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| Registros recuperados : 591 | |
| 161. |  | BRASIL, E. C.; ALVES, V. M. C.; MARRIEL, I. E.; PITTA, G. V. E.; CARVALHO, J. G. de. Matéria seca e acúmulo de nutrientes em genótipos de milho contrastantes quanto a aquisição de fósforo. Ciência e agrotecnologia, Lavras, v. 31, n. 3, p. 704-712, 2007.| Biblioteca(s): Embrapa Amazônia Oriental; Embrapa Milho e Sorgo. |
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| 162. | | MARRIEL, I. E.; NEVES, A. L.; NEVES, A. A.; OLIVEIRA, A. C. de; OLIVEIRA-PAIVA, C. A.; SCHAFFERT, R. E. Metabolic diversity of diazotrophic bacteria isolates from Brazilian maize and sorghum cultivars by the biolog system. In: INTERNATIONAL SYMPOSIUM ON NITROGEN FIXATION WITH NON-LEGUMES, 11., 2008, Gent, Belgium. Abstracts... Belgium: Universiteit Gent, 2008. p. 40.| Biblioteca(s): Embrapa Milho e Sorgo. |
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| 163. | | MOREIRA, E. D. S.; MARRIEL, I. E.; GONTIJO NETO, M. M.; MELO, I. G.; LANA, A. M. Q. Microbiological activity under silvipastoral systems in the central region of Minas Gerais, Brazil. In: CONGRESO LATINOAMERICANO DE MICROBIOLOGIA, 24.; CONGRESO CHILENO DE MICROBIOLOGIA, 40.; REUNIÓN ANUAL DE LA ASSOCIACIÓN CHILENA DE INMUNOLOGIA, 2.; REUNIÓN DE LA SOCIEDAD LATINOAMERICANA DE TUBERCULOSIS Y OTRAS MICOBACTERIOSIS, 9., 2018, Santiago, Chile. Libro de resúmenes. Santiago: Asociación Latinoamericana de Microbiología, 2018. p. 1222.| Biblioteca(s): Embrapa Milho e Sorgo. |
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| 164. | | PAGANO, M. C.; UTIDA, M. K.; GOMES, E. A.; MARRIEL, I. E.; CABELLO, M. N.; SCOTTI, M. R. Plant-type dependent changes in arbuscular mycorrhizal communities as soil quality indicator in semi-arid Brazil. Ecological Indicators, v. 11, n. 2, p. 643-650, 2011.| Biblioteca(s): Embrapa Milho e Sorgo. |
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| 165. | | MARRIEL, I. E.; VASCONCELLOS, C. A.; FRANCA, G. E. de; SANTANA, D. P.; KONZEN, E. A.; OLIVEIRA, A. C. de. Perfil metabólico da comunidade microbiana como indicador da qualidade biológica do solo. In: CONGRESSO BRASILEIRO DE CIENCIA DO SOLO, 28., 2001, Londrina. Ciência do solo: fator de produtividade competitiva com sustentabilidade. Londrina: SBCS, 2001. p. 73.| Biblioteca(s): Embrapa Milho e Sorgo. |
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| 166. | | MARRIEL, I. E.; GUIMARAES, L. J. M.; SOARES, M. O.; GUIMARAES, P. E.; OLIVEIRA, A. C. de; MIRANDA, G. V. Performance de linhagens endogâmicas de milho melhoradas e não melhoradas para eficiência no uso de nitrogênio influenciada pela adubação nitrogenda. In: CONGRESSO NACIONAL DE MILHO E SORGO, 27.; SIMPOSIO BRASILEIRO SOBRE A LAGARTA-DO-CARTUCHO, SPODOPTERA FRUGIPERDA, 3.; WORKSHOP SOBRE MANEJO E ETIOLOGIA DA MANCHA BRANCA DO MILHO, 2008, Londrina. Agroenergia, produção de alimentos e mudanças climáticas: desafios para milho e sorgo: trabalhos e palestras. [Londrina]: IAPAR; [Sete Lagoas]: Embrapa Milho e Sorgo, 2008. 1 CD-ROM.| Biblioteca(s): Embrapa Milho e Sorgo. |
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| 169. | | OLIVEIRA-PAIVA, C. A.; SCHAFFERT, R. E.; ALVES, V. M. C.; BRASIL, E. C.; MARRIEL, I. E. Pêlos radiculares em genótipos de sorgo contrastantes para fósforo. In: CONGRESSO NACIONAL DE MILHO E SORGO, 24., 2002, Florianópolis, SC. Meio ambiente e a nova agenda para o agronegócio de milho e sorgo: [resumos expandidos]. Sete Lagoas: ABMS: Embrapa Milho e Sorgo; Florianópolis: Epagri, 2002.| Biblioteca(s): Embrapa Milho e Sorgo. |
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| 172. | | MOTA, Y. C. C.; HORTA, L. P.; SILVA, C. M. da; FÁTIMA, A. de; MARRIEL, I. E.; MODOLO, L. V. Eficiência no solo e estabilidade térmica de novos inibidores de urease. In: REUNIÃO BRASILEIRA DE FERTILIDADE DO SOLO E NUTRIÇÃO DE PLANTAS, 31.; REUNIÃO BRASILEIRA SOBRE MICORRIZAS, 15.; SIMPÓSIO BRASILEIRO DE MICROBIOLOGIA DO SOLO, 13.; REUNIÃO BRASILEIRA DE BIOLOGIA DO SOLO, 10., 2014, Araxá. Fertilidade e biologia do solo: integração e tecnologias para todos: anais. Araxá: Núcleo Regional Leste da Sociedade Brasileira de Ciência do Solo, 2014. FertBio 2014.| Biblioteca(s): Embrapa Milho e Sorgo. |
