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| Registros recuperados : 18 | |
| 3. |  | NASCIMENTO, H. M. do; MAGALHÃES, F. M. da S.; OLIVEIRA, H. C. de; VIDAL, M. C. Chácara do Sr. Heleno: uma unidade em transição agroecológica no Distrito Federal. Cadernos de Agroecologia, Porto Alegre, v. 13, n. 1, jul. 2018. 5 p. não paginado. Edição dos anais do VI Congresso Latino-Americano (CLAA), X Congresso Brasileiro (CBA), V Seminário do DF e Entorno (SEMDF). 2017. Brasília, DF.| Biblioteca(s): Embrapa Hortaliças. |
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| 5. | | CAMPOS, F. G.; IBELLI, A. M. G.; CANTAO, M. E.; OLIVEIRA, H. C. de; PEIXOTO, J. de O.; LEDUR, M. C.; GUIMARÃES, S. E. F. Identification of long non-coding RNAS (LNCRNAS) in swine fetus. In: BRAZILIAN CONGRESS OF GENETICS, 68., 2023, Ouro Preto. Paleogenomics: sequencing ancient DNA. E-book. Ribeirão Preto: Sociedade Brasileira de Genética, 2023. p. 319.| Biblioteca(s): Embrapa Suínos e Aves. |
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| 8. | | DAL PIZZOL, M. S.; IBELLI, A. M. G.; CANTAO, M. E.; CAMPOS, F. G.; OLIVEIRA, H. C. de; PEIXOTO, J. de O.; FERNANDES, L. T.; TAVERNARI, F. de C.; MORES, M. A. Z.; BASTOS, A. P. A.; LEDUR, M. C. Differential expression of miRNAs associated with pectoral myopathies in young broilers: insights from a comparative transcriptome analysis. BMC Genomics, v. 25, n. 104, p. 1-14, 2024.| Biblioteca(s): Embrapa Pecuária Sudeste; Embrapa Suínos e Aves. |
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| 9. | | LORENZETTI, W. R.; IBELLI, A. M. G.; PEIXOTO, J. de O.; MORES, M. A. Z.; SAVOLDI, I. R.; CARMO, K. B. do; OLIVEIRA, H. C. de; LEDUR, M. C. Identification of endogenous normalizing genes for expression studies in inguinal ring tissue for scrotal hernias in pigs. Plos One, v. 13, n.9, e0204348, 2018.| Biblioteca(s): Embrapa Suínos e Aves. |
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| 10. | | RODRIGUES, A. F. G.; IBELLI, A. M. G.; PEIXOTO, J. de O.; CANTAO, M. E.; OLIVEIRA, H. C. de; SAVOLDI, I. R.; SOUZA, M. R.; MORES, M. A. Z.; CARREÑO, L. O. D.; LEDUR, M. C. Genes and SNPs Involved with Scrotal and Umbilical Hernia in Pigs. Genes, v. 12, n. 166, 2021.| Biblioteca(s): Embrapa Suínos e Aves. |
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| 11. | | ABREU, E. F. M.; TINOCO, M. L. P.; JESUS, C. C. de; OLIVEIRA, H. C. de; RAMALHO, C. S.; ANDRADE, E. C. de; VIANNA, G. R.; ARAGAO, F. J. L. Embriogênese somática do mamoeiro e estabelecimento de um protocolo de seleção com Glufosinato de Amônio (GA) visando à geração de plantas geneticamente modificadas. In: SIMPÓSIO DO PAPAYA BRASILEIRO, 5., 2011, Porto Seguro. Inovação e sustentabilidade: anais. Porto Seguro: Embrapa Mandioca e Fruticultura, 2011. PDF. T27.| Biblioteca(s): Embrapa Recursos Genéticos e Biotecnologia. |
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| 12. | | ABREU, E. F. M.; TINOCO, M. L. P.; JESUS, C. C. de; OLIVEIRA, H. C. de; RAMALHO, C. S.; ANDRADE, E. C. de; VIANNA, G. R.; ARAGAO, F. J. L. Embriogênese somática do mamoeiro e estabelecimento de um protocolo de seleção com Glufosinato de Amônio (GA) visando à geração de plantas geneticamente modificadas. In: SIMPÓSIO DO PAPAYA BRASILEIRO, 5., 2011, Porto Seguro. Inovação e sustentabilidade: anais. Porto Seguro: Embrapa Mandioca e Fruticultura, 2011. 1 CD-ROM. PDF. T27.| Biblioteca(s): Embrapa Mandioca e Fruticultura. |
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| 13. | | CAMPOS, F. G.; IBELLI, A. M. G.; OLIVEIRA, H. C. de; CANTAO, M. E.; PEIXOTO, J. de O.; TEIXEIRA, S. A.; COSTA, K. A.; LEDUR, M. C.; GUIMARÃES, S. E. F. Manual para identificação de RNAs longos não codificantes (lncRNAs) por meio de ferramentas bioinformáticas na análise de transcriptomas. Concórdia: Embrapa Suínos e Aves, 2023. 41 p. (Embrapa Suínos e Aves. Documentos, 244).| Biblioteca(s): Embrapa Suínos e Aves. |
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| 14. | | DAL PIZZOL, M. S.; IBELLI, A. M. G.; CANTAO, M. E.; PEIXOTO, J. de O.; FERNANDES, L. T.; MORES, M. A. Z.; CAMPOS, F. G.; OLIVEIRA, H. C. de; LEDUR, M. C. MicroRNAS da via de sinalização da insulina envolvidos na manifestação de white striping em frangos de corte aos 28 dias de idade. In: WORKSHOP DE CIÊNCIA, TECNOLOGIA E INOVAÇÃO, 7., 2023, Francisco Beltrão. Anais... Francisco Beltrão: UTFPR, 2023. p. 429-438.| Biblioteca(s): Embrapa Suínos e Aves. |
