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| Registros recuperados : 7 | |
| 5. |  | LINDSAY, D. S.; RIPPEY, N. S.; POWE, T. A.; SARTIN, E. A.; DUBEY, J. P.; BLAGBURN, B. L. Abortions, fetal death, and stillbirths in pregnant pygmy goats inocu-lated with tachyzoites of Neospora caninum. American Journal of Veterinary Research, v.56, n.9, p.1176-1180, 1995.| Biblioteca(s): Embrapa Caprinos e Ovinos. |
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| 6. | | KATITI, L. M.; JORGES, F. S.; GONZALEZ, J. M.; ZAJAC, A. M.; LINDSAY, D. S.; CHAGAS, A. C. de S.; AMARANTE, A. F. T. Anthelmintic effect of plant extracts containing condensed and hydrolyzable tannins on Caenorhabditis elegans, and their antioxidant capacity. Veterinary Parasitlogy, v. 192, n. 1-3, p. 218-227, feb. 2013.| Biblioteca(s): Embrapa Pecuária Sudeste. |
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| 7. | | KATIKI, L. M.; FERREIRA, J. F. S.; ZAJAC, A. M.; MASLER, C.; LINDSAY, D. S.; CHAGAS, A. C. de S.; AMARANTE, A. F. T. Caenorhabditis elegans as a model to screen plant extracts and compounds as natural anthelmintics for veterinary use. Veterinary Parasitology, v. 182, n. 2-4, p. 264-268, dec. 2011.| Biblioteca(s): Embrapa Pecuária Sudeste. |
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| Registros recuperados : 7 | |
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 | Acesso ao texto completo restrito à biblioteca da Embrapa Pecuária Sudeste. Para informações adicionais entre em contato com cppse.biblioteca@embrapa.br. |
Registro Completo
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Biblioteca(s): |
Embrapa Pecuária Sudeste. |
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Data corrente: |
22/11/2012 |
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Data da última atualização: |
10/03/2023 |
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Tipo da produção científica: |
Artigo em Periódico Indexado |
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Circulação/Nível: |
A - 1 |
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Autoria: |
KATITI, L. M.; JORGES, F. S.; GONZALEZ, J. M.; ZAJAC, A. M.; LINDSAY, D. S.; CHAGAS, A. C. de S.; AMARANTE, A. F. T. |
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Afiliação: |
LUCIANA M. KATIKI, INSTITUTO DE ZOOTECNIA/NOVA ODESSA; JORGE F. S. FERREIRA, Appalachian Farming Systems Research Center (USDA-ARS); JAVIER M. GONZALEZ, Appalachian Farming Systems Research Center (USDA-ARS); ANNE M. ZAJAC, Virginia-Maryland Regional College of Veterinary Medicine; DAVID S. LINDSAY, Virginia-Maryland Regional College of Veterinary Medicine; ANA CAROLINA DE SOUZA CHAGAS, CPPSE; ALESSANDRO F. T. AMARANTE, Universidade Estadual Paulista. |
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Título: |
Anthelmintic effect of plant extracts containing condensed and hydrolyzable tannins on Caenorhabditis elegans, and their antioxidant capacity. |
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Ano de publicação: |
2013 |
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Fonte/Imprenta: |
Veterinary Parasitlogy, v. 192, n. 1-3, p. 218-227, feb. 2013. |
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DOI: |
http://dx.doi.org/10.106/j.vetpar.2012.09.30. |
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Idioma: |
Inglês |
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Conteúdo: |
Although tannin-rich forages are known to increase protein uptake and to reduce gastrointestinal nematode infections in grazing ruminants, most published research involves forages with condensed tannins (CT), while published literature lacks information on the anthelmintic capacity, nutritional benefits, and antioxidant capacity of alternative forages containing hydrolyzable tannins (HT). We evaluated the anthelmintic activity and the antioxidant capacity of plant extracts containing either mostly CT, mostly HT, or both CT and HT. Extracts were prepared with 70% acetone, lyophilized, redissolved to doses ranging from 1.0 mg/mL to 25 mg/mL, and tested against adult Caenorhabditis elegans as a test model. The extract concentrations that killed 50% (LC50) or 90% (LC90) of the nematodes in 24 h were determined and compared to the veterinary anthelmintic levamisole (8 mg/mL). Extracts were quantified for CT by the acid butanol assay, for HT (based on gallic acid and ellagic acid) by high-performance liquid chromatography (HPLC) and total phenolics, and for their antioxidant activity by the oxygen radical absorbance capacity (ORAC) assay. Extracts with mostly CT were Lespedeza cuneata, Salix X sepulcralis, and Robinia pseudoacacia. Extracts rich in HT were Acer rubrum, Rosa multiflora, and Quercus alba, while Rhus typhina had both HT and CT. The extracts with the lowest LC50 and LC90 concentrations, respectively, in the C. elegans assay were Q. alba (0.75 and 1.06 mg/mL), R. typhina collected in 2007 (0.65 and 2.74 mg/mL), A. rubrum (1.03 and 5.54 mg/mL), and R. multiflora (2.14 and 8.70 mg/mL). At the doses of 20 and 25 mg/mL, HT-rich, or both CT- and HT-rich, extracts were significantly more lethal to adult C. elegans than extracts containing