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| 173. | | FONSECA, L. M. F. da; REIS, D. P. dos; RIBAS, R. N. R.; OLIVEIRA-PAIVA, C. A.; MARRIEL, I. E. Eficiência no uso de nitrogênio em genótipo de milho inoculado com diferentes estirpes de Azospirillum sp. Hechos Microbiológicos, v. 5, n. 2, p. 96, 2014. Suplemento.
Edição das Memorias do 22º Congreso Latinoamericano de Microbiologia e 4º Congreso Colombiano de Microbiologia, Cartagena, 2014.| Biblioteca(s): Embrapa Milho e Sorgo. |
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| 174. | | MARRIEL, I. E.; PACHECO, C. A. P.; PURCINO, A. A. C.; MAGALHAES, J. R.; OLIVEIRA, A. C. Eficiência no uso de nitrogênio em populaçõpes de milho cultivadas sobre estresse. In: CONGRESSO BRASILEIRO DE FISIOLOGIA VEGETAL, 3., 1991, Viçosa, MG. Resumos... Vicosa: SBFV, 1991. p. 37.| Biblioteca(s): Embrapa Milho e Sorgo. |
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| 175. | | OLIVEIRA-PAIVA, C. A.; VASCONCELLOS, C. A.; MARRIEL, I. E.; PEREIRA FILHO, I. A.; SA, N. M. H. de. Efeito da temperatura sobre a fixação de N2 do feijoeiro. In: REUNIÃO BRASILEIRA DE FERTILIDADE DO SOLO E NUTRIÇÃO DE PLANTAS, 23.; REUNIÃO BRASILEIRA SOBRE MICORRIZAS, 7.; SIMPÓSIO BRASILEIRO DE MICROBIOLOGIA DO SOLO, 5.; REUNIÃO BRASILEIRA DE BIOLOGIA DO SOLO, 2., 1998. Caxambu, MG. FertBIO 98: resumos. Lavras: UFLA: SBCS: SBM, 1998. p. 181.| Biblioteca(s): Embrapa Milho e Sorgo. |
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| 176. | | ANDRADE, C. de L. T.; ALVARENGA, R. C.; COELHO, A. M.; MARRIEL, I. E.; TEIXEIRA, E. G. Dinâmica de água e soluto em um latossolo cultivado com milho irrigado: 2 - Lixiviação de nitrogênio. In: CONGRESSO NACIONAL DE IRRIGAÇÃO E DRENAGEM, 14.; ENCONTRO LATINOAMERICANO DE IRRIGAÇÃO, DRENAGEM E CONTROLE DE ENCHENTES, 1., 2004, Porto Alegre. Anais...Porto Alegre: ABID, 2004. 1 CD-ROM.| Biblioteca(s): Embrapa Milho e Sorgo. |
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| 178. | | OLIVEIRA, C. A. de; MUZZI, M. R. S.; PURCINO, H. A.; MARRIEL, I. E.; SÁ, N. M. H. de. Decomposition of Arachis pintoi and Hyparrhenia rufa litters in monoculture and intercropped systems under lowland soil. Pesquisa Agropecuária Brasileira, Brasília, DF, v. 38, n. 9, p. 1089-1095, set. 2003 ítulo em português: Decomposição da serrapilheira de Arachis pintoi e Hyparrhenia rufa em sistemasde monocultura e consórcio sob solo de várzea.| Biblioteca(s): Embrapa Algodão; Embrapa Unidades Centrais. |
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| 179. | | OLIVEIRA-PAIVA, C. A.; MUZZI, M. R. S.; PURCINO, H. A.; MARRIEL, I. E.; SA, N. M. H. de. Decomposition of Arachis pintoi and Hyparrhenia rufa litters in monoculture and intercropped systems under lowland soil. Pesquisa Agropecuária Brasileira, Brasília, v. 38, n. 9, p. 1089-1095, set. 2003.| Biblioteca(s): Embrapa Milho e Sorgo. |
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| 180. | | BRASIL, E. C.; ALVES, V. M. C.; MARRIEL, I. E.; OLIVEIRA, C. A. de; CARVALHO, J. G. de. Diversidade microbiana na rizosfera de híbridos de milho contrastantes na eficiência para fósforo sob condições controladas. In: REUNIAO BRASILEIRA DE FERTILIDADE DO SOLO E NUTRICAO DE PLANTAS, 25., REUNIAO BRASILEIRA SOBRE MICORRIZAS,9., SIMPOSIO BRASILEIRO DE MICROBIOLOGIA DO SOLO, 7, REUNIAO BRASILEIRA DE BIOLOGIA DO SOLO,4, 2002. Rio de Janeiro. FertBIO 2002: [resumos expandidos]. Rio de Janeiro: SBM: SBCS, 2002. 1 CD-ROM.| Biblioteca(s): Embrapa Amazônia Oriental. |
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| Registros recuperados : 591 | |
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Registro Completo
|
Biblioteca(s): |
Embrapa Milho e Sorgo. |
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Data corrente: |
12/08/2019 |
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Data da última atualização: |
24/01/2020 |
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Tipo da produção científica: |
