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| Registros recuperados : 38 | |
| 10. |  | MAGALHÃES, P. M. de; FIGUEIRA, G. M.; PEREIRA, B.; MONTANARI JÚNIOR, I. Conservação da espécie Maytenus ilicifolia, Mart. ex Reiss (espinheira-santa) através da técnica de propagação por sementes. Revista do Instituto Florestal, São Paulo, v. 4, pt. 2, p. 519-522, mar. 1992. Edição dos Anais do Congresso Florestal de Essências Nativas, 2., 1992, São Paulo. Edição especial.| Biblioteca(s): Embrapa Florestas. |
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| 16. | | CHAVES, F. C. M.; MAGALHÃES, P. M. de; HIDALGO, A. de F.; POHLIT, A. M. Produção de biomassa de Artemisia annua L. em três ecossistemas amazônicos. In: CONGRESSO BRASILEIRO DE OLERICULTURA, 49., 2009, Águas de Lindóia. Água na horticultura: novas atitudes e uso sustentável. Horticultura Brasileira, v. 27, n. 2, S2564-S2569, ago. 2009. Suplemento.| Biblioteca(s): Embrapa Amazônia Ocidental. |
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| 17. | | VAZ, A. P. A.; SCARANARI, C.; BATISTA, L. A. R.; FIGUEIRA, G. M.; SARTORATTO, A.; MAGALHÃES, P. M. de. Biomassa e composição química de genótipos melhorados de espécies medicinais cultivadas em quatro municípios paulistas. Pesquisa Agropecuária Brasileira, Brasília, DF, v. 41, n. 5, p. 869-872, maio 2006 Notas Científicas.
Título em inglês: Biomass and chemical composition of improved genotypes of medicinal plant species cultivated in four cities of São Paulo State, Brazil.| Biblioteca(s): Embrapa Unidades Centrais. |
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| 19. | | MANTOVANI, S.; MATTOSO, E.; FIGUEIRA, G. M.; MAGALHÃES, P. M. de; PEREIRA, B.; SILVA, D. B. da; MARSAIOLI, A. J. Avaliação química de espécies do gênero Mentha da coleção de plantas medicinais e aromáticas do CPQBA/UNICAMP. In: SIMPÓSIO BRASILEIRO DE ÓLEOS ESSENCIAIS, 3., 2005, Campinas. Campinas: Instituto Agronômico, 2005. p. 96.| Biblioteca(s): Embrapa Recursos Genéticos e Biotecnologia. |
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| 20. | | CHAVES, F. C. M.; MAGALHÃES, P. M. de; HIDALGO, A. de F.; FALCÃO, N. P. de S.; POHLIT, A. M. Produção de mudas de Artemisia annua L. em diferentes substratos na cidade de Manaus, Estado do Amazonas. In: CONGRESSO BRASILEIRO DE OLERICULTURA, 47.; SIMPÓSIO BRASILEIRO SOBRE CUCURBITÁCEAS, 4., 2007, Porto Seguro, BA. Resgatando e valorizando as hortaliças subutilizadas. Horticultura Brasileira, v. 25, n. 1, ago. 2007. 1 CD-ROM.| Biblioteca(s): Embrapa Amazônia Ocidental. |
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| Registros recuperados : 38 | |
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 | Acesso ao texto completo restrito à biblioteca da Embrapa Pecuária Sudeste. Para informações adicionais entre em contato com cppse.biblioteca@embrapa.br. |
Registro Completo
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Biblioteca(s): |
Embrapa Pecuária Sudeste. |
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Data corrente: |
09/11/2017 |
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Data da última atualização: |
21/11/2017 |
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Tipo da produção científica: |
Artigo em Periódico Indexado |
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Circulação/Nível: |
B - 3 |
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Autoria: |
SILVA, I. C. da; MAGALHAES, P. M. de; SOUSA, I. M. de O.; FOGLIO, M. A.; LEONARDECZ, E.; ESTEVES, S. N.; CHAGAS, A. C. de S. |
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Afiliação: |
Ives Charlie da Silva, UNESP; Pedro Melillo de Magalhães, UNICAMP; Ilza Maria de Oliveira Sousa, UNICAMP; Mary Ann Foglio, UNICAMP; Eduardo Leonardecz, UFSCar; SERGIO NOVITA ESTEVES, CPPSE; ANA CAROLINA DE SOUZA CHAGAS, CPPSE. |
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Título: |
Anthelmintic activity of Artemisia annua in sheepmodel. |
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Ano de publicação: |
2017 |
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Fonte/Imprenta: |
Journal of Medicinal Plants Research, v. 11, n. 7, p. 137-143, 2017. |
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DOI: |
10.5897/JMPR2016.6318 |
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Idioma: |
Inglês |
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Conteúdo: |
Artemisia annua L. is a well-known source of artemisinin, an antimalarial drug. This compound has been used in traditional medicine to treat malaria for many years. The anthelmintic property of A. annua has also been attributed to artemisinin, hence the belief that artemisinin could be useful as an alternative anthelmintic to control Haemonchus contortus in livestock. The present study focused on evaluating the anthelmintic activity of A. annua against H. contortus by oral administration on infected sheep in a controlled clinical trial. The trial was conducted using 24 male sheep of the Santa Inês breed, with average weight of 20 kg, artificially infected with H. contortus (Embrapa 2010 isolate). The animals were kept in metabolic cages and randomly divided into four homogeneous groups with six animals each, being: (T1) negative control (untreated), (T2) positive control: 10 mg/kg BW of levamisole phosphate, (T3) fed 10% A. annua (0.2% BW), (T4) fed 