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 | Acesso ao texto completo restrito à biblioteca da Embrapa Semiárido. Para informações adicionais entre em contato com cpatsa.biblioteca@embrapa.br. |
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Registro Completo |
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Biblioteca(s): |
Embrapa Semiárido. |
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Data corrente: |
30/05/2017 |
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Data da última atualização: |
31/08/2017 |
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Tipo da produção científica: |
Artigo em Periódico Indexado |
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Autoria: |
OLIVEIRA JÚNIOR, R. G. de; FERRAZ, C. A. A.; SILVA, J. C.; OLIVEIRA, A. P. de; DINIZ, T. C.; SILVA, M. G. e; QUINTANS JÚNIOR, L. J.; SOUZA, A. V. de; SANTOS, U. S. dos; TURATTI, I. C. C.; LOPES, N. P.; LORENZO, V. P.; ALMEIDA, J. R. G. da S. |
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Afiliação: |
RAIMUNDO GONÇALVES DE OLIVEIRA JÚNIOR, UNIVASF; CHRISTIANE ADRIELLY ALVES FERRAZ, UNIVASF; JULIANE CABRAL SILVA, UNIVASF; ANA PAULA DE OLIVEIRA, UNIVASF; TÂMARA COIMBRA DINIZ, UNIVASF; MARIANA GAMA E SILVA, UNIVASF; LUCINDO JOSÉ QUINTANS JÚNIOR, Universidade Federal de Sergipe; ANA VALERIA VIEIRA DE SOUZA, CPATSA; UILIANE SOARES DOS SANTOS; IZABEL CRISTINA CASANOVA TURATTI, Faculty of Pharmaceutical Sciences of Ribeirão Preto, University of São Paulo; NORBERTO PEPORINE LOPES, Faculty of Pharmaceutical Sciences of Ribeirão Preto, University of São Paulo; VITOR PRATES LORENZO, Federal Institute of Education, Science and Technology Sertão Pernambucano; JACKSON ROBERTO GUEDES DA SILVA ALMEIDA, UNIVASF. |
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Título: |
Antinociceptive effect of the essential oil from Croton conduplicatus Kunth (Euphorbiaceae). |
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Ano de publicação: |
2017 |
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Fonte/Imprenta: |
Molecules, v. 22, n. 6, p. 1-14, may. 2017. |
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DOI: |
10.3390/molecules22060900 |
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Idioma: |
Inglês |
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Conteúdo: |
Medicinal plants have been widely used in the treatment of chronic pain. In this study, we describe the antinociceptive effect of the essential oil from Croton conduplicatus (the EO 25, 50, and 100 mg/kg, i.p.), a medicinal plant native to Brazil. Antinociceptive activity was investigated by measuring the nociception induced by acetic acid, formalin, hot plate and carrageenan. A docking study was performed with the major constituents of the EO (E-caryophyllene, caryophyllene oxide, and camphor). The EO reduced nociceptive behavior at all doses tested in the acetic acid-induced nociception test (p< 0.05). The same was observed in both hases (neurogenic and inflammatory) of the formalin test. When the hot-plate test was conducted, the EO (50 mg/kg) extended the latency time after 60 min of treatment. The EO also reduced leukocyte migration at all doses, suggesting that its antinociceptive effect involves both central and peripheral mechanisms. Pretreatment with glibenclamide and atropine reversed the antinociceptive effect of the EO on the formalin test, suggesting the involvement of K ATP channels and muscarinic receptors. The docking study revealed a satisfactory interaction profile between the major components of the EO and the different muscarinic receptor subtypes (M2, M3, and M4). These results corroborate the medicinal use of C. conduplicatus in folk medicine |
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Palavras-Chave: |
Croton conduplicatus; Essential oil; Planta nativa; Quebra faca. |
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Thesagro: |
Caatinga; Óleo essencial; Planta medicinal; Vegetação Nativa. |
