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4. | | SERRA, V.; TIZIOTO, P. C.; OLIVEIRA, P. S. N. de; LIMA, A. O. de; GASPARIN, G.; COUTINHO, L. L.; MOURÃO, G. B.; REGITANO, L. C. de A. Análise de qualidade de RNA para estudo do perfil transcriptômico de animais extremos para eficiência alimentar da raça Nelore. In: JORNADA CIENTÍFICA - EMBRAPA SÃO CARLOS, 5., 2013, São Carlos, SP. Anais... São Carlos, SP: Embrapa Pecuária Sudeste: Embrapa Instrumentação , 2013. p. 12 (Embrapa Pecuária Sudeste. Documentos, 110). Editado por Ana Rita de Araújo nogueira, simone Cristina Méo Nicura Biblioteca(s): Embrapa Pecuária Sudeste. |
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5. | | DINIZ, W. J. S.; ROSA, K. O. da; TIZIOTO, P. C.; MOURÃO, G. B.; OLIVEIRA, P. S. N. de; SOUZA, M. M. de; REGITANO, L. C. de A. FABP1 and SLC2A5 expression levels affect feed efficiency-related traits. Agri Gene, v. 15, p. 1-7, e100100, mar. 2020. Biblioteca(s): Embrapa Pecuária Sudeste. |
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9. | | TIZIOTO, P. C.; MEIRELLES, S. L.; SOUZA, M. M. de; OLIVEIRA, P. S. N. de; SIQUEIRA, F.; ROSA, A. do N.; TULLIO, R. R. Screening for single nucleotide polymorphisms in MYOD1 gene and its association with meat tenderness in cattle. In: INTERNATIONAL CONFERENCE OF BRAZIL ASSOCIATION AND COMPUTER BIOLOGY 7.; INTERNATIONAL CONFERENCE OF THE IBEROAMERICAN SOCIETY FOR BIOINFORMATICS, 3., 2011, Florianópolis. Proceedings... Florianóplis: ABC3C: SolBio, 2011. ID 126 Biblioteca(s): Embrapa Gado de Corte; Embrapa Pecuária Sudeste. |
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10. | | OLIVEIRA, P. S. N. de; TIZIOTO, P. C.; NORONHA, C. T.; MALAGO JUNIOR, W.; MUDADU, M. de A.; REGITANO, L. C. de A. A SNP in NEUROD1 is associated with production traits in Nelore beef cattle. In: REUNIÃO ANUAL DA SOCIEDADE BRASILEIRA DE ZOOTECNIA, 51., 2014, Barra dos Coqueiros. A produção animal frente às mudanças climáticas e tecnológicas - anais. Barra dos coqueiros: Sociedade Brasileira de Zootecnia, 2014. 1 CD-ROM. Biblioteca(s): Embrapa Pecuária Sudeste. |
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11. | | DINIZ, W. J. da S.; COUTINHO, L. L.; TIZIOTO, P. C.; CESAR, A. S. M.; GROMBONI, C. F.; NOGUEIRA, A. R. de A.; OLIVEIRA, P. S. N. de; SOUZA, M. M. de; REGITANO, L. C. de A. Iron content affects lipogenic gene expression in the muscle of nelore beef cattle. Plos One, aug. 2016. Biblioteca(s): Embrapa Pecuária Sudeste. |
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12. | | DINIZ, W. J. S.; ROSA, K. O.; COUTINHO, L. L.; TIZIOTO, P. C.; OLIVEIRA, P. S. N. de; SOUZA, M. M. de S.; CHAVES, A. S.; LANNA, D. P. D.; MOURÃO, G. B.; REGITANO, L. C. de A. KCNJ11 gene expression is associated to feed consumption and growth traits in Nelore beef cattle. Agri Gene, v. 9, p. 1-4, 2018. Biblioteca(s): Embrapa Pecuária Sudeste. |
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13. | | ROCHA, M. I. P.; SOUZA, M. M. de; ZERLOTINI NETO, A.; TIZIOTO, P. C.; OLIVEIRA, P. S. N. de; LIMA, A. O. de; AFONSO, J.; COUTINHO, L. L.; REGITANO, L. C. de A.; NICIURA, S. C. M. Allele-specific gene expression in liver of Nelore cattle extremes for feed efficiency. In: INTERNATIONAL SOCIETY FOR ANIMAL GENETICS CONFERENCE, 36., 2017, Dublin. Proceedings... Dublin: University College Dublin, 2017. p. 156 - 157. Biblioteca(s): Embrapa Pecuária Sudeste. |
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14. | | OLIVEIRA, P. S. N. de; TIZIOTO, P. C.; OLIVEIRA, G. B.; CESAR, A. S. M.; DINIZ, W. J. da S.; LIMA, A. O. de; REECY, J. M.; COUTINHO, L. L.; REGITANO, L. C. de A. Differentially expressed miRNAs in skeletal muscle related to feed efficiency in Nellore cattle. Journal of Animal Science, v. 94, e-suppl. 5; Journal of Dairy Science, v. 99, e-suppl. 1, p. 159, jul. 2016. Biblioteca(s): Embrapa Pecuária Sudeste. |