20% A. annua (0.4% BW). EPG counts were conducted on days -3, -2, -1, 0 (treatment day), 3, 7, 10, 14, 17, 21, 24 and 28 post-treatment. After extraction of the artemisinin in plant material, it was quantified in triplicate and analyzed by high-performance liquid chromatography with infrared detection. The average efficacy in the positive control treated with levamisole was 89%. Moderate anthelmintic efficacy against H. contortus was observed in the groups fed 0.2 and 0.4% BW A. annua for 30 days (32.9 and 14.8%, respectively), mainly from day 21 post treatment (47.1 and 25.2%, respectively). At the highest dose, the animals avoided eating due to the compound?s bitter taste. It is concluded that A. annua presents moderate anthelmintic activity in sheep in both doses. The lowest dose was accepted by animals and seems to have practical use. Oral administration was safe and after further in vivo trials could be introduced in organic farms in tropical countries. MenosArtemisia annua L. is a well-known source of artemisinin, an antimalarial drug. This compound has been used in traditional medicine to treat malaria for many years. The anthelmintic property of A. annua has also been attributed to artemisinin, hence the belief that artemisinin could be useful as an alternative anthelmintic to control Haemonchus contortus in livestock. The present study focused on evaluating the anthelmintic activity of A. annua against H. contortus by oral administration on infected sheep in a controlled clinical trial. The trial was conducted using 24 male sheep of the Santa Inês breed, with average weight of 20 kg, artificially infected with H. contortus (Embrapa 2010 isolate). The animals were kept in metabolic cages and randomly divided into four homogeneous groups with six animals each, being: (T1) negative control (untreated), (T2) positive control: 10 mg/kg BW of levamisole phosphate, (T3) fed 10% A. annua (0.2% BW), (T4) fed 20% A. annua (0.4% BW). EPG counts were conducted on days -3, -2, -1, 0 (treatment day), 3, 7, 10, 14, 17, 21, 24 and 28 post-treatment. After extraction of the artemisinin in plant material, it was quantified in triplicate and analyzed by high-performance liquid chromatography with infrared detection. The average efficacy in the positive control treated with levamisole was 89%. Moderate anthelmintic efficacy against H. contortus was observed in the groups fed 0.2 and 0.4% BW A. annua for 30 days (32.9 and 14.8%, respectively), m... Mostrar Tudo |
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Thesaurus NAL: |
artemisinin; gastrointestinal nematodes; sesquiterpenoids. |
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Categoria do assunto: |
L Ciência Animal e Produtos de Origem Animal |
|
Marc: |
LEADER 02655naa a2200241 a 4500
001 2079284
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008 2017 bl uuuu u00u1 u #d
024 7 $a10.5897/JMPR2016.6318$2DOI
100 1 $aSILVA, I. C. da
245 $aAnthelmintic activity of Artemisia annua in sheepmodel.$h[electronic resource]
260 $c2017
520 $aArtemisia annua L. is a well-known source of artemisinin, an antimalarial drug. This compound has been used in traditional medicine to treat malaria for many years. The anthelmintic property of A. annua has also been attributed to artemisinin, hence the belief that artemisinin could be useful as an alternative anthelmintic to control Haemonchus contortus in livestock. The present study focused on evaluating the anthelmintic activity of A. annua against H. contortus by oral administration on infected sheep in a controlled clinical trial. The trial was conducted using 24 male sheep of the Santa Inês breed, with average weight of 20 kg, artificially infected with H. contortus (Embrapa 2010 isolate). The animals were kept in metabolic cages and randomly divided into four homogeneous groups with six animals each, being: (T1) negative control (untreated), (T2) positive control: 10 mg/kg BW of levamisole phosphate, (T3) fed 10% A. annua (0.2% BW), (T4) fed 20% A. annua (0.4% BW). EPG counts were conducted on days -3, -2, -1, 0 (treatment day), 3, 7, 10, 14, 17, 21, 24 and 28 post-treatment. After extraction of the artemisinin in plant material, it was quantified in triplicate and analyzed by high-performance liquid chromatography with infrared detection. The average efficacy in the positive control treated with levamisole was 89%. Moderate anthelmintic efficacy against H. contortus was observed in the groups fed 0.2 and 0.4% BW A. annua for 30 days (32.9 and 14.8%, respectively), mainly from day 21 post treatment (47.1 and 25.2%, respectively). At the highest dose, the animals avoided eating due to the compound?s bitter taste. It is concluded that A. annua presents moderate anthelmintic activity in sheep in both doses. The lowest dose was accepted by animals and seems to have practical use. Oral administration was safe and after further in vivo trials could be introduced in organic farms in tropical countries.
650 $aartemisinin
650 $agastrointestinal nematodes
650 $asesquiterpenoids
700 1 $aMAGALHAES, P. M. de
700 1 $aSOUSA, I. M. de O.
700 1 $aFOGLIO, M. A.
700 1 $aLEONARDECZ, E.
700 1 $aESTEVES, S. N.
700 1 $aCHAGAS, A. C. de S.
773 $tJournal of Medicinal Plants Research$gv. 11, n. 7, p. 137-143, 2017.
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