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| Registros recuperados : 27 | |
| 9. |  | SILVA, A. P. da; SANCHES, N. F.; OLIVEIRA, G. B. de; FANCELLI, M.; NASCIMENTO, A. S. do. Avaliação da longevidade de adultos da joaninha predadora Cryptolaemus montrouzieri criada com a dieta extrato de levedura Bionis® YE MF e açúcar, no substrato grão de milho estourado. In : JORNADA CIENTÍFICA EMBRAPA MANDIOCA E FRUTICULTURA, 12., 2018. Ciência profissional : resumos. Cruz das Almas, BA: Embrapa Mandioca e Fruticultura, 2019. 1 p.| Biblioteca(s): Embrapa Mandioca e Fruticultura. |
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| 11. | | CARDOSO, I. M.; SOUZA, H. N. de; BONFIM, V. R.; SOUTO, R. L.; CARVALHO, A. F. de; OLIVEIRA, G. B. de; FEITAL, D. G. Sistemas agroflorestais: contribuições para a sustentabilidade. In: MONTOYA VILCAHUAMAN, L. J.; RIBASKI, J.; MACHADO, A. M. B. (Ed.). Sistemas agroflorestais e desenvolvimento com proteção ambiental: perspectivas, análises e tendências. Colombo: Embrapa Florestas, 2006. p. 97-113.| Biblioteca(s): Embrapa Florestas. |
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| 12. | | OLIVEIRA, G. B. de; CESAR, A. S. M.; FELICIO, A. M.; POLETI, M. D.; REGITANO, L. C. de A.; COUTINHO, L. L. Gene network regulated by microRNAs suggests modulation of fat deposition in cattle. Journal of Animal Science, v. 94, e-suppl. 5; Journal of Dairy Science, v. 99, e-suppl. 1, p. 159, jul. 2016.| Biblioteca(s): Embrapa Pecuária Sudeste. |
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| 13. | | SOUZA, H. N. de; CARDOSO, I. M.; BONFIM, V. R.; SOUTO, R. L.; CARVALHO, A. F. de; OLIVEIRA, G. B. de; GJORUP, D. F. Experimentação participativa com sistemas agroflorestais na Zona da Mata de Minas Gerais. In: CONGRESSO BRASILEIRO DE SISTEMAS AGROFLORESTAIS, 5., 2004, Curitiba. SAFs: desenvolvimento com proteção ambiental: anais. Colombo: Embrapa Florestas, 2004. p. 464-466. (Embrapa Florestas. Documentos, 98).| Biblioteca(s): Embrapa Florestas. |
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| 14. | | OLIVEIRA, G. B. de; CESAR, A. S. M.; FELÍCIO, A. M.; KAPPELER, B. I. G.; POLETI, M. D.; REGITANO, L. C. de A.; COUTINHO, L. L. Evidence of miRNA regulation of intramuscular fat deposition in beef cattle. In: PLANT AND ANIMAL GENOME CONFERENCE, 24., 2016, San Diego. Anais... San Diego: PAG, 2016.| Biblioteca(s): Embrapa Pecuária Sudeste. |
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| 15. | | SOUTO, R. L.; OLIVEIRA, G. B. de; CARDOSO, I. M.; SOUZA, H. N. de; BONFIM, V. R.; GJORUP, D. F.; CARVALHO, A. F. de. Metodologia de sistematização da experimentação participativa comsistemas agroflorestais na Zona da Mata de Minas Gerais. In: CONGRESSO BRASILEIRO DE SISTEMAS AGROFLORESTAIS, 5., 2004, Curitiba. SAFs: desenvolvimento com proteção ambiental: anais. Colombo: Embrapa Florestas, 2004. p. 55-57. (Embrapa Florestas. Documentos, 98).| Biblioteca(s): Embrapa Florestas. |
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| 16. | | OLIVEIRA, G. B. de; MOTA, W. F. da; MAGALHÃES, V. R.; ALVES, F. G.; SILVEIRA, E. K. C. P.; TARCHETTI, G. P. Produção de mudas de tomateiro rasteiro com a utilização de substratos alternativos ao produto comercialmente utilizado. Horticultura Brasileira, Brasília, v. 22, n. 2, jul. 2004. Suplemento 2. Trabalho apresentado no 44º Congresso Brasileiro de Olericultura, 2004. Publicado também como resumo em: Horticultura Brasileira, Brasília, v. 22, n. 2, p. 465, jul. 2004. Suplemento.| Biblioteca(s): Embrapa Hortaliças. |
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| 17. | | SILVA, D. M. da; SILVA, U. T. F. da; NASCIMENTO, A. S. do; SANCHES, N. F.; OLIVEIRA, G. B. de; GAMA, F. de C.; PARANHOS, B. A. J. Preferência de Cryptolaemus montrouzieri (Col.: Coccinellidae) sobre ninfas de Maconellicoccus hirsutus (Hemip.: Pseudococcidae) e ovos de Ceratitis capitata (Dip.: Tephritidae). In : JORNADA CIENTÍFICA EMBRAPA MANDIOCA E FRUTICULTURA, 12., 2018. Ciência profissional : resumos. Cruz das Almas, BA: Embrapa Mandioca e Fruticultura, 2019. 1 p.| Biblioteca(s): Embrapa Mandioca e Fruticultura. |