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15. | | OLIVEIRA, P. S. N. DE; ANDRADE, B. G.; CARDOSO, T. F.; PASCHOAL, J. J.; JOSAHKIAN, L. A.; ALMEIDA, L. F.; MARCONDES, C. R.; MOURÃO, G. B.; COUTINHO, L. L.; REECY, J. M.; REGITANO, L. C. de A. Differentially expressed miRNAs in the stool of Bos indicus divergent for feed efficiency. Italian Journal of Animal Science, v. 22, supplement 1, 2023. p. 193-194. Congress of the Animal Science and Production Association, 25., Monopoli (BARI – ITALY), June 13–16, 2023. Biblioteca(s): Embrapa Pecuária Sudeste. |
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16. | | SOMAVILLA, A. L.; REGITANO, L. C. de A.; ROSA, G. J. M.; MOKRY, F. B.; MUDADU, M. de A.; TIZIOTO, P. C.; OLIVEIRA, P. S. N. de; SOUZA, M. M. de; COUTINHO, L. L.; MUNARI, D. P. Genome-enabled prediction of breeding values for feedlot average daily weight gain in nelore cattle. G3: Genes, Genomes, Genetics, v. 7, p. 1-17, 2017. Biblioteca(s): Embrapa Agricultura Digital; Embrapa Pecuária Sudeste. |
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17. | | BUSS, C. E.; TIZIOTO, P. C.; OLIVEIRA, P. S. N. de; MUDADU, M. de A.; CESAR, A. S. M.; VENTURA, R. V.; AFONSO, J.; LIMA, A. O. de; COUTINHO, L. L.; TULLIO, R. R.; REGITANO, L. C. de A. Genome-wide efficient mixed-model study for meat quality in Nellore cattle. Journal of Animal Science, v. 94, e-suppl. 5; Journal of Dairy Science, v. 99, e-suppl. 1, p. 159, jul. 2016. Biblioteca(s): Embrapa Pecuária Sudeste. |
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18. | | DINIZ, W. J. da S.; CESAR, A. S. M.; GEISTLINGER, L.; TIZIOTO, P. C.; OLIVEIRA, P. S. N. de; AFONSO, J.; ROCHA, M. I. P.; LIMA, A. O. de; BUSS, C. E.; COUTINHO, L. L.; REGITANO, L. C. de A. Co-expression network analysis identifies genes associated with iron content in bovine muscle. In: WORKSHOP ON OMICS STRATEGIES APPLIED TO LIVESTOCK SCIENCE, 1., 2017, Piracicaba, SP. Proceedings... São Carlos, SP: Embrapa Pecuária Sudeste, 2017. p. 19. (Embrapa Pecuária Sudeste. Documentos, 125) Editores: Luiz Lehmann Coutinho, ESALQ/USP; Luciana Correia de Almeida Regitano, Embrapa Pecuária Sudeste; Gerson Barreto Mourão, ESALQ/USP; Aline Silva Mello Cesar, ESALQ/USP; Bárbara Silva Vignato, FZEA/USP; Mirele Daiana Poleti,... Biblioteca(s): Embrapa Pecuária Sudeste. |
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19. | | DINIZ, W. J. da S.; CESAR, A. S. M.; GEISTLINGER, L.; TIZIOTO, P. C.; OLIVEIRA, P. S. N. de; AFONSO, J.; ROCHA, M. I. P.; LIMA, A. O. de; BUSS, C. E.; COUTINHO, L. L.; REGITANO, L. C. de A. Co-expression network analysis identifies genes associated with meat tenderness. In: INTERNATIONAL SOCIETY FOR ANIMAL GENETICS CONFERENCE, 36., 2017, Dublin. Proceedings... Dublin: University College Dublin, 2017. p. 144. Biblioteca(s): Embrapa Pecuária Sudeste. |
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20. | | OLIVEIRA, P. S. N. DE; ANDRADE, B. G.; CONTEVILLE, L. C.; CARDOSO, T. F.; PASCHOAL, J. J.; JOSAHKIAN, L. A.; ALMEIDA, L. F.; MARCONDES, C. R.; MOURÃO, G. B.; COUTINHO, L. L.; REECY, J. M.; REGITANO, L. C. de A. Microbial diversity in the stool of Bos indicus divergent for feed efficiency. Italian Journal of Animal Science, v. 22, supplement 1, 2023. p. 194. Congress of the Animal Science and Production Association, 25., Monopoli (BARI – ITALY), June 13–16, 2023. Biblioteca(s): Embrapa Pecuária Sudeste. |
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Registro Completo
Biblioteca(s): |
Embrapa Agricultura Digital; Embrapa Pecuária Sudeste. |
Data corrente: |
27/05/2022 |
Data da última atualização: |
20/06/2022 |
Tipo da produção científica: |
Artigo em Periódico Indexado |
Circulação/Nível: |
A - 1 |
Autoria: |
