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| Acesso ao texto completo restrito à biblioteca da Embrapa Gado de Leite. Para informações adicionais entre em contato com cnpgl.biblioteca@embrapa.br. |
Registro Completo |
Biblioteca(s): |
Embrapa Gado de Leite. |
Data corrente: |
12/04/2011 |
Data da última atualização: |
26/06/2023 |
Tipo da produção científica: |
Resumo em Anais de Congresso |
Autoria: |
AMORIM. L. S.; FONSECA, J. F. da; SIQUEIRA, L. G. B.; VIANA, J. H. M.; ZAMBRINI, F. N.; SEIDEL, G. E.; TORRES, C. A. A. |
Afiliação: |
LINCOLN S. AMORIM, UFV; JEFERSON FERREIRA DA FONSECA, CNPC; LUIZ GUSTAVO BRUNO SIQUEIRA, CNPGL; JOAO HENRIQUE MOREIRA VIANA, CNPGL; FABIANA N. ZAMBRINI; GEORGE E. SEIDEL, COLORADO STATE UNIVERSITY; CIRO A. A. TORRES, UFV. |
Título: |
Association of dietary urea with plasma and follicular fluid concentration of hormones and metabolites in goats. |
Ano de publicação: |
2010 |
Fonte/Imprenta: |
In: ANNUAL MEETING OF THE EUROPEAN SOCIETY FOR PAEDIATRIC GASTROENTEROLOGY, HEPATOLOGY AND NUTRITION, 43., 2010, Istanbul. Abstracts... Ankara: Hacettepe University, 2010. |
Idioma: |
Português |
Palavras-Chave: |
Caprinos. |
Categoria do assunto: |
L Ciência Animal e Produtos de Origem Animal |
Marc: |
LEADER 00712nam a2200181 a 4500 001 1885664 005 2023-06-26 008 2010 bl uuuu u00u1 u #d 100 1 $aAMORIM. L. S. 245 $aAssociation of dietary urea with plasma and follicular fluid concentration of hormones and metabolites in goats.$h[electronic resource] 260 $aIn: ANNUAL MEETING OF THE EUROPEAN SOCIETY FOR PAEDIATRIC GASTROENTEROLOGY, HEPATOLOGY AND NUTRITION, 43., 2010, Istanbul. Abstracts... Ankara: Hacettepe University$c2010 653 $aCaprinos 700 1 $aFONSECA, J. F. da 700 1 $aSIQUEIRA, L. G. B. 700 1 $aVIANA, J. H. M. 700 1 $aZAMBRINI, F. N. 700 1 $aSEIDEL, G. E. 700 1 $aTORRES, C. A. A.
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Embrapa Gado de Leite (CNPGL) |
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| Acesso ao texto completo restrito à biblioteca da Embrapa Pecuária Sudeste. Para informações adicionais entre em contato com cppse.biblioteca@embrapa.br. |
Registro Completo
Biblioteca(s): |
Embrapa Pecuária Sudeste. |
Data corrente: |
02/12/2015 |
Data da última atualização: |
15/03/2023 |
Tipo da produção científica: |
Artigo em Periódico Indexado |
Circulação/Nível: |
A - 2 |
Autoria: |
CHAGAS, A. C. de S.; DOMINGUES, L. F.; ALEMÁN GAINZA, Y.; BARIONI JUNIOR, W.; ESTEVES, S. N.; NICIURA, S. C. M. |
Afiliação: |
ANA CAROLINA DE SOUZA CHAGAS, CPPSE; LUCIANA FERREIRA DOMINGUES; Yousmel Alemán Gainza, CENTRO NACIONAL DE SANIDAD AGROPECUARIA; WALDOMIRO BARIONI JUNIOR, CPPSE; SERGIO NOVITA ESTEVES, CPPSE; SIMONE CRISTINA MEO NICIURA, CPPSE. |
Título: |
Target selected treatment with levamisole to control the development of anthelmintic resistance in a sheep flock. |
Ano de publicação: |
2016 |
Fonte/Imprenta: |
Parasitology Research, v. 115, n. 3, p. 1131-1139, mar. 2016. |
DOI: |
10.1007/s00436-015-4844-x |
Idioma: |
Inglês |
Conteúdo: |
Levamisole phosphate, chosen based on its 100 % efficacy demonstrated by a previous fecal egg count reduction test (FECRT), was used as the exclusive anthelmintic treatment in the Embrapa Southeast Livestock sheep flock from 2009 to 2014 in a target selected treatment scheme. In the present study, the effectiveness of this nematode control scheme was evaluated after 5 years by FECRT, larval development test (LDT), and a molecular test to assess the development of levamisole resistance in Haemonchus contortus. Animals were submitted to treatments with albendazole, levamisole, closantel, ivermectin, moxidectin, and monepantel. Eggs per gram of feces (EPG) counts and fecal cultures were performed, and anthelmintic efficacy was calculated by the RESO 4.0 program. The helminths of the flock (GIN Embrapa2014) were compared to susceptible (McMaster) and resistant (Embrapa2010) H. contortus isolates in the LDT to estimate the LC50 and LC90 of levamisole and in a molecular test to evaluate the 63-bp indel in the acr8 gene associated with levamisole resistance. In the FECRT, parasites were susceptible to monepantel (99.6 %) and closantel (98.3 %), but resistant to moxidectin (93.8 %), levamisole (70.4 %), ivermectin (48.1 %), and albendazole (0 %). In the coproculture on D14, and the control group presented 80 % H. contortus and 20 % Trichostrongylus sp., while in the monepantel group L1 were observed as well as Oesophagostomum sp. L3. LDT and resistance factors provided good separation between susceptible and resistant parasites. The genotypic frequencies of the 63-bp insertion in the acr8 gene in H. contortus were 11.9, 6.7, and 0 % in GIN Embrapa2014, Embrapa2010, and McMaster isolates, respectively. After 5 years of exclusive use, the nematodes developed resistance to levamisole, detected by FECRT and by increase in LC50 and LC90 for levamisole in the LDT. The 63-bp indel was not confirmed as a molecular marker of levamisole resistance in our isolates. The target selected treatment scheme was effective to control helminths in the sheep flock for 5 years, when levamisole?s inefficacy was perceived because of no change in