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| 18. | | SILVA, D. M. da; SILVA, U. T. F. da; NASCIMENTO, A. S. do; SANCHES, N. F.; OLIVEIRA, G. B. de; GAMA, F. de C.; PARANHOS, B. A. J. Preferência de Cryptolaemus montrouzieri (Col.: Coccinellidae) sobre ninfas de Maconellicoccus hirsutus (Hemip.: Pseudococcidae) e ovos de Ceratitis capitata (Dip.: Tephritidae). In: JORNADA CIENTÍFICA EMBRAPA MANDIOCA E FRUTICULTURA, 12., 2018. Ciência profissional: resumos. Cruz das Almas, BA: Embrapa Mandioca e Fruticultura, 2019.| Biblioteca(s): Embrapa Semiárido. |
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| 19. | | BENEVIDES, L. de J.; SILVA NETO, A. M. da; DIAS, V. S.; BENEVIDES, C. M. de J.; LOPES, M. V.; BRAVO, I. S. J.; OLIVEIRA, G. B. de; NASCIMENTO, A. S. do. Subprodutos agroindustriais na elaboração de dietas para moscas-das-frutas (Ceratitis capitata). In: JORNADA CIENTÍFICA EMBRAPA MANDIOCA E FRUTICULTURA TROPICAL, 3., 2009, Cruz das Almas. Anais... Cruz das Almas: Embrapa Mandioca e Fruticultura Tropical, 2009. 1 CD-ROM.| Biblioteca(s): Embrapa Mandioca e Fruticultura. |
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| 20. | | NASCIMENTO, A. S. do; JOACHIM-BRAVO, I. S.; BENEVIDES, C. M. de J.; LOPES, M. V.; OLIVEIRA, G. B. de; BENEVIDES, L. de J.; SILVA NETO, A. M.; DIAS, V. S. Aprimorando a técnica do inseto estéril para fruticultura do Semiárido: avaliação de dietas de baixo custo para criação massal da mosca do mediterrâneo, ceratitis capitata. In: FUNDAÇÃO DE AMPARO À PESQUISA DO ESTADO DA BAHIA. Semiárido: Edital Temático de Apoio a Pesquisas voltadas à resolução de problemas do Semiárido baiano 2007. Salvador, 2012, p. 135-140.| Biblioteca(s): Embrapa Mandioca e Fruticultura. |
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| Registros recuperados : 27 | |
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Registro Completo
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Biblioteca(s): |
Embrapa Agricultura Digital; Embrapa Pecuária Sudeste. |
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Data corrente: |
20/12/2018 |
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Data da última atualização: |
19/02/2019 |
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Tipo da produção científica: |
Artigo em Periódico Indexado |
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Circulação/Nível: |
A - 1 |
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Autoria: |
CESAR, A. S. M.; REGITANO, L. C. de A.; REECY, J. M.; POLETI, M. D.; OLIVEIRA, P. S. N. de; OLIVEIRA, G. B. de; MOREIRA, G. C. M.; MUDADU, M. de A.; TIZIOTO, P. L.; KOLTES, J. E.; Fritz-Waters, E.; KRAMER, L.; GARRICK, D.; BEIKI, H.; GEISTLINGER, L.; MOURÃO, G. B.; ZERLOTINI NETO, A.; COUTINHO, L. L. |
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Afiliação: |
ALINE S. M. CESAR, USP, Iowa State University; LUCIANA CORREIA DE ALMEIDA REGITANO, CPPSE; JAMES M. REECY, Iowa State University; MIRELE D. POLETI, USP; Priscila Silva Neubern de Oliveira, Bolsista/Embrapa Pecuária Sudeste; GABRIELLA B. DE OLIVEIRA, USP; GABRIEL C. M. MOREIRA, USP; MAURICIO DE ALVARENGA MUDADU, CNPTIA; POLYANA C. TIZIOTO, USP; JAMES EUGENE KOLTES, Iowa State University; Elyn Fritz-Waters, Iowa State University; LUKE KRAMER, Iowa State University; DORIAN GARRICK, Massey University; HAMID BEIKI, Iowa State University; LUDWIG GEISTLINGER, Bolsista/Embrapa Pecuária Sudeste; GERSON B. MOURÃO, USP; ADHEMAR ZERLOTINI NETO, CNPTIA; Luiz Lehmann Coutinho, USP. |
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Título: |
Identification of putative regulatory regions and transcription factors associated with intramuscular fat content traits. |
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Ano de publicação: |
2018 |
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Fonte/Imprenta: |
BMC Genomics, v. 19, p. 1-20, 2018. |
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DOI: |
https://doi.org/10.1186/s12864-018-4871-y |
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Idioma: |
Inglês |
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Notas: |
Article number: 499. Na publicação: Luciana C. A. Regitano, Maurício A. Mudadu, Adhemar Zerlotini. |
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Conteúdo: |
