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| Registros recuperados : 192 | |
| Registros recuperados : 192 | |
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 | Acesso ao texto completo restrito à biblioteca da Embrapa Gado de Leite. Para informações adicionais entre em contato com cnpgl.biblioteca@embrapa.br. |
Registro Completo
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Biblioteca(s): |
Embrapa Gado de Leite. |
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Data corrente: |
29/10/2021 |
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Data da última atualização: |
29/10/2021 |
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Tipo da produção científica: |
Artigo em Periódico Indexado |
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Circulação/Nível: |
A - 2 |
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Autoria: |
FAYER, L.; ZANETTE, R. S. S.; SIQUEIRA, J. T. C.; OLIVEIRA, E. R.; ALMEIDA, C. G.; GERN, J. C.; SOUSA, S. M.; OLIVEIRA, L. R. C. de; BRANDAO, H. de M.; MUNK, M. |
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Afiliação: |
LEONARA FAYER, Universidade Federal de juiz de Fora; RAFAELLA S. S. ZANETTE, Universidade Federal de Juiz de Fora; JULIANA T. C. SIQUEIRA, Universidade Federal de Juiz de Fora; EDUARDA R. OLIVEIRA, Universidade Federal de Juiz de Fora; CAMILA G. ALMEIDA; JULIANA CARINE GERN, CNPGL; SAULO M. SOUSA, Universidade Federal de Juiz de Fora; LUIZ F. C. DE OLIVEIRA, Universidade Federal de Juiz de Fora; HUMBERTO DE MELLO BRANDAO, CNPGL; MICHELE MUNK, Universidade Federal de Juiz de Fora. |
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Título: |
The distinct effect of titanium dioxide nanoparticles in primary and immortalized cell lines. |
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Ano de publicação: |
2021 |
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Fonte/Imprenta: |
Toxicology Research, v. 10, n. 3, p. 511-522, 2021. |
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DOI: |
https://doi.org/10.1093/toxres/tfab040 |
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Idioma: |
Inglês |
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Conteúdo: |
The titanium dioxide nanoparticles (NPs) have been applied to biomedical, pharmaceutical, and food additive fields. However, the effect on health and the environment are conf licting; thus, it has been reviewing several times. In this context, establishing standard robust protocols for detecting cytotoxicity and genotoxicity of nanomaterials became essential for nanotechnology development. The cell type and the intrinsic characteristics of titanium dioxide NPs can inf luence nanotoxicity. In this work, the cyto- and genotoxicity effects of standard reference material titanium dioxide NPs in primary bovine fibroblasts and immortalized Chinese hamster ovary epithelial (CHO) cells were determined and compared for the first time. Titanium dioxide NPs exposure revealed no cytotoxicity for primary bovine fibroblasts, while only higher concentrations tested (10 ?g/ml) induce genotoxic effects in this cell model. In contrast, the lower concentrations of the titanium dioxide NPs cause the cyto- and genotoxic effects in CHO cells. Therefore, our finding indicates that the CHO line was more sensitive toward the effects of titanium dioxide NPs than the primary bovine fibroblast, which should be valuable for their environmental risk assessment. |
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Palavras-Chave: |
Avaliação de risco; Célula CHO; Fibroblasto; Nanomaterial; Nanotoxicidade. |
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Thesagro: |
Bovino. |
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Categoria do assunto: |
L Ciência Animal e Produtos de Origem Animal |
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Marc: |
LEADER 02160naa a2200313 a 4500
001 2135714
005 2021-10-29
008 2021 bl uuuu u00u1 u #d
024 7 $ahttps://doi.org/10.1093/toxres/tfab040$2DOI
100 1 $aFAYER, L.
245 $aThe distinct effect of titanium dioxide nanoparticles in primary and immortalized cell lines.$h[electronic resource]
260 $c2021
520 $aThe titanium dioxide nanoparticles (NPs) have been applied to biomedical, pharmaceutical, and food additive fields. However, the effect on health and the environment are conf licting; thus, it has been reviewing several times. In this context, establishing standard robust protocols for detecting cytotoxicity and genotoxicity of nanomaterials became essential for nanotechnology development. The cell type and the intrinsic characteristics of titanium dioxide NPs can inf luence nanotoxicity. In this work, the cyto- and genotoxicity effects of standard reference material titanium dioxide NPs in primary bovine fibroblasts and immortalized Chinese hamster ovary epithelial (CHO) cells were determined and compared for the first time. Titanium dioxide NPs exposure revealed no cytotoxicity for primary bovine fibroblasts, while only higher concentrations tested (10 ?g/ml) induce genotoxic effects in this cell model. In contrast, the lower concentrations of the titanium dioxide NPs cause the cyto- and genotoxic effects in CHO cells. Therefore, our finding indicates that the CHO line was more sensitive toward the effects of titanium dioxide NPs than the primary bovine fibroblast, which should be valuable for their environmental risk assessment.
650 $aBovino
653 $aAvaliação de risco
653 $aCélula CHO
653 $aFibroblasto
653 $aNanomaterial
653 $aNanotoxicidade
700 1 $aZANETTE, R. S. S.
700 1 $aSIQUEIRA, J. T. C.
700 1 $aOLIVEIRA, E. R.
700 1 $aALMEIDA, C. G.
700 1 $aGERN, J. C.
700 1 $aSOUSA, S. M.
700 1 $aOLIVEIRA, L. R. C. de
700 1 $aBRANDAO, H. de M.
700 1 $aMUNK, M.
773 $tToxicology Research$gv. 10, n. 3, p. 511-522, 2021.
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