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| 15. | | IBELLI, A. M. G.; PEIXOTO, J. de O.; FERNANDES, L. T.; DAL PIZZOL, M. S.; DAHMER, D. R.; CAMPOS, F. G.; OLIVEIRA, H. C. de; TAVERNARI, F. de C.; CANTAO, M. E.; LEDUR, M. C. Mirna expression profile differs between chicken lines with different growth rates. In: BRAZILIAN CONGRESS OF GENETICS, 68., 2023, Ouro Preto. Paleogenomics: sequencing ancient DNA. E-book. Ribeirão Preto: Sociedade Brasileira de Genética, 2023. p. 292.| Biblioteca(s): Embrapa Suínos e Aves. |
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| 16. | | OLIVEIRA, M. S. de; OLIVEIRA, H. C. de; ANDRADE, E. H. de A.; GUILHON, G. M. S.; VENTURIERI, G. C.; SOUZA FILHO, A. P. da S.; VASCONCELOS, M. A. M. de; BORGES, J. L. M.; DANTAS FILHO, H. A. Compostos voláteis presentes na própolis de Apis mellifera coletada em São João de Pirabas, Estado do Pará. In: REUNIÃO ANUAL DA SOCIEDADE BRASILEIRA DE QUÍMICA, 35., 2012, Águas de Lindóia. Responsabilidade, ética e progresso social: trabalhos. [São Paulo]: SBQ, 2012. 1 CD-ROM.| Biblioteca(s): Embrapa Amazônia Oriental. |
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| 17. | | TEIXEIRA, S. A.; IBELLI, A. M. G.; CANTAO, M. E.; OLIVEIRA, H. C. de; LEDUR, M. C.; PEIXOTO, J. de O.; MARQUES, D. B. D.; COSTA, K. A.; COUTINHO, L. L.; GUIMARÃES, S. E. F. Sex determination using RNA-sequencing analyses in early prenatal pig development. Genes, v. 10, n. 1010, 2019.| Biblioteca(s): Embrapa Suínos e Aves. |
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| 18. | | GARCIA, I. S.; TEIXEIRA, S. A.; COSTA, K. A.; MARQUES, D. B. D.; RODRIGUES, G. de A.; COSTA, T. C.; GUIMARÃES, J. D.; OTTO, P. I.; SARAIVA, A.; IBELLI, A. M. G.; CANTAO, M. E.; OLIVEIRA, H. C. de; LEDUR, M. C.; PEIXOTO, J. de O.; GUIMARÃES, S. E. F. L-Arginine supplementation of gilts during early gestation modulates energy sensitive pathways in pig conceptuses. Molecular Reproduction and Development, v. 7, p. 19-34, 2020.| Biblioteca(s): Embrapa Suínos e Aves. |
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| Registros recuperados : 18 | |
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Registro Completo
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Biblioteca(s): |
Embrapa Pecuária Sudeste; Embrapa Suínos e Aves. |
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Data corrente: |
09/05/2024 |
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Data da última atualização: |
27/05/2024 |
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Tipo da produção científica: |
Artigo em Periódico Indexado |
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Circulação/Nível: |
A - 2 |
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Autoria: |
DAL PIZZOL, M. S.; IBELLI, A. M. G.; CANTAO, M. E.; CAMPOS, F. G.; OLIVEIRA, H. C. de; PEIXOTO, J. de O.; FERNANDES, L. T.; TAVERNARI, F. de C.; MORES, M. A. Z.; BASTOS, A. P. A.; LEDUR, M. C. |
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Afiliação: |
MARIANE SPUDEIT DAL PIZZOL, UNIVERSIDADE DO ESTADO DE SANTA CATARINA; ADRIANA MERCIA GUARATINI IBELLI, CPPSE; MAURICIO EGIDIO CANTAO, CNPSA; FRANCELLY GERALDA CAMPOS, UNIVERSIDADE FEDERAL DE VIÇOSA; HANIEL CEDRAZ DE OLIVEIRA, UNIVERSIDADE FEDERAL DE VIÇOSA; JANE DE OLIVEIRA PEIXOTO, CNPSA; LANA TEIXEIRA FERNANDES; FERNANDO DE CASTRO TAVERNARI, CNPSA; MARCOS ANTONIO ZANELLA MORES, CNPSA; ANA PAULA ALMEIDA BASTOS, CNPSA; MONICA CORREA LEDUR, CNPSA. |
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Título: |
Differential expression of miRNAs associated with pectoral myopathies in young broilers: insights from a comparative transcriptome analysis. |
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Ano de publicação: |
2024 |
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Fonte/Imprenta: |
BMC Genomics, v. 25, n. 104, p. 1-14, 2024. |
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DOI: |
https://doi.org/10.1186/s12864-024-09983-9 |
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Idioma: |
Inglês |
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Conteúdo: |