Background: Integration of high throughput DNA genotyping and RNA-sequencing data allows for the identification of genomic regions that control gene expression, known as expression quantitative trait loci (eQTL), on a whole genome scale. Intramuscular fat (IMF) content and carcass composition play important roles in metabolic and physiological processes in mammals because they influence insulin sensitivity and consequently prevalence of metabolic diseases such as obesity and type 2 diabetes. However, limited information is available on the genetic variants and mechanisms associated with IMF deposition in mammals. Thus, our hypothesis was that eQTL analyses could identify putative regulatory regions and transcription factors (TFs) associated with intramuscular fat (IMF) content traits. Results: We performed an integrative eQTL study in skeletal muscle to identify putative regulatory regions and factors associated with intramuscular fat content traits. Data obtained from skeletal muscle samples of 192 animals was used for association analysis between 461,466 SNPs and the transcription level of 11,808 genes. This yielded 1268 cis- and 10,334 trans-eQTLs, among which we identified nine hotspot regions that each affected the expression of > 119 genes. These putative regulatory regions overlapped with previously identified QTLs for IMF content. Three of the hotspots respectively harbored the transcription factors USF1, EGR4 and RUNX1T1, which are known to play important roles in lipid metabolism. From co-expression network analysis, we further identified modules significantly correlated with IMF content and associated with relevant processes such as fatty acid metabolism, carbohydrate metabolism and lipid metabolism. Conclusion: This study provides novel insights into the link between genotype and IMF content as evident from the expression level. It thereby identifies genomic regions of particular importance and associated regulatory factors. These new findings provide new knowledge about the biological processes associated with genetic variants and mechanisms associated with IMF deposition in mammals. MenosBackground: Integration of high throughput DNA genotyping and RNA-sequencing data allows for the identification of genomic regions that control gene expression, known as expression quantitative trait loci (eQTL), on a whole genome scale. Intramuscular fat (IMF) content and carcass composition play important roles in metabolic and physiological processes in mammals because they influence insulin sensitivity and consequently prevalence of metabolic diseases such as obesity and type 2 diabetes. However, limited information is available on the genetic variants and mechanisms associated with IMF deposition in mammals. Thus, our hypothesis was that eQTL analyses could identify putative regulatory regions and transcription factors (TFs) associated with intramuscular fat (IMF) content traits. Results: We performed an integrative eQTL study in skeletal muscle to identify putative regulatory regions and factors associated with intramuscular fat content traits. Data obtained from skeletal muscle samples of 192 animals was used for association analysis between 461,466 SNPs and the transcription level of 11,808 genes. This yielded 1268 cis- and 10,334 trans-eQTLs, among which we identified nine hotspot regions that each affected the expression of > 119 genes. These putative regulatory regions overlapped with previously identified QTLs for IMF content. Three of the hotspots respectively harbored the transcription factors USF1, EGR4 and RUNX1T1, which are known to play important roles in l... Mostrar Tudo |
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Palavras-Chave: |
Ácidos graxos; Doenças metabólicas; EQTL; Expressão gênica; Expression quantitative trait loci. |
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Thesaurus NAL: |
Fatty acids; Gene expression; Mammals; Metabolic diseases. |
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Categoria do assunto: |
--
L Ciência Animal e Produtos de Origem Animal |
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URL: |
https://ainfo.cnptia.embrapa.br/digital/bitstream/item/189052/1/AP-Identification-Cesar-etal.pdf
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Marc: |
LEADER 03558naa a2200457 a 4500
001 2106227
005 2019-02-19
008 2018 bl uuuu u00u1 u #d
024 7 $ahttps://doi.org/10.1186/s12864-018-4871-y$2DOI
100 1 $aCESAR, A. S. M.
