lead to the umbilical hernia such as bacterial infections, management conditions and genetic factors. Since the genetic components involved with UH are poorly understood, this study aimed to identify polymorphisms and genes associated with the manifestation of umbilical hernia in pigs using exome and transcriptome sequencing in a case and control design. Results: In the exome sequencing, 119 variants located in 58 genes were identified differing between normal and UH-affected pigs, and in the umbilical ring transcriptome, 46 variants were identified, located in 27 genes. Comparing the two methodologies, we obtained 34 concordant variants between the exome and transcriptome analyses, which were located in 17 genes, distributed in 64 biological processes (BP). Among the BP involved with UH it is possible to highlight cell adhesion, cell junction regulation, embryonic morphogenesis, ion transport, muscle contraction, within others. Conclusions: We have generated the first exome sequencing related to normal and umbilical hernia-affected pigs, which allowed us to identify several variants possibly involved with this disorder. Many of those variants present in the DNA were confirmed with the RNA-Seq results. The combination of both exome and transcriptome sequencing approaches allowed us to better understand the complex molecular mechanisms underlying UH in pigs and possibly in other mammals, including humans. Some variants found in genes and other regulatory regions are highlighted as strong candidates to the development of UH in pigs and should be further investigated. 650 $aAnimal genetics 650 $aSequence analysis 650 $aSingle nucleotide polymorphism 650 $aSwine 650 $aAbacate 650 $aGenética Animal 650 $aSuíno 653 $aDefeitos congênitos 653 $aHérnia umbilical 653 $aRNA sequencing 653 $aRNA-Seq 653 $aSequenciamento de exoma 653 $aSNP 700 1 $aIBELLI, A. M. G. 700 1 $aCANTAO, M. E. 700 1 $aPEIXOTO, J. de O. 700 1 $aMORES, M. A. Z. 700 1 $aLAGOS, E. B. 700 1 $aLOPES, J. S. 700 1 $aZANELLA, R. 700 1 $aLEDUR, M. C. 773 $tBMC Genomics$gv. 22, n. 818, 2021.
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