Data/hora: 02/06/2024 07:17:30

Biblioteca(s): 	Embrapa Florestas.	
Data corrente: 	10/01/2022	
Data da última atualização: 	14/02/2022	
Autoria: 	LOURENÇON, T. V.; LIMA, G. G. de; RIBEIRO, C. S. P.; HANSEL, F. A.; MACIEL, G. M.; SILVA, K. da; WINNISCHOFER, S. M. B.; BOLZON DE MUNIZ, G. I.; MAGALHAES, W. L. E.	
Afiliação: 	TAINISE V. LOURENÇON, Doutoranda da UFPR; GABRIEL G. DE LIMA, Pós-doutorando da UFPR; CAROLINA S. P. RIBEIRO, UFPR; FABRICIO AUGUSTO HANSEL, CNPF; GISELLE M. MACIEL, UFPR; KRISLE DA SILVA, CNPF; SHEILA M. B. WINNISCHOFER, UTFPR; GRACIELA I. BOLZON DE MUNIZ, UFPR; WASHINGTON LUIZ ESTEVES MAGALHAES, CNPF.	
Título: 	Antioxidant, antibacterial and antitumoural activities of kraft lignin fromhardwood fractionated by acid precipitation.	
Ano de publicação: 	2021	
Fonte/Imprenta: 	International Journal of Biological Macromolecules, v. 166, p. 1535-1542, Jan. 2021.	
DOI: 	https://doi.org/10.1016/j.ijbiomac.2020.11.033	
Idioma: 	Inglês	
Conteúdo: 	Kraft lignin, so far useful for energy generation, has been gathering considerable attention as an alternative ma-terial to replace fossil-based resources mainly due to its high phenolic content. However, the wide molecularweight distribution and chemical composition heterogeneity led to the development of fractionation methods.Herein, to narrow such characteristics weusedeucalypt kraft lignin fractionated atpH's 9,7, 5 and 3 bysequentialacid precipitation. These lignin fractions werefirst characterised by simultaneous pyrolysis andtrimethylsilylation (SPyT) with N-Methyl-N-(trimethylsilyl) trifluoroacetamide with posterior tests of antioxi-dant, antibacterial, and antitumour activities. We observed higher ratio of syringyl/guaiacyl groups and increasein antioxidant activity in those fractions with lower molecular weight (precipitated at lower pH's). Fractions pre-cipitated at pH's 9 and 7 have shown an outstanding antibacterial activity againstfive bacteria. Moreover, frac-tions 7 and 5 presented at cytotoxicity tests higher ability to inhibit the growth of U87MG and T98G gliomacells, while only a slight inhibition of adult humanfibroblasts (non-tumour cells) was detected.	
Palavras-Chave: 	Antibacterial; Antitumoral; Antitumoural; Hardwood lignin; IC50; Radical scavenging; Technical lignin.	
Thesagro: 	Antioxidante; Bactericida; Lignina.	
Categoria do assunto: 	X Pesquisa, Tecnologia e Engenharia	
Registro original: 	Embrapa Florestas (CNPF)	
Exemplares: 	CNPF - (57995-1) - UPC - AP - DD -  -  -  - DIS