245 $aIdentification of putative regulatory regions and transcription factors associated with intramuscular fat content traits.$h[electronic resource]
260 $c2018
500 $aArticle number: 499. Na publicação: Luciana C. A. Regitano, Maurício A. Mudadu, Adhemar Zerlotini.
520 $aBackground: Integration of high throughput DNA genotyping and RNA-sequencing data allows for the identification of genomic regions that control gene expression, known as expression quantitative trait loci (eQTL), on a whole genome scale. Intramuscular fat (IMF) content and carcass composition play important roles in metabolic and physiological processes in mammals because they influence insulin sensitivity and consequently prevalence of metabolic diseases such as obesity and type 2 diabetes. However, limited information is available on the genetic variants and mechanisms associated with IMF deposition in mammals. Thus, our hypothesis was that eQTL analyses could identify putative regulatory regions and transcription factors (TFs) associated with intramuscular fat (IMF) content traits. Results: We performed an integrative eQTL study in skeletal muscle to identify putative regulatory regions and factors associated with intramuscular fat content traits. Data obtained from skeletal muscle samples of 192 animals was used for association analysis between 461,466 SNPs and the transcription level of 11,808 genes. This yielded 1268 cis- and 10,334 trans-eQTLs, among which we identified nine hotspot regions that each affected the expression of > 119 genes. These putative regulatory regions overlapped with previously identified QTLs for IMF content. Three of the hotspots respectively harbored the transcription factors USF1, EGR4 and RUNX1T1, which are known to play important roles in lipid metabolism. From co-expression network analysis, we further identified modules significantly correlated with IMF content and associated with relevant processes such as fatty acid metabolism, carbohydrate metabolism and lipid metabolism. Conclusion: This study provides novel insights into the link between genotype and IMF content as evident from the expression level. It thereby identifies genomic regions of particular importance and associated regulatory factors. These new findings provide new knowledge about the biological processes associated with genetic variants and mechanisms associated with IMF deposition in mammals.
650 $aFatty acids
650 $aGene expression
650 $aMammals
650 $aMetabolic diseases
653 $aÁcidos graxos
653 $aDoenças metabólicas
653 $aEQTL
653 $aExpressão gênica
653 $aExpression quantitative trait loci
700 1 $aREGITANO, L. C. de A.
700 1 $aREECY, J. M.
700 1 $aPOLETI, M. D.
700 1 $aOLIVEIRA, P. S. N. de
700 1 $aOLIVEIRA, G. B. de
700 1 $aMOREIRA, G. C. M.
700 1 $aMUDADU, M. de A.
700 1 $aTIZIOTO, P. L.
700 1 $aKOLTES, J. E.
700 1 $aFritz-Waters, E.
700 1 $aKRAMER, L.
700 1 $aGARRICK, D.
700 1 $aBEIKI, H.
700 1 $aGEISTLINGER, L.
700 1 $aMOURÃO, G. B.
700 1 $aZERLOTINI NETO, A.
700 1 $aCOUTINHO, L. L.
773 $tBMC Genomics$gv. 19, p. 1-20, 2018.
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Embrapa Pecuária Sudeste (CPPSE) |
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