SOUZA, M. M. de; NICIURA, S. C. M.; ROCHA, M. I. P.; PAN, Z.; ZHOU, H.; BRUSCADIN, J. J.; DINIZ, W. J. da S.; AFONSO, J.; OLIVEIRA, P. S. N. de; MOURÃO, G. B.; ZERLOTINI NETO, A.; COUTINHO, L. L.; KOLTES, J. E.; REGITANO, L. C. de A. |
Afiliação: |
MARCELA MARIA DE SOUZA, IOWA STATE UNIVERSITY; SIMONE CRISTINA MEO NICIURA, CPPSE; MARINA IBELLI PEREIRA ROCHA, UFSCAR; ZHANGYUAN PAN, UNIVERSITY OF CALIFORNIA; HUAIJUN ZHOU, UNIVERSITY OF CALIFORNIA; JENNIFER JESSICA BRUSCADIN, UFSCAR; WELLISON JARLES DA SILVA DINIZ, AUBURN UNIVERSITY; JULIANA AFONSO; PRISCILA SILVA NEUBERN DE OLIVEIRA, UFSCAR; GERSON B. MOURÃO, ESALQ/USP; ADHEMAR ZERLOTINI NETO, CNPTIA; LUIZ LEHMANN COUTINHO, ESALQ/USP; JAMES E. KOLTES, IOWA STATE UNIVERSITY; LUCIANA CORREIA DE ALMEIDA REGITANO, CPPSE. |
Título: |
DNA methylation may affect beef tenderness through signal transduction in Bos indicus. |
Ano de publicação: |
2022 |
Fonte/Imprenta: |
Epigenetics & Chromatin, v. 15, n. 1, p. 1-16, 2022. |
DOI: |
https://doi.org/10.1186/s13072-022-00449-4 |
Idioma: |
Inglês |
Notas: |
Article number: 15. |
Conteúdo: |
Abstract. Background:Beef tenderness is a complex trait of economic importance for the beef industry. Understanding the epigenetic mechanisms underlying this trait may help improve the accuracy of breeding programs. However, little is known about epigenetic effects on Bos taurus muscle and their implications in tenderness, and no studies have been conducted in Bos indicus.Results:Comparing methylation profile of Bos indicus skeletal muscle with contrasting beef tenderness at 14 days after slaughter, we identified differentially methylated cytosines and regions associated with this trait. Interestingly, muscle that became tender beef had higher levels of hypermethylation compared to the tough group. Enrichment analysis of predicted target genes suggested that differences in methylation between tender and tough beef may affect signal transduction pathways, among which G protein signaling was a key pathway. In addition, different meth-ylation levels were found associated with expression levels of GNAS, PDE4B, EPCAM and EBF3 genes. The differentially methylated elements correlated with EBF3 and GNAS genes overlapped CpG islands and regulatory elements. GNAS, a complex imprinted gene, has a key role on G protein signaling pathways. Moreover, both G protein signaling pathway and the EBF3 gene regulate muscle homeostasis, relaxation, and muscle cell-specificity.Conclusions:We present differentially methylated loci that may be of interest to decipher the epigenetic mecha-nisms affecting tenderness. Supported by the previous knowledge about regulatory elements and gene function, the methylation data suggests EBF3 and GNAS as potential candidate genes and G protein signaling as potential candi-date pathway associated with beef tenderness via methylation. MenosAbstract. Background:Beef tenderness is a complex trait of economic importance for the beef industry. Understanding the epigenetic mechanisms underlying this trait may help improve the accuracy of breeding programs. However, little is known about epigenetic effects on Bos taurus muscle and their implications in tenderness, and no studies have been conducted in Bos indicus.Results:Comparing methylation profile of Bos indicus skeletal muscle with contrasting beef tenderness at 14 days after slaughter, we identified differentially methylated cytosines and regions associated with this trait. Interestingly, muscle that became tender beef had higher levels of hypermethylation compared to the tough group. Enrichment analysis of predicted target genes suggested that differences in methylation between tender and tough beef may affect signal transduction pathways, among which G protein signaling was a key pathway. In addition, different meth-ylation levels were found associated with expression levels of GNAS, PDE4B, EPCAM and EBF3 genes. The differentially methylated elements correlated with EBF3 and GNAS genes overlapped CpG islands and regulatory elements. GNAS, a complex imprinted gene, has a key role on G protein signaling pathways. Moreover, both G protein signaling pathway and the EBF3 gene regulate muscle homeostasis, relaxation, and muscle cell-specificity.Conclusions:We present differentially methylated loci that may be of interest to decipher the epigenetic mecha-nisms affec... Mostrar Tudo |
