Data/hora: 03/06/2024 14:04:42

Biblioteca(s): 	Embrapa Cerrados.	
Tipo da produção científica: 	Artigo em Periódico Indexado	
Circulação/Nível: 	B - 1	
Data corrente: 	29/08/2013	
Data da última atualização: 	25/11/2013	
Autoria: 	OKINO, C. H.; ALESSI, A. C.; MONTASSIER, M. de F. S.; ROSA, A. J. de M.; WANG, X.; MONTASSIER, H. J.	
Afiliação: 	CINTIA HIROMI OKINO, CNPSA; ANTONIO CARLOS ALESSI; MARIA DE FÁTIMA SILVA MONTASSIER; ARTUR JORDAO DE MAGALHAES ROSA, CPAC; XIUQING WANG; HÉLIO JOSÉ MONTASSIER.	
Título: 	Humoral and Cell-Mediated Immune Responses to Different Doses of Attenuated Vaccine Against Avian Infectious Bronchitis Virus.	
Ano de publicação: 	2013	
Fonte/Imprenta: 	Viral Immunology, Nova York, v. 26, n. 4, p. 1-9, 2013.	
DOI: 	10.1089/vim.2013.0015	
Idioma: 	Inglês	
Conteúdo: 	The antibody and cellular immune responses against infectious bronchitis virus (IBV) were evaluated at mucosal sites of chickens after immunization with various doses of an attenuated vaccine at 1 day of age. The correlation of these immune responses with protection of tracheal tissues was evaluated after experimental infection of these birds. Significantly reduced tracheal pathologic effects, measured according to ciliostasis and histology lesions, and reduced viral load were observed only in the full-dose vaccinated group at 5 days post-infection (dpi), while incomplete protection was observed for the subdose vaccinated groups. Moreover, birds of vaccinated groups, especially with full dose, developed higher levels of lachrymal IBV-specific IgG and IgA and increased the expression of cell-mediated immunity (CMI) genes, such as gamma interferon (IFN gamma), CD8+ T cell marker, and granzyme homolog A more rapidly. In addition, these humoral and cellular immune responses evaluated at mucosal sites correlated significantly with tracheal protection against homologous IBV challenge in a vaccine dose-dependent manner. The results indicate that IgG, IgA and CD8+ T cell responses developed at mucosal sites after IBV vaccination of day-old chicks, could be taken as good correlates of protection against this virus. (AU)	
Palavras-Chave: 	Bronquite infecciosa aviária.	
Thesagro: 	Imunologia; Vacina; Virologia; Vírus.	
Thesaurus Nal: 	Aviculture; Immune response; Infectious Bronchitis; Vaccination.	
Categoria do assunto: 	--
L Ciência Animal e Produtos de Origem Animal	
Registro original: 	Embrapa Cerrados (CPAC)	
Exemplares: 	CNPSA - (19440-1) - ADD - AP - DD -  -  -  - DIS
CPAC - (33737-1) - UPC - AP - PP - CRI8041 -  - 2013.08041 - DIS