Abstract: Introduction: White Striping (WS) and Wooden Breast (WB) pectoral myopathies are relevant disorders for con- temporary broiler production worldwide. Several studies aimed to elucidate the genetic components associated with the occurrence of these myopathies. However, epigenetic factors that trigger or differentiate these two condi- tions are still unclear. The aim of this study was to identify miRNAs differentially expressed (DE) between normal and WS and WB-affected broilers, and to verify the possible role of these miRNAs in metabolic pathways related to the manifestation of these pectoral myopathies in 28-day-old broilers. Results: Five miRNAs were DE in the WS vs control (gga-miR-375, gga-miR-200b-3p, gga-miR-429-3p, gga-miR- 1769-5p, gga-miR-200a-3p), 82 between WB vs control and 62 between WB vs WS. Several known miRNAs were associated with WB, such as gga-miR-155, gga-miR-146b, gga-miR-222, gga-miR-146-5p, gga-miR- 29, gga-miR-21-5p, gga-miR-133a-3p and gga-miR-133b. Most of them had not previously been associated with the development of this myopathy in broilers. We also have predicted 17 new miRNAs expressed in the broilers pectoral muscle. DE miRNA target gene ontology analysis enriched 6 common pathways for WS and WB compared to control: autophagy, insulin signaling, FoxO signaling, endocytosis, and metabolic pathways. The WS vs control contrast had two unique path- ways, ERBB signaling and the mTOR signaling, while WB vs control had 14 unique pathways, with ubiquitin-mediated proteolysis and endoplasmic reticulum protein processing being the most significant. Conclusions: We found miRNAs DE between normal broilers and those affected with breast myopathies at 28 days of age. Our results also provide novel evidence of the miRNAs role on the regulation of WS and in the differentiation of both WS and WB myopathies. Overall, our study provides insights into miRNA-mediated and pathways involved in the occurrence of WS and WB helping to better understand these chicken growth disorders in an early age. These findings can help developing new approaches to reduce these complex issues in poultry production pos- sibly by adjustments in nutrition and management conditions. Moreover, the miRNAs and target genes associated with the initial stages of WS and WB development could be potential biomarkers to be used in selection to reduce the occurrence of these myopathies in broiler production. MenosAbstract: Introduction: White Striping (WS) and Wooden Breast (WB) pectoral myopathies are relevant disorders for con- temporary broiler production worldwide. Several studies aimed to elucidate the genetic components associated with the occurrence of these myopathies. However, epigenetic factors that trigger or differentiate these two condi- tions are still unclear. The aim of this study was to identify miRNAs differentially expressed (DE) between normal and WS and WB-affected broilers, and to verify the possible role of these miRNAs in metabolic pathways related to the manifestation of these pectoral myopathies in 28-day-old broilers. Results: Five miRNAs were DE in the WS vs control (gga-miR-375, gga-miR-200b-3p, gga-miR-429-3p, gga-miR- 1769-5p, gga-miR-200a-3p), 82 between WB vs control and 62 between WB vs WS. Several known miRNAs were associated with WB, such as gga-miR-155, gga-miR-146b, gga-miR-222, gga-miR-146-5p, gga-miR- 29, gga-miR-21-5p, gga-miR-133a-3p and gga-miR-133b. Most of them had not previously been associated with the development of this myopathy in broilers. We also have predicted 17 new miRNAs expressed in the broilers pectoral muscle. DE miRNA target gene ontology analysis enriched 6 common pathways for WS and WB compared to control: autophagy, insulin signaling, FoxO signaling, endocytosis, and metabolic pathways. The WS vs control contrast had two unique path- ways, ERBB signaling and the mTOR signaling, while WB vs control had 14 unique pathways, ... Mostrar Tudo |
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Palavras-Chave: |
Epigenética; Peito; RNAs pequenos; Small RNAs; White striping; Wooden breast. |
|
Thesagro: |
Galinha; RNA. |
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Thesaurus NAL: |
Chickens; Epigenetics. |
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Categoria do assunto: |
--
G Melhoramento Genético |
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URL: |
https://ainfo.cnptia.embrapa.br/digital/bitstream/doc/1164173/1/DifferentialExpressionMiRNAS.pdf
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|
Marc: |
LEADER 03529naa a2200373 a 4500
001 2164173
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008 2024 bl uuuu u00u1 u #d
024 7 $ahttps://doi.org/10.1186/s12864-024-09983-9$2DOI
100 1 $aDAL PIZZOL, M. S.
