Data/hora: 05/06/2024 06:24:56

Biblioteca(s): 	Embrapa Meio Ambiente.	
Tipo da produção científica: 	Artigo em Periódico Indexado	
Circulação/Nível: 	A - 1	
Data corrente: 	23/07/2018	
Data da última atualização: 	23/07/2018	
Autoria: 	MOURA, M. A. M. de; OLIVEIRA, R.; JONSSON, C. M.; DOMINGUES, I.; SOARES, A. M. V. da M.; NOGUEIRA, A. J. A.	
Afiliação: 	MONICA ACAUI MARCONDES DE MOURA, IB Campinas; RHAUL OLIVEIRA, UnB; CLAUDIO MARTIN JONSSON, CNPMA; INES DOMINGUES, Universidade de Aveiro; AMADEU MORTAGUA VELHO DA MAIA SOARES, Universidade de Aveiro.	
Título: 	The sugarcane herbicide ametryn induces oxidative stress and developmental abnormalities in zebrafish embryos.	
Ano de publicação: 	2018	
Fonte/Imprenta: 	Environmental Science and Pollution Research, v. 25, n. 14, p. 13416-13425, 2018.	
ISSN: 	1614-7499	
Idioma: 	Inglês	
Conteúdo: 	Abstract: Ametryn (AMT) is one of the most widely used herbicides in tropical sugarcane crops, the main culture of São Paulo State, Brazil. It is known as a diffuse pollutant, being found in surface water and sediment of water bodies adjacent to the crop fields. In the present study, the toxicity of AMT to zebrafish (Danio rerio) embryos was evaluated using developmental and biochemical endpoints. At the biochemical level, lactate dehydrogenase responded at the lowest concentration tested (4 ?g L-1) indicating a high demand of energy required to cope with the stress condition. Antioxidant enzyme levels were changed at intermediate/high concentrations while oxidative damage (lipid peroxidation) was observed at the last concentration tested (10 mg L-1). This suggests that, like for other herbicides from the triazine group, oxidative stress is a major pathway of toxicity for AMT. Several developmental effects such as oedemas and tail deformities were also observed. The 96 h-EC50 values calculated for different developmental parameters were between 17 and 29 mg L-1. AMT also affected hatching (96 h-EC50 = 22.5 mg L-1) and positioning in the water column (96 h-EC50 = 13.2 mg L-1). In a previous work of the group, lethal toxicity of AMT showed to be much higher to adults than to embryos. However, in the present work, sublethal endpoints assessed suggest that important effects are observed at lower concentrations, improving the sensitivity of the embryo test. Moreover, in this work, sublethal effects were observed for concentrations in the same range as the ones found in the environment, and thus, given that this chemical is widely used in tropical fields, a refined evaluation of risk should be performed based on the monitoring of sublethal and long-term parameters and considering mixture scenarios.	
Thesagro: 	Cana de Açúcar; Herbicida; Peixe de Água Doce; Toxidez.	
Thesaurus Nal: 	Agricultural runoff; Agrochemicals; Ametryn; Danio rerio; Embryotoxicity; Oxidative stress.	
Categoria do assunto: 	H Saúde e Patologia	
Registro original: 	Embrapa Meio Ambiente (CNPMA)	
Exemplares: 	CNPMA - (16136-1) - UPC - AP - DD -  -  -  - DIS