Artigo em Periódico Indexado |
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Circulação/Nível: |
A - 2 |
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Autoria: |
OLIVEIRA, G. P.; LOPES, B. A.; MARRIEL, I. E.; LANA, U. G. de P.; TAKAHASHIA, J. A. |
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Afiliação: |
Geane P. Oliveira, Universidade Fedral de Minas Gerais; Barbara O. Lopes, Universidade Fedral de Minas Gerais; IVANILDO EVODIO MARRIEL, CNPMS; UBIRACI GOMES DE PAULA LANA, CNPMS; Jacqueline A. Takahashia, Universidade Fedral de Minas Gerais. |
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Título: |
Design of intelligent molecules as models for production of new anti-Alzheimer's medicines using epigenetic modulation. |
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Ano de publicação: |
2019 |
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Fonte/Imprenta: |
Chemical Engineering Transactions, v. 74, p. 1561-1566, 2019. |
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DOI: |
10.3303/CET1974261 |
|
Idioma: |
Inglês |
|
Conteúdo: |
Alzheimer's disease is a neurodegenerative illness, so far without cure, that affects an increasing number of people around the world. Due to the adverse effects caused by drugs for treating this disease currently in clinical use, it is necessary to search for more effective and less aggressive therapeutic resources. In this work a modern technological alternative was used to build new drugs useful for the treatment of Alzheimer's disease from fungi. This strategy consists on the development of pools of fungal molecules able of act in intelligent synergistic mechanisms to block acetylcholinesterase, enzyme involved in the development of Alzheimer's disease. Expression of pools containing new secondary metabolites can be achieved by adding DNA methyltransferase inhibitors to the fermentative process. This fast in vitro approach was used to build a combination of fungal metabolites containing acetylcholinesterase inhibitors. Biosynthesis elicitation was achieved by adding DNA methyltransferases inhibitors (hydralazine and procainamide) to solid culture media and then filamentous fungi Aspergillus chevalieri, Talaromyces calidicanius, Clonostachys rogersoniana, Fusarium nygamai, and Penicillium sp. were added. Straightforward HPLC analysis showed elicitation of new compounds by all species, being hydralazine the most effective epigenetic modifier especially towards T. calidicanius. Procainamide was able to enable expression of several major new secondary metabolites as for A. chevalieri (RT 51 min), and F. nygamai (RT 21.5 min). In general, the pools of molecules expressed after epigenetic modulation were more effective in acetylcholinesterase inhibition than the metabolites expressed without modulation. Modulation of C. rogersoniana by procainamide increased approximately four times the biosynthesis of antiacetylcholinesterase metabolites in relation to the control. T. calidicanius and Penicillium species modulated with procainamide produced a pool of metabolites about twice more active in regarding to the basal metabolome, while the pool of metabolites from C. rogersoniana and T. calidicanius were five and three times more active (40.34 ± 0.15% and 48.54 ± 1.34%, respectively) than the non-modulated extracts. MenosAlzheimer's disease is a neurodegenerative illness, so far without cure, that affects an increasing number of people around the world. Due to the adverse effects caused by drugs for treating this disease currently in clinical use, it is necessary to search for more effective and less aggressive therapeutic resources. In this work a modern technological alternative was used to build new drugs useful for the treatment of Alzheimer's disease from fungi. This strategy consists on the development of pools of fungal molecules able of act in intelligent synergistic mechanisms to block acetylcholinesterase, enzyme involved in the development of Alzheimer's disease. Expression of pools containing new secondary metabolites can be achieved by adding DNA methyltransferase inhibitors to the