245 $aDifferential expression of miRNAs associated with pectoral myopathies in young broilers$binsights from a comparative transcriptome analysis.$h[electronic resource]
260 $c2024
520 $aAbstract: Introduction: White Striping (WS) and Wooden Breast (WB) pectoral myopathies are relevant disorders for con- temporary broiler production worldwide. Several studies aimed to elucidate the genetic components associated with the occurrence of these myopathies. However, epigenetic factors that trigger or differentiate these two condi- tions are still unclear. The aim of this study was to identify miRNAs differentially expressed (DE) between normal and WS and WB-affected broilers, and to verify the possible role of these miRNAs in metabolic pathways related to the manifestation of these pectoral myopathies in 28-day-old broilers. Results: Five miRNAs were DE in the WS vs control (gga-miR-375, gga-miR-200b-3p, gga-miR-429-3p, gga-miR- 1769-5p, gga-miR-200a-3p), 82 between WB vs control and 62 between WB vs WS. Several known miRNAs were associated with WB, such as gga-miR-155, gga-miR-146b, gga-miR-222, gga-miR-146-5p, gga-miR- 29, gga-miR-21-5p, gga-miR-133a-3p and gga-miR-133b. Most of them had not previously been associated with the development of this myopathy in broilers. We also have predicted 17 new miRNAs expressed in the broilers pectoral muscle. DE miRNA target gene ontology analysis enriched 6 common pathways for WS and WB compared to control: autophagy, insulin signaling, FoxO signaling, endocytosis, and metabolic pathways. The WS vs control contrast had two unique path- ways, ERBB signaling and the mTOR signaling, while WB vs control had 14 unique pathways, with ubiquitin-mediated proteolysis and endoplasmic reticulum protein processing being the most significant. Conclusions: We found miRNAs DE between normal broilers and those affected with breast myopathies at 28 days of age. Our results also provide novel evidence of the miRNAs role on the regulation of WS and in the differentiation of both WS and WB myopathies. Overall, our study provides insights into miRNA-mediated and pathways involved in the occurrence of WS and WB helping to better understand these chicken growth disorders in an early age. These findings can help developing new approaches to reduce these complex issues in poultry production pos- sibly by adjustments in nutrition and management conditions. Moreover, the miRNAs and target genes associated with the initial stages of WS and WB development could be potential biomarkers to be used in selection to reduce the occurrence of these myopathies in broiler production.
650 $aChickens
650 $aEpigenetics
650 $aGalinha
650 $aRNA
653 $aEpigenética
653 $aPeito
653 $aRNAs pequenos
653 $aSmall RNAs
653 $aWhite striping
653 $aWooden breast
700 1 $aIBELLI, A. M. G.
700 1 $aCANTAO, M. E.
700 1 $aCAMPOS, F. G.
700 1 $aOLIVEIRA, H. C. de
700 1 $aPEIXOTO, J. de O.
700 1 $aFERNANDES, L. T.
700 1 $aTAVERNARI, F. de C.
700 1 $aMORES, M. A. Z.
700 1 $aBASTOS, A. P. A.
700 1 $aLEDUR, M. C.
773 $tBMC Genomics$gv. 25, n. 104, p. 1-14, 2024.
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Embrapa Pecuária Sudeste (CPPSE) |
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