the clinical situation of treated animals. Through this scheme, it was possible to promote reversion towards susceptibility or increase of efficacy for other chemical classes. Thus, this is a valid recommendation to control worms and to delay the development of resistance, preserving other anthelmintic classes for future use. MenosLevamisole phosphate, chosen based on its 100 % efficacy demonstrated by a previous fecal egg count reduction test (FECRT), was used as the exclusive anthelmintic treatment in the Embrapa Southeast Livestock sheep flock from 2009 to 2014 in a target selected treatment scheme. In the present study, the effectiveness of this nematode control scheme was evaluated after 5 years by FECRT, larval development test (LDT), and a molecular test to assess the development of levamisole resistance in Haemonchus contortus. Animals were submitted to treatments with albendazole, levamisole, closantel, ivermectin, moxidectin, and monepantel. Eggs per gram of feces (EPG) counts and fecal cultures were performed, and anthelmintic efficacy was calculated by the RESO 4.0 program. The helminths of the flock (GIN Embrapa2014) were compared to susceptible (McMaster) and resistant (Embrapa2010) H. contortus isolates in the LDT to estimate the LC50 and LC90 of levamisole and in a molecular test to evaluate the 63-bp indel in the acr8 gene associated with levamisole resistance. In the FECRT, parasites were susceptible to monepantel (99.6 %) and closantel (98.3 %), but resistant to moxidectin (93.8 %), levamisole (70.4 %), ivermectin (48.1 %), and albendazole (0 %). In the coproculture on D14, and the control group presented 80 % H. contortus and 20 % Trichostrongylus sp., while in the monepantel group L1 were observed as well as Oesophagostomum sp. L3. LDT and resistance factors provided good separati... Mostrar Tudo |
Palavras-Chave: |
Acr8 gene; Genetic marker; Haemonchuscontortus isolates FECRT; Levamisole resistance; Reversion. |
Categoria do assunto: |
G Melhoramento Genético |
Marc: |
LEADER 03293naa a2200253 a 4500 001 2030316 005 2023-03-15 008 2016 bl uuuu u00u1 u #d 024 7 $a10.1007/s00436-015-4844-x$2DOI 100 1 $aCHAGAS, A. C. de S. 245 $aTarget selected treatment with levamisole to control the development of anthelmintic resistance in a sheep flock.$h[electronic resource] 260 $c2016 520 $aLevamisole phosphate, chosen based on its 100 % efficacy demonstrated by a previous fecal egg count reduction test (FECRT), was used as the exclusive anthelmintic treatment in the Embrapa Southeast Livestock sheep flock from 2009 to 2014 in a target selected treatment scheme. In the present study, the effectiveness of this nematode control scheme was evaluated after 5 years by FECRT, larval development test (LDT), and a molecular test to assess the development of levamisole resistance in Haemonchus contortus. Animals were submitted to treatments with albendazole, levamisole, closantel, ivermectin, moxidectin, and monepantel. Eggs per gram of feces (EPG) counts and fecal cultures were performed, and anthelmintic efficacy was calculated by the RESO 4.0 program. The helminths of the flock (GIN Embrapa2014) were compared to susceptible (McMaster) and resistant (Embrapa2010) H. contortus isolates in the LDT to estimate the LC50 and LC90 of levamisole and in a molecular test to evaluate the 63-bp indel in the acr8 gene associated with levamisole resistance. In the FECRT, parasites were susceptible to monepantel (99.6 %) and closantel (98.3 %), but resistant to moxidectin (93.8 %), levamisole (70.4 %), ivermectin (48.1 %), and albendazole (0 %). In the coproculture on D14, and the control group presented 80 % H. contortus and 20 % Trichostrongylus sp., while in the monepantel group L1 were observed as well as Oesophagostomum sp. L3. LDT and resistance factors provided good separation between susceptible and resistant parasites. The genotypic frequencies of the 63-bp insertion in the acr8 gene in H. contortus were 11.9, 6.7, and 0 % in GIN Embrapa2014, Embrapa2010, and McMaster isolates, respectively. After 5 years of exclusive use, the nematodes developed resistance to levamisole, detected by FECRT and by increase in LC50 and LC90 for levamisole in the LDT. The 63-bp indel was not confirmed as a molecular marker of levamisole resistance in our isolates. The target selected treatment scheme was effective to control helminths in the sheep flock for 5 years, when levamisole?s inefficacy was perceived because of no change in the clinical situation of treated animals. Through this scheme, it was possible to promote reversion towards susceptibility or increase of efficacy for other chemical classes. Thus, this is a valid recommendation to control worms and to delay the development of resistance, preserving other anthelmintic classes for future use. 653 $aAcr8 gene 653 $aGenetic marker 653 $aHaemonchuscontortus isolates FECRT 653 $aLevamisole resistance 653 $aReversion 700 1 $aDOMINGUES, L. F. 700 1 $aALEMÁN GAINZA, Y. 700 1 $aBARIONI JUNIOR, W. 700 1 $aESTEVES, S. N. 700 1 $aNICIURA, S. C. M. 773 $tParasitology Research$gv. 115, n. 3, p. 1131-1139, mar. 2016.
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