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Registro Completo |
Biblioteca(s): |
Embrapa Gado de Leite. |
Data corrente: |
20/12/2011 |
Data da última atualização: |
05/02/2024 |
Tipo da produção científica: |
Artigo em Periódico Indexado |
Autoria: |
BRUGIOLO, A. S. S.; ALVES, C. C. de S.; GOUVEIA, A. C. C.; DIAS, A. T.; RODRIGUES, M. F.; PACÍFICO, L. G. G.; AARESTRUP, B. J. V.; MACHADO, M. A.; DOMINGUES, R.; TEIXEIRA, H. C.; GAMEIRO, J.; FERREIRA, A. P. |
Afiliação: |
ALESSA SIN SINGER BRUGIOLO, UFJF; CAIO CÉSAR DE SOUZA ALVES, UFJF; ANA CLÁUDIA CARVALHO GOUVEIA, UFJF; ALYRIA TEIXEIRA DIAS, UFJF; MICHELE FERNANDES RODRIGUES, UFJF; LUCILA GROSSI GONÇALVES PACÍFICO, FIOCRUZ; BEATRIZ JULIÃO VIEIRA AARESTRUP, UFJF; MARCO ANTONIO MACHADO, CNPGL; ROBERT DOMINGUES, UFJF; HENRIQUE COUTO TEIXEIRA, UFJF; JACY GAMEIRO, UFJF; ANA PAULA FERREIRA, UFJF. |
Título: |
Effects of aqueous extract of Echinodorus grandiflorus on the immune response in ovalbumin-induced pulmonary allergy. |
Ano de publicação: |
2011 |
Fonte/Imprenta: |
Annals of Allergy, Asthma & Immunology, v. 106, n. 6, p. 481-488, 2011. |
DOI: |
https://doi.org/10.1016/j.anai.2011.01.008 |
Idioma: |
Inglês |
Conteúdo: |
Background - Asthma is a disease characterized by intermittent obstruction of the airways and chronic inflammation that affects approximately 300 million people worldwide. The immune response in asthma is predominantly TH2, with high levels of total and allergen-specific IgE and bronchial eosinophilia. Asthma treatment is aimed at controlling the disease, and the drugs used currently have systemic adverse effects and generally are not effective in difficult-to-control cases. Objective - To investigate the effect of aqueous extract of Echinodorus grandiflorus, a plant used in folk medicine for its diuretic and anti-inflammatory properties, in a model of pulmonary allergy. Methods - BALB/c mice were intraperitoneally sensitized and nasally challenged with ovalbumin. Aqueous extract and dexamethasone treatments (0.1 mL/d per mouse) were initiated on day 32 and concluded on day 40. Eight hours after the last challenge evaluations, of serum, bronchoalveolar lavage, and lung tissue were performed. Results - Oral treatment with the extract markedly reduced the number of total cells and eosinophils in bronchoalveolar lavage. The eosinophil peroxidase activity in lung tissue, the levels of ovalbumin-specific IgE in serum, the levels of CCL11, and the gene expression of interleukin 4 and interleukin 13 in lung tissue were also lower after treatment. Conclusions - These results suggest that the aqueous extract of E grandiflorus is able to modulate allergic pulmonary inflammation and may be useful as a potential therapeutic agent for asthma. MenosBackground - Asthma is a disease characterized by intermittent obstruction of the airways and chronic inflammation that affects approximately 300 million people worldwide. The immune response in asthma is predominantly TH2, with high levels of total and allergen-specific IgE and bronchial eosinophilia. Asthma treatment is aimed at controlling the disease, and the drugs used currently have systemic adverse effects and generally are not effective in difficult-to-control cases. Objective - To investigate the effect of aqueous extract of Echinodorus grandiflorus, a plant used in folk medicine for its diuretic and anti-inflammatory properties, in a model of pulmonary allergy. Methods - BALB/c mice were intraperitoneally sensitized and nasally challenged with ovalbumin. Aqueous extract and dexamethasone treatments (0.1 mL/d per mouse) were initiated on day 32 and concluded on day 40. Eight hours after the last challenge evaluations, of serum, bronchoalveolar lavage, and lung tissue were performed. Results - Oral treatment with the extract markedly reduced the number of total cells and eosinophils in bronchoalveolar lavage. The eosinophil peroxidase activity in lung tissue, the levels of ovalbumin-specific IgE in serum, the levels of CCL11, and the gene expression of interleukin 4 and interleukin 13 in lung tissue were also lower after treatment. Conclusions - These results suggest that the aqueous extract of E grandiflorus is able to modulate allergic pulmonary inflammation and ma... Mostrar Tudo |
Palavras-Chave: |
Allergic pulmonary inflammation. |
Thesaurus Nal: |
Asthma; Immune response. |
Categoria do assunto: |
H Saúde e Patologia |
Marc: |