fermentative process. This fast in vitro approach was used to build a combination of fungal metabolites containing acetylcholinesterase inhibitors. Biosynthesis elicitation was achieved by adding DNA methyltransferases inhibitors (hydralazine and procainamide) to solid culture media and then filamentous fungi Aspergillus chevalieri, Talaromyces calidicanius, Clonostachys rogersoniana, Fusarium nygamai, and Penicillium sp. were added. Straightforward HPLC analysis showed elicitation of new compounds by all species, being hydralazine the most effective epigenetic modifier especially towards T. calidicanius. Procainamide was able to enable expression of several major new secondary metabolites as for A. c... Mostrar Tudo |
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Palavras-Chave: |
Doença neurodegenerativa; Moléculas fúngicas. |
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Thesagro: |
Doença; Fungo; Medicamento. |
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Categoria do assunto: |
S Ciências Biológicas |
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URL: |
https://ainfo.cnptia.embrapa.br/digital/bitstream/item/200581/1/Design-intelligent.pdf
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Marc: |
LEADER 02999naa a2200241 a 4500
001 2111258
005 2020-01-24
008 2019 bl uuuu u00u1 u #d
024 7 $a10.3303/CET1974261$2DOI
100 1 $aOLIVEIRA, G. P.
245 $aDesign of intelligent molecules as models for production of new anti-Alzheimer's medicines using epigenetic modulation.$h[electronic resource]
260 $c2019
520 $aAlzheimer's disease is a neurodegenerative illness, so far without cure, that affects an increasing number of people around the world. Due to the adverse effects caused by drugs for treating this disease currently in clinical use, it is necessary to search for more effective and less aggressive therapeutic resources. In this work a modern technological alternative was used to build new drugs useful for the treatment of Alzheimer's disease from fungi. This strategy consists on the development of pools of fungal molecules able of act in intelligent synergistic mechanisms to block acetylcholinesterase, enzyme involved in the development of Alzheimer's disease. Expression of pools containing new secondary metabolites can be achieved by adding DNA methyltransferase inhibitors to the fermentative process. This fast in vitro approach was used to build a combination of fungal metabolites containing acetylcholinesterase inhibitors. Biosynthesis elicitation was achieved by adding DNA methyltransferases inhibitors (hydralazine and procainamide) to solid culture media and then filamentous fungi Aspergillus chevalieri, Talaromyces calidicanius, Clonostachys rogersoniana, Fusarium nygamai, and Penicillium sp. were added. Straightforward HPLC analysis showed elicitation of new compounds by all species, being hydralazine the most effective epigenetic modifier especially towards T. calidicanius. Procainamide was able to enable expression of several major new secondary metabolites as for A. chevalieri (RT 51 min), and F. nygamai (RT 21.5 min). In general, the pools of molecules expressed after epigenetic modulation were more effective in acetylcholinesterase inhibition than the metabolites expressed without modulation. Modulation of C. rogersoniana by procainamide increased approximately four times the biosynthesis of antiacetylcholinesterase metabolites in relation to the control. T. calidicanius and Penicillium species modulated with procainamide produced a pool of metabolites about twice more active in regarding to the basal metabolome, while the pool of metabolites from C. rogersoniana and T. calidicanius were five and three times more active (40.34 ± 0.15% and 48.54 ± 1.34%, respectively) than the non-modulated extracts.
650 $aDoença
650 $aFungo
650 $aMedicamento
653 $aDoença neurodegenerativa
653 $aMoléculas fúngicas
700 1 $aLOPES, B. A.
700 1 $aMARRIEL, I. E.
700 1 $aLANA, U. G. de P.
700 1 $aTAKAHASHIA, J. A.
773 $tChemical Engineering Transactions$gv. 74, p. 1561-1566, 2019.
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