Palavras-Chave: |
EBF3; Epigenoma; Epigenome; Força de cisalhamento; GNAS; Muscle; Músculo de nelore; Nelore; RRBS; Shear force. |
Thesagro: |
Bos Indicus; Bos Taurus; Metilação; Músculo. |
Thesaurus NAL: |
Cattle; DNA methylation; Methylation. |
Categoria do assunto: |
-- X Pesquisa, Tecnologia e Engenharia |
URL: |
https://ainfo.cnptia.embrapa.br/digital/bitstream/doc/1144144/1/DNA-MethylationMay.pdf
|
Marc: |
LEADER 03129naa a2200505 a 4500 001 2144144 005 2022-06-20 008 2022 bl uuuu u00u1 u #d 024 7 $ahttps://doi.org/10.1186/s13072-022-00449-4$2DOI 100 1 $aSOUZA, M. M. de 245 $aDNA methylation may affect beef tenderness through signal transduction in Bos indicus.$h[electronic resource] 260 $c2022 500 $aArticle number: 15. 520 $aAbstract. Background:Beef tenderness is a complex trait of economic importance for the beef industry. Understanding the epigenetic mechanisms underlying this trait may help improve the accuracy of breeding programs. However, little is known about epigenetic effects on Bos taurus muscle and their implications in tenderness, and no studies have been conducted in Bos indicus.Results:Comparing methylation profile of Bos indicus skeletal muscle with contrasting beef tenderness at 14 days after slaughter, we identified differentially methylated cytosines and regions associated with this trait. Interestingly, muscle that became tender beef had higher levels of hypermethylation compared to the tough group. Enrichment analysis of predicted target genes suggested that differences in methylation between tender and tough beef may affect signal transduction pathways, among which G protein signaling was a key pathway. In addition, different meth-ylation levels were found associated with expression levels of GNAS, PDE4B, EPCAM and EBF3 genes. The differentially methylated elements correlated with EBF3 and GNAS genes overlapped CpG islands and regulatory elements. GNAS, a complex imprinted gene, has a key role on G protein signaling pathways. Moreover, both G protein signaling pathway and the EBF3 gene regulate muscle homeostasis, relaxation, and muscle cell-specificity.Conclusions:We present differentially methylated loci that may be of interest to decipher the epigenetic mecha-nisms affecting tenderness. Supported by the previous knowledge about regulatory elements and gene function, the methylation data suggests EBF3 and GNAS as potential candidate genes and G protein signaling as potential candi-date pathway associated with beef tenderness via methylation. 650 $aCattle 650 $aDNA methylation 650 $aMethylation 650 $aBos Indicus 650 $aBos Taurus 650 $aMetilação 650 $aMúsculo 653 $aEBF3 653 $aEpigenoma 653 $aEpigenome 653 $aForça de cisalhamento 653 $aGNAS 653 $aMuscle 653 $aMúsculo de nelore 653 $aNelore 653 $aRRBS 653 $aShear force 700 1 $aNICIURA, S. C. M. 700 1 $aROCHA, M. I. P. 700 1 $aPAN, Z. 700 1 $aZHOU, H. 700 1 $aBRUSCADIN, J. J. 700 1 $aDINIZ, W. J. da S. 700 1 $aAFONSO, J. 700 1 $aOLIVEIRA, P. S. N. de 700 1 $aMOURÃO, G. B. 700 1 $aZERLOTINI NETO, A. 700 1 $aCOUTINHO, L. L. 700 1 $aKOLTES, J. E. 700 1 $aREGITANO, L. C. de A. 773 $tEpigenetics & Chromatin$gv. 15, n. 1, p. 1-16, 2022.
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Embrapa Pecuária Sudeste (CPPSE) |
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