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Thesaurus Nal: |
Medicinal plants. |
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Categoria do assunto: |
F Plantas e Produtos de Origem Vegetal |
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Marc: |
LEADER 02510naa a2200385 a 4500
001 2070195
005 2017-08-31
008 2017 bl uuuu u00u1 u #d
024 7 $a10.3390/molecules22060900$2DOI
100 1 $aOLIVEIRA JÚNIOR, R. G. de
245 $aAntinociceptive effect of the essential oil from Croton conduplicatus Kunth (Euphorbiaceae).$h[electronic resource]
260 $c2017
520 $aMedicinal plants have been widely used in the treatment of chronic pain. In this study, we describe the antinociceptive effect of the essential oil from Croton conduplicatus (the EO 25, 50, and 100 mg/kg, i.p.), a medicinal plant native to Brazil. Antinociceptive activity was investigated by measuring the nociception induced by acetic acid, formalin, hot plate and carrageenan. A docking study was performed with the major constituents of the EO (E-caryophyllene, caryophyllene oxide, and camphor). The EO reduced nociceptive behavior at all doses tested in the acetic acid-induced nociception test (p< 0.05). The same was observed in both hases (neurogenic and inflammatory) of the formalin test. When the hot-plate test was conducted, the EO (50 mg/kg) extended the latency time after 60 min of treatment. The EO also reduced leukocyte migration at all doses, suggesting that its antinociceptive effect involves both central and peripheral mechanisms. Pretreatment with glibenclamide and atropine reversed the antinociceptive effect of the EO on the formalin test, suggesting the involvement of K ATP channels and muscarinic receptors. The docking study revealed a satisfactory interaction profile between the major components of the EO and the different muscarinic receptor subtypes (M2, M3, and M4). These results corroborate the medicinal use of C. conduplicatus in folk medicine
650 $aMedicinal plants
650 $aCaatinga
650 $aÓleo essencial
650 $aPlanta medicinal
650 $aVegetação Nativa
653 $aCroton conduplicatus
653 $aEssential oil
653 $aPlanta nativa
653 $aQuebra faca
700 1 $aFERRAZ, C. A. A.
700 1 $aSILVA, J. C.
700 1 $aOLIVEIRA, A. P. de
700 1 $aDINIZ, T. C.
700 1 $aSILVA, M. G. e
700 1 $aQUINTANS JÚNIOR, L. J.
700 1 $aSOUZA, A. V. de
700 1 $aSANTOS, U. S. dos
700 1 $aTURATTI, I. C. C.
700 1 $aLOPES, N. P.
700 1 $aLORENZO, V. P.
700 1 $aALMEIDA, J. R. G. da S.
773 $tMolecules$gv. 22, n. 6, p. 1-14, may. 2017.
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Embrapa Semiárido (CPATSA) |
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| Registros recuperados : 101 | |
| 6. |  | AGUIAR, M. I.; FIALHO, J. S.; CAMPANHA, M. M.; OLIVEIRA, T. S. Carbon sequestration and nutrient reserves under different land use systems. Revista Árvore, Viçosa, MG, v. 38, n. 1, p. 81-93, 2014.| Tipo: Artigo em Periódico Indexado | Circulação/Nível: A - 2 |
| Biblioteca(s): Embrapa Milho e Sorgo. |
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| 9. | | MENDES, N. O. M.; COUTO, H. A. R. do; OLIVEIRA, T. S. D. de. A logística reversa de cartuchos e tonners no município de Belém-PA. In: SIMPÓSIO DE ESTUDOS E PESQUISAS EM CIÊNCIAS AMBIENTAIS NA AMAZÔNIA, 6., 2017, Belém, PA. Anais. Belém, PA: UEPA, 2017. v. 2, p. 278-285.| Tipo: Artigo em Anais de Congresso |
| Biblioteca(s): Embrapa Amazônia Oriental. |
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| 14. | | OLIVEIRA, T. S. de; COSTA, L. M. da; CRUZ, C. D.; HORN, H. A. Metais pesados como indicadores de materiais de origem em uma topolitosequência do triangulo mineiro, Estado de Minas Gerais. Pesquisa Agropecuária Brasileira, Brasília, DF, v. 34, n. 8, p. 1451-65, ago. 1999 Título em inglês: Heavy metals as indicators of parent rocks in a topolithosequence in Triângulo Mineiro, State of Minas Gerais, Brazil.| Biblioteca(s): Embrapa Unidades Centrais. |
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| Registros recuperados : 101 | |
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