LEADER 02517naa a2200301 a 4500 001 1910453 005 2024-02-05 008 2011 bl uuuu u00u1 u #d 024 7 $ahttps://doi.org/10.1016/j.anai.2011.01.008$2DOI 100 1 $aBRUGIOLO, A. S. S. 245 $aEffects of aqueous extract of Echinodorus grandiflorus on the immune response in ovalbumin-induced pulmonary allergy.$h[electronic resource] 260 $c2011 520 $aBackground - Asthma is a disease characterized by intermittent obstruction of the airways and chronic inflammation that affects approximately 300 million people worldwide. The immune response in asthma is predominantly TH2, with high levels of total and allergen-specific IgE and bronchial eosinophilia. Asthma treatment is aimed at controlling the disease, and the drugs used currently have systemic adverse effects and generally are not effective in difficult-to-control cases. Objective - To investigate the effect of aqueous extract of Echinodorus grandiflorus, a plant used in folk medicine for its diuretic and anti-inflammatory properties, in a model of pulmonary allergy. Methods - BALB/c mice were intraperitoneally sensitized and nasally challenged with ovalbumin. Aqueous extract and dexamethasone treatments (0.1 mL/d per mouse) were initiated on day 32 and concluded on day 40. Eight hours after the last challenge evaluations, of serum, bronchoalveolar lavage, and lung tissue were performed. Results - Oral treatment with the extract markedly reduced the number of total cells and eosinophils in bronchoalveolar lavage. The eosinophil peroxidase activity in lung tissue, the levels of ovalbumin-specific IgE in serum, the levels of CCL11, and the gene expression of interleukin 4 and interleukin 13 in lung tissue were also lower after treatment. Conclusions - These results suggest that the aqueous extract of E grandiflorus is able to modulate allergic pulmonary inflammation and may be useful as a potential therapeutic agent for asthma. 650 $aAsthma 650 $aImmune response 653 $aAllergic pulmonary inflammation 700 1 $aALVES, C. C. de S. 700 1 $aGOUVEIA, A. C. C. 700 1 $aDIAS, A. T. 700 1 $aRODRIGUES, M. F. 700 1 $aPACÍFICO, L. G. G. 700 1 $aAARESTRUP, B. J. V. 700 1 $aMACHADO, M. A. 700 1 $aDOMINGUES, R. 700 1 $aTEIXEIRA, H. C. 700 1 $aGAMEIRO, J. 700 1 $aFERREIRA, A. P. 773 $tAnnals of Allergy, Asthma & Immunology$gv. 106, n. 6, p. 481-488, 2011.
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Embrapa Gado de Leite (CNPGL) |
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Biblioteca(s): |
Embrapa Pecuária Sudeste. |
Data corrente: |
07/11/2023 |
Data da última atualização: |
07/11/2023 |
Tipo da produção científica: |
Resumo em Anais de Congresso |
Autoria: |
GOMES, H. C. S. F.; OKINO, C. H.; TONELLI, M. F.; OLIVEIRA, M. C. de S.; OLIVEIRA, H. N. DE. |
Afiliação: |
HAYALA CAROLINE SILVA FERREIRA GOMES, UNIVERSIDADE ESTADUAL PAULISTA; CINTIA HIROMI OKINO, CPPSE; MARIA FERNANDA TONELLI, UNICEP; MARCIA CRISTINA DE SENA OLIVEIRA, CPPSE; HENRIQUE NUNES DE OLIVEIRA, UNIVERSIDADE ESTADUAL PAULISTA. |
Título: |
Gene expression of Toll-Like 2 and 4 receptors and T gama delta WC1 cells receptors related to the levels of infection in cattles naturally infected by agents of tick-borne diseases. |
Ano de publicação: |
2021 |
Fonte/Imprenta: |
In: BRAZILIAN CONGRESS OF GENETICS, 66.; SIMPÓSIO DE CITOGENÉTICA E GENÉTICAS DE PEIXES, 19.; REUNIÃO DE GENÉTICA DE MICRORGANISMOS, 32.; CONGRESSO LATINO-AMERICANO DE GENÉTICA PARA CONSERVAÇÃO, 2., 2021. [Abstracts]. Ribeirão Preto: Sociedade Brasileira de Genética, 2021. |
Páginas: |
p. 216. |
Idioma: |
Inglês |
Conteúdo: |
Bovine babesiosis is an infectious disease caused by protozoa Babesia bovis and B. bigemina, intraerythrocyte parasites that produce intravascular hemolytic anemia. |
Thesaurus NAL: |
Gene expression; Immune response; Tick-borne diseases. |
Categoria do assunto: |
G Melhoramento Genético |
URL: |
https://ainfo.cnptia.embrapa.br/digital/bitstream/doc/1157920/1/GeneExpressionTollLike.pdf
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Marc: |
LEADER 01116nam a2200205 a 4500 001 2157920 005 2023-11-07 008 2021 bl uuuu u00u1 u #d 100 1 $aGOMES, H. C. S. F. 245 $aGene expression of Toll-Like 2 and 4 receptors and T gama delta WC1 cells receptors related to the levels of infection in cattles naturally infected by agents of tick-borne diseases.$h[electronic resource] 260 $aIn: BRAZILIAN CONGRESS OF GENETICS, 66.; SIMPÓSIO DE CITOGENÉTICA E GENÉTICAS DE PEIXES, 19.; REUNIÃO DE GENÉTICA DE MICRORGANISMOS, 32.; CONGRESSO LATINO-AMERICANO DE GENÉTICA PARA CONSERVAÇÃO, 2., 2021. [Abstracts]. Ribeirão Preto: Sociedade Brasileira de Genética$c2021 300 $ap. 216. 520 $aBovine babesiosis is an infectious disease caused by protozoa Babesia bovis and B. bigemina, intraerythrocyte parasites that produce intravascular hemolytic anemia. 650 $aGene expression 650 $aImmune response 650 $aTick-borne diseases 700 1 $aOKINO, C. H. 700 1 $aTONELLI, M. F. 700 1 $aOLIVEIRA, M. C. de S. 700 1 $aOLIVEIRA, H. N. DE
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