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Registro Completo |
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Biblioteca(s): |
Embrapa Recursos Genéticos e Biotecnologia. |
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Data corrente: |
16/02/2005 |
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Data da última atualização: |
09/03/2005 |
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Autoria: |
LEITE, J. R. S. A.; SILVA, L. P.; RODRIGUES, M. I. S.; PRATES, M. V.; BRAND, G. D.; LACAVA, B. M.; AZEVEDO, R. B.; BOCCA, A. L.; ALBUQUERQUE, S.; BLOCH JUNIOR, C. |
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Título: |
Phylloseptins: a novel class of anti-bacterial and anti-protozoan peptides from Phyllomeduza genus. |
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Ano de publicação: |
2005 |
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Fonte/Imprenta: |
Peptides. |
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Idioma: |
Inglês |
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Conteúdo: |
Six novel peptides called phylloseptins (PS-1, -2, -3, -4, -5, and -6) showing anti-bacterial (PS-1) and anti-protozoan (PS-4 and -5) activities were isolated from the skin secretion of the Brazilian tree-frogs, Phyllomedusa hypochondrialis and Phyllomedusa oreades. Phylloseptins have a primary structure consisting of 19?21 amino acid residues (1.7?2.1 kDa). They have common structural features, such as a highly conserved N-terminal region and C-terminal amidation. Phylloseptin-1 (FLSLIPHAINAVSAIAKHN-NH2) demonstrated a strong effect against Gram-positive and Gram-negative bacteria (MICs ranging from 3 to 7.9 µM), without showing significant hemolytic activity (<0.6% at the MIC range) towards mammalian cells. Atomic force microscopy experiments indicated that the bacteriolytic properties of these peptides might be related to their disruptive action on the cell membrane, characterized by a number of bubble-like formations, preceding every cell lysis. PS-4 and PS-5 showed anti-protozoan activity with IC50 at about 5 µM for Trypanossoma cruzi. |
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Palavras-Chave: |
Phyllomedusa hypochondrialis; Phyllomedusa oreades. |
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Categoria do assunto: |
-- |
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URL: |
https://www.sciencedirect.com
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Marc: |
LEADER 01758naa a2200253 a 4500
001 1185517
005 2005-03-09
008 2005 bl --- 0-- u #d
100 1 $aLEITE, J. R. S. A.
245 $aPhylloseptins$ba novel class of anti-bacterial and anti-protozoan peptides from Phyllomeduza genus.
260 $c2005
520 $aSix novel peptides called phylloseptins (PS-1, -2, -3, -4, -5, and -6) showing anti-bacterial (PS-1) and anti-protozoan (PS-4 and -5) activities were isolated from the skin secretion of the Brazilian tree-frogs, Phyllomedusa hypochondrialis and Phyllomedusa oreades. Phylloseptins have a primary structure consisting of 19?21 amino acid residues (1.7?2.1 kDa). They have common structural features, such as a highly conserved N-terminal region and C-terminal amidation. Phylloseptin-1 (FLSLIPHAINAVSAIAKHN-NH2) demonstrated a strong effect against Gram-positive and Gram-negative bacteria (MICs ranging from 3 to 7.9 µM), without showing significant hemolytic activity (<0.6% at the MIC range) towards mammalian cells. Atomic force microscopy experiments indicated that the bacteriolytic properties of these peptides might be related to their disruptive action on the cell membrane, characterized by a number of bubble-like formations, preceding every cell lysis. PS-4 and PS-5 showed anti-protozoan activity with IC50 at about 5 µM for Trypanossoma cruzi.
653 $aPhyllomedusa hypochondrialis
653 $aPhyllomedusa oreades
700 1 $aSILVA, L. P.
700 1 $aRODRIGUES, M. I. S.
700 1 $aPRATES, M. V.
700 1 $aBRAND, G. D.
700 1 $aLACAVA, B. M.
700 1 $aAZEVEDO, R. B.
700 1 $aBOCCA, A. L.
700 1 $aALBUQUERQUE, S.
700 1 $aBLOCH JUNIOR, C.
773 $tPeptides.
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Registro original: |
Embrapa Recursos Genéticos e Biotecnologia (CENARGEN) |
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| 1. |  | MARESTONE, B. S.; TORRES, JUNIOR, R. A. A.; SILVA, L. O. C.; MENEZES, G. R. de O.; MUNIZ, C. A. S. D.; RIBEIRO, E. L. A. Genetic parameters for traditional and novel ultrasound carcass traits in Nellore cattle. Tropical Animal Health and Production, v. 54, article 34, 2022.| Tipo: Artigo em Periódico Indexado | Circulação/Nível: B - 1 |
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| Registros recuperados : 1 | |
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