only CT. All extracts were high in antioxidant capacity, with ORAC values ranging from 1800 moles to 4651 moles of trolox equivalents/g, but ORAC did not correlate with anthelmintic activity. The total phenolics test had a positive and highly significant (r = 0.826, p ≤ 0.01) correlation with total hydrolyzable tannins. Plants used in this research are naturalized to the Appalachian edaphoclimatic MenosAlthough tannin-rich forages are known to increase protein uptake and to reduce gastrointestinal nematode infections in grazing ruminants, most published research involves forages with condensed tannins (CT), while published literature lacks information on the anthelmintic capacity, nutritional benefits, and antioxidant capacity of alternative forages containing hydrolyzable tannins (HT). We evaluated the anthelmintic activity and the antioxidant capacity of plant extracts containing either mostly CT, mostly HT, or both CT and HT. Extracts were prepared with 70% acetone, lyophilized, redissolved to doses ranging from 1.0 mg/mL to 25 mg/mL, and tested against adult Caenorhabditis elegans as a test model. The extract concentrations that killed 50% (LC50) or 90% (LC90) of the nematodes in 24 h were determined and compared to the veterinary anthelmintic levamisole (8 mg/mL). Extracts were quantified for CT by the acid butanol assay, for HT (based on gallic acid and ellagic acid) by high-performance liquid chromatography (HPLC) and total phenolics, and for their antioxidant activity by the oxygen radical absorbance capacity (ORAC) assay. Extracts with mostly CT were Lespedeza cuneata, Salix X sepulcralis, and Robinia pseudoacacia. Extracts rich in HT were Acer rubrum, Rosa multiflora, and Quercus alba, while Rhus typhina had both HT and CT. The extracts with the lowest LC50 and LC90 concentrations, respectively, in the C. elegans assay were Q. alba (0.75 and 1.06 mg/mL), R. typhi... Mostrar Tudo |
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Palavras-Chave: |
Antioxidant capacity; Hydrolyzable tannins; Tree tannins. |
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Thesaurus NAL: |
small ruminants; tannins. |
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Categoria do assunto: |
H Saúde e Patologia |
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Marc: |
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024 7 $ahttp://dx.doi.org/10.106/j.vetpar.2012.09.30.$2DOI
100 1 $aKATITI, L. M.
245 $aAnthelmintic effect of plant extracts containing condensed and hydrolyzable tannins on Caenorhabditis elegans, and their antioxidant capacity.$h[electronic resource]
260 $c2013
520 $aAlthough tannin-rich forages are known to increase protein uptake and to reduce gastrointestinal nematode infections in grazing ruminants, most published research involves forages with condensed tannins (CT), while published literature lacks information on the anthelmintic capacity, nutritional benefits, and antioxidant capacity of alternative forages containing hydrolyzable tannins (HT). We evaluated the anthelmintic activity and the antioxidant capacity of plant extracts containing either mostly CT, mostly HT, or both CT and HT. Extracts were prepared with 70% acetone, lyophilized, redissolved to doses ranging from 1.0 mg/mL to 25 mg/mL, and tested against adult Caenorhabditis elegans as a test model. The extract concentrations that killed 50% (LC50) or 90% (LC90) of the nematodes in 24 h were determined and compared to the veterinary anthelmintic levamisole (8 mg/mL). Extracts were quantified for CT by the acid butanol assay, for HT (based on gallic acid and ellagic acid) by high-performance liquid chromatography (HPLC) and total phenolics, and for their antioxidant activity by the oxygen radical absorbance capacity (ORAC) assay. Extracts with mostly CT were Lespedeza cuneata, Salix X sepulcralis, and Robinia pseudoacacia. Extracts rich in HT were Acer rubrum, Rosa multiflora, and Quercus alba, while Rhus typhina had both HT and CT. The extracts with the lowest LC50 and LC90 concentrations, respectively, in the C. elegans assay were Q. alba (0.75 and 1.06 mg/mL), R. typhina collected in 2007 (0.65 and 2.74 mg/mL), A. rubrum (1.03 and 5.54 mg/mL), and R. multiflora (2.14 and 8.70 mg/mL). At the doses of 20 and 25 mg/mL, HT-rich, or both CT- and HT-rich, extracts were significantly more lethal to adult C. elegans than extracts containing only CT. All extracts were high in antioxidant capacity, with ORAC values ranging from 1800 moles to 4651 moles of trolox equivalents/g, but ORAC did not correlate with anthelmintic activity. The total phenolics test had a positive and highly significant (r = 0.826, p ≤ 0.01) correlation with total hydrolyzable tannins. Plants used in this research are naturalized to the Appalachian edaphoclimatic
650 $asmall ruminants
650 $atannins
653 $aAntioxidant capacity
653 $aHydrolyzable tannins
653 $aTree tannins
700 1 $aJORGES, F. S.
700 1 $aGONZALEZ, J. M.
700 1 $aZAJAC, A. M.
700 1 $aLINDSAY, D. S.
700 1 $aCHAGAS, A. C. de S.
700 1 $aAMARANTE, A. F. T.
773 $tVeterinary Parasitlogy$gv. 192, n. 1-3, p. 218-227, feb. 2013.
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