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| Registros recuperados : 378 | |
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 | Acesso ao texto completo restrito à biblioteca da Embrapa Caprinos e Ovinos. Para informações adicionais entre em contato com cnpc.biblioteca@embrapa.br. |
Registro Completo
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Biblioteca(s): |
Embrapa Agroindústria de Alimentos; Embrapa Caprinos e Ovinos. |
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Data corrente: |
13/12/2023 |
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Data da última atualização: |
13/12/2023 |
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Tipo da produção científica: |
Artigo em Periódico Indexado |
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Circulação/Nível: |
A - 3 |
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Autoria: |
PEREIRA, A. M. de S.; LIMA, L. C. de A. S.; LIMA, L. W. S.; MENEZES, T. M.; VIEIRA, A. M.; FRANCO, E. de S.; PAZ, S. T.; MAIA, C. S.; EGITO, A. S. do; SANTOS, K. M. O. dos; BURITI, F. C. A.; MAIA, M. B. de S. |
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Afiliação: |
ÁUREA MARCELA DE SOUZA PEREIRA, Federal University of Pernambuco; LARISSA CAROLINE DE ALMEIDA SOUSA LIMA, Federal University of Pernambuco; LAISA WANESSA SANTOS LIMA, Federal University of Pernambuco; TAMIRES MEIRA MENEZES, Federal University of Pernambuco; ÂNGELA MAGALHÃES VIEIRA, Aggeu Magalhães Institute, Oswaldo Cruz Foundation; ERYVELTON DE SOUZA FRANCO, Brazilian University Center (UNIBRA); SILVÂNIA TAVARES PAZ, Federal University of Pernambuco; CARINA SCANONI MAIA, Federal University of Pernambuco; ANTONIO SILVIO DO EGITO VASCONCELOS, CNPC; KARINA MARIA OLBRICH DOS SANTOS, CTAA; FLÁVIA CAROLINA ALONSO BURITI, State University of Paraíba; MARIA BERNADETE DE SOUSA MAIA, Federal University of Pernambuco. |
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Título: |
Safety evaluation of goat milk added with the prebiotic inulin fermented with the potentially probiotic native culture Limosilactobacillus mucosae CNPC007 in co-culture with Streptococcus thermophilus QGE: analysis of acute and repeated dose oral toxicity. |
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Ano de publicação: |
2023 |
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Fonte/Imprenta: |
Probiotics Antimicrob Proteins, v. 15, n. 3, p. 716-727, 2023. |
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DOI: |
https://doi.org/10.1007/s12602-021-09898-x |
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Idioma: |
Inglês |
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Conteúdo: |
Abstract: Despite functional goat milk products having emerged due to their importance for human nutrition and health, few studies have assessed the safety of consumption of goat dairy products containing potentially probiotic autochthonous lactic acid bacteria supplemented with prebiotic carbohydrates. Aiming this field, this study evaluated the safety of goat’s milk fermented with Streptococcus thermophilus QGE, the autochthonous Limosilactobacillus mucosae CNPC007 culture, and the prebiotic inulin, through single- and repeated-dose oral toxicity tests (SDT and RDT, respectively) in animals. Ten female Swiss Webster mice were used for SDT evaluation — 2 groups, SDTc (20 mL/kg of filtered water) and SDTt (20 mL/kg of fermented milk) — and 40 Wistar rats for RDT — RDT3, RDT6, and RDT12 (treated with fermented milk at doses of 3 mL/kg, 6 mL/kg, and 12 mL/kg, respectively) and also RDTc (12 mL/kg of filtered water). For SDT, no signs of mortality or toxicity were observed, and the animals maintained the expected weight gain and feed intake. The RDT trials did not show mortality or signs of toxicity, as well as no change in body weight and organs, in the hematological and biochemical parameters, and also in relation to morphology and histology. Since the fermented milk did not cause any toxic effect in the conditions evaluated, it can be said that its no-adverse effect level (NOAEL) was considered to be higher than 20 mL/kg/day. Thus, the fermented milk with L. mucosae CNPC007 and inulin was considered to be of low toxicity, safe for use in rodents, and allowed for use in further studies. MenosAbstract: Despite functional goat milk products having emerged due to their importance for human nutrition and health, few studies have assessed the safety of consumption of goat dairy products containing potentially probiotic autochthonous lactic acid bacteria supplemented with prebiotic carbohydrates. Aiming this field, this study evaluated the safety of goat’s milk fermented with Streptococcus thermophilus QGE, the autochthonous Limosilactobacillus mucosae CNPC007 culture, and the prebiotic inulin, through single- and repeated-dose oral toxicity tests (SDT and RDT, respectively) in animals. Ten female Swiss Webster mice were used for SDT evaluation — 2 groups, SDTc (20 mL/kg of filtered water) and SDTt (20 mL/kg of fermented milk) — and 40 Wistar rats for RDT — RDT3, RDT6, and RDT12 (treated with fermented milk at doses of 3 mL/kg, 6 mL/kg, and 12 mL/kg, respectively) and also RDTc (12 mL/kg of filtered water). For SDT, no signs of mortality or toxicity were observed, and the animals maintained the expected weight gain and feed intake. The RDT trials did not show mortality or signs of toxicity, as well as no change in body weight and organs, in the hematological and biochemical parameters, and also in relation to morphology and histology. Since the fermented milk did not cause any toxic effect in the conditions evaluated, it can be said that its no-adverse effect level (NOAEL) was considered to be higher than 20 mL/kg/day. Thus, the fermented milk with L. mucosae CNPC007 ... Mostrar Tudo |
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Palavras-Chave: |
Alimento funcional; Autochthonous; Autochthonous lactic acid bacteria; Bactéria lática; Coculture techniques; Cultured milk products; In vivo assay; No-adverse efect level; Prebiótico. |
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Thesagro: |
Fermentação Lática; Leite de Cabra; Leite Fermentado; Tecnologia de Alimento. |
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Thesaurus NAL: |
Dairy products; Females; Fermented milk; Food safety; Food technology; Goat milk; Goats; Inulin; Lactic acid bacteria; Lactic fermentation; Mice; Prebiotics; Rats; Streptococcus thermophilus. |
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Categoria do assunto: |
Q Alimentos e Nutrição Humana |
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Marc: |
LEADER 03475naa a2200589 a 4500
001 2159590
005 2023-12-13
008 2023 bl uuuu u00u1 u #d
024 7 $ahttps://doi.org/10.1007/s12602-021-09898-x$2DOI
100 1 $aPEREIRA, A. M. de S.
245 $aSafety evaluation of goat milk added with the prebiotic inulin fermented with the potentially probiotic native culture Limosilactobacillus mucosae CNPC007 in co-culture with Streptococcus thermophilus QGE$banalysis of acute and repeated dose oral toxicity.$h[electronic resource]
260 $c2023
520 $aAbstract: Despite functional goat milk products having emerged due to their importance for human nutrition and health, few studies have assessed the safety of consumption of goat dairy products containing potentially probiotic autochthonous lactic acid bacteria supplemented with prebiotic carbohydrates. Aiming this field, this study evaluated the safety of goat’s milk fermented with Streptococcus thermophilus QGE, the autochthonous Limosilactobacillus mucosae CNPC007 culture, and the prebiotic inulin, through single- and repeated-dose oral toxicity tests (SDT and RDT, respectively) in animals. Ten female Swiss Webster mice were used for SDT evaluation — 2 groups, SDTc (20 mL/kg of filtered water) and SDTt (20 mL/kg of fermented milk) — and 40 Wistar rats for RDT — RDT3, RDT6, and RDT12 (treated with fermented milk at doses of 3 mL/kg, 6 mL/kg, and 12 mL/kg, respectively) and also RDTc (12 mL/kg of filtered water). For SDT, no signs of mortality or toxicity were observed, and the animals maintained the expected weight gain and feed intake. The RDT trials did not show mortality or signs of toxicity, as well as no change in body weight and organs, in the hematological and biochemical parameters, and also in relation to morphology and histology. Since the fermented milk did not cause any toxic effect in the conditions evaluated, it can be said that its no-adverse effect level (NOAEL) was considered to be higher than 20 mL/kg/day. Thus, the fermented milk with L. mucosae CNPC007 and inulin was considered to be of low toxicity, safe for use in rodents, and allowed for use in further studies.
650 $aDairy products
650 $aFemales
650 $aFermented milk
650 $aFood safety
650 $aFood technology
650 $aGoat milk
650 $aGoats
650 $aInulin
650 $aLactic acid bacteria
650 $aLactic fermentation
650 $aMice
650 $aPrebiotics
650 $aRats
650 $aStreptococcus thermophilus
650 $aFermentação Lática
650 $aLeite de Cabra
650 $aLeite Fermentado
650 $aTecnologia de Alimento
653 $aAlimento funcional
653 $aAutochthonous
653 $aAutochthonous lactic acid bacteria
653 $aBactéria lática
653 $aCoculture techniques
653 $aCultured milk products
653 $aIn vivo assay
653 $aNo-adverse efect level
653 $aPrebiótico
700 1 $aLIMA, L. C. de A. S.
700 1 $aLIMA, L. W. S.
700 1 $aMENEZES, T. M.
700 1 $aVIEIRA, A. M.
700 1 $aFRANCO, E. de S.
700 1 $aPAZ, S. T.
700 1 $aMAIA, C. S.
700 1 $aEGITO, A. S. do
700 1 $aSANTOS, K. M. O. dos
700 1 $aBURITI, F. C. A.
700 1 $aMAIA, M. B. de S.
773 $tProbiotics Antimicrob Proteins$gv. 15, n. 3, p. 716-727, 2023.
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Embrapa Caprinos e Ovinos (CNPC) |
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