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| Registros recuperados : 21 | |
| 1. |  | CHAVES, F. C. M.; CAMARGO, J. V. S.; PINTO, A. C. DA S.; NOGUEIRA, K. L.; POHLIT, A. M. Produção de biomassa, teor e rendimento de extrato de Piper peltata em função de arranjos espaciais. In: INTERNATIONAL SYMPOSIUM ON MEDICINAL AND NUTRACEUTICAL PLANTS, 3.; CONFERENCE OF NATIONAL INSTITUTE OF SCIENCE & TECHNOLOGY FOR TROPICAL FRUITS, 3., 2012, Aracaju. [Abstracts...]. Aracaju: ISHS; UFS; SBCTA, 2012. 1 CD-ROM.| Biblioteca(s): Embrapa Amazônia Ocidental. |
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| 2. | | SILVA, M. C. C.; MEDEIROS, J. F.; BARROS, A. D.; ALMEIDA, A. H.; ALVES, L. P.; NOGUEIRA, K. D. Producao de cultivares de melao submetidas a diferentes niveis de salinidade da agua e cobertura do solo. In: CONGRESSO NACIONAL DE IRRIGACAO E DRENAGEM, 11., 2001, Fortaleza. Anais... Fortaleza: ABID, 2001. p.273-278.| Biblioteca(s): Embrapa Hortaliças. |
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| 3. | | PINTO, A. C. da S.; LUCENA, J. F. de; NOGUEIRA, K. L.; POHLIT, A. M.; CHAVES, F. C. M. Preparação de derivados semi-sintéticos de catecol e 4-nerolidilcatecol e atividade citotóxica em Artemia franciscana. In: REUNIÃO ANUAL DA SOCIEDADE BRASILEIRA DE QUÍMICA, 30., 2007, Águas de Lindóia, SP. Resumos... Águas de Lindóia: Sociedade Brasileira de Química, 2007.| Biblioteca(s): Embrapa Amazônia Ocidental. |
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| 8. | | NOGUEIRA, K. D.; MEDEIROS, J. F.; SARMENTO, D. H. A.; ALVES, L. P.; SILVA, M. C. C.; DUARTE, S. R.; BARROS, A. D. Analise de crescimento do melao Cantaloupe sob condicoes de diferentes niveis de salinidade da agua e frequencia de irrigacao. In: CONGRESSO NACIONAL DE IRRIGACAO E DRENAGEM, 11., 2001, Fortaleza. Anais... Fortaleza: ABID, 2001. p.17-21.| Biblioteca(s): Embrapa Hortaliças. |
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| 9. | | PINTO, A. C. S.; NOGUEIRA, K. L.; CHAVES, F. C. M.; SILVA, L. V. S. da; TADEI, W. P.; POHLIT, A. M. Adulticidal activity of dillapiol and semi-synthetic derivatives of dillapiol against adults of Aedes aegypti (L.) (Culicidae). Journal of Mosquito Research, v. 2, n. 1, p. 1-7, jun. 2012.| Biblioteca(s): Embrapa Amazônia Ocidental. |
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| 10. | | MIRANDA, C. M.; NOGUEIRA, K. P.; QUEIROZ, I. dos S.; SILVA, P. H. da; LEDO, C. A. da S.; FERREIRA, C. F. Fingerprint de varieades elites de mandioca via marcadores ISSR. In: CONGRESSO BRASILEIRO DE MANDIOCA, 16.; CONGRESSO LATINO-AMERICANO E CARIBENHO DE MANDIOCA, 2015, Foz do Iguaçu. Integração: segurança alimentar e geração de renda: anais. Foz do Iguaçu: SBM, 2015. 1 CD-ROM. 4p.| Biblioteca(s): Embrapa Mandioca e Fruticultura. |
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| 11. | | KORB, A.; NAZARENO, E. R. de; COSTA, L. D.; NOGUEIRA, K. da S.; DALSENTER, P. R.; TUON, F. F. B.; POMBA, M. C. Tipagem molecular e resistência aos antimicrobianos em isolados de Escherichia coli de frangos de corte e de tratadores na Região Metropolitana de Curitiba, Paraná. Pesquisa Veterinária Brasileira, Brasília, DF, v. 35, n. 3, p. 258-264, mar. 2015.| Biblioteca(s): Embrapa Unidades Centrais. |
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| 12. | | SILVA, M. C. de C.; MEDEIROS, J. F. de; ALVES, L. P.; CARNEIRO, C. R.; SARMENTO, D. H. A.; NOGUEIRA, K. D. Qualidade de meloes submetidos a diferentes niveis de salinidade da agua e cobertura do solo. Horticultura Brasileira, Brasília, DF, v. 19, n. 2, jul. 2001. 1 CD-ROM. Suplemento. Trabalho apresentado no 41. Congresso Brasileiro de Olericultura, 2001.
Também publicado em: Horticultura Brasileira, Brasília, DF, v. 19, n. 2, p. 221, jul. 2001. Resumo.| Biblioteca(s): Embrapa Hortaliças. |
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| 14. | | LIMA, E. S.; PINTO, A. C. S.; NOGUEIRA, K. L.; SILVA, L. F. R. e; ALMEIDA, P. D. O. de; VASCONCELLOS, M. C. de; CHAVES, F. C. M.; TADEI, W. P.; POHLIT, A. M. Stability and Antioxidant Activity of Semi-synthetic Derivatives of 4-Nerolidylcatechol. Molecules, v. 18, n. 1, p. 178-189, jan. 2013.| Biblioteca(s): Embrapa Amazônia Ocidental. |
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| 15. | | OSCO, L. P.; NOGUEIRA, K.; RAMOS, A. P. M.; PINHEIRO, M. M. F.; FURUYA, D. E. G.; GONÇALVES, W. N.; JORGE, L. A. de C.; MARCATO JUNIOR, J.; SANTOS, J. A. Semantic segmentation of citrus-orchard using deep neural networks and multispectral UAV-based imagery. Precision Agriculture, v. 22, n. 4,2021. 1171-1188| Biblioteca(s): Embrapa Instrumentação. |
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| 16. | | BRONDANI, C.; MENDONÇA, J. A.; BORBA, T. C. de O.; RANGEL, P. H. N.; CORDEIRO, A. C. C.; MOURA NETO, F. P.; UTUMI, M. M.; PEREIRA, J. A.; CRUZEIRO, G. V.; LOPES JUNIOR, S.; BASSINELLO, P. Z.; LIMA, G. P.; SILVEIRA, R. D. da; NOGUEIRA, K. F. D'E.; MARTIN-DIDONET, C.; BRONDANI, R. P. V. Catálogo descritivo dos acessos da Coleção Nuclear de Arroz da Embrapa - CNAE versão 1.0. Santo Antônio de Goiás: Embrapa Arroz e Feijão, 2007. 566 p. (Embrapa Arroz e Feijão. Documentos on-line, 205).| Biblioteca(s): Embrapa Rondônia. |
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| 17. | | BRONDANI, C.; MENDONÇA, J. A.; BORBA, T. C. de O.; RANGEL, P. H. N.; CORDEIRO, A. C. C.; MOURA NETO, F. P.; UTUMI, M. M.; PEREIRA, J. A.; CRUZEIRO, G. V.; LOPES JUNIOR, S.; BASSINELLO, P. Z.; LIMA, G. P.; SILVEIRA, R. D. da; NOGUEIRA, K. F. D'E.; MARTIN-DIDONET, C.; BRONDANI, R. P. V. Catálogo descritivo dos acessos da Coleção Nuclear de Arroz da Embrapa - CNAE versão 1.0. Santo Antônio de Goiás: Embrapa Arroz e Feijão, 2007. 566 p. (Embrapa Arroz e Feijão. Documentos, 205).| Biblioteca(s): Embrapa Arroz e Feijão. |
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| 18. | | POHLIT, A. M.; PINTO, A. C. da S.; CAVALCANTI, B. C.; PESSOA, C. do O.; SILVA, E. C. C. e; CHAVES, F. C. M.; NOGUEIRA, K. L.; LOTUFO, L.; SILVA, L. F. R. e; MELO, M. R. S.; VIEIRA, P. P. R.; MAUSE, R.; AMORIM, R. C. da N.; TADEI, W. P.; ANDRADE-NETO, V. de. Biopharmaceuticals synthesis. In: CARIOCA, J. O. B. (Ed.). Brazilian network on green chemistry - awareness, responsability and action. Benfica: UFC, 2008. p. 347-372.| Biblioteca(s): Embrapa Amazônia Ocidental. |
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| 19. | | ANDRADE-NETO, V. F. de; POHLIT, A. M.; PINTO, A. C. S.; SILVA, E. C. C.; NOGUEIRA, K. L.; MELO, M. R. S.; HENRIQUE, M. C.; AMORIM, R. C. N.; SILVA, L. F. R.; COSTA, M. R. F.; NUNOMURA, R. C. S.; NUNOMURA, S. M.; ALECRIM, W. D.; ALECRIM, M. das G. C.; CHAVES, F. C. M.; VIEIRA, P. P. R. In vitro inhibition of Plasmodium falciparum by substances isolated from Amazonian antimalarial plants. Memórias do Instituto Oswaldo Cruz, Rio de Janeiro, v. 102, n. 3, p. 359-365, jun. 2007.| Biblioteca(s): Embrapa Amazônia Ocidental. |
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| 20. | | SILVA, L. F. R. e; NOGUEIRA, K. L.; PINTO, A. C. da S.; KATZIN, A. M.; SUSSMANN, R. A. C.; MUNIZ, M. P.; ANDRADE NETO, V. F. de; CHAVES, F. C. M.; COUTINHO, J. P.; LIMA, E. S.; KRETTLI, A. U.; TADEI, W. P.; POHLIT, A. M. In vivo antimalarial activity and mechanisms of action of 4-Nerolidylcatechol derivatives. Antimicrobial Agents and Chemotherapy, v. 59, n. 6, p. 3271-80, Jun. 2015.| Biblioteca(s): Embrapa Amazônia Ocidental. |
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| Registros recuperados : 21 | |
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Registro Completo
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Biblioteca(s): |
Embrapa Amazônia Ocidental. |
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Data corrente: |
04/04/2013 |
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Data da última atualização: |
29/01/2018 |
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Tipo da produção científica: |
Artigo em Periódico Indexado |
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Circulação/Nível: |
A - 1 |
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Autoria: |
LIMA, E. S.; PINTO, A. C. S.; NOGUEIRA, K. L.; SILVA, L. F. R. e; ALMEIDA, P. D. O. de; VASCONCELLOS, M. C. de; CHAVES, F. C. M.; TADEI, W. P.; POHLIT, A. M. |
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Afiliação: |
Emerson Silva Lima, UFAM; Ana Cristina Silva Pinto, INPA; Karla Lagos Nogueira, INPA; Luiz Francisco Rocha e Silva, INPA; Patricia Danielle Oliveira de Almeida, UFAM; Marne Carvalho de Vasconcellos, UFAM; FRANCISCO CELIO MAIA CHAVES, CPAA; Wanderli Pedro Tadei, INPA; Adrian Martin Pohlit, INPA. |
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Título: |
Stability and Antioxidant Activity of Semi-synthetic Derivatives of 4-Nerolidylcatechol. |
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Ano de publicação: |
2013 |
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Fonte/Imprenta: |
Molecules, v. 18, n. 1, p. 178-189, jan. 2013. |
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ISSN: |
1420-3049 |
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DOI: |
10.3390/molecules18010178 |
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Idioma: |
Inglês |
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Conteúdo: |
4-nerolidylcatechol (4-NC) is an unstable natural product that exhibits important antioxidant, anti-inflammatory and other properties. It is readily obtainable on a multi-gram scale through straightforward solvent extraction of the roots of cultivated Piper peltatum or P. umbellatum, followed by column chromatography on the resulting extract. Semi-synthetic derivatives of 4-NC with one or two substituent groups (methyl, acetyl, benzyl, benzoyl) on the O atoms have been introduced that have increased stability compared to 4-NC and significant in vitro inhibitory activity against the human malaria parasite Plasmodium falciparum. Antioxidant and anti-inflammatory properties may be important for the antiplasmodial mode of action of 4-NC derivatives. Thus, we decided to investigate the antioxidant properties, cytotoxicity and stability of 4-NC derivatives as a means to explore the potential utility of these compounds. 4-NC showed high antioxidant activity in the DPPH and ABTS assays and in 3T3-L1 cells (mouse embryonic fibroblast), however 4-NC was more cytotoxic (IC50 = 31.4 µM) and more unstable than its derivatives and lost more than 80% of its antioxidant activity upon storage in solution at −20 °C for 30 days. DMSO solutions of mono-O-substituted derivatives of 4-NC exhibited antioxidant activity and radical scavenging activity in the DPPH and ABTS assays that was comparable to that of BHA and BHT. In the cell-based antioxidant model, most DMSO solutions of derivatives of 4-NC were less active on day 1 than 4-NC, quercetin and BHA and more active antioxidants than BHT. After storage for 30 days at −20 °C, DMSO solutions of most of the derivatives of 4-NC were more stable and exhibited more antioxidant activity than 4-NC, quercetin and BHA and exhibited comparable antioxidant activity to BHT. These findings point to the potential of derivatives of 4-NC as antioxidant compounds. Menos4-nerolidylcatechol (4-NC) is an unstable natural product that exhibits important antioxidant, anti-inflammatory and other properties. It is readily obtainable on a multi-gram scale through straightforward solvent extraction of the roots of cultivated Piper peltatum or P. umbellatum, followed by column chromatography on the resulting extract. Semi-synthetic derivatives of 4-NC with one or two substituent groups (methyl, acetyl, benzyl, benzoyl) on the O atoms have been introduced that have increased stability compared to 4-NC and significant in vitro inhibitory activity against the human malaria parasite Plasmodium falciparum. Antioxidant and anti-inflammatory properties may be important for the antiplasmodial mode of action of 4-NC derivatives. Thus, we decided to investigate the antioxidant properties, cytotoxicity and stability of 4-NC derivatives as a means to explore the potential utility of these compounds. 4-NC showed high antioxidant activity in the DPPH and ABTS assays and in 3T3-L1 cells (mouse embryonic fibroblast), however 4-NC was more cytotoxic (IC50 = 31.4 µM) and more unstable than its derivatives and lost more than 80% of its antioxidant activity upon storage in solution at −20 °C for 30 days. DMSO solutions of mono-O-substituted derivatives of 4-NC exhibited antioxidant activity and radical scavenging activity in the DPPH and ABTS assays that was comparable to that of BHA and BHT. In the cell-based antioxidant model, most DMSO solutions of derivatives... Mostrar Tudo |
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Palavras-Chave: |
Antioxidantes; Piper peltatum. |
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Categoria do assunto: |
-- |
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URL: |
https://ainfo.cnptia.embrapa.br/digital/bitstream/item/80487/1/molecules-18-00178-v2.pdf
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Marc: |
LEADER 02680naa a2200265 a 4500
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008 2013 bl uuuu u00u1 u #d
022 $a1420-3049
024 7 $a10.3390/molecules18010178$2DOI
100 1 $aLIMA, E. S.
245 $aStability and Antioxidant Activity of Semi-synthetic Derivatives of 4-Nerolidylcatechol.
260 $c2013
520 $a4-nerolidylcatechol (4-NC) is an unstable natural product that exhibits important antioxidant, anti-inflammatory and other properties. It is readily obtainable on a multi-gram scale through straightforward solvent extraction of the roots of cultivated Piper peltatum or P. umbellatum, followed by column chromatography on the resulting extract. Semi-synthetic derivatives of 4-NC with one or two substituent groups (methyl, acetyl, benzyl, benzoyl) on the O atoms have been introduced that have increased stability compared to 4-NC and significant in vitro inhibitory activity against the human malaria parasite Plasmodium falciparum. Antioxidant and anti-inflammatory properties may be important for the antiplasmodial mode of action of 4-NC derivatives. Thus, we decided to investigate the antioxidant properties, cytotoxicity and stability of 4-NC derivatives as a means to explore the potential utility of these compounds. 4-NC showed high antioxidant activity in the DPPH and ABTS assays and in 3T3-L1 cells (mouse embryonic fibroblast), however 4-NC was more cytotoxic (IC50 = 31.4 µM) and more unstable than its derivatives and lost more than 80% of its antioxidant activity upon storage in solution at −20 °C for 30 days. DMSO solutions of mono-O-substituted derivatives of 4-NC exhibited antioxidant activity and radical scavenging activity in the DPPH and ABTS assays that was comparable to that of BHA and BHT. In the cell-based antioxidant model, most DMSO solutions of derivatives of 4-NC were less active on day 1 than 4-NC, quercetin and BHA and more active antioxidants than BHT. After storage for 30 days at −20 °C, DMSO solutions of most of the derivatives of 4-NC were more stable and exhibited more antioxidant activity than 4-NC, quercetin and BHA and exhibited comparable antioxidant activity to BHT. These findings point to the potential of derivatives of 4-NC as antioxidant compounds.
653 $aAntioxidantes
653 $aPiper peltatum
700 1 $aPINTO, A. C. S.
700 1 $aNOGUEIRA, K. L.
700 1 $aSILVA, L. F. R. e
700 1 $aALMEIDA, P. D. O. de
700 1 $aVASCONCELLOS, M. C. de
700 1 $aCHAVES, F. C. M.
700 1 $aTADEI, W. P.
700 1 $aPOHLIT, A. M.
773 $tMolecules$gv. 18, n. 1, p. 178-189, jan. 2013.
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Embrapa Amazônia Ocidental (CPAA) |
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