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Registros recuperados : 7 | |
1. | | SOARES, A. C.; SOARES, J. C.; PASCHOALIN, R. T.; RODRIGUES, V. C.; MELENDEZ, M. E.; REIS, R. M.; CARVALHO, A. L.; MATTOSO, L. H. C.; OLIVEIRA, O. N. Immunosensors containing solution blow spun fibers of poly(lactic acid) to detect p53 biomarker. Materials Science & Engineering C, v. 115, 2020. 1-10 Biblioteca(s): Embrapa Instrumentação. |
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2. | | SOARES, J. C.; IWAKI, L. E. O.; SOARES, A. C.; RODRIGUES, V. C.; MELENDEZ, M. E.; FREGNANI, J. H. T. G.; REIS, M. R.; CARVALHO, A. L.; CORREA, D. S.; OLIVEIRA JUNIOR, O. N. Immunosensor for pancreatic cancer based on electrospun nanofibers coated with carbon nanotubes or gold nanoparticles. ACS Omega, v. 2, p. 6975-6983, 2017. Biblioteca(s): Embrapa Instrumentação. |
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3. | | WIZIACK, N. K. L.; SCAPULATEMPO NETO, C.; MELENDEZ, M. E.; SANTIS, J. J. de; SOARES, A. C.; SOARES, J. C.; CORREA, D. S.; MATTOSO, L. H. C.; CARVALHO, A. L.; OLIVEIRA JR, O. N.; LEITE, F. de L. Evaluation of p53 biosensor for use in early non-invasive detection of cancer. In: BRAZILIAN MRS MEETING, 14., 2015, Rio de Janeiro. Program book... Rio de Janeiro: SBPMat, 2015. 2 p. Biblioteca(s): Embrapa Instrumentação. |
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4. | | SOARES, J. C.; MELENDEZ, M. E.; SOARES, A. C.; ARANTES, L. M. R. B.; RODRIGUES, V. C.; CARVALHO, A. L.; REIS, R. M.; MATTOSO, L. H. C.; OLIVEIRA JUNIOR, O. N. Detection of HPV16 in cell lines deriving from cervical and head and neck cancer using a genosensor made with a DNA probe on a layer-by-layer matrix. Materials Chemistry Frontiers, v. 4, n. 11, 2020. 3258-3266 Biblioteca(s): Embrapa Instrumentação. |
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5. | | PEREIRA, C. M.; CARVALHO, A. C. de; SILVA, F. R. da; MELENDEZ, M. E.; LESSA, R. C.; ANDRADE, V. C. C.; KOWALSKI, L. P.; VETTORE, A. L.; CARVALHO, A. L. In vitro and in silico validation of CA3 and FHL1 downregulation in oral cancer. BMC Cancer, v. 18, p. 1-10, 2018. Article number: 193. Biblioteca(s): Embrapa Agricultura Digital. |
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6. | | MATERÓN, E. M.; GÓMEZ, F. R.; ALMEIDA, M. B.; SHIMIZU, F. M.; WONG, A.; TEODORO, K. B. R.; SILVA, F. S. R.; LIMA, M. J. A.; ANGELIM, M. K. S. C.; MELENDEZ, M. E.; PORRAS, N.; VIEIRA, P. M.; CORREA, D. S.; CARRILHO, E.; OLIVEIRA, Jr., O. N.; AZEVEDO, R. B.; GONÇALVES, D. Colorimetric Detection of SARS-CoV-2 Using Plasmonic Biosensors and Smartphones ACS Applied Materials & Interfaces, v. 14, 2022 54527–54538 Biblioteca(s): Embrapa Instrumentação. |
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7. | | SOARES, J. C.; SOARES, A. C.; RODRIGUES, V. C.; OITICICA, P. R. A.; RAYMUNDO-PEREIRA, P. A.; BOTT-NETO, J. L.; BUSCAGLIA, L. A.; CASTRO, L. D. C. de; RIBAS, L. C.; SCABINI, L.; BRAZACA, L. C.; CORREA, D. S.; MATTOSO, L. H. C.; OLIVEIRA, M. C. F. de; CARVALHO, A. C. P. L. de; CARRILHO, E.; BRUNO, O. M.; MELENDEZ, M. E.; OLIVEIRA JR, O. N. Detection of a SARS-CoV-2 sequence with genosensors using data analysis based on information visualization and machine learning techniques. Materials Chemistry Frontiers, v. 5, 2021. 5658-5670 Biblioteca(s): Embrapa Instrumentação. |
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Registros recuperados : 7 | |
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Registro Completo
Biblioteca(s): |
Embrapa Instrumentação. |
Data corrente: |
05/06/2020 |
Data da última atualização: |
16/08/2022 |
Tipo da produção científica: |
Artigo em Periódico Indexado |
Circulação/Nível: |
A - 1 |
Autoria: |
SOARES, A. C.; SOARES, J. C.; PASCHOALIN, R. T.; RODRIGUES, V. C.; MELENDEZ, M. E.; REIS, R. M.; CARVALHO, A. L.; MATTOSO, L. H. C.; OLIVEIRA, O. N. |
Afiliação: |
LUIZ HENRIQUE CAPPARELLI MATTOSO, CNPDIA. |
Título: |
Immunosensors containing solution blow spun fibers of poly(lactic acid) to detect p53 biomarker. |
Ano de publicação: |
2020 |
Fonte/Imprenta: |
Materials Science & Engineering C, v. 115, 2020. |
Páginas: |
1-10 |
ISSN: |
0928-4931 |
DOI: |
https://doi.org/10.1016/j.msec.2020.111120 |
Idioma: |
Inglês |
Conteúdo: |
This paper reports on biosensors made with a matrix of polylactic acid (PLA) fibers, which are suitable for immobilization of the anti-p53 active layer for detection of p53 biomarker. The PLA fibers were produced with solution blow spinning, a method that is advantageous for its simplicity and possibility to tune the fiber properties. For the biosensors, the optimized time to deposit the fibers was 60 s, with which detection of p53 could be achieved with the limit of detection of 11 pg/mL using electrical impedance spectroscopy. This sensitivity is also sufficient to detect the p53 biomarker in patient samples, which was confirmed by distinguishing samples from cell lines with distinct p53 concentrations in a plot where the impedance spectra were visualized with the interactive document mapping (IDMAP) technique. The high sensitivity and selectivity of the biosensors may be attributed to the specific interaction between the active layer and p53 modeled with a Langmuir-Freundlich and Freundlich isotherms and inferred from the analysis of the vibrational bands at 1550, 1650 and 1757 cm−1 using polarization-modulated infrared reflection absorption spectroscopy (PM-IRRAS). The successful immobilization of the active layer is evidence that the approach based on solution blown spun fibers may be replicated to other types of biosensors. |
Palavras-Chave: |
Immunosensor; PLA fibers; Solution blow spinning. |
Categoria do assunto: |
-- |
Marc: |
LEADER 02209naa a2200289 a 4500 001 2123069 005 2022-08-16 008 2020 bl uuuu u00u1 u #d 022 $a0928-4931 024 7 $ahttps://doi.org/10.1016/j.msec.2020.111120$2DOI 100 1 $aSOARES, A. C. 245 $aImmunosensors containing solution blow spun fibers of poly(lactic acid) to detect p53 biomarker.$h[electronic resource] 260 $c2020 300 $a1-10 520 $aThis paper reports on biosensors made with a matrix of polylactic acid (PLA) fibers, which are suitable for immobilization of the anti-p53 active layer for detection of p53 biomarker. The PLA fibers were produced with solution blow spinning, a method that is advantageous for its simplicity and possibility to tune the fiber properties. For the biosensors, the optimized time to deposit the fibers was 60 s, with which detection of p53 could be achieved with the limit of detection of 11 pg/mL using electrical impedance spectroscopy. This sensitivity is also sufficient to detect the p53 biomarker in patient samples, which was confirmed by distinguishing samples from cell lines with distinct p53 concentrations in a plot where the impedance spectra were visualized with the interactive document mapping (IDMAP) technique. The high sensitivity and selectivity of the biosensors may be attributed to the specific interaction between the active layer and p53 modeled with a Langmuir-Freundlich and Freundlich isotherms and inferred from the analysis of the vibrational bands at 1550, 1650 and 1757 cm−1 using polarization-modulated infrared reflection absorption spectroscopy (PM-IRRAS). The successful immobilization of the active layer is evidence that the approach based on solution blown spun fibers may be replicated to other types of biosensors. 653 $aImmunosensor 653 $aPLA fibers 653 $aSolution blow spinning 700 1 $aSOARES, J. C. 700 1 $aPASCHOALIN, R. T. 700 1 $aRODRIGUES, V. C. 700 1 $aMELENDEZ, M. E. 700 1 $aREIS, R. M. 700 1 $aCARVALHO, A. L. 700 1 $aMATTOSO, L. H. C. 700 1 $aOLIVEIRA, O. N. 773 $tMaterials Science & Engineering C$gv. 115, 2020.
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