Data/hora: 08/06/2024 17:23:07

Biblioteca(s): 	Embrapa Amapá.	
Tipo da produção científica: 	Artigo em Periódico Indexado	
Circulação/Nível: 	A - 2	
Data corrente: 	04/12/2019	
Data da última atualização: 	09/12/2019	
Autoria: 	OLIVEIRA, L. C. D.; BRASILIENSE, A. R. P.; DIAS, M. K. R. D.; YOSHIOKA, E. T. O.; TAVARES-DIAS, M.	
Afiliação: 	LÍGIA CARVALHO DIAS OLIVEIRA, UNIFAP. PPG EM BIODIVERSIDADE TROPICAL; ALEXANDRE RENATO PINTO BRASILIENSE, UNIFAP. PPG EM BIODIVERSIDADE TROPICAL; MÁRCIA KELLY REIS DIAS, UNIFAP. PPG EM BIODIVERSIDADE TROPICAL; ELIANE TIE OBA YOSHIOKA, CPAF-AP; MARCOS TAVARES DIAS, CPAF-AP.	
Título: 	Toxicological, hematological and immunological effects of levamisole and ivermectin diet supplementation on Colossoma macropomum (Serrasalmidae).	
Ano de publicação: 	2019	
Fonte/Imprenta: 	Diseases of Aquatic Organisms, v. 136, n. 3, p. 255-263, Nov. 2019.	
DOI: 	10.3354/dao03413	
Idioma: 	Inglês	
Conteúdo: 	This study investigated the toxicological, hematological and immunological effects of diets supplemented with levamisole and ivermectin on Colossoma macropomum. Fish were fed for 24, 96 and 240 h with diets containing 300, 600, 900 and 1200 mg of levamisole kg_1 of feed. None of the levamisole concentrations caused either mortality or behavioral alterations among the fish over 10 d of feeding. In comparison, a single feeding of ivermectin at 4500, 9000, 13 500 or 18 000 mg kg_1 caused 100% mortality among the fish within 10 h. There were no alterations in erythrocyte parameters or albumin in any treatments with levamisole after 24, 96 and 240 h of feeding. At concentrations of 900 and 1200 mg kg_1, levamisole caused decreases in the albuminto-globulin ratio compared to the control group and the 300 and 600 mg kg_1 diet treatment groups. Levels of glucose and total plasma protein were higher in the fish fed with 600, 900 and 1200 mg kg_1 than in the controls and the 300 mg kg_1 diet treatment group. After 10 d of receiving feed supplemented with levamisole, globulin levels were higher in the 600 mg kg_1 group than in the controls. Respiratory burst activity of leukocytes also increased in the fish supplemented with the 900 and 1200 mg kg_1 diets compared to the controls and other treatments. This is the first study to investigate how diets supplemented with these drugs affect C. macropomum. Our research indicates that all the levamisole concentrations tested can be used in the diet of C. macro pomum for antiparasitic treatments against helminth species, and that dietary treatments with levamisole can stimulate components of the innate immune system.	
Palavras-Chave: 	Anthelminthics.	
Thesagro: 	Dieta; Peixe de Água Doce; Tambaqui.	
Thesaurus Nal: 	Diet; Freshwater fish; Hematologic agents.	
Categoria do assunto: 	S Ciências Biológicas	
Registro original: 	Embrapa Amapá (CPAF-AP)	
Exemplares: 	CPAF-AP - (18211-1) - UPC - AP